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Arterial Disease

Scientists Identify Gene Predisposing to Artery-Damaging Disease

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A genetic discovery by a team led by Dianna Milewicz, M.D., Ph.D., of The University of Texas Health Science Center at Houston (UTHealth) could help explain a cause of a mysterious artery-damaging disease that may affect up to an estimated 5 million Americans and often strikes without warning.

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Ancient Enzyme Morphed Shape to Carry Out New Functions in Humans

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New research led by scientists at The Scripps Research Institute (TSRI) reveals that a human enzyme has changed little from its days as a bacterial enzyme.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 12-Dec-2016 11:00 AM EST

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Researchers Identify Potentially Druggable Mutant p53 Proteins That Promote Cancer Growth

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Truncated p53 proteins, presumed unimportant, now point to new drug targets for some of 'the hardest cancers'

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Hunting the Wild Fava, Are Barley Sprouts Good for Dairy Cattle? Watermelon's Effect on Blood Vessels, and More in the Food Science News Source

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Lymphoma, Lymphoma Research, Lymphoma treatment, Diffuse large B-cell lymphoma, Clinical Trial, Clinical Trial participation, oral cancer drugs

UNMC Seeking Lymphoma Patients for Oral Two-Drug Study

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Most cancer treatments come in the form of chemotherapy given intravenously. This is unique because it uses a combination of two oral medications.

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Mount Sinai, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, Stem Cell, stem cell memory

Stem Cell Memories May Hold Answer to Their Reproduction, Mount Sinai Study Finds

Blood-forming stem cells are able to count and store memories of the number of times that they divide, findings which could have major implications for disease research, scientists at the Icahn School of Medicine at Mount Sinai have found.

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Less Satisfaction in Breast Cancer Patients Who Have Radiation and Implants, Personalized Cancer Vaccine for AML, Model to Predict if Chemotherapy Will Work for Aggressive Breast Cancer, and More in the Cancer News Source

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 15-Dec-2016 2:00 PM EST

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Cancer, biomarkers, Lab-on-a-chip, Genomic, Blood Testing, Biomicrofluidics, Diagnostics, Molecular Biology, Hong Cai, Matthew Stott, Damla Ozcelik, Joshua W. Parks, Aaron R. Hawkins, Holger Schmidt

EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 13-Dec-2016 11:00 AM EST

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How to Make a Motor Neuron

A team of scientists has uncovered details of the cellular mechanisms that control the direct programming of stem cells into motor neurons.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 12-Dec-2016 4:00 PM EST

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clinical trial, Head And Neck Cancer, Standard Of Care, squamous cell cancer of the head and neck, Squamous Cell, princess margaret cancer centre, University Health Network

Study Shows New Treatment Strategy in Head and Neck Cancer Not Better Than Current Standard of Care

Results of the largest Canadian clinical trial to date comparing standard treatment for locally advanced squamous cell head and neck cancer with an experimental treatment, did not show the new treatment is superior.

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Idiopathic Pulmonary Fibrosis (Ipf), Surfactant Research, Journal of Clinical Investigation Insight, JCI Insight, Cincinnati Children's Hospital Medical Center, Pediatric, news, single-cell analysis, single cell genomics

Scientists Unlock Genetic Code of Diseased Lung Cells to Find New Treatments for IPF

Researchers cracked the complete genetic code of individual cells in healthy and diseased human lung tissues to find potential new molecular targets for diagnosing and treating the lethal lung disease Idiopathic Pulmonary Fibrosis (IPF). Scientists from Cincinnati Children’s Hospital Medical Center, in collaboration with investigators at Cedars-Sinai Medical Center in Los Angeles, publish their findings Dec. 8 in the Journal of Clinical Investigation Insights (JCI Insight).

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Cancer, Cancer Center, Israel, Oncoproteins, RNF4, Ubiquitin, Ubiquitin Ligase Enzyme

Researchers Discover Enzyme Crucial to Tumor Development

Technion researchers have discovered a biological pathway that plays an important role in tumor development. The findings could lead to cancer-fighting drugs that work by shortening the half-life of select cancer-promoting proteins known as oncoproteins.

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Molecular Biology, Pharmaceutical Chemistry, Cancer, Immunology, Inflammation, Chemokine Receptor, Structural Biology, Drug Development

Researchers Reveal 3D Structure of Cell’s Inflammation Sensor and Its Inhibitors

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Researchers at the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego have now determined the 3D structure of CCR2 simultaneously bound to two inhibitors. Understanding how these molecules fit together may better enable pharmaceutical companies to develop anti-inflammatory drugs that bind and inhibit CCR2 in a similar manner. The study is published December 7 by Nature.

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New Studies Take a Second Look at Coral Bleaching Culprit

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Scientists have called superoxide out as the main culprit behind coral bleaching: The idea is that as this toxin build up inside coral cells, the corals fight back by ejecting the tiny energy- and color-producing algae living inside them. In doing so, they lose their vibrancy, turn a sickly white, and are left weak, damaged, and vulnerable to disease.

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Leukemia, Acute Myeloid Leukemia (AML), Stem Cells, Gene signature, princess margaret cancer centre, University Health Network

Stem Cell-Based Test Predicts Leukemia Patients’ Response to Therapy to Help Tailor Treatment

Leukemia researchers at Princess Margaret Cancer Centre have developed a 17-gene signature derived from leukemia stem cells that can predict at diagnosis if patients with acute myeloid leukemia (AML) will respond to standard treatment.

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TET Proteins Drive Early Neurogenesis

The fate of stem cells is determined by series of choices that sequentially narrow their available options until stem cells’ offspring have found their station and purpose in the body. Their decisions are guided in part by TET proteins rewriting the epigenome, the regulatory layer of chemical flags that adorn the genome and influence gene activity, report researchers at La Jolla Institute for Allergy and Immunology and UC San Diego.

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cardiac stem cell research, Pulmonary Arterial Hypertension, Heart Institute, cardiosphere-derived cells , CDCs, Eduardo Marban

Cedars-Sinai Medical Center to Expand Clinical Safety and Effectiveness Evaluation of Cardiac Cell Therapy After Winning $7.3 Million California Institute for Regenerative Medicine Grant

Researchers from the Cedars-Sinai Heart Institute and the Cedars-Sinai Department of Medicine are expanding their ongoing evaluation of a novel cell-based therapeutic candidate into the area of pulmonary arterial hypertension (PAH). This work will be supported by a recently-awarded $7.3 million grant from the California Institute for Regenerative Medicine.







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