This research illustrates the importance of a well-known cytokine called interleukin-13 in protecting cells against SARS-CoV-2, which helps explain the mystery of why people with allergic asthma fair better against COVID despite having a chronic lung condition.
Already checked regularly for worsening symptoms via automated text messages, COVID-19 patients with pulse oximeters in a home monitoring program had similar recovery to those without them.
A University of Minnesota-led research team analyzed the fundamental properties and structures of the naturally occurring substances that help human lungs expand and contract, providing insight into how the substances help us breathe.
Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.
Scientists have developed a treatment for pulmonary fibrosis by using nanoparticles coated in mannose — a type of sugar — to stop a population of lung cells called macrophages that contribute to lung tissue scarring. The cell-targeting method holds promise for preventing this severe lung scarring disease, which can result in life-threatening complications like shortness of breath.
Researchers have identified a family of proteins that is significantly elevated in the saliva of patients hospitalized with COVID-19. The proteins, known as ephrin ligands, could potentially serve as a biomarker to help doctors identify patients who are at risk for serious illness.
Babies and toddlers who need a tracheostomy – a tube surgically inserted into their windpipe to help relieve breathing problems – are at a high risk of accumulating fluid behind their eardrum when on a ventilator. That’s the conclusion of a new study, published in the International Journal of Pediatric Otorhinolaryngology, by UT Southwestern head and neck surgeons. This buildup of fluid, called a middle ear effusion, can put them at risk for ear infections, hearing loss, and delays in speech and language development.
Cedars-Sinai Cancer experts will present their latest advances in treatments and research at the American Association for Clinical Research (AACR) Annual Meeting 2022 in New Orleans, April 8-13. They will share their innovations to improve the quality of patient care.
Tumor biopsies are currently the most common tool for diagnosing lung cancer. However, according to a new paper published by the University of Kentucky and Manipal Academy of Higher Education, there is evidence that liquid biopsies – obtained from a blood sample – have the potential to replace tumor biopsies that require patients to undergo a surgical procedure.
For the first time at Northwestern Medicine, surgeons have successfully performed a double-lung transplant on a patient with terminal lung cancer. The patient, 54-year-old Albert Khoury of Chicago, is a non-smoker who was diagnosed with lung cancer at the start of the COVID-19 pandemic. Six months after his transplant, Khoury’s new lungs are working well, and he currently has no signs of cancer left in his body, giving hope to other patients with advanced stages of this deadly disease.
Mount Sinai researchers have developed a novel method to identify aggressive early-stage lung cancers and target drugs known as aurora kinase inhibitors to tumors that are especially likely to respond to them.
The $5.8 million center at Texas Biomed is one of the inaugural Interdisciplinary NexGen TB Research Advancement Centers (IN-TRAC) funded by the U.S. National Institute of Allergy and Infectious Diseases.
The lower airways of patients with cystic fibrosis (CF) have unique biochemical features that correlate with the complex communities of lung bacteria typical of this disease, according to a multicenter study led by researchers from Ann & Robert H. Lurie Children’s Hospital of Chicago. These findings offer insights into the underlying biological mechanisms driving infection and inflammation in the CF lungs, and may help develop novel targeted therapies and more precise diagnostics to improve the care of children with CF.
A multicenter research team co-led by The University of Texas MD Anderson Cancer Center developed the first drug to treat the uncontrolled secretion of mucins in the airways, which causes potentially life-threatening symptoms in millions of Americans with common lung diseases.
Engineers and scientists have developed proof of concept for a robot that can reach some of the smallest bronchial tubes in the lungs - to take tissue samples or deliver cancer therapy.
In support of World TB Day, March 24, the Forum of International Respiratory Societies (FIRS), of which the American Thoracic Society is a founding member, calls on the tuberculosis community to challenge ourselves to think differently, champion science and embrace evidence-based innovation if we are to end TB.
Millions of athletes worldwide have been wrestling with the challenges of working out under stay-at-home orders and evolving COVID-19 mandates and concerned about wearing a face mask if training in public or outside.
Mount Sinai Study finds that youth exposed to environmental tobacco smoke experienced significantly lower odds of wheezing when maintaining a higher quality diet
UC San Diego study shows neuroendocrine cells in the lungs drive a developmental lung disease, and a similar brain-lung interaction may contribute to COVID-19 symptoms. The findings suggest neuropeptides may be a promising therapeutic target for conditions with excess lung fluid.
Wellinks®, a digital health care company offering the first-ever integrated, virtual Chronic Obstructive Pulmonary Disease (COPD) management solution, today announced results from a study that found that older adults with COPD were highly engaged and satisfied with Wellinks.
A Yale Cancer Center research team has identified novel oncogenic gene fusions in lung and pancreatic cancer, as well as sarcoma.
Most patients with severe COVID who are put on ventilators regain consciousness after removal of respiratory support, but recovery may take weeks after the period of mechanical ventilation has ended, according to a new study by investigators at Weill Cornell Medicine, Columbia University Vagelos College of Physicians and Surgeons, Harvard Medical School, NewYork-Presbyterian and Massachusetts General Hospital.
A Johns Hopkins Children’s Center-led study in animals suggests that high doses of a widely used antibiotic called rifampin may safely treat and reduce the duration of treatment for the deadliest form of tuberculosis that affects the brain.
The ATS 2022 International Conference Program is now live! After two years of virtual conferences, ATS 2022 promises to bring you a dynamic, expansive offering of scientific content in pulmonary, critical care and sleep. Join us in San Francisco, California starting May 13*.
