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Newswise: Targeted therapy pralsetinib achieves high response rates in advanced cancers with RET gene fusions
Released: 29-May-2020 10:20 AM EDT
Targeted therapy pralsetinib achieves high response rates in advanced cancers with RET gene fusions
University of Texas M. D. Anderson Cancer Center

The targeted therapy pralsetinib appears to have high response rates and durable activity in patients with a broad variety of tumors harboring RET gene fusions, according to results from the international Phase I/II ARROW trial, led by researchers at The University of Texas MD Anderson Cancer Center.

Released: 29-May-2020 10:15 AM EDT
Next Frontier in Bacterial Engineering
Harvard Medical School

A new technique overcomes a serious hurdle in the field of bacterial design and engineering Researchers develop method to identify proteins that enable highly efficient bacterial design Approach has potential to boost efforts in bacterial design to tackle infectious diseases, bacterial drug resistance, environmental cleanup and more

Newswise: Adoptive T-cell therapy ADP-A2M4 targeting MAGE-A4 shows early activity in patients with advanced solid tumors
Released: 29-May-2020 10:05 AM EDT
Adoptive T-cell therapy ADP-A2M4 targeting MAGE-A4 shows early activity in patients with advanced solid tumors
University of Texas M. D. Anderson Cancer Center

The adoptive T-cell therapy ADP-A2M4, which is engineered to express a T-cell receptor (TCR) directed against the MAGE-A4 cancer antigen, achieved responses in patients with multiple solid tumor types, including synovial sarcoma, head and neck cancer and lung cancer, according to results from a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

Newswise:Video Embedded newswise-expert-panels-on-covid-19-pandemic-notable-excerpts-quotes-and-videos-available
VIDEO
Released: 29-May-2020 9:50 AM EDT
Newswise Expert Panels on COVID-19 Pandemic: Notable excerpts, quotes and videos available
Newswise

Newswise is hosting a series of Expert Panels discussion unique aspects of the COVID-19 Outbreak. This tip sheet includes some notable quotes from the panelists.

Released: 29-May-2020 9:00 AM EDT
Education Won’t Be Normal After COVID: Newswise Live Event for June 4, 2PM EDT
Newswise

Will schools reopen in the fall? If schools remain closed, what will be the impact on students’ education, long-term? How has the pandemic already impacted students, from elementary through higher ed; how are schools at all levels adapting to teaching virtually, and how to safely return to teaching in person - June 4, 2020 from 2-3 PM EDT

access_time Embargo lifts in 2 days
Embargo will expire: 3-Jun-2020 9:00 AM EDT Released to reporters: 29-May-2020 9:00 AM EDT

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Newswise: Huntsman Cancer Institute Researchers Demonstrate Better Outcomes, Lower Cost in First-Ever Oncology Hospital-at-Home Evaluation
Released: 29-May-2020 8:55 AM EDT
Huntsman Cancer Institute Researchers Demonstrate Better Outcomes, Lower Cost in First-Ever Oncology Hospital-at-Home Evaluation
Huntsman Cancer Institute at the University of Utah

Researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) presented the first outcomes evaluation of an adult oncology hospital-at-home program today at the 2020 American Society of Clinical Oncology (ASCO) annual meeting. The study evaluated patients participating in HCI’s Huntsman at Home. The data demonstrate strong evidence for this care model, showing improved patient outcomes, including reduced hospitalizations and decreased visits to the emergency department.

Newswise: Study Shows Clinical Evidence of Anti-Tumor Activity in Patients with Metastatic Castration-Resistant Prostate Cancer
Released: 29-May-2020 8:00 AM EDT
Study Shows Clinical Evidence of Anti-Tumor Activity in Patients with Metastatic Castration-Resistant Prostate Cancer
Yale Cancer Center

Results of a Phase I clinical trial conducted by researchers at the Yale Cancer Center have shown that ARV-110, an androgen receptor PROTAC® protein degrader, demonstrates anti-tumor responses in patients with metastatic castration-resistant prostate cancer.

Released: 29-May-2020 6:50 AM EDT
Those with IDD more likely to die from COVID-19, study shows
Syracuse University

A new study published recently in ScienceDirect by researchers from Syracuse University and SUNY Upstate Medical University shows that people with intellectual and developmental disabilities (IDD) are more likely to die from COVID-19 than those without IDD.

