An international research effort led by Duke Cancer Institute scientists has been working to better understand the genetic underpinnings of the most prevalent form of this cancer -- diffuse large B cell lymphoma – and how those genes might play a role in patients’ responses to therapies.
Researchers from the University of Toledo (Ohio) College of Medicine and Life Sciences have discovered more than 12,000 different types of noncoding RNA (circRNAs) in the kidney tissue of rats. This type of genetic material, previously thought to have no function, may play a significant role in regulating blood pressure in heart and kidney disease.
No disorder appears to kill more people than atherosclerosis, and hopeful experimental treatments with "good cholesterols" have failed. New research reapproaches them with carefully designed cholesterols in an organ-on-a-chip in highly reproducible experiments.
Researchers have shown, for the first time, that reduced dietary potassium promotes elevated aortic stiffness in a mouse model. Such arterial stiffness in humans is predictive of heart disease and death from heart disease, and it represents an important health problem for the nation.
Women who develop high blood pressure in their 40s may be more likely to develop dementia years later, according to a study published in the October 4, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology.
To reduce the burden of anemia, health officials need a better picture of the disease's global impact, an understanding made viable by a portable and affordable way to analyze blood. Researchers at the University of Washington developed a device smaller than a toaster that can detect the level of hemoglobin in whole blood samples using optical absorbance. The work is published this week in AIP Advances.
Proactive monitoring of blood levels of the therapeutic drug infliximab was associated with improved outcomes including lower risk of surgery and hospitalization.
New insight into how the protein antithrombin works could lead to treatments not only for patients with antithrombin deficiency, but also to better-designed drugs for other blood disorders.
Shlomo Melmed, MB, ChB, executive vice president, Academic Affairs, and dean of the medical faculty at Cedars-Sinai, has won the 2018 Outstanding Scholarly Physician Award from the Endocrine Society, the largest global membership organization representing professionals in endocrinology. The annual award recognizes outstanding contributions to the practice of clinical endocrinology in academic settings.
Southern Illinois University School of Medicine and the University of Chicago Medicine will use a $1.13 million federal grant to study the opioid epidemic affecting the state’s 16 southernmost counties.
A review of the weight gain risks and challenges faced by women in midlife has led Mayo Clinic researchers to a series of recommendations for this patient population. The findings are published in this month's edition of Mayo Clinic Proceedings.
To pass the nearly 180 days she was a patient in Seattle Children’s Cancer Unit with graft-versus-host disease (GVHD), London Bowater took orders from her doctors, nurses and other patients and families for friendship bracelets that she would braid from her hospital bed.
Magnetic resonance imaging appears to be safe for patients with cardiac implantable electronic devices, even for chest imaging, according to a new study by researchers from the Intermountain Medical Center Heart Institute.
UNC School of Medicine cardiologist Anil Gehi, MD, will use a $1.7 million grant from the Bristol-Myers Squibb Foundation to further innovate a care model, launched in 2015, that reduced hospitalizations for patients with atrial fibrillation (Afib) presenting in the emergency room by more than 30 percentage points in its first year.
• Among hemodialysis patients admitted to the hospital, nearly a quarter of admissions were followed by an unplanned readmission within 30 days. • Most readmissions were for a diagnosis different than the one for the initial hospitalization. • A small proportion of patients accounted for a disproportionate number of readmissions.
A team of researchers from Memorial Sloan Kettering Cancer Center (MSK) and Weill-Cornell Medical College have identified, for the first time, a new molecular pathway that is required for acute myeloid leukemia (AML) development. This work could provide a rationale for targeting the RNA methylation program in myeloid leukemia.
UVA has administered its first dose of an experimental gene therapy for a deadly form of treatment-resistant pediatric leukemia.
A genetic fault has been identified in people with an aggressive type of leukaemia that can significantly affect how they respond to treatment.
A new study finds that genetic testing can help determine the safest dose of the blood thinner warfarin, with fewer side effects, in patients undergoing joint replacement surgery.
A new study led by Washington University School of Medicine in St. Louis shows that dosing warfarin (Coumadin and others) is safer — producing fewer adverse events such as hemorrhage — when key elements of a patient’s genetic makeup are considered.
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