A clinical trial involving hundreds of participants has shown that one of the most frequently prescribed antidepressants may not benefit millions of patients who also have chronic kidney disease.
• Insomnia was linked with increased risks of early death, rapid kidney function decline, and kidney failure in a group of US veterans. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• Among children with impaired kidney function, those with high blood pressure at night experienced a faster time to kidney failure than children with normal blood pressure. This decline was even more pronounced in patients with high blood pressure during both day and night when compared with children with normal blood pressure. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• In a recent analysis, African American patients were less likely to be wait-listed than White patients. This difference was influenced by factors including age, comorbidities, socio-economic status, being on dialysis, having a living donor, transplant knowledge, and social support. • Results from the study will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• In patients with chronic kidney disease, there was a dose-dependent inverse association between caffeine consumption and early death. • Results from the analysis will be presented at ASN Kidney Week 2017 October 31–November 5 at the Ernest N. Morial Convention Center in New Orleans, LA.
• A particular protein is found in abundance in the kidneys of patients with an aggressive form of kidney disease called fibrillary glomerulonephritis. The discovery may improve diagnosis, and eventually, treatment. • The protein was identified by two research groups, working independently.
Embedding a decision support tool in the hospital electronic health record increases detection of acute kidney injury, reducing its severity and improving survival. The results address one of the most costly and deadly conditions affecting hospitalized patients, providing evidence that computers analyzing changes in renal function can alert doctors of acute kidney injury before the condition is obvious clinically.
Two longtime advocates for the 40 million Americans affected by kidney diseases recently received national recognition from the American Society of Nephrology (ASN) during Kidney Week 2017 for ongoing efforts in the fight to end this serious public health crisis.
Goal is personalized therapies for tens of millions of people with two most common diseases
Researchers at the University of Minnesota have created a new lab-grown, first-of-its-kind nonsynthetic, decellularized graft that becomes repopulated with cells by the recipient’s own cells when implanted.
Briefing will feature presentations of High-Impact Clinical Trials. Dr. Pascale Lane and Dr. Kelly Hyndman will moderate and provide context and expert commentary on the science presented.
The United States Renal Data System 2017 report highlights current trends in kidney disease in the nation
• Five leaders in the kidney health community are being honored by the American Society of Nephrology (ASN), the world’s largest organization of kidney disease specialists. • The award winners will be honored at ASN Kidney Week, the world’s premier nephrology meeting where more than 13,000 kidney health professionals from around the world will gather in New Orleans, LA from October 31–November 5.
• In a recent analysis of individuals on dialysis for at least 10 years, those who then received a kidney transplant lived longer than those who stayed on dialysis. • Transplant recipients were at higher risk of death for 180 days after transplantation, however, and they did not derive survival benefit until 657 days after transplantation.
Women account for half of all cases of high blood pressure (hypertension) in the U.S., yet the majority of hypertension research focuses on men. A review of more than 80 studies highlights sex differences in hypertension-related kidney (renal) disease and explores possible reasons why women respond differently than men. The article, published in the American Journal of Physiology—Renal Physiology, emphasizes the need for more hypertension research in females.
• Keryx Biopharmaceuticals, Inc. has committed to contributing $1 million over five years to the ASN Foundation for Kidney Research Securing the Future Campaign • ASN has matched the donation to endow a Career Development Grant named for Joseph V. Bonventre, MD, PhD, FASN, Chief of the Division of Renal Medicine at Brigham and Women’s Hospital in Boston, MA
The American Society of Nephrology (ASN), the world’s largest organization of kidney health professionals, released a new analysis of the future nephrology workforce, authored by George Washington University (GW) researchers. • GW details an improved job market for new nephrologists, although international medical graduates still face employment challenges. The report noted that lifestyle concerns are important to fellows and may be discouraging applicants to the specialty. More than 40 million Americans have kidney diseases, the 9th leading cause of death in the U.S.
Today, at the 2017 American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) Annual Meeting, Adeniyi Borire, MBBS, was honored with the 2017 Golseth Young Investigator Award for his abstract, Effects of Haemodialysis on Intraneural Blood Flow in End-Stage Kidney Disease.
• Compared with healthy peers, young adults with kidney failure needing renal replacement therapy had lower quality of life, worse for dialysis patients compared with transplant patients. • Young adults on renal replacement therapy were more likely to be unemployed and to live in the family home, and they were less likely to be married or have a partner.
• In a study of hospitalized patients in Canada, the mildest forms of acute kidney injury (AKI) resulted in adjusted costs that were 1.2 to 1.3 times greater than those for patients without AKI. • More severe AKI were associated with costs that were 1.8 to 2.5 times greater. • The incremental cost of AKI in Canada was estimated to be more than $200 million (Canadian dollars) per year.
