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Researchers have designed a molecule that slows the effects of one of SARS-CoV-2's more dangerous components – an enzyme called a protease that cuts off the immune system's communications and helps the virus replicate. While much more needs to happen to develop a drug, scientists can begin to imagine what that drug could look like – thanks to new images of the molecule bound to the protease.

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A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

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Scientists report using a single-atom-thick nanomaterial to build a device that can simultaneously detect the presence of the viruses that cause COVID-19 and the flu — at much lower levels and much more quickly than conventional tests for either. They will present their results at ACS Spring 2023.

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Researchers examined how a country’s number of published 3D protein structures for coronaviruses correlated with its economic output and population. The findings reveal important insights into how different countries' research establishments respond to disease outbreaks.

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People infected with SARS-CoV-2, the virus that causes COVID-19, may experience genome structure changes that not only may explain our immunological symptoms after infection, but also potentially link to long COVID, according to a new study by researchers at UTHealth Houston.

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Nearly a third of Americans (29%) say COVID-19 made them more worried than ever about having obesity prompting about 28 million people to consider weight-loss methods they hadn’t thought about before the pandemic began, including nearly 6.4 million thought about turning to either weight-loss surgery or taking prescription anti-obesity drugs for the first time, according to a new survey whose findings were published online in the peer-reviewed journal, Surgery for Obesity and Related Diseases (SOARD).

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UC San Diego researchers describe why SARS-CoV-2 subvariants spread more rapidly than the original virus strain, and how an early treatment might have made people more susceptible to future infections.

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Post-acute sequelae SARS-CoV-2 infection (PASC), also known as long-haul COVID-19, is positively associated with posttraumatic stress disorder (PTSD), says new research presented at Physiatry ’23, the Association of Academic Physiatrists (AAP) annual meeting.

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A UCLA-led team has developed an inexpensive, universal oral COVID-19 vaccine that prevented severe respiratory illness and weight loss when tested in hamsters, which are naturally susceptible to SARS-CoV-2. It proved as effective as vaccines administered by injection or intranasally in the research. If ultimately approved for human use, it could be a weapon against all COVID-19 variants and boost uptake, particularly in low- and middle-income countries, and among those with an aversion to needles.

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Early COVID-19 pandemic suspicions about dogs’ resistance to the disease have given way to a long-haul clinical data gap as new variants of the virus have emerged.

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The magnitude and quality of a key immune cell’s response to vaccination with two doses of the Pfizer-BioNTech COVID-19 vaccine were considerably lower in people with prior SARS-CoV-2 infection compared to people without prior infection, a study has found.

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Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

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New research from Leela Nageswaran, assistant professor of operations management in the University of Washington Foster School of Business, considers whether individuals should be able to select their vaccine type.

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Anthony DiStefano, professor of public health at Cal State Fullerton, believes that the sudden social isolation that occurred during the COVID-19 pandemic had an influence on mental health and drug overdose deaths.

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Research is shedding light on why ‘breakthrough’ Omicron infections occur in vaccinated individuals and suggests those who are both vaccinated and experienced previous infection have better protection against getting sick again.

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COVID-19 has caused significant global panic after its rapid emergence more than 3 years ago.

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The Acute Hospital Rehabilitation Intensive Service (ARISE) program, developed in 2020 by the Johns Hopkins Department of Physical Medicine and Rehabilitation (PM&R), may increase the chances of patients hospitalized with COVID-19 getting discharged to their home rather than to a rehabilitation facility that provides post-hospitalization care services.

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UVA Health researchers have identified a potential treatment to prevent severe COVID-19 in patients at great risk.

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The next pandemic that cascades through the human population could be caused by a new influenza virus strain concocted in animals, against which humans will have little to no immunity.

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In reviewing data from previous studies, a team lead by researchers at the University of Chicago and the French National Institute of Health and Medical Research (Inserm) found that individuals who had fewer than six hours of sleep per night in the days surrounding vaccination had a blunted antibody response. That indicates efforts to promote heathy sleep duration ahead of an immunization could be an easy way to improve vaccine effectiveness.

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Sleeping fewer than six hours per night around the time of vaccination was associated with a robust decrease in antibody response, researchers found.

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According to a new study published by Mayo Clinic researchers, the COVID-19 pandemic was linked to a 17% increase in the death rate in Minnesota during the first year of the pandemic compared to the two previous years.

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After three years of pandemic living, loneliness, isolation and lack of social contact have finally started to decline among older adults, a new poll shows.

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The constant evolution of new COVID-19 variants makes it critical for clinicians to have multiple therapies in their arsenal for treating drug-resistant infections. Researchers have now discovered that a new class of oral drugs that acts directly on human cells can inhibit a diverse range of pathogenic SARS-CoV-2 strains. In their newly published study, the team found a novel mechanism through which the gene that expresses angiotensin converting enzyme-2 (ACE-2)—the cellular receptor to which SARS-CoV-2 binds so that it can enter and infect the cell—is turned on.

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The rapid transition from in-person to care to telemedicine visits at the start of the COVID 19 pandemic did not adversely affect the quality of care – and even improved some aspects of care – for patients with major depression in a major integrated health system, according to a new report. The study appears as part of a special "Virtual Visits" supplement to Medical Care, published in the Lippincott portfolio by Wolters Kluwer.

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Researchers at the California Academy of Sciences, along with a collaborator at Denison University, have developed an innovative new model to assess how the California economy might have fared without economic closures to slow the spread of the coronavirus pandemic.

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A new class of oral drugs can inhibit a wide range of SARS-CoV-2 variants, researchers report, potentially identifying new antiviral agents providing broad activity against the constantly emerging new strains of the COVID-19 virus