Newswise:Video Embedded new-view-on-how-tissues-flow-in-the-embryo
VIDEO
Released: 29-May-2020 6:15 AM EDT
New View on How Tissues Flow in the Embryo
Columbia University School of Engineering and Applied Science

Watching and measuring what happens in tissues inside the human embryo is currently not possible, and it’s difficult to do in mammalian models. Because humans and the fruit fly Drosophila share so many biological similarities, Columbia Engineering and Syracuse University researchers tackled this problem by focusing on fruit flies. The team reports today that they can predict when the tissue will begin to rapidly flow just by looking at cell shapes in the tissue.

27-May-2020 9:25 AM EDT
Nilotinib Appears Safe and Affects Biomarkers In Alzheimer’s Disease Clinical Trial
Georgetown University Medical Center

A Georgetown University Medical Center clinical trial investigating the cancer drug nilotinib in people with Alzheimer’s disease finds that it is safe and well-tolerated, and researchers say the drug should be tested in a larger study to further determine its safety and efficacy as a potential disease-modifying strategy.

Newswise: Researchers Develop Experimental Rapid COVID-19 Test Using Innovative Nanoparticle Technique
Released: 28-May-2020 6:35 PM EDT
Researchers Develop Experimental Rapid COVID-19 Test Using Innovative Nanoparticle Technique
University of Maryland School of Medicine

Scientists from the University of Maryland School of Medicine (UMSOM) developed an experimental diagnostic test for COVID-19 that can visually detect the presence of the virus in 10 minutes. It uses a simple assay containing plasmonic gold nanoparticles to detect a color change when the virus is present. The test does not require the use of any advanced laboratory techniques, such as those commonly used to amplify DNA, for analysis. The authors published their work last week in the American Chemical Society’s nanotechnology journal ACS Nano.

Released: 28-May-2020 6:05 PM EDT
Phase III Trial Shows Avelumab an Immunotherapy Treatment for Advanced Urothelial Cancer Prolongs Overall Survival
Seattle Cancer Care Alliance

During a plenary session of the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program, findings will be presented from the global phase III JAVELIN Bladder 100 randomized study conducted by investigators from Seattle Cancer Care Alliance, Fred Hutchinson Cancer Research Center and University of Washington Medicine along with several other research centers. The results demonstrated significantly prolonged overall survival of patients with locally advanced (unresectable) or metastatic urothelial cancer when treated with first-line immunotherapy avelumab plus best supportive care (BSC) compared to BSC alone (following disease control on induction chemotherapy).

Released: 28-May-2020 6:05 PM EDT
Tackling airborne transmission of COVID-19 indoors
University of Surrey

Preventing airborne transmission of Covid-19 should be the next front of the battle against the virus, argue experts from the University of Surrey.

Released: 28-May-2020 5:10 PM EDT
Mental health outcomes among health care workers during COVID-19 pandemic in Italy
JAMA - Journal of the American Medical Association

Symptoms of posttraumatic stress disorder, depression, anxiety and insomnia among health care workers in Italy during the COVID-19 pandemic are reported in this observational study.

Newswise: Atlantic Health System Leads Phase 1 Study on CPI-613® (Devimistat), First-in-Class Treatment for Pancreatic Cancer to be Presented at American Society of Clinical Oncology (ASCO) 2020
Released: 28-May-2020 5:00 PM EDT
Atlantic Health System Leads Phase 1 Study on CPI-613® (Devimistat), First-in-Class Treatment for Pancreatic Cancer to be Presented at American Society of Clinical Oncology (ASCO) 2020
Atlantic Health System

Dr. Alistar has pioneered the use of CPI-613® (devimistat), a unique first-in-class treatment for locally advanced or metastatic pancreatic cancer, in combination with two chemotherapy drugs. Devimistat uniquely targets enzymes involved in cancer cell metabolism, against pancreatic cancer. The study’s efficacy data suggest devimistat has synergy with chemotherapy.The current study was funded by the drug’s manufacturer, New Jersey-based Rafael Pharmaceuticals and by Atlantic Health System.

Newswise:Video Embedded study-shows-profound-benefit-with-targeted-therapy-for-patients-with-early-stage-nsclc
VIDEO
28-May-2020 5:00 PM EDT
Study Shows Profound Benefit with Targeted Therapy for Patients with Early Stage NSCLC
Yale Cancer Center

According to findings led by researchers at Yale Cancer Center, treatment with the targeted therapy osimertinib following surgery significantly improves disease-free survival (DFS) in patients with early-stage, non-small cell lung cancer (NSCLC) with EGFR gene mutations.

