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A reporter's PressPass is required to access this story until the embargo expires on 4/28/2014 11:00 AM EDT

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New Approach for Surgery Patients Cuts Hospital Stays and Costs

Changes in managing patients before, during and after colorectal surgery cut hospital stays by two days and reduced readmission rates, according to researchers who led a study of the approach at Duke University Hospital.

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Pain Curbs Sex Drive in Female Mice, but Not in Males

A study published in the April 23 issue of The Journal of Neuroscience found that pain from inflammation greatly reduced sexual motivation in female mice in heat -- but had no such effect on male mice.

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New Drugs Offer Hope for Migraine Prevention

Two new studies may offer hope for people with migraine. The two studies released today will be presented at the American Academy of Neurology’s 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014.

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Safer Alternatives to Nonsteroidal Antinflamatory Pain Killers

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Building on previous work that showed that deleting an enzyme in the COX-2 pathway in a mouse model of heart disease slowed the development of atherosclerosis, researchers have now extended this observation by clarifying that the consequence of deleting the enzyme mPEGS-1 differs, depending on the cell type in which it is taken away. They are now working on ways to deliver inhibitors of mPGES-1 selectively to the macrophages.

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Penn Medicine Researchers Uncover Hints of a Novel Mechanism Behind General Anesthetic Action

Despite decades of common use for surgeries of all kinds, the precise mechanism through which general anesthesia works on the body remains a mystery. New research led by the Perelman School of Medicine at the University of Pennsylvania investigated the common anesthetic sevoflurane and found that it binds at multiple key cell membrane protein locations that may contribute to the induction of the anesthetic response. Their findings will appear online in PNAS (Proceedings of the National Academy of Science).

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Codeine Often Prescribed to Children, Despite Available Alternatives

Despite its potentially harmful effects in children, codeine continues to be prescribed in U.S. emergency rooms, according to new research from UCSF Benioff Children’s Hospital San Francisco.

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Low Tolerance for Pain? The Reason May Be In Your Genes

– Researchers may have identified key genes linked to why some people have a higher tolerance for pain than others, according to a study released today that will be presented at the American Academy of Neurology’s 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014.

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'Nano-Anesthesia': A New Approach to Local Anesthesia?

A technique using anesthesia-containing nanoparticles—drawn to the targeted area of the body by magnets—could one day provide a useful alternative to nerve block for local anesthesia in patients, suggests an experimental study in the April issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

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Adding Dexmedetomidine Reduces Anesthesia Dose Required for Surgery

For patients undergoing surgery, adding a sedative drug called dexmedetomidine can reduce the necessary doses of other anesthetic drugs, reports a study in the April issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

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