Scientists from the Florida campus of The Scripps Research Institute have been awarded $1.2 million from the National Cancer Institute of the National Institutes of Health to accelerate development of drug candidates to curb one of the most important drivers of human cancer.
An international team of nuclear physicists announced the first scientific results from the Cryogenic Underground Observatory for Rare Events (CUORE) experiment. CUORE is designed to confirm the existence of the Majorana neutrino, which scientists believe could hold the key to why there is an abundance of matter over antimatter.
The Cedars-Sinai Heart Institute completed 120 adult heart transplants and two adult heart-lung transplants in 2014, setting a new national standard for the most adult heart transplants performed in a single year.
With a $30 million lead gift in 2004, Evelyn and Ernest Rady and the Rady Family Foundation helped establish UC San Diego’s world-class, entrepreneurial business school—the Rady School of Management. They also contributed $5 million toward the expansion of the business school’s campus, and gave other significant gifts to ensure excellence at the school.
Scientists at The Scripps Research Institute (TSRI) have identified a molecule in the brain that triggers schizophrenia-like behaviors, brain changes and global gene expression in an animal model. The research gives scientists new tools for someday preventing or treating psychiatric disorders such as schizophrenia, bipolar disorder and autism.
Stanford University and the Department of Energy’s SLAC National Accelerator Laboratory have established the first endowed professorship that is reserved specifically for joint appointments between the two.
Salk scientists discover a single protein that energizes muscles and the brain
The American Association of Critical-Care Nurses announces the recipients of its annual research grants, with total available funding of $160,000.
We age in part thanks to “friendly fire” from the immune system — inflammation and chemically active molecules called reactive oxygen species that help fight infection, but also wreak molecular havoc, contributing to frailty, disability and disease. The CD33rSiglec family of proteins are known to help protect our cells from becoming inflammatory collateral damage, prompting researchers at the University of California, San Diego School of Medicine to ask whether CD33rSiglecs might help mammals live longer, too.
New research forthcoming in Management Science determines that the “shelf life” of malaria-fighting drugs plays a significant role in how donors should subsidize the medicine in order to ensure better affordability for patients.
EMBARGOED HEART RESEARCH: Middle-aged athletes are at low risk for having a sudden cardiac arrest while playing sports, and those who do have a greater chance of surviving the usually-fatal condition, shows a new Cedars-Sinai Heart Institute study.
A new UCLA study takes another step toward the early understanding of a degenerative brain condition called chronic traumatic encephalopathy, or CTE, which affects athletes in contact sports who are exposed to repetitive brain injuries. Using a new imaging tool, researchers found a strikingly similar pattern of abnormal protein deposits in the brains of retired NFL players who suffered from concussions.
Research suggests that HIV induces age-associated changes to the DNA, which in turn lead to earlier onset of age-related illnesses such as some cancers, renal and kidney disease, frailty, osteoporosis and neurocognitive diseases by more than 14 years.
Professor James Hicks, director of UCI’s Exercise Medicine & Sport Sciences Initiative, leads novel probe of impact injuries in water polo. The goal of the three-pronged study – aided by the popular sport’s national governing body – is to compile scientific data on risk, prevalence and protection.
Scientists at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have published the world’s largest set of data on the complete elastic properties of inorganic compounds, increasing by an order of magnitude the number of compounds for which such data exists.
Methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic-resistant superbug, can cause life-threatening skin, bloodstream and surgical site infections or pneumonia. Researchers at the University of California, San Diego School of Medicine now report that cigarette smoke may make matters worse. The study, published March 30 by Infection and Immunity, shows that MRSA bacteria exposed to cigarette smoke become even more resistant to killing by the immune system.
In work that reconciles two competing views of brain structures involved in memory and spatial perception, researchers at University of California, San Diego School of Medicine have conducted experiments that suggest the hippocampus – a small region in the brain’s limbic system – is dedicated largely to memory formation and not to spatial skills, such as navigation. The study is published in this week’s issue of the Proceedings of the National Academy of Sciences.
The San Diego Supercomputer Center (SDSC) will begin addressing a rapidly emerging area of interest in data science by holding its first Graph Analytics “boot camp” on Thursday, April 23rd, at its location on the UC San Diego campus in La Jolla, California.