22-May-2020 12:25 PM EDT
Inequities in Access to Kidney Transplantation Exist Even with Universal Healthcare
American Society of Nephrology (ASN)

• In a study of patients with newly diagnosed kidney failure at 71 kidney centers in the UK, older age, additional illnesses, obesity, and lower socioeconomic status were associated with a lower likelihood of being put on transplant waiting list.

Newswise: Developing Culturally Responsive Strategies to Help African American Women Overcome Barriers to Good Heart Health
Released: 28-May-2020 4:40 PM EDT
Developing Culturally Responsive Strategies to Help African American Women Overcome Barriers to Good Heart Health
University of Kentucky

Research has shown African American women have disproportionately higher rates of cardiovascular disease risk factors compared to their white counterparts. UK College of Health Sciences assistant professor Brandi White has been working with African American women living in public housing on Lexington’s East End to develop culturally responsive strategies to overcome social and economic barriers to a heart-healthy lifestyle and reduce their cardiovascular disease risk.

Released: 28-May-2020 4:40 PM EDT
Bone Researcher Provides Expert Commentary in Publication’s Controversial Reversal of Long-Held Theory
University of Arkansas for Medical Sciences

The latest issue of PLOS Genetics includes two publications that challenge the basic assumptions behind 24 years of bone and metabolism research, and given the magnitude of the potential paradigm shift, the editors turned to Stavros C. Manolagas, M.D., Ph.D., of the University of Arkansas for Medical Sciences (UAMS) to provide expert commentary and context.

Released: 28-May-2020 3:50 PM EDT
Users of high-potency cannabis four times more likely to report associated problems
University of Bristol

Users of high-potency cannabis are four times more likely to report associated problems, and twice as likely to report anxiety disorder, than users of lower-potency strains, according to new research from the University of Bristol.

Newswise: Patients still not telling MDs about use of natural health products
Released: 28-May-2020 2:50 PM EDT
Patients still not telling MDs about use of natural health products
McMaster University

The research team conducted the patient survey between November 2018 and February 2019 at the Robert Schad Naturopathic Clinic in Toronto. Based on 277 completed questionnaires, 99 per cent of the patients surveyed were using natural health products, and 46 per cent were using natural health products and prescription medications concurrently. Of those using natural health products, 42 per cent did not disclose use to their primary care physician.

Released: 28-May-2020 2:40 PM EDT
Anesthesia Practices See Major Financial Hit as Physician Anesthesiologists Pivot During COVID-19 to Treat Patients in Critical Care and ICUs, ASA Survey Highlights
American Society of Anesthesiologists (ASA)

A recent survey of anesthesia administrators and executive members of the American Society of Anesthesiologists (ASA) finds a majority of physician anesthesiologists pivoted from working in the operating room to treating COVID-19 patients in critical care units and ICUs, making the most of their expertise in intubation, ventilation strategies, and critical care medicine, which includes all aspects of resuscitation with multiorgan failure.

Released: 28-May-2020 2:20 PM EDT
Kidney Health Initiative Urges the Acceleration of Home Therapy Technology in Response to Coronavirus 2019 (Covid-19)
American Society of Nephrology (ASN)

The COVID-19 pandemic highlights the vulnerability of people with kidney failure who rely on in-center hemodialysis. People with kidney failure are at high risk of severe COVID-19 complications and are exposed to infection due to a kidney replacement therapy process that requires traveling to a dialysis facility multiple times a week.

Released: 28-May-2020 1:35 PM EDT
Autism severity can change substantially during early childhood
UC Davis MIND Institute

A UC Davis MIND Institute study found that around 30% of young children with autism have less severe autism symptoms at age 6 than they did at age 3, with some losing their autism diagnoses entirely. It also found that girls tend to show greater reduction and less rise in their autism symptom severity than boys with autism. Children with higher IQs were more likely to show a reduction in their symptoms.

Released: 28-May-2020 12:55 PM EDT
Stem Cell Treatments ‘Go Deep’ to Regenerate Sun-Damaged Skin
Wolters Kluwer Health: Lippincott Williams and Wilkins

For a while now, some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they’ve been getting good results, it’s been unclear exactly how these treatments – using adult stem cells harvested from the patient’s own body – work to rejuvenate “photoaged” facial skin.

Newswise: Online tool created to track development of coronavirus vaccines
Released: 28-May-2020 12:55 PM EDT
Online tool created to track development of coronavirus vaccines
University of Notre Dame

Notre Dame researchers create online tool to track development of coronavirus vaccines.

