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Medicine

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P53, P53 Mutations, Rac1, Tumorigenesis, Rutgers University, New Jersey

Targeting a Binding Protein in Mutated p53 Could Yield New Cancer Treatment Strategies

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Research by Rutgers Cancer Institute of New Jersey investigators shows the targeting of a binding protein of mutant p53 known as Rac1 could lead to new therapeutic strategies for patients whose cancer carries mutations in the p53 gene.

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Heart Attack, Reprogrammed Cells, Cardiomyocytes, Fibroblasts, Pathology and Laboratory Medicine

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 26-Sep-2017 12:00 PM EDT

Science

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Planarians, freshwater flatworms, Asexual Reproduction, Biomechanics, Biophysics, Proceedings Of The Natinal Academy Of Sciences

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 25-Sep-2017 3:00 PM EDT

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Find the Expert You Need in the Newswise Expert Directory

Need an expert in a hurry? Need to pitch an expert in a hurry? Find experts and manage your experts in the Newswise Expert Directory. Our database of experts is growing daily. Search by institution, name, subject, keywords, and place.

Medicine

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Neuroblastoma, tumor-associated macrophages, Tumor Microenvironment, Stat3, MYC

When Good Immune Cells Turn Bad

Investigators at CHLA have identified the molecular pathway used to foster neuroblastoma and demonstrated use of a clinically available agent, ruxolitinib, to block the pathway.

Medicine

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Gene Therapy, Neurobiology, Medicine

Unique Gene Therapy Prevents, Reverses Multiple Sclerosis in Animal Model

Multiple sclerosis can be inhibited or reversed using a novel gene therapy technique that stops the disease’s immune response in mouse models, University of Florida Health researchers have found.

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Insulin Resistance, Diabetes, Endocrinology, Metabolism, Metabolic Conditions, Exosome, Cell Biology, Genetics

Exosomes are the Missing Link to Insulin Resistance in Diabetes

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Chronic tissue inflammation resulting from obesity is an underlying cause of insulin resistance and type 2 diabetes. But the mechanism by which this occurs has remained cloaked, until now. In a paper, University of California San Diego School of Medicine researchers identified exosomes — extremely small vesicles or sacs secreted from most cell types — as the missing link.

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Scientists Sequence Asexual Tiny Worm—Whose Lineage Stretches Back 18 Million Years

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A team of scientists has sequenced, for the first time, a tiny worm that belongs to a group of exclusively asexual species that originated approximately 18 million years ago—making it one of the oldest living lineages of asexual animals known.

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gene activation, Genetics, Cell And Developmental Biology, DNA, Leukemia, Lymphoma

Locking Down the Big Bang of Immune Cells

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Scientists have found that ignored pieces of DNA play a critical role in the development of immune cells (T cells). These areas activate a change in the structure of DNA that brings together crucial elements necessary for T cell formation. This “big bang” discovery may aid in combating diseases.

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Cancer, Head And Neck Cancer, Immunotherapy, Cell Biology, Check-point inhibitor

Drug Combination May Improve Impact of Immunotherapy in Head and Neck Cancer

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Checkpoint inhibitor-based immunotherapy has been shown to be very effective in recurrent and metastatic head and neck cancer but only in a minority of patients. University of California San Diego School of Medicine researchers may have found a way to double down on immunotherapy’s effectiveness.







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