Cells of the intestine, liver and pancreas are difficult to produce from stem cells. Writing in Cell Stem Cell April 2, researchers at University of California, San Diego School of Medicine have discovered that chromosomes in laboratory stem cells open slowly over time, in the same sequence that occurs during embryonic development. It isn’t until certain chromosomal regions have acquired the “open” state that they are able to respond and become liver or pancreatic cells.
Sanford-Burnham Medical Research Institute (Sanford-Burnham) today announced that it has signed a licensing agreement to further develop a first-in-class small molecule with Daiichi Sankyo for the treatment of cardiovascular-metabolic disease. The small molecule is based on longstanding, groundbreaking biology work by a Sanford-Burnham scientist and his laboratory team, who for decades focused their research on treating a consequence of cardiovascular-metabolic disease.
Scientists from the Florida campus of The Scripps Research Institute have been awarded $3.3 million by the National Institutes of Health to identify biomarkers to accelerate drug development for disorders including autism spectrum disorder, epilepsy and some types of intellectual disability.
Michael Neely, MD, a pediatric infectious diseases specialist at Children’s Hospital Los Angeles, helps explain the facts about measles, and how parents can prevent further outbreak. MD, a pediatric infectious diseases specialist at Children’s Hospital Los Angeles, helps explain the facts about measles, how parents can prevent further outbreak, and what CHLA can do to help prevent infection and to treat those who have already been infected.
Collaborative relationships between nurses and physicians decrease rates of healthcare-associated infections (HAIs) in critical care, according to an article in the April issue of Critical Care Nurse
An international team has for the first time precisely tracked the surprisingly rapid process by which light rearranges the outermost electrons of a metal compound and turns it into an active catalyst – a substance that promotes chemical reactions.
Ann Almgren and Esmond Ng of Lawrence Berkeley National Laboratory’s Computational Research Division (CRD) are among the 2015 class of 31 mathematicians named as Fellows of SIAM, the Society for Industrial and Applied Mathematics.
In the April 2015 issue of Genome Research, a team including DOE JGI researchers compared two ways of using next generation Illumina sequencing machines to help with a metagenomics challenge where the more commonly used sequencing machines generate data in short lengths, while short-read assemblers may not be able to distinguish among multiple occurrences of the same or similar sequences, making it difficult to identify all the members in a microbial community.
Tropical forests play major roles in regulating Earth's climate, but there are large uncertainties over how they'll respond over the next 100 years as the planet's climate warms. An expansive new project led by scientists from Berkeley Lab aims to bring the future of tropical forests and the climate system into much clearer focus. The project is called the Next Generation Ecosystem Experiments-Tropics, or NGEE-Tropics.
Leaders from Children’s Hospital Los Angeles (CHLA) and the National Center for Maternal and Child Health (NCMCH), Mongolia’s flagship pediatric medical facility, marked 20 years of institutional collaboration Tuesday with a special “telemedicine” program and celebration honoring past accomplishments and outlining future efforts to better the health care of Mongolian children.
Researchers at UC Davis have illuminated an important distinction between mice and humans: how human livers heal. The difference centers on a protein called PPARα, which activates liver regeneration. Normally, mouse PPARα is far more active and efficient than the human form, allowing mice to quickly regenerate damaged livers. However, the research shows that protein fibroblast growth factor 21 (FGF21) can boost the regenerative effects of human PPARα. The findings suggest that the molecule could offer significant therapeutic benefits for patients who have had a liver transplant or suffer from liver disease. The study was published in the journal Oncotarget.
A collaboration of Berkeley Lab and UC San Diego researchers has recorded the first direct observations of the micro-scale mechanisms behind the ability of skin to resist tearing. The results could be applied to the improvement of artificial skin, or to the development of thin film polymers for flexible electronics.
By age 60, more than 50 percent of men in the United States suffer from benign prostatic hyperplasia, a condition that leads to annoying changes in urinary flow. While medical therapy is usually the first line of treatment, a new minimally invasive implant can dramatically reduce symptoms for men.
