Research reveals that phage viruses that undergo special evolutionary training increase their capacity to subdue bacteria. The results provide hope for the antibiotic resistance crisis, a rising threat as deadly bacteria continue to evolve to render many modern drugs ineffective.
Research from Washington University School of Medicine in St. Louis shows that international travelers often return home with new bacterial strains jostling for position among the thousands that normally reside within the gut microbiome. Such travel is contributing to the rapid global increase and spread of antimicrobial resistance.
New research from the University of Georgia suggests a component of bacteria’s cell walls may hold the key to crushing the antibiotic-resistant microbes.
The National Institute of Allergy and Infectious Diseases, NIAID, part of the National Institutes of Health, NIH, has awarded $2.5 million in grants to support research on bacteriophage therapy, and Texas A&M AgriLife Research is among the grant recipients.
For centuries, people in Baltic nations have used ancient amber for medicinal purposes. Now, scientists report compounds that help explain its therapeutic effects and that could lead to new medicines to combat antibiotic-resistant infections. They will present their results at ACS Spring 2021.
Sabrina L. Spencer, PhD, is a CU Boulder researcher and CU Cancer Center member. Spencer recently won the Damon Runyon-Rachleff Innovation Award and the Emerging Leader Award. She will use the grants to continue her research on drug resistance in cancer cells.
Researchers from Cancer Science Institute of Singapore at NUS and A*STAR’s Genome Institute of Singapore as well as their collaborators have discovered the molecular pathway that interferes with breast cancer drugs, and found an additional drug that will reverse the effect. This discovery could give cancer patients more hope of overcoming the disease.
The bacterial equivalent of a traffic jam causes multilayered biofilms to form in the presence of antibiotics, shows a study published today in eLife.
Diphtheria - a relatively easily-preventable infection - is evolving to become resistant to a number of classes of antibiotics and in future could lead to vaccine escape, warn an international team of researchers from the UK and India.
The study in mice, “A Multifaceted Cellular Damage Repair and Prevention Pathway Promotes High Level Tolerance to Beta-lactam Antibiotics,” published Feb. 3 in the journal EMBO Reports, reveals how tolerance occurs, thanks to a system that mitigates iron toxicity in bacteria that have been exposed to penicillin.
A new study identifies a mechanism that makes bacteria tolerant to penicillin and related antibiotics, findings that could lead to new therapies that boost the effectiveness of these treatments.
While most adults over 50 understand that overuse of antibiotics is a problem, and say they’re cautious about taking the drugs, a sizable minority have used antibiotics for something other than their original purpose, and appear to think the drugs could help treat colds, which are caused by viruses not bacteria.
Iowa State University researchers received a $1 million grant to study how manure management systems in livestock production may give rise to antibiotic resistance. Human, animal and environmental health interact in complex ways that influence the pace at which antibiotic resistance spreads, and the researchers hope their work will shed light on these connections.
In a new article featured on this month’s cover of Cancer Research, Moffitt Cancer Center researchers, in collaboration with Oxford University, report results from their study using mathematical modeling to show that cell turnover impacts drug resistance and is an important factor that governs the success of adaptive therapy.
Chu-Young Kim, Ph.D., associate professor of chemistry and biochemistry at The University of Texas at El Paso, is helping combat the threat of superbugs – illnesses caused by drug-resistant bacteria – by returning to nature. His work is supported by a $1.2 million grant from the National Institutes of Health (NIH) to develop a biological method for producing new versions of current antibiotics that have become ineffective due to resistance
For Michigan State University’s Felicia Wu, the surprise isn’t that people who work with livestock are at higher risk of picking up antibiotic-resistant bacteria, but instead how much higher their risk levels are. “This is a bit of a wakeup call,” said Wu, John. A Hannah Distinguished Professor in the Departments of Food Science and Human Nutrition and Agricultural, Food and Resource Economics. “I don’t think there was much awareness that swine workers are at such high risk, for example. Or that large animal vets are also at extremely high risk.”
A new vaccine development platform has proven effective in protecting against deadly, hard-to-treat infections caused by multi-drug resistant (MDR) bacteria, thanks to a collaborative endeavor led by Dr. Michael J. Daly, a professor in the Uniformed Services University's (USU) Department of Pathology, Dr. Gregory J. Tobin, president of Biological Mimetics, Inc., and Dr. Daniel Zurawski at the Walter Reed Army Institute of Research. This could ultimately help prevent battlefield infections, as well as common hospital-acquired infections in patients undergoing routine surgeries.
Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research at Chalmers University of Technology, Sweden, shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans. This work has also led to new tools for resistance researchers.
The Monell Chemical Senses Center has received a two-year, $890,000 grant from the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation. Monell scientists and collaborators will develop a new way to classify fever-inducing diseases using distinct signatures of volatile chemicals from urine and saliva.
Researchers captured and comparted hi-res images of ribosome structures from sensitive and resistant bacteria and report that a water molecule needed for antibiotic binding was not present in the ribosomes from the drug-resistant bugs.
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