A small black lump, about an inch or so in width, rests on the bottom of a sealed plastic container. It doesn’t look like much – in fact, it doesn’t look like anything. But this little black lump has untold potential, full of secrets for the researchers at Kentucky Research Alliance for Lung Disease (K-RALD) to discover about the pandemic that has ravaged the world for more than two years.
Some patients with severe COVID-19 who are treated with extracorporeal membrane oxygenation (ECMO) may experience significant lung recovery and return to normal lives with “meaningful” long-term outcomes.
Don't miss these articles in our Staff Picks channel
Investigators at Cedars-Sinai have identified a potential new therapy for COVID-19: a biologic substance created by reengineered human skin cells.
A real-time electronic decision support system helped clinicians at community hospitals provide best practice care for emergency department patients with pneumonia, resulting in decreased intensive care unit admission, more appropriate antibiotic use, and 38% lower overall mortality according to a new study by researchers at Intermountain Healthcare in Salt Lake City.
Today, the American Thoracic Society joined the chorus of voices worldwide condemning the violence in Ukraine.
Researchers found a unique immune cell plays a key role in the chronic inflammation and scarring in the lungs and skin of people with scleroderma, or systemic sclerosis. After injecting mice with biodegradable PLG nanoparticles, which are used in medical sutures, researchers found that the nanoparticles specifically targeted these inflammatory cells and prevented skin and lung fibrosis. Researchers say it's a promising step towards targeted treatment for patients with early scleroderma.
Nirsevimab showed 74.5 percent efficacy against medically attended lower respiratory tract infections caused by respiratory syncytial virus (RSV) in healthy infants, according to an international, randomised, placebo-controlled Phase 3 clinical trial. It is the first potential immunization against RSV in the general infant population, with a single dose providing safe protection across the entire RSV season. Results were published in the New England Journal of Medicine.
In the latest update to the pulmonary function tests technical standard series, the American Thoracic Society and European Respiratory Society address the uncertainty around the interpretation of the tests which are essential in determining the extent of respiratory dysfunction. The update was recently published in the European Respiratory Journal ahead of a planned webinar series by the ATS.
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Approximately 23,700 children in the U.S. undergo invasive mechanical ventilation for acute respiratory failure annually. Although most survive, little is known if they have worse long-term neurocognitive function than children who do not undergo such procedures. There are concerns about neurotoxic effects of critical illness and its treatment on the developing brain. Therefore, infants and young children may be uniquely susceptible to adverse neurocognitive outcomes after invasive mechanical ventilation.
An international research team from universities including Chalmers University of Technology, Sweden, the University of Padua and the University of Udine in Italy, and the University of Vienna, Austria, has developed a new theoretical model to better assess the risks of spreading viruses such as Covid-19 – with and without a face mask.
An analysis of data from 1,480 COVID-19 patients hospitalized in March 2020 at 57 U.S. hospitals is one of the few studies conducted in diverse, multicenter patient populations that describes patients’ illness trajectory, patterns of organ failure, therapies and clinical outcomes.
E-cigarette vapers and hookah smokers are more than twice as likely to exhale particles through their nose compared with cigarette smokers, who favor exhaling the emissions from their mouth, a new study shows. The finding makes it plausible that the former group is at risk for inflammation and cancers of the nose, sinuses, and throat, conditions seen less often in cigarette smokers, according to the study authors.
Antibiotics provide no benefit in preventing future recurrent wheezing in babies hospitalized with respiratory syncytial virus (RSV), according to a new study led by Washington University School of Medicine in St. Louis. And there is some evidence that antibiotics may make wheezing worse.
Virtual visits allow providers to assess home setup and safety—and help families breathe easier. An innovative telehealth program at Children’s Hospital Los Angeles is offering an extra layer of support to a particularly fragile patient population: children on home mechanical ventilation.Through the program, which began in February 2020, all families have a virtual video visit with their pulmonologist and nurse care manager within 48 hours of their child being newly discharged from the hospital on a ventilator.
The Latest Research News in Cardiovascular Health
Loyola University Chicago Stritch School of Medicine and Loyola Medicine, its academic medical center partner and a member of Trinity Health, announce the appointment of Marilyn Glassberg Csete, MD, as chair of the department of medicine, effective July 1, 2022.
After two years of virtual conferences, the ATS 2022 International Conference will be live and in-person. San Francisco will play host to the largest gathering of scientists and clinicians in pulmonary, critical care, and sleep medicine.
Medication against the nonhuman primate version of HIV given two weeks after infection helped keep tuberculosis in check.
Asymptomatic COVID infection in generally healthy unvaccinated adults is likely much less common than previously reported, according to a new study published Feb. 14 in Open Forum Infectious Diseases by researchers at the Uniformed Services University of the Health Sciences (USU).
In a small study of long COVID-19 patients, those with and without coronary artery disease demonstrated improvement of a variety of symptoms, including fatigue, breathing difficulties and chest discomfort, after undergoing 15-35 hours of enhanced external counterpulsation (EECP) therapy.
. In a new article published in Nature Communications, the laboratory of Elsa R. Flores, Ph.D., in collaboration with the Baylor College of Medicine and MD Anderson Cancer Center, shows how the protein ΔNp63 contributes to disease development through the regulation of stem cells and crucial elements known as enhancers, which regulate genes that control cell identity.
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