Neutralizing antibody levels against the original COVID-19 virus and omicron variants in vaccinated adults tend to decline by at least 15% per month after a single booster shot, a new study using serum from human blood samples suggests.
The Canadian Society of Allergy and Clinical Immunology (CSACI) and the American College of Asthma, Allergy and Immunology (ACAAI) are partnering for the first-ever North American Pediatric Allergy and Asthma Congress (NAPAAC).
A new study by UT Southwestern’s Simmons Cancer Center scientists suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer. The finding, published in Nature Communications, could eventually be used to develop new strategies to augment the anti-tumor effect of cancer immunotherapies, the study authors said.
Scientists at St. Jude Children’s Research Hospital discovered how some cancer cells survive treatment and cause cancer to recur, along with a potential way to stop the process.
A UC San Francisco-led team of international researchers has outlined the comprehensive immune landscape and microbiome of pancreatic cysts as they progress from benign cysts to pancreatic cancer. Their findings, publishing August 31 in Lancet Gastroenterology and Hepatology, could reveal the mechanism of neoplastic progression and provide targets for immunotherapy to inhibit progression or treat invasive disease.
A Roundup of the Latest Medical Discoveries and Faculty News at Cedars-Sinai
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Adding an ingredient called an adjuvant can help vaccines elicit a more robust immune response. In a study in ACS Infectious Diseases, researchers report a substance that boosted the immune response to an experimental COVID-19 shot in mice by 25 times, compared to injection with the vaccine alone.
A first-of-its-kind study conducted in collaboration with LSU’s School of Kinesiology, LSU Athletics, Pennington Biomedical Research Center and Our Lady of the Lake researched how the immune system of elite student-athletes responded to the COVID-19 virus.
Amoebae receive surprising support in defense against viruses: The bacteria they are infected with prevent them from being destroyed by giant viruses. A research team led by microbiologist Matthias Horn from the Centre for Microbiology and Environmental Systems Science at the University of Vienna have investigated how a virus infection proceeds when the amoebae are simultaneously infected with chlamydia. The research team shows for the first time that intracellular bacteria known as symbionts protect their host against viruses. Amoebae are protists, i.e. single-celled microorganisms with a cell nucleus. Protists play a key role in food webs and ecosystem processes. Consequently, the results of the study suggest that the interaction between symbionts and viruses influence the flow of nutrients in ecosystems. The study is now published in the journal PNAS.
A study led by LSU Health New Orleans cancer researchers describes a novel therapeutic strategy to overcome tumor-induced immunosuppression.
In the normal small intestine, the levels of SFB and Th17 cells are both maintained constant as they counterbalance each other.
With COVID-19 vaccines pushing down costs of mRNA technology, a study in mice from Cummings School of Veterinary Medicine experts sparks hope for next generation treatments and potential applications to developing world and veterinary diseases
If bacteria enter the body, it often takes just a few minutes for the innate immune system to recognise them as foreign and set the immune defence in motion.
Using publicly available data on COVID variant rates, researchers from the University of Hawai'i are investigating how mutations in the virus' genome impact its ability to spread and weaken immune responses.
A substance produced by gut microorganisms can lead to scarring and blood vessel damage in patients with scleroderma, a new study suggests. Researchers say they will examine whether drugs or food products, like virgin olive oil, can block the formation of the compound in the gut to treat fibrosis.
The human body contains 600 to 800 lymph nodes, which are specialised organs that trigger immune responses.
The latest research and expert commentary on the monkeypox outbreak.
Un estudio dirigido por los científicos del Centro Oncológico Integral de Mayo Clinic descubrió que la adición de brentuximab vedotina a la quimioterapia estándar mejora la supervivencia general de los pacientes con linfoma de Hodgkin, comparado con la administración de solo la quimioterapia estándar.
Um estudo conduzido por pesquisadores do Centro de Câncer da Mayo Clinic descobriu que adicionar o brentuximab vedotina ao tratamento quimioterápico padrão aumenta a taxa geral de sobrevida de pacientes com linfoma de Hodgkin, em comparação com o padrão de tratamento atual que usa somente a quimioterapia.
وجدت دراسة قادها باحثون من مركز مايو كلينك الشامل للسرطان أن إضافة دواء برنتوكسيماب فيدوتين إلى العلاج الكيميائي المعتاد يحسّن فرص النجاة لدى مرضى لمفومة هودجكيِن بشكل عام، بالمقارنة مع المعيار الحالي للعلاج الكيميائي وحده.
