Researchers analyzed data from more than 1,000 breast cancer patients and found that breast cancer behaves differently than other cancers that are currently treated with immunotherapy. They identified seven clusters of breast cancer patients based on the immune evasion mechanisms that breast cancer uses to avoid detection.
Researchers found that excitatory neurons – those that are more likely to trigger an action (as opposed to inhibitory neurons, which are less likely to prompt neural activity) – are more vulnerable to accumulations of abnormal tau protein, which is increasingly being implicated in Alzheimer’s disease.
A new study finds that some brain cells protect themselves from Alzheimer’s with a cellular cleaning system that sweeps away toxic proteins associated with the disease.
Researchers at Queen’s University Belfast have discovered a new way to analyse bowel cancer tumours, which could lead to more personalised treatments and better prognosis for patients.
Medical researchers at Melbourne's Murdoch Children's Research Institute have made a new discovery about how a baby's sex is determined - it's not just about the X-Y chromosomes, but involves a 'regulator' that increases or decreases the activity of genes which decide if we become male or female.
A team of Rutgers scientists have taken an important step toward the goal of making diseased hearts heal themselves – a new model that would reduce the need for bypass surgery, heart transplants or artificial pumping devices.
The Biophysical Society (BPS) announced that Jennifer Pesanelli has been selected as the next Executive Officer of the Society. Current Executive Officer Ro Kampman announced her retirement in June. Pesanelli joins BPS from the Federation of American Societies for Experimental Biology (FASEB), where she has held a number of positions over the last 20 years.
Researchers have developed genetically modified pigs that are protected from classical swine fever virus (CSFV), according to a study published December 13 in the open-access journal PLOS Pathogens by Hongsheng Ouyang of Jilin University, and colleagues. As noted by the authors, these pigs offer potential benefits over commercial vaccination and could reduce economic losses related to classical swine fever.
Kennesaw State University researcher Daniel Morris recently received a three-year $403,000 grant from the National Institutes of Health to improve the delivery of protein therapeutics and the CRISPR/Cas gene-editing technology to living cells.
Gene trees, much like family trees, trace the lineage of a particular gene from its deep ancestral roots to its still-growing stems. By comparing gene trees to species trees, which map the evolutionary history of species, scientists can learn which species have which genes, what new functions those genes gained over time, and which functions they may have lost. Now, scientists at the Okinawa Institute for Science and Technology Graduate University (OIST) have unveiled a new tool to perform these analyses quickly and without computational headaches.
Research in mouse cells identifies defective metabolic pathway in aging immune T cells. The pathway is critical for switching T cells from dormancy into illness-fighting mode. In experiments, researchers restored lagging T-cell function by adding small-molecule compounds. Findings suggest possible mechanism behind weakened immunity common in the elderly.
Ebola virus (green) infects human cells much more easily when you remove the protective RBBP6 protein (compare left to right). Researchers have discovered a human protein that helps fight the Ebola virus and could one day lead to an effective therapy against the deadly disease, according to a new study from Northwestern University, Georgia State University, University of California, San Francisco (UCSF) and the Gladstone Institutes published today, Dec.
In an effort to better understand frontotemporal dementia, an international team of researchers, led by Washington University School of Medicine in St. Louis, has found that a lone mutation in a single gene that causes an inherited form of the disorder makes it harder for neurons in the brain to communicate with one another, leading to neurodegeneration.
Isaac H. Clothier Jr. Professor of Biology Amy Cheng Vollmer was recently a guest on Key Conversations, a podcast from the Phi Beta Kappa (PBK) Society that features dialogues with PBK Visiting Scholars.
Researchers at Stanford University, Palo Alto, California, have created a noninvasive technology that detects when nerve cells fire based on changes in shape. The method could be used to observe nerve activity in light-accessible parts of the body, such as the eye, which would allow physicians to quantitatively monitor visual function at the cellular level.
Conventional math cannot adequately model the interaction of multiple genes over multiple time frames – a necessary foundation for any cancer-fighting drugs. The study, published in “Frontiers in Physiology” by Mahboobeh Ghorbani, Edmond Jonckheere and Paul Bogdan of the Ming Hsieh Department of Electrical Engineering, is the first study that accounts for the memory, cross-dependence and fractality of gene expression
Researchers from the University of Texas MD Anderson Cancer Center have discovered that ovarian cancer cells spread, or metastasize, to new tissue after being caught in DNA "webs" extruded by immune cells. The study, which will be published December 19 in the Journal of Experimental Medicine, reveals that preventing immune cells from forming these webs reduces metastasis in mice, suggesting that similar treatments could be used to limit the spread of ovarian cancer in humans.
A medida que el nuevo año se aproxima, entre las resoluciones de muchas personas está alcanzar un buen estado físico y mejorar el bienestar. Ahora, los científicos descubren que ambas mejoras pueden llevar a vivir más largo.
A company in Israel has unveiled the world’s first lab-grown steak, grown in a petri dish with the taste and texture of one that comes from a cow. Jan Dutkiewicz, a postdoctoral fellow in political science at Johns Hopkins University has researched the emergence of cellular agriculture. He is available to talk about the new steak and offer perspective on the development.
Like people in a large company, proteins in cells constantly interact with each other to perform various jobs. To develop new disease therapies, researchers are trying to control these interactions with small-molecule drugs that cause specific proteins to associate more or less with their “coworkers.” Now, researchers reporting in ACS’ journal Analytical Chemistry have developed a method to visualize whether drugs are regulating protein–protein interactions inside cells.
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