Newswise: Research News Tip Sheet: Story Ideas From Johns Hopkins
Released: 28-May-2020 12:50 PM EDT
Research News Tip Sheet: Story Ideas From Johns Hopkins
Johns Hopkins Medicine

During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every Tuesday throughout the duration of the outbreak.

Newswise: New grant will help scientists advance human immune model in pigs
Released: 28-May-2020 12:45 PM EDT
New grant will help scientists advance human immune model in pigs
Iowa State University

Scientists at Iowa State University are poised to take a significant step forward in human health by transferring a human immune system into pigs. The research was recently awarded a nearly $3 million grant from the National Institutes of Health to develop the technology over the next four years. The research could pave the way to new treatments for a wide range of health problems, from cancer to severe burns.

Newswise: University of Miami Coronavirus Study Targets Possible Sexual Transmission
Released: 28-May-2020 12:25 PM EDT
University of Miami Coronavirus Study Targets Possible Sexual Transmission
University of Miami Health System, Miller School of Medicine

Men who tested positive for COVID-19 are now being enrolled in a unique study led by the University of Miami Miller School of Medicine to determine the interaction of the virus with semen.

Newswise: Ludwig Lausanne Study Charts the Immune Landscape 
of Multiple Brain Cancers
Released: 28-May-2020 12:15 PM EDT
Ludwig Lausanne Study Charts the Immune Landscape of Multiple Brain Cancers
Ludwig Cancer Research

A Ludwig Cancer Research study has profiled, in a sweeping comparative analysis, the distinct immune landscapes of tumors that arise in the brain, or gliomas, and those that metastasize to the organ from the lungs, breast and skin.

Newswise: MSK: Cancer Isn’t Sheltering in Place
Released: 28-May-2020 12:10 PM EDT
MSK: Cancer Isn’t Sheltering in Place
Memorial Sloan Kettering Cancer Center

As the height of the COVID-19 outbreak in New York City and the Tri-State area begins to subside, Memorial Sloan Kettering Cancer Center oncologists are urging patients to schedule cancer screenings and treatments now – as the long-term toll of missed diagnoses and delayed treatments could be devastating for patients and their loved ones across the region and the country.

Newswise: Colorado tool, My-DST, may pick best multiple myeloma treatment
Released: 28-May-2020 12:10 PM EDT
Colorado tool, My-DST, may pick best multiple myeloma treatment
University of Colorado Cancer Center

University of Colorado Cancer Center team uses liquid biopsy to predict multiple myeloma drug resistance and sensitivity.

Released: 28-May-2020 12:10 PM EDT
Restoring Nerve-Muscle Communication in ALS
Thomas Jefferson University

A new study finds that restoring the protein SV2 in a genetic form of ALS can correct abnormalities in transmission and even prevent cells from dying, providing a new target for future therapies.

Newswise: New drug combinations help overcome resistance to immunotherapy
Released: 28-May-2020 11:55 AM EDT
New drug combinations help overcome resistance to immunotherapy
University of California, Los Angeles (UCLA), Health Sciences

A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way.

Released: 28-May-2020 11:35 AM EDT
TCT 2020 Is Now a Virtual Event: TCT Connect
Cardiovascular Research Foundation (CRF)

The Cardiovascular Research Foundation (CRF) has announced that Transcatheter Cardiovascular Therapeutics (TCT) 2020 will now take place as a virtual event called TCT Connect. The event will take place online October 14-18, 2020 and feature live case-based transmissions from around the globe, late-breaking clinical trials and science, virtual training, and countless opportunities to learn and engage with the brightest minds in interventional cardiovascular medicine.

Newswise:Video Embedded at-home-screening-for-ovarian-breast-cancers-is-effective
VIDEO
Released: 28-May-2020 11:30 AM EDT
At-home screening for ovarian, breast cancers is effective
University of Washington School of Medicine and UW Medicine

At-home genetic-testing kits for breast and ovarian cancer risk are just as effective, and in some cases even more so, than the typical protocol for genetic testing, which requires repeated office visits and counseling, according to a study led by UW Medicine researchers.

Newswise: Morgridge joins online COVID-19 discussion with Fearless Science webinar series
Released: 28-May-2020 11:25 AM EDT
Morgridge joins online COVID-19 discussion with Fearless Science webinar series
Morgridge Institute for Research

The Morgridge Institute for Research will broadcast a free webinar on Tuesday, June 2 to offer insight on the basic science behind the COVID-19 pandemic, the state of virology research at Morgridge, and how that research will provide new ways to combat emerging viral threats.

