Senescent cells are cells that have permanently stopped dividing in response to cellular stress but have not died. As organisms age, the number of senescent cells in the body increases.
Dr. Song Soo-chang's research team at the Center for Biomaterials, Korea Institute of Science and Technology (KIST, President Yoon Seok-jin), revealed the first development of poly(organophosphazene) hydrogel-based temperature-sensitive bioink that stably maintained its physical structure only by temperature control without photocuring, induced tissue regeneration, and then biodegraded in the body after a certain period of time.
Scientists from the University of California, Irvine, the University of Michigan and the University of Texas MD Anderson Cancer Center have made a significant contribution to the field of pancreatic cancer research. Their new study presents several crucial themes in the biology of pancreatic cancer that can serve as hallmarks for pancreatic cancer therapy.
Brian McDermott, a Case Western Reserve scientist, is reporting a discovery about unexpected asymmetry on the hair cells of zebrafish that allow them to detect movement with greater sensitivity from the back than the front. “This shows that fish have hair cells that are actually tuned to sense different water directions,” McDermott said. “In humans, our cochleas have hair cells that are similarly tuned to be able to hear different frequencies.” McDermott said the finding also advances our understanding of “the long-sought mechanotransduction (Mec) channel” in living creatures.
A team of Cornell researchers and their colleagues want to learn how to fix cardiac malformations by analyzing brain cancer or plants with a five-year, $3 million grant from the National Science Foundation.
Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer that often kills within a year of diagnosis. Surgery is almost impossible because of the tumors’ location. Chemotherapy has debilitating side effects. New treatment options are desperately needed.
An international coalition of biomedical researchers co-led by Alexander Bick, MD, PhD, at Vanderbilt University Medical Center has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients’ risk of blood cancer. The technique, called PACER, led to the identification of a gene that, when activated, drives clonal expansion.
New research from the McKelvey School of Engineering at Washington University in St. Louis has found that cancer cells can sense a layer of cells beneath the top collagen layer on which they normally travel, while normal cells cannot.
Coaxing blood cells from patients to develop into three-dimensional brain “organoids” is allowing scientists at University of Utah Health to gain insights into pediatric bipolar disorder.
Researchers of the Genome Dynamics Project team at Tokyo Metropolitan Institute of Medical Science ·revealed new mechanism controlling cellular proliferation in response to serum, which triggers growth of resting cells.
Dopamine, a brain chemical long associated with pleasure, motivation and reward-seeking, also appears to play an important role in why exercise and other physical efforts feel “easy” to some people and exhausting to others, according to results of a study of people with Parkinson’s disease led by Johns Hopkins Medicine researchers. Parkinson’s disease is marked by a loss of dopamine-producing cells in the brain over time.
Proteins are components of every cell. How they have changed in the course of evolution for the purpose of taking on new functions in the body, has long been a subject of research.
Investigators from Cedars-Sinai Cancer are collaborating on a streamlined clinical trial design in a study called Pragmatica-Lung.
New smart-drug treatment options for pancreatic cancer, immuno-oncology treatments and real-time immune-monitoring strategies are among the research topics to be presented by investigators at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) at the American Association for Cancer Research (AACR) annual meeting held April 14-19 at the Orange County Convention Center in Orlando, Florida.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. This special edition features presentations by MD Anderson researchers at the American Association for Cancer Research (AACR) Annual Meeting 2023.
UC San Diego scientists find a protein associated with liver cancer may actually be the key to protecting against it. By blocking ferroptosis, a form of liver cell death, the protein prevents liver damage and its progression to cancer.
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Researchers reporting in ACS Central Science have developed a new testing platform that encapsulates B cells — some of the most important components of the immune system — into miniature “organoids” to make vaccine screening quicker and greatly reduce the number of animals needed for testing.
Omicron subvariants of SARS-CoV-2 — the virus behind COVID-19 — have shown an uncanny knack for evading antibodies produced either by vaccines or exposure to earlier versions of the virus, leading to many breakthrough infections. However, in order to sicken people, these viral variants must also avoid “killer” T cells, immune cells that are unleashed when the immune system detects foreign pathogens.
Cell secretions like proteins, antibodies, and neurotransmitters play an essential role in immune response, metabolism, and communication between cells.
Four distinguished researchers from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania will receive 2023 Scientific Achievement Awards from the American Association for Cancer Research (AACR), during the AACR Annual Meeting 2023.
In a new study published in The FASEB Journal, investigators demonstrated the potential of a molecule that may help overcome some of the devastating symptoms of Duchenne muscular dystrophy (DMD), the most common life-limiting congenital neuromuscular disorder. The agent promotes the activity of AMP-activated protein kinase (AMPK), an important fuel-sensing enzyme that is present in all mammalian cells.
Research led by scientists at UCLA Jonsson Comprehensive Cancer Center found that responses to a type of immunotherapy called PD-1 checkpoint blockade in patients with advanced melanoma depended on whether or not they had previously received another immunotherapy – CTLA-4 blockade – as well as other factors.