Religion Dispatches hires award-winning journalist Cathleen Falsani as Senior Editor for new project
To find a standard 3D neuron reconstruction algorithm, BigNeuron will sponsor a series of international hackathons and workshops where contending algorithms will be ported onto a common software platform to analyze neuronal physical structure using the same core dataset. All ported algorithms will be bench-tested at the Department of Energy's NERSC and ORNL, as well as Human Brain Project supercomputing centers.
Scientists from The Scripps Research Institute have uncovered the unique mechanism of a powerful natural product with wide-ranging antifungal, antibacterial, anti-malaria and anti-cancer effects. The new study sheds light on the natural small molecule known as borrelidin.
Researchers at the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences produced 3D maps of molecular and microbial variations across the body. These maps provide a baseline for studies of the interplay between the molecules that make up our skin, our microbiomes, our personal hygiene routines and other environmental factors. The study, published March 30 by PNAS, may help further our understanding of the skin’s role in human health and disease.
In the first study of its kind, scientists at Lawrence Berkeley National Laboratory quantitatively show that electric vehicles (EVs) will meet the daily travel needs of drivers longer than commonly assumed. They found that batteries that have lost 20 percent of their originally rated energy storage capacity can still meet the daily travel needs of more than 85 percent of U.S. drivers.
a team of UCLA researchers has shown for the first time in a large cohort of patients that electroconvulsive therapy (ECT), sometimes referred to as shock treatment, change certain areas of the brain that play a role in how people feel, learn and respond to positive and negative environmental factors.
The March tip sheet from Cedars-Sinai includes information on exercise and sexual function, gut bacteria and weight loss surgery, students learning about exercise and brain health, an international nanomedicine conference and more.
We’ve all observed them: online trolls who post insensitive and inflammatory comments on the Internet to provoke and upset as many people as possible. If we could just eliminate trolls from the Internet the world would be a friendlier place, right? Not exactly, says HSU Communication Lecturer Whitney Phillips.
Characterizing associations between socioeconomic factors and children’s brain development, a team of investigators reports correlative links between family income and brain structure. Relationships between the brain and family income were strongest in the lowest end of the economic range – suggesting that interventional policies aimed at these children may have the largest societal impact.
UCSF Benioff Children’s Hospital Oakland hosted its 8th annual St. Baldrick’s Foundation signature head-shaving event on March 13 and March 14 and made over $215,000 for life-saving childhood cancer research. Two-hundred and forty-two participants shaved their heads to support the event that seeks conquer childhood cancers. Shave-a-thon participants at UCSF Benioff Children’s Hospital Oakland have cumulatively raised $1.4 million for the St. Baldrick's Foundation, the largest non-government funder of childhood cancer grants worldwide.
A team of investigators at Children’s Hospital Los Angeles and the University of Southern California have developed the first fully implantable micropacemaker designed for use in a fetus with complete heart block. The investigators anticipate the first human use of the device in the near future.
A new study led by Scripps Institution of Oceanography at UC San Diego researchers has revealed that the thickness of Antarctica’s floating ice shelves has recently decreased by as much as 18 percent in certain areas over nearly two decades, providing new insights on how the Antarctic ice sheet is responding to climate change.
Most children with HIV who have low levels of a key immune cell eventually recover levels of this cell after they begin treatment.
The program for the upcoming health-care symposium is being finalized, featuring more than 200 presentations by researchers, physicians and other health-care providers, medical device designers, policy-makers, health IT professionals, and biomedical engineers.
Researchers at the University of California, San Diego School of Medicine have discovered a control switch for the unfolded protein response (UPR), a cellular stress relief mechanism drawing major scientific interest because of its role in cancer, diabetes, inflammatory disorders and several neural degenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS).
Researchers have found a powerful relationship between prenatal polycyclic aromatic hydrocarbon (PAH) exposure and disturbances in parts of the brain that support information processing and behavioral control.
The Scripps Research Institute has named Christopher A. Lee, formerly of PCI (Project Concern International), as director of philanthropy on the institute’s La Jolla, California campus.
AACN Advanced Critical Care features a symposium collection of four articles with specific examples of how clinical nurse specialists contribute to the delivery of optimal care to patients and the fiscal operations of healthcare institutions.
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