Moffitt Cancer Center Researchers Develop Interactive Tool to Estimate Genetic Diversity and Ancestry of Cancer Cell Lines
Moffitt Cancer CenterCancer is a highly varied disease, with genetic differences among different tumor types, individuals and ancestral populations. These genetic differences can impact disease aggressiveness, the type of disease, and the response to therapy. It is important that scientists have proper tools and model systems to study how these variations affect cancer development and devise effective therapies for patients of all genetic backgrounds. In a new paper published in Cancer Research, Moffitt Cancer Center researchers, in collaboration with scientists at Ponce Health Sciences University in Puerto Rico, investigated this issue by creating an online tool that can be used by scientists to determine the genetic ancestral origin of more than 1300 different cell lines.