Released: 28-May-2020 11:05 AM EDT
Study Shows Uptick in At-Home Pediatric Fractures During COVID-19 Pandemic
Children's Hospital of Philadelphia

COVID-19 social distancing measures, including the closure of schools and parks and the indefinite cancellation of team sports, have led to a nearly 60% decrease overall in pediatric fractures but an increase in the proportion of fractures sustained at home, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The findings, published in the Journal of Pediatric Orthopaedics, suggest a need for increased awareness of at-home safety measures.

access_time Embargo lifts in 2 days
Embargo will expire: 2-Jun-2020 11:00 AM EDT Released to reporters: 28-May-2020 11:00 AM EDT

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Released: 28-May-2020 10:50 AM EDT
PCR and CRF Announce Partners in Learning Virtual Sessions
Cardiovascular Research Foundation (CRF)

PCR and CRF are pleased to announce the creation of virtual Partners in Learning sessions that will be broadcast during the PCR e-Course (June 25-27, 2020) and CRF’s TVT Connect meeting (June 18-28, 2020). The sessions, which will cover coronary artery disease in TAVI patients and TAVI in low risk patients, are part of a collaborative educational series from the two groups.

Newswise: Combination therapy well-tolerated and highly effective for patients with IDH1-mutated acute myeloid leukemia (AML)
Released: 28-May-2020 10:30 AM EDT
Combination therapy well-tolerated and highly effective for patients with IDH1-mutated acute myeloid leukemia (AML)
University of Texas M. D. Anderson Cancer Center

A combination therapy of ivosenidib (IVO) plus venetoclax (VEN) with or without azacitidine (AZA) was found to be effective against a specific genetic subtype of acute myeloid leukemia (AML) in a Phase Ib/II trial led by researchers at The University of Texas MD Anderson Cancer Center. The results of this trial may support a novel course of action for patients with AML harboring an IDH1 mutation who have historically had few treatment options.

Newswise: Novel targeted drug induced positive response for patients with von Hippel-Lindau disease–associated kidney cancer
Released: 28-May-2020 10:15 AM EDT
Novel targeted drug induced positive response for patients with von Hippel-Lindau disease–associated kidney cancer
University of Texas M. D. Anderson Cancer Center

In an international trial led by researchers at The University of Texas MD Anderson Cancer Center, treatment with MK-6482, the small molecule inhibitor of hypoxia-inducible factor (HIF)-2a was well tolerated and resulted in clinical responses for patients with von Hippel-Lindau disease (VHL)–associated renal cell carcinoma (RCC).

25-May-2020 8:55 AM EDT
Alcohol Use in Early Adolescence may Alter Reward Motivation
Research Society on Alcoholism

The brain responds to rewarding stimuli by increasing the release of a neurotransmitter called dopamine. When we feel motivated, it is because our brain anticipates this dopamine reward. The transition from early to mid-adolescence is associated with increased reward sensitivity and reward-seeking behavior, a consequence of normal brain development. This heightened sensitivity or prioritization of reward can be thought of as reflecting a greater motivation to obtain rewards. A new study, published in Alcoholism: Clinical and Experimental Research, has addressed whether drinking alcohol in early adolescence might impact the brain’s reward systems, by examining associations between alcohol initiation and subsequent changes in reward motivation while accounting for baseline scores. Differences between boys and girls were also evaluated.

Released: 28-May-2020 9:40 AM EDT
As hospitals walk the tightrope of patient data-sharing, one system offers a new balance
Michigan Medicine - University of Michigan

Every major medical center in America sits on a gold mine of patient data that could be worth millions of dollars to companies that could use it to develop new treatments and technologies. A new framework could help them do so more responsibly, going beyond the minimum legal requirements and respecting patients by giving them more say in how their individual data may be used.

Released: 28-May-2020 9:15 AM EDT
Featured research from NUTRITION 2020 LIVE ONLINE
American Society for Nutrition (ASN)

Press materials are now available for NUTRITION 2020 LIVE ONLINE, a dynamic virtual event showcasing new research findings and timely discussions on food and nutrition. The online meeting will be held June 1–4, 2020.

access_time Embargo lifts in 2 days
Embargo will expire: 2-Jun-2020 2:30 PM EDT Released to reporters: 28-May-2020 9:00 AM EDT

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