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Medicine

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Tulane Univeristy, Tulane University School of Medicine, Cancer, p53 protein, MDM2, phldb3

Tulane Researchers Find Tumor-Suppressing Protein Actually Promotes Cancer

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Tulane University researchers have discovered that the protein PHLDB3, thought to be a potential tumor suppressor, actually allows cancer cells to thrive in pancreatic, prostate, colon, breast, lung, and other common cancers. The discovery could explain how cancer is able to overcome p53 – a key tumor-suppressing protein.

Science

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B Cells, Lymphoma, germinal center

Research Helps Explain How B Cell Metabolism Is Controlled

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New research from Sanford Burnham Prebys Medical Discovery Institute (SBP) addresses the lack of knowledge about how B cell metabolism adapts to each of their various environments-- development in the bone marrow, proliferation and hypermutation in the lymph nodes and spleen and circulation in the blood. New findings show that the protein GSK3 acts as a metabolic sensor, or checkpoint, that promotes the survival of circulating B cells while limiting growth and proliferation of B cells in germinal centers.

Medicine

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St. Jude Children's Research Hospital, AMKL, pediatric leukemia, next-generation sequencing, Acute Megakaryoblastic Leukemia, genetic alteration, therapy guidelines

Research Leads to New Treatment Recommendations for a High-Risk Pediatric Leukemia

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International researchers led by St. Jude Children’s Research Hospital have identified genetic alterations that can be used to guide treatment of pediatric acute megakaryoblastic leukemia, which has a dismal prognosis.

Science

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LSD, Pharmacology, Serotonin receptors, Acid, Psychedelic Drug Effects

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 26-Jan-2017 12:00 PM EST

Science

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Cell Biology, Physiology, gastro intestinal cancer

A Gene’s Journey From Covert to Celebrated

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Unmasking a previously misunderstood gene, Gpr182, University of North Carolina scientists discover an unlikely potential drug target for gastrointestinal cancers.

Medicine

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Blue Ridge, Rankings, Ophthalmology, Preventive Medicine, Otolarygology, Microbiology, Neurology, Urology, Physiology, NIH Award, Blue Ridge Institute for Medical Research, medical school rankings, Nih Grants, Nih Funding

Keck School of Medicine of USC Receives its Highest National Institutes of Health Funding Ranking to Date

Keck School of Medicine of the University of Southern California (USC) recently received the school’s highest ranking in National Institutes of Health (NIH) funding since the Blue Ridge Institute for Medical Research began its annual ranking of medical schools in 2006. The rankings represent total NIH funding granted from October 1, 2015 through September 30, 2016. The USC Department of Ophthalmology and Department of Preventive Medicine at the Keck School of Medicine of USC both ranked No. 2 nationally among the nation’s ophthalmology and preventive medicine departments receiving NIH funds. The Keck School of Medicine of USC also ranked No. 1 in NIH funds received per principal investigator.

Medicine

Science

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Biomedical Engineering, Engineering, Space, MARS, 100 Year Starship, Health, Healing, bone, Muscle, Tissues, Wounds, Soft Tissue, Gravity, Tissue Engineering, Regenerative Medicine, skin, Retina, Mechanical Engineering, aeronautical engineering, Science, Biology, Chemistry, Aging, Solar System, Astronaut, Diabetes, Elderly, Burns, Bruch’s membrane, eye, Immune Cells, Ma

Space-Age Challenge: Healing Broken Bones, Wounds and Internal Organs

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Ronke Olabisi once dreamed of becoming an astronaut. Now she’s conducting research that could help space travelers and Earth-dwellers heal faster and stay healthy. “If healing people faster on Earth is going to be helpful, then it’s really going to be helpful in space,” said Olabisi, an assistant professor in Rutgers’ Department of Biomedical Engineering.

Science

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Paleontology, Evolution, Lizard, new species, Cretaceous Period, Paleoecology, Fossil

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 24-Jan-2017 7:05 PM EST

Science

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A Quark Like No Other, Biophysics Plays Key Role in Immune System Signaling and Response, ALMA Reveals Sun in New Light, and MORE in the Physics News Source Sponsored by AIP

Click here to go directly to the Physics News Source Sponsored by AIP.

