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Next-Gen Melanoma Drug, TAK-733, Excels in Lab Tests

A University of Colorado Cancer Center study published online this week in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733, a small molecule inhibitor of MEK1/2.

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Study Identifying Cell of Origin for Large, Disfiguring Nerve Tumors Lays Groundwork for Development of New Therapies

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UT Southwestern Medical Center researchers have determined the specific type of cell that gives rise to large, disfiguring tumors called plexiform neurofibromas, a finding that could lead to new therapies for preventing growth of these tumors.

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Dermatologists Share Skin Care Tips for Your 40s and 50s

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Studies have demonstrated that exposure to ultraviolet (UV) radiation from the sun and indoor tanning damages the DNA in our skin cells. This not only increases a person’s risk for skin cancer, it can also lead to premature skin aging in the form of wrinkles and sun spots. November is National Healthy Skin Month – the perfect time to learn how to maintain healthy skin care habits.

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Triplet Threat from the Sun

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The most obvious effects of too much sun exposure are cosmetic, like wrinkled and rough skin. Some damage, however, goes deeper—ultraviolet light can damage DNA and cause proteins in the body to break down into smaller, sometimes harmful pieces that may also damage DNA, increasing the risk of skin cancer and cataracts. Understanding the specific pathways by which this degradation occurs is an important step in developing protective mechanisms against it.

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Ebola Highlights Disparity of Disease Burden in Developed vs. Developing Countries

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Study highlights need to monitor disease in developing countries even when burden of diseases is low.

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Penn Medicine Researchers Zero in on Psoriasis-Hypertension Link

Patients with more severe psoriasis are also more likely to have uncontrolled hypertension, according to new research by a team at the Perelman School of Medicine at the University of Pennsylvania. Through a cross-sectional study using information collected from a medical records database, the results provide further evidence of a strong link between psoriasis and hypertension. Full results are now available in JAMA Dermatology.

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Unusual Skin Cancer Linked to Chronic Allergy From Metal Orthopedic Implant

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In rare cases, patients with allergies to metals develop persistent skin rashes after metal devices are implanted near the skin. New research suggests these patients may be at increased risk of an unusual and aggressive form of skin cancer.

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Caring for Pierced Ears: Tips From Dermatologists

Although ear piercings are more common and can be less risky than other body piercings, they can still cause complications if not handled safely. For anyone thinking about getting their ears pierced, dermatologists urge people to take care of their pierced skin to avoid infection.

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New Study Links Socioeconomic Factors and Fashion Trends Over the Past Century to Increased Incidence of Melanoma

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Dermatology researchers at NYU Langone Medical Center examined extenuating factors, such as socioeconomic trends and changes in fashion, that may have contributed to rise in melanoma over the past century.

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Antioxidant Found in Grapes Uncorks New Targets for Acne Treatment

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UCLA researchers have demonstrated how resveratrol, an antioxidant derived from grapes and found in wine, works to inhibit growth of the bacteria that causes acne. The team also found that combining resveratrol with a common acne medication, benzoyl peroxide, may enhance the drug’s ability to kill the bacteria and could translate into new treatments.

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