Feature Channels: Blood

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The study found the drug can help the most severely injured trauma patients.

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Researchers have identified genetic mutations that appear to protect women from severe bleeding after childbirth, a leading cause of maternal death.

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Two studies presented at the American College of Surgeons (ACS) Clinical Congress 2020 provide evidence that STOP THE BLEED training is effective and has made a lifesaving difference around the world.

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Drugs to lower blood pressure of the type ACE inhibitors or angiotensin II receptor blockers reduce the mortality rate of influenza and pneumonia.

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Although there is still uncertainty about the clinical benefits and role of convalescent plasma to treat COVID-19, new research suggests that the earlier plasma is collected after the donor's recovery from COVID-19, the better, as antibodies start to disappear after three months of symptom onset.

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In a systematic review of the worldwide published data on "Venous thromboembolism (VTE) in COVID-19 patients", Cihan Ay, Stephan Nopp, and Florian Moik from the Department of Medicine I, Clinical Division of Haematology and Haemostaseology, now for the first time, provide an in-depth analysis on the risk of VTE in patients hospitalised for COVID-19.

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A new study published in the journal Critical Care Explorations shows for the first time that part of the stress response in people and animals involves increasing the levels of a naturally circulating element in blood. The discovery demonstrates a biological mechanism that rapidly responds to severe physiologic stress and potentially serves to protect us from further damage due to life-threatening conditions.

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“She’s a bundle of joy, she’s a blessing. She’s just life.” That’s what Cariorl Mayfield of Niagara Falls, NY, says about his young daughter, Chasity, a year after she went through a complex series of therapies at the Roswell Park Oishei Children’s Cancer and Blood Disorders Program to treat the leukemia she was diagnosed with at only 5 weeks old.

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Developed in Canada, the UM171 molecule was used in a blood transplant by a Montreal medical team on a young man suffering from severe aplastic anemia, an autoimmune disease.

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Networking California for Sickle Cell Care Initiative supports expansion of San Diego’s only adult sickle cell disease clinic at UC San Diego Health which offers child-to-adult transition health services to patients like Vanessa Hughes.

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Sickle cell disease is a lifelong inherited disorder of the red blood cells that poses many challenges for the people and families living with it. Rutgers Cancer Institute expert shares more on the basics of sickle cell disease and how the illness is managed.

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Researchers report first clinically actionable findings for a rare blood vessel disease in a study of four unrelated families, all with the same genetic variant.

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NCCN publishes a new patient and caregiver resource focused on a childhood cancer type. Free NCCN Guidelines for Patients: Pediatric Acute Lymphoblastic Leukemia (ALL) shares the latest expert advice for treating infants, children, and adolescents with the most common pediatric malignancy.

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in a study with potential impacts on a variety of neurological diseases, Virginia Tech researchers have provided the first experimental evidence from a living organism to show that an abundant, star-shaped brain cell known as an astrocyte is essential for blood-brain barrier health.

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A new University of Kentucky College of Medicine study may provide answers for why so many COVID-19 patients experience thrombosis, or the formation of blood clots that obstruct blood flow through the circulatory system.

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Children who take oral steroids to treat asthma or autoimmune diseases have an increased risk of diabetes, high blood pressure, and blood clots, according to Rutgers researchers.

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During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.

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Some critically ill patients with septic shock need medications called vasopressors to correct dangerously low blood pressure. When high doses of vasopressors are needed or blood pressure isn’t responding well, the steroid hydrocortisone is often used. In this situation, earlier treatment with hydrocortisone reduces the risk of death and other adverse outcomes, reports a study in SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, Official Journal of the Shock Society. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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Adults with fatter legs -- meaning they have a higher percentage of total body fat tissue in their legs -- were less likely than those with a lower percentage to have high blood pressure, according to new research to be presented Sept. 10-13, 2020, at the virtual American Heart Association's Hypertension 2020 Scientific Sessions.

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A study released by Houston Methodist Sept. 10 in the Journal of Clinical Investigation takes researchers closer to developing a uniform, universal COVID-19 antibody test. The multicenter collaboration tested alternative ways to measure COVID-19 antibody levels that’s faster, easier and can inexpensively be used on a larger scale to accurately identify potential donors for plasma therapy with the best chance of helping patients infected with SARS-CoV-2.

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A new paper by vascular surgeons at the University of Miami Miller School of Medicine, published in the Journal of Vascular Surgery, describes how thrombosis (blood clots in the circulatory system) was an early indication of infection in a COVID-19 patient.

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After nearly 15 years on an upward trend, awareness among Americans about their high blood pressure and rates of blood pressure control are now on the decline. many groups, including older adults and Black adults, are less likely than they were in earlier years to control their blood pressure.