Medicine

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Social Environment, Health, mice

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 25-Jan-2017 2:00 PM EST

Medicine

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Stem Cells, Immunotherapy, Cancer, zika virus, Infectious Diseases, Pregnancy, Public Health, Pediatrics, Neurology, Natural Killer Cells

CIRM Approves New Funding to UC San Diego Researchers Fighting Zika Virus and Cancer

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The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine (CIRM) has approved a pair of $2 million awards to University of California San Diego School of Medicine researchers to advance studies of new treatments for Zika virus infections and the use of stem cell-derived natural killer (NK) cells to target ovarian cancer and other malignancies.

Medicine

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laboratory technology, cell reprogramming, Precision Medicine, Cancer Drug, Cells

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 26-Jan-2017 11:00 AM EST

Medicine

Science

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Virus, Bacteria communication, Phages, Sorek

Viruses Overheard Talking to One Another

For the first time, viruses have been found to communicate with one another, leaving short “posts” for kin and descendants. The messages help the viruses reading them decide how to proceed with the process of infection, according to Weizmann Institute research.

Medicine

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Cancer, Tumor, Cell Biology, Lung Cancer

Molecular Subgroups of Non-Small Cell Lung Cancer Predict Tumor Behavior, Reveal Treatment Targets

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EGFR mutations is associated with a longer median overall survival (almost double) compared with those without EGFR mutations when treated with specific targeted agents.

Science

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Genomics, Metagenomics, DNA, Database, Protein, Protein structures, Protein Function, Computational, HPC, Computing, Biology, Science, DOE Office of Science

Seeking Structure with Metagenome Sequences

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In the January 20, 2017 issue of Science, University of Washington-led team, in collaboration with researchers at the DOE Joint Genome Institute, reports that structural models have been generated for 12 percent of the protein families that had previously had no structural information available.

Science

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Bioethics, Organoids, Human Embryonic Stem Cells, Animal Testing, Tissue Engineering, Regenerative Medicine

Scientists Initiate First Ethical Guidelines for Organs Cultivated in Vitro

In the latest edition of the journal “Science”, Jürgen Knoblich, a leading authority on stem cells and deputy director of the IMBA (Institute for Molecular Biotechnology of the Austrian Academy of Sciences), together with international experts, presents a first ethical guideline for research into human organ models. In the article, he also argues for critical and responsible engagement with the new technology.

Medicine

Science

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Biology, Cancer, Protein, Lipid, Fat, Stem Cells, Molecular Biology, Chemistry, waxes, triacylglycerols, Aging, Senescent

As Cells Age, the Fat Content Within Them Shifts

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As cells age and stop dividing, their fat content changes, along with the way they produce and break down fat and other molecules classified as lipids. By providing broad insights into the connection between lipids and cellular aging, the findings open the door for additional research that could one day support the development of lipid-based approaches to preventing cell death or hastening it in cancerous tumors.

Medicine

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Nyu Langone, Agnel Sfeir, Mitochondria, Genetics, common deletion, strand displacement, Pearson syndrome, Kearns-Sayre, ophthalmopl

Roots of Related Genetic Diseases Found in Cell Powerhouses

Scientists at NYU Langone Medical Center have discovered the mechanisms behind a genetic change known to cause a set of related diseases.

Science

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Joint Genome Institute, Fungi, Bacteria, fungal-bacterial mutualisms, Department of Energy Office of Science, Bioenergy

Of Mutualism and Lipid Metabolism in Fungi

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Novel mechanism in bacterial-fungal symbiosis could have biodiesel production applications

Medicine

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Research, Cancer, Pancreatic Cancer, Stomach Cancer, Colon Cancer

‘Collateral’ Lethality May Offer New Therapeutic Approach for Cancers of the Pancreas, Stomach and Colon

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Cancer cells often delete genes that normally suppress tumor formation. These deletions also may extend to neighboring genes, an event known as “collateral lethality,” which may create new options for development of therapies for several cancers.







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