UNC School of Medicine scientists demonstrated that stimulating a brain region called Supramammilary nucleus (SuM) located in the hypothalamus effectively enhanced adult-born neurons in the otherwise impaired Alzheimer’s brains of mice.
Yale Cancer Center (YCC) and Smilow Cancer Hospital (SCH) physicians and scientists are presenting research studies at the 2023 American Association for Cancer Research (AACR) Annual Meeting at the Orange County Convention Center in Orlando, Florida, April 14 to 19th.
Inflammatory bowel disease, or IBD, describes Crohn’s disease and ulcerative colitis, two chronic diseases that cause inflammation in the intestines. IBD, which affects about 3 million adults in the United States, is an autoimmune disorder — a condition in which the body’s immune system attacks healthy tissues.
A team of researchers compared the genomes of woolly mammoths with modern day elephants to find out what made woolly mammoths unique, both as individuals and as a species. The investigators report April 7 in the journal Current Biology that many of the woolly mammoth’s trademark features—including their woolly coats and large fat deposits—were already genetically encoded in the earliest woolly mammoths, but these and other traits became more defined over the species’ 700,000+ year existence.
A team of scientists led by those in Trinity College Dublin has discovered new mechanisms involved in establishing cellular identity, a process that ensures the billions of different cells in our bodies do the correct job.
Acute myeloid leukemia (AML) is an aggressive blood cancer that causes uncontrolled accumulation of white blood cells. Because of the poor outcomes of this disease, researchers across the globe have been on the hunt for new ways to treat AML, while preserving normal blood development.
A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children’s Hospital of Philadelphia (CHOP). The findings, published today in Science Immunology, could pave the way for new treatments for autoimmune diseases that target the immune system selectively.
Proteins are the key players for virtually all molecular processes within the cell. To fulfil their diverse functions, they have to interact with other proteins. Such protein-protein interactions are mediated by highly complementary surfaces, which typically involve many amino acids that are positioned precisely to produce a tight, specific fit between two proteins. However, comparatively little is known about how such interactions are created during evolution.
Human embryo development and early organ formation remain largely unexplored due to ethical issues surrounding the use of embryos for research as well as limited availability of materials to study.
Experts from Fred Hutchinson Cancer Center will present their latest findings on targets in RIT1-driven cancers, ROR1 CAR T-cell immunotherapy, interplay of the microbiome and genetics in colorectal cancer and more at the annual meeting of the American Association for Cancer Research, to be held April 14-19 in Orlando, Florida.
ASBMB calls upon NIAID to expand the use of research supplements, support scientists with disabilities and those in the LGBTQ+ community
Even after three years since the emergence of COVID-19, much remains unknown about how it causes severe disease, including the widespread organ damage beyond just the lungs. Increasingly, scientists are learning that organ dysfunction results from damage to the blood vessels, but why the virus causes this damage is unclear.
Researchers have developed a method to produce fat tissue grown from cells at large scale. The cultured fat will help add flavor and texture to cultured meat that more closely replicates the look, feel and taste of meat derived from farm animals.
Scientists at St. Jude Children’s Research Hospital have found that human ribosomes decode mRNA slower than bacteria, with implications for drug development.
In a twist on the question, “Which came first, the chicken or the egg?”, scientists have long faced a similar question about how human adenovirus replicates: “Which comes first, assembly of the viral particle, or packaging of the viral genome?” Now, in a new study published today in Nature, researchers at Children’s Hospital of Philadelphia (CHOP) have answered that question, showing that viral proteins use a process called phase separation to coordinate production of viral progeny.
The Federation of American Societies for Experimental Biology awarded Diana Libuda, PhD, Associate Professor of Biology at the University of Oregon Institute of Molecular Biology, with the Excellence in Science Early-career Investigator Award.
The Federation of American Societies for Experimental Biology (FASEB) awarded Elaine S. Jaffe, MD, Distinguished Investigator at the National Institutes of Health’s National Cancer Institute (NCI), with the Excellence in Science Lifetime Achievement Award.
The Federation of American Societies for Experimental Biology (FASEB) awarded Paola Arlotta, PhD, Professor of Stem Cell and Regenerative Biology at Harvard University, with its Excellence in Science Mid-career Investigator Award.
The Federation of American Societies for Experimental Biology (FASEB) announced the recipients of its 2023 Excellence in Science Awards. For more than 30 years, these awards have highlighted outstanding achievements by women in the biological sciences.
In a new study published in the January issue of Autophagy, they found that after traumatic brain injury, the brain’s immune system cells’ internal recycling function slowed dramatically, allowing waste products to build up and interfere with recovery from injury.
Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.
Is our brain able to regenerate? And can we harness this regenerative potential during aging or in neurodegenerative conditions? These questions sparked intense controversy within the field of neuroscience for many years.
Fat molecules serve as energy storage for fat cells. They consist of three fatty acids attached to a backbone of glycerol. They are therefore also called triglycerides. It has long been suspected that molecules do not remain unchanged during their storage period.
Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging.
New research from Washington University School of Medicine in St. Louis suggests that transposable elements in various cancers potentially may be used to direct novel immunotherapies to tumors that don’t typically respond to immune-based treatments.
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