Just like land plants, algae use sunlight as an energy source. Many green algae actively move in the water; they can approach the light or move away from it. For this they use special sensors (photoreceptors) with which they perceive light.
The collaborative research between the Kornberg School of Dentistry and the College of Engineering uses stem cells to regrow the pulp-dentin complex that makes up the center of a tooth.
MD Anderson researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers.
Using one of the most powerful microscopes in the world, scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) and University of North Carolina at Chapel Hill (UNC-Chapel Hill) have identified a dense, dynamic and disorganized actin filament nanoscaffold—resembling a haystack—that is induced in response to a molecular signal. This is the first time researchers have directly visualized, at the molecular level, a structure that is triggered in response to a cellular signal—a key finding that expands our understanding of how cells move. The study was published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS).
A landmark study has found that a newer targeted drug is significantly more effective than standard therapy for treating elderly patients with chronic lymphocytic leukemia (CLL). The drug, ibrutinib, attacks cancer cells without damaging normal cells, thus causing fewer side effects.
UCLA researchers led by Dr. Donald Kohn have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life-threatening autoimmune syndrome called IPEX.
Berkeley scientists have turned CRISPR-Cas9 genome editing technology into a synthetic immune response. Their engineered "ProCas9" is safely turned off until a plant or animal virus infects the cell. ProCas9 can be programmed to initiate an immune reaction in response to specific viral threats, like Zika and West Nile.
Our DNA is under constant attack. The delicate molecule that contains our genetic information is extremely vulnerable to everything from environmental agents, such as radiation, to the chemicals in the air we breathe and the food we eat. Genome instability can lead to genetic disorders, chronic diseases and a predisposition to cancer.
Researchers have demonstrated—using fat cells derived from human stem cells—that individual genetic variation can be used to predict whether the TZD rosiglitazone will produce the unwanted side effect of increasing cholesterol levels in certain individuals.
A genome-wide study of nearly 45,000 people has identified 16 regions of DNA associated with epilepsy. The International League Against Epilepsy (ILAE) Consortium on Complex Epilepsies did the analysis, which is the largest of its kind. It was published in a recent issue of Nature Communications.
For the past 15 years, LIPID MAPS has served scientists working to specify and classify lipids in order to develop techniques, tools and terms to better study them. Now with new support, the database will continue advancing the study of these fatty acids and the field of lipidomics.
Microbiome community linked to lower influenza susceptibility
روتشستر، مينيسوتا — نشر باحثون من Mayo Clinic، بالتعاون مع باحثين من كلية ويك فورست للطب و مركز العلوم الصحية بجامعة تكساس في سان أنطونيو، نتائج دراسة سريرية حول سلامة وجدوى إزالة خلايا مُسنّة من مجموعة صغيرة من المرضى المصابين بالتليف الرئوي. وعُرِضت نتائج الدراسة في مجلة الطب الحيوي "إي بايو مديسن" EBioMedicine.
Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered that squamous cell skin cancers do not require increased glucose to power their development and growth, contrary to a long-held belief about cancer metabolism. The findings could bring about a better understanding of many cancers' metabolic needs and lead to the development of more effective therapies for squamous cell skin cancer and other forms of epithelial cancer.
LOUISVILLE, Ky. - Scientists at the University of Louisville have shown that a microbial metabolite, Urolithin A, derived from a compound found in berries and pomegranates, can reduce and protect against inflammatory bowel disease (IBD). Millions of people worldwide suffer from IBD in the form of either ulcerative colitis or Crohn's disease, and few effective long-term treatments are available.
A special edition of National Geographic on "The Future of Medicine" highlights the innovative stem-cell science of Cedars-Sinai, showing how investigators are seeking to use stem cells and Organ-Chips to tailor personalized treatments for individual patients. Downloadable video available.
ROCHESTER, Minnesota. — Pesquisadores e colaboradores da Mayo Clinic demonstraram em ratos que a obesidade aumenta o nível de células “zumbis” ou senescentes no cérebro e que essas células, por sua vez, estão ligadas à ansiedade. Quando drogas senolíticas são usadas para limpar essas células, os comportamentos ansiosos nos ratos se dissipam. Esses resultados aparecem na revista Cell Metabolism.
John “Chip” Tilton, MD, of Case Western Reserve University School of Medicine will receive $300,000 from the Dr. Ralph and Marian Falk Medical Research Trust to develop a virus-based “nanoPOD” (nanoscale PrOtein Delivery) platform to help treat rare genetic diseases. Tilton’s project will address a major challenge in developing nanoscale therapeutics: finding ways to deliver them to the right location inside the body.
Los investigadores de Mayo Clinic junto con otros colaboradores de la Escuela de Medicina de la Universidad de Wake Forest y del Centro de Ciencias de la Salud de la Universidad de Texas en San Antonio publicaron los resultados de un ensayo clínico sobre la seguridad y la factibilidad de extraer células senescentes en un pequeño grupo de pacientes con fibrosis pulmonar.
Wistar, along with partners Penn Medicine and Inovio Pharmaceuticals, Inc. announce the FDA has approved the initiation of a first-in-human clinical trial investigating safety and tolerability of a novel synthetic DNA-encoded monoclonal antibody (DMAb) therapeutic technology for the prevention of Zika virus infection.
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