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HIV Patients Experience Better Kidney Transplant Outcomes than Hepatitis C Patients

HIV (human immunodeficiency virus)-positive kidney transplant patients experienced superior outcomes when compared to kidney transplant patients with Hepatitis C and those infected with both HIV and Hepatitis C, according to a study led by researchers at the Perelman School of Medicine at the University of Pennsylvania and published online in Kidney International.

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For Most Children with HIV and Low Immune Cell Count, Cells Rebound After Treatment

Most children with HIV who have low levels of a key immune cell eventually recover levels of this cell after they begin treatment.

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Study Reports Excellent Outcomes Among HIV+ Kidney Transplant Recipients

• Compared with uninfected (HIV-/HCV-) kidney transplant recipients, mono-infected HIV+ (HIV+/HCV-) recipients had similar 5-year and 10-year kidney survival rates, while HIV+ recipients co-infected with HCV (HIV+/HCV+) had worse kidney survival rates. • Patient survival among mono-infected HIV+ recipients was similar to uninfected recipients but was significantly lower for co-infected recipients.

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First National Kidney Graft Survival Study of HIV-Positive Recipients

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Kidney recipients infected only with HIV do as well as uninfected recipients, but HIV-infected recipients co-infected with hepatitis C virus have poorer outcomes.

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New Lead Against HIV Could Finally Hobble the Virus’s Edge

Since HIV emerged in the ‘80s, drug “cocktails” transformed the deadly disease into a manageable one. But the virus is adept at developing resistance to drugs, and treatment regimens require tweaking that can be costly. Now scientists at the 249th National Meeting & Exposition of the American Chemical Society are announcing new progress toward affordable drugs that could potentially thwart the virus’s ability to resist them.

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Common Herpes Medication Reduces HIV-1 Levels, Independent of Herpes Infection

Case Western Reserve researchers are part of an international team that has discovered that Valacyclovir reduces HIV-1 levels — even when patients do not have herpes. Results were published online in Clinical Infectious Disease.

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Cellular Scissors Chop Up HIV Virus

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Salk scientists re-engineered the bacterial defense system CRISPR to recognize HIV inside human cells and destroy the virus, offering a potential new therapy.

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Gorilla Origins of the Last Two AIDS Virus Lineages Confirmed

Two of the four known groups of human AIDS viruses (HIV-1 groups O and P) have originated in western lowland gorillas, according to an international team of scientists.

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Research Captures Transient Details of HIV Genome Packaging

Once HIV-1 has hijacked a host cell to make copies of its own RNA genome and viral proteins, it must assemble these components into new virus particles. The orchestration of this intricate assembly process falls to a viral protein known as Gag. For one thing, Gag must be able to discern viral RNA from the host cell’s and squirrel it away inside new viral particles — no easy task considering only two to three percent of the RNA found in the cytoplasm is from HIV-1. Exactly how Gag selectively packages viral RNA has been widely speculated but never directly observed.

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Scripps Research Institute Scientists Announce Anti-HIV Agent So Powerful It Can Work in a Vaccine

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In a remarkable new advance against the virus that causes AIDS, scientists from The Scripps Research Institute have announced the creation of a novel drug candidate so potent and universally effective, it might work as part of an unconventional vaccine.