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Proteins Conspire to Make Breast Cancer Cells Resistant to Drug Treatment

Sanford-Burnham researchers discover that the interaction between two proteins called BCAR1 and BCAR3 is responsible for resistance to antiestrogen drugs, paving the way for improved diagnostic and treatment strategies.

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Dual Role: Key Cell Division Proteins Also Power Up Mitochondria

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An international team led by researchers at UC Davis has shown that the cyclin B1/Cdk1 protein complex, which plays a key role in cell division, also boosts the mitochondrial activity to power that process. This is the first time the complex has been shown to perform both jobs. This newfound ability could make cyclin B1/Cdk1 an excellent target to control cellular energy production, potentially advancing cancer care and regenerative medicine. The research was published online today in the journal Developmental Cell.

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Friction Harnessed by Proteins Helps Organize Cell Division

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A football-shaped structure, known as the mitotic spindle, makes cell division possible for many living things. This piece of cellular architecture, responsible for dividing up genetic material, is in constant flux. The filaments that form it grow and shrink, while motor-like molecules burn energy pushing them about. To ensure the complex process proceeds in an orderly fashion, molecular fasteners pin the filaments together in certain places, and new research in Tarun Kapoor’s Laboratory of Chemistry and Cell Biology helps explain how they do it.

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UNC Researchers Develop Insights Into Proteins Linked to Cell Movement

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Cell movement plays an important role in a host of biological functions from embryonic development to repairing wounded tissue. It also enables cancer cells to break free from their sites of origin and migrate throughout the body.

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Fighting Neuroblastomas by Blocking Their DNA Replication, Repair

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PCNA is a protein essential to DNA repair and replication, and City of Hope researchers are targeting it in neuroblastoma cells in order to halt tumor growth and induce cell death.

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A reporter's PressPass is required to access this story until the embargo expires on 4/20/2014 1:00 PM EDT

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New Method Isolates Immune Cells for Researchers to Study How They Ward Off Oral Diseases

Case Western Reserve University dental researchers have found a less invasive way to extract single rare immune cells from the mouth to study how the mouth’s natural defenses ward off infection and inflammation.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 4/21/2014 9:00 AM EDT

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New Study Identifies microRNA’s Role in Breast Cancer Metastasis

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City of Hope researchers found that a microRNA called miR-105 helps cancer metastasize by breaking down the building blocks of blood vessels' barriers, allowing the cancer cells to enter the bloodstream.

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Regenerating Muscle in Duchenne Muscular Dystrophy: Age Matters

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Researchers reveal novel cellular and molecular elements of muscle repair. The study explains how drugs can induce regeneration, while preventing fibrosis and fat deposition, in dystrophic muscle at early stages of Duchenne muscular dystrophy.

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