一项由妙佑医疗国际综合癌症中心的研究人员牵头的研究表明，相比目前单纯采用化疗的标准疗法，在标准化疗疗法中添加brentuximab vedotin可提高霍奇金淋巴瘤患者的总体存活期。
New findings reveal how recovery progresses following inflammation triggered by injury or illness
Investigators at Cedars-Sinai have proposed a theory for how SARS-CoV-2, the virus that causes COVID-19, infects the body. Their hypothesis, published in Frontiers in Immunology, could explain why some people still have symptoms long after the initial infection.
Media are invited to pre-register for the ACAAI Annual Scientific Meeting in Louisville, KY, November 10-14.
Rutgers Cancer Institute of New Jersey expert shares advice on health and wellness as students transition back into the classroom.
Researchers have successfully engineered human immune cells to model an infection common among immunocompromised people in a breakthrough discovery, paving the way for new drug testing and treatments.
The immune system of vertebrates is a powerful weapon against external pathogens and cancerous cells. T cells play a curcial role in this context.
Call them “little pinches” or “the thing that gets you a cool Bugs Bunny Band-Aid,” childhood vaccines offer big rewards. A Penn State Health pediatrician offers advice for new parents.
Cedars-Sinai investigators have developed a method to help identify which human gut microbes are most likely to contribute to a slew of inflammatory diseases like obesity, liver disease, inflammatory bowel disease, cancer and some neurological diseases.
The majority of people who were likely infected with the Omicron variant of SARS-CoV-2, the virus that causes COVID-19, didn’t know they had the virus, according to a new study from Cedars-Sinai investigators. The findings are published in JAMA Network Open.
The immune cells that protect us from infection and cancer seek out a wide array of fuel sources to power their function — including some long thought to be cellular waste products. The findings, published in Cell Metabolism, lay the foundation for future personalized dietary recommendations designed to supercharge the immune system and augment therapies for cancer and other diseases.
When it comes to COVID-19 immunity, antibodies do not tell the whole story, according to Cedars-Sinai professor of Medicine Stanley C. Jordan, MD.
As SARS-CoV-2 has evolved and mutated, therapeutic antibodies that worked early in the pandemic have become less effective, and newer variants, especially Omicron, have developed ways to evade the antibodies we make in response to vaccines.
The laboratory of Hai-Hui “Howard” Xue at the CDI published the findings of the complex and cascading molecular interactions modulating T-cell immunology in the August issue of the journal Nature Immunology.
Scientists have clarified the cellular mechanisms of asthma. The results open new perspectives for effective therapy of the disease.
A University of Minnesota assistant professor is part of a team that has developed a new way to effectively deliver vaccines through the nose that could lead to better protection against diseases like HIV and COVID-19.
A research team at the University of Oklahoma published a study in the journal Advanced Science that presents a new approach to triggering an adaptive immune response.
Most people in the United States have some degree of immune protection against Covid-19, either from vaccination, infection, or a combination of the two. But, just how much protection does any individual person have?
Below are some of the latest articles that have been added to the Food Science channel on Newswise, a free source for journalists.
College of Medicine researchers found that replication protein A works with an ally called the WAS protein to ‘save the day’ and prevent potential cancers from developing.
A cancer therapy model in which existing medication can be used to degrade for only a required period of time and reduce the protein responsible for programmed cell death has been developed. The team utilizes the small-molecule-assisted shutoff -- or SMASh -- degron system in both cultured cells and mice in vivo. Cancer cell growth was suppressed in wild-type mice.
We rate this claim as mostly true. Among the ways monkeypox can spread is by "Touching objects, fabrics (clothing, bedding, or towels), and surfaces that have been used by someone with monkeypox," according to the Centers for Disease Control and Protection.
A specific group of bacteria-killing proteins inside the immune system could hold the key to developing smarter and more effective drugs capable of eliminating certain infectious diseases including meningitis, pneumonia and sepsis, according to scientists from The Australian National University (ANU).
A team of Rutgers researchers and others inject parasitic worms into mice to study how injured cells trigger an immune response.
A research team, comprised of Associate Professor Tomonari Sumi of the Research Institute for Interdisciplinary Science at Okayama University and Associate Professor Kouji Harada of the Center for IT-based Education (CITE) at Toyohashi University of Technology, has developed a mathematical model of the immune response within infected hosts that considers systemic infection of a novel coronavirus (SARS-CoV-2), and demonstrated by conducting experimental computer simulations that persistent viral infections within hosts potentially cause long COVID or post-acute sequelae of COVID-19.
The COVID-19 pandemic has wreaked havoc worldwide. While most infected individuals experience mild symptoms, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus may cause severe pneumonia, acute respiratory distress syndrome, and organ damage in some patients, particularly those with comorbidities.
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