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Early findings from researchers at Children’s Hospital of Philadelphia (CHOP) show that convalescent plasma appears to be a safe and possibly effective treatment for children with life-threatening cases of COVID-19. The results were published online Friday by the journal Pediatric Blood and Cancer.

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Scientists from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago were the first to examine endothelial cells – one of the main sources of blood production – for clues as to why people with Down syndrome have higher prevalence of leukemia. They identified a new set of genes that are overexpressed in endothelial cells of patients with Down syndrome. This creates an environment conducive to leukemia, which is characterized by uncontrolled development and growth of blood cells. Their findings, published in the journal Oncotarget, point to new potential targets for treatment and possibly prevention of leukemia, in people with Down syndrome and in the general population.

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Robert M. Carey, MD, has been named a Distinguished Scientist of the American Heart Association for his “extraordinary contributions” to cardiovascular research.

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An innovative genetic study of blood protein levels, led by researchers in the MRC Integrative Epidemiology Unit (MRC-IEU) at the University of Bristol, has demonstrated how genetic data can be used to support drug target prioritisation by identifying the causal effects of proteins on diseases.

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To better understand the properties of blood cells, an international team led by UdeM’s Guillaume Lettre has been examining variations in the DNA of 746,667 people worldwide.

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Unprecedented analysis of proteins and metabolites in patient serum provides new biomarkers associated with a patient’s risk of dying from Staphylococcus aureus bacteremia.

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University of Illinois Chicago researchers have found associations among disrupted sleep, blood pressure and changes in the gut microbiome.The research aimed to determine whether 28-day period of disrupted sleep changed the microbiota in rats.

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Why so many COVID-19 patients get blood clots (thrombosis) remains uncertain.

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A new and quicker method of diagnosing diseases in patients has been created by researchers at the University of Leeds.

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A new University of Kentucky College of Medicine study provides insight into how a protein called angiotensinogen contributes to blood pressure regulation and atherosclerosis.

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In laboratory studies, Johns Hopkins Kimmel Cancer Center and Johns Hopkins University researchers observed a key step in how cancer cells may spread from a primary tumor to a distant site within the body, a process known as metastasis.

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Emergency medical technicians (EMTs), military medics, and emergency room physicians could one day be better able to treat victims of vehicular accidents, gunshot wounds, and battlefield injuries thanks to a new device under development that may more accurately assess the effects of blood loss due to hemorrhage.

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A shape memory foam material developed by Lawrence Livermore National Laboratory (LLNL) researchers is the foundation of a lifesaving medical device that has won a national technology transfer award.

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Researchers are beginning to understand more about how to treat a rare but deadly type of blood cancer known as Philadelphia chromosome-negative myeloproliferative neoplasms.

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The NCCN Virtual Nursing Forum and Annual Congress: Hematologic Malignancies (#NCCNhem20) will provide the latest evidence and expert consensus on emerging practices and debates in blood cancer treatment, online October 8-10.

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Cerebral venous thrombosis (CVT) occurs when a blood clot forms in one of the veins in the brain, preventing blood from draining out of the brain. A new analysis has found that the incidence of CVT in the United States is higher than previously reported and has increased over time. The study is published in the August 26, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study found the increase occurred mainly in men and older women. Consistent with prior data, the incidence of CVT remained highest in younger women and it did not increase across the study. Researchers also found the incidence of CVT in Black people is higher than in people of other racial and ethnic groups.

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Study is the basis of a new international clinical trial

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Patients who develop cytomegalovirus infections after allogeneic stem cell transplantation may be able to develop an immunity against the virus, strengthen their immune system and reduce reliance on strong antiviral medications, a team from Roswell Park reports in the journal Biology of Blood and Marrow Transplantation.

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Liquid biopsies hold promise of finding cancer in blood before they can form new tumors

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Mount Sinai scientists have identified two markers of inflammation that reliably predict the severity of COVID-19 cases and likelihood of survival, providing a foundation for a diagnostic platform and therapeutic targets, according to a study published in Nature Medicine in August.

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New research has shown some of our least favourite vegetables could be the most beneficial when it comes to preventing advanced blood vessel disease.

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A new pilot study from the Icahn School of Medicine at Mount Sinai suggests that COVID-19 is causing significant dilation of the blood vessels of the lung, specifically the capillaries.

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August 19, 2020 (DALLAS, TEXAS) – For decades, physicians have known that many kinds of cancer cells often spread first to lymph nodes before traveling to distant organs through the bloodstream. New research from Children’s Medical Center Research Institute at UT Southwestern (CRI) provides insight into why this occurs, opening up new targets for treatments that could inhibit the spread of cancer.

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Using a multimillion-dollar grant from the NIH, physician-scientists at The University of Texas Health Science Center at Houston (UTHealth) will investigate whether convalescent plasma infusions can prevent the progression of COVID-19 in one of the first randomized clinical trials in the country.