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Healthy Lifestyle May Buffer Against Stress-Related Cell Aging

A new study from UC San Francisco is the first to show that while the impact of life’s stressors accumulate overtime and accelerate cellular aging, these negative effects may be reduced by maintaining a healthy diet, exercising and sleeping well.

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Cell's Recycling Center Implicated in Division Decisions

Most cells do not divide unless there is enough oxygen present to support their offspring, but certain cancer cells and other cell types circumvent this rule. Researchers have now identified a mechanism that overrides the cells’ warning signals, enabling cancers to continue to divide even without a robust blood supply.

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Whitehead Institute Researchers Create “Naïve” Pluripotent Human Embryonic Stem Cells

Embryonic stem cell (ESC) research has been hampered by the inability to transfer research and tools from mouse ESC studies to their human counterparts, in part because human ESCs are “primed” and slightly less plastic than the mouse cells. Now researchers in the lab of Whitehead Institute Founding Member Rudolf Jaenisch have discovered how to manipulate and maintain human ESCs into a “naïve” or base pluripotent state similar to that of mouse ESCs without the use of any reprogramming factors.

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It Takes Two to Court

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Researchers at the Stowers Institute for Medical Research, have identified the functions of two classes of pheromone receptors, and found pheromones crucial to triggering the mating process in mice.

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Joslin Scientists Create the First IPS Cells to Offer Human Model of Insulin Resistance

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Scientists at Joslin Diabetes Center now have created the first iPSCs that offer a human model of insulin resistance, a key driver of type 2 diabetes.

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Manipulation of Key Protein’s Action in the Brain Holds Potential for Development of Drugs to Fight Obesity and Diabetes

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A protein that controls when genes are switched on or off plays a key role in specific areas of the brain to regulate metabolism, UT Southwestern Medical Center researchers have found.

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Researchers Create the First Model of the DNA 'Replication Fork'

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Human cells make new copies of their DNA billions of times each day, a crucial process upon which life itself depends. However, scientists do not fully understand how cells unzip the double-stranded DNA molecule before replicating both halves of it. New work at Rockefeller may help change that.

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The Signal and the Noise

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UNC's Henrik Dohlman is like a mechanic for cells. He takes them apart to see how they function. He can tell you what part is like a gas pedal and which part is like the brakes. Now he’s can show us why these brakes don’t work the same even in cells that are genetically identical.

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When Temperatures Get Cold, Newly-Discovered Process Helps Fruit Flies Cope

Cold-blooded animals cannot regulate their body temperature, so their cells are stressed when facing temperature extremes. Worse still, even at slightly colder temperatures, some biological processes in the cell are slowed down more than others, which should throw the cells’ delicate chemical balance out of whack. Yet, those cells manage to keep their biological processes coordinated. Now researchers have found out how they do that.

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Speedy Computation Enables Scientists to Reconstruct an Animal’s Development Cell by Cell

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Researchers at the Howard Hughes Medical Institute’s Janelia Research Campus have developed a new computational method that can rapidly track the three-dimensional movements of cells in such data-rich images. Using the method, the Janelia scientists can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell.

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