University of Pittsburgh scientists are unlocking the complexities of a recently discovered cell death process that plays a key role in health and disease, and new findings link their discovery to asthma, kidney injury and brain trauma. The results, reported today in the journal Cell, are the early steps toward drug development that could transform emergency and critical care treatment.
Physicists in France have proven theoretically that active sieving, as opposed to its passive counterpart, can improve the separation abilities of filtration systems. These new views on how active sieving could improve systems such as those used in water purification and dialysis were reported this week in The Journal of Chemical Physics. Active sieving also has the potential to filter molecules based on movement dynamics, opening up a whole new avenue in the field of membrane science based on the ability to tune osmotic pressure.
• Most surveyed Canadian kidney specialists recommended follow-up kidney evaluations for the majority of patients hospitalized with acute kidney injury. • Real-world practice showed that only a minority of such patients in Alberta currently receive follow-up with a kidney specialist.
Finding new clues about the molecular origins of disease is the goal for a comprehensive atlas of variation in gene expression.
Four multidisciplinary studies will focus on genetics and associated mechanisms of hyperuricemia gout, an inflammatory arthritis.
• From 2008-2015, the number of kidneys donated after circulatory death that were obtained by the country’s 58 donor service areas varied substantially. • The outcomes associated with these organs were generally excellent. • The use of these organs could be increased if “cold ischemia times” are limited.
A university spinoff has received a stage two grant to test a potential solution for malfunctioning vascular access.
New discoveries about the mechanism responsible for heat generation in the body related to fat tissue oppose classical views in the field and could lead to new ways to fight metabolic disorders associated with obesity, according to a study led by Georgia State University.
Researchers from the University of Toledo (Ohio) College of Medicine and Life Sciences have discovered more than 12,000 different types of noncoding RNA (circRNAs) in the kidney tissue of rats. This type of genetic material, previously thought to have no function, may play a significant role in regulating blood pressure in heart and kidney disease.
No disorder appears to kill more people than atherosclerosis, and hopeful experimental treatments with "good cholesterols" have failed. New research reapproaches them with carefully designed cholesterols in an organ-on-a-chip in highly reproducible experiments.
A new, inexpensive urine test accurately identifies patients at risk for kidney damage after open heart surgery, allowing for corrective action before permanent injury occurs.
The National Institutes of Health (NIH) has awarded two five-year grants to Wake Forest Baptist Medical Center worth more than $5 million to prospectively study the effects of a genetic variation in organ donors that appears to contribute to survival of kidneys after transplantation.
• Among hemodialysis patients admitted to the hospital, nearly a quarter of admissions were followed by an unplanned readmission within 30 days. • Most readmissions were for a diagnosis different than the one for the initial hospitalization. • A small proportion of patients accounted for a disproportionate number of readmissions.
Loyola Medicine physicians have proposed a simple new system to improve the reporting of robotic surgeries performed by surgeons in training. The system, called RoboLog, was successfully piloted on 310 urologic robotic surgeries, according to a study published in the Journal of Surgical Education.
Outdoor air pollution may increase the risk of chronic kidney disease and contribute to kidney failure, Washington University School of Medicine in St. Louis and the Veterans Affairs (VA) St. Louis Health Care System. Scientists culled national VA databases to evaluate the effects of air pollution and kidney disease on nearly 2.5 million people over a period of 8.5 years, beginning in 2004. The scientists compared VA data on kidney function to air-quality levels collected by the Environmental Protection Agency (EPA) as well as the National Aeronautics and Space Administration (NASA). The study is published Sept. 21 in the Journal of the American Society of Nephrology.
• In a study of US veterans, researchers found a linear relationship between air pollution levels and risk of experiencing kidney function decline and of developing kidney disease or kidney failure.
• From 2006 to 2010, almost two thirds of US dialysis patients received at least one opioid prescription every year and >20% received chronic prescriptions. • More than 25% of dialysis patients using opioids received doses exceeding recommendations • Use of opioid medications was linked with higher risks of early death, discontinuation of dialysis, and the need for hospitalization in dialysis patients.
Washington, DC (September 20, 2017)—The world’s largest gathering of kidney health professionals will join forces in New Orleans from October 31–November 5, 2017, and serve as a major forum for the dissemination of advances in basic, clinical, and translational research as well as advances in clinical practice to the basic science and clinical community during the American Society of Nephrology’s Kidney Week 2017.
A new UCLA-led study published in the September issue of the peer-reviewed journal Transplantation traces how the first three “kidney voucher” cases led to 25 lifesaving kidney transplants across the United States.
Advocates from the American Society of Nephrology (ASN) and the 21 other health care organizations listed below are meeting with their representatives and senators today. They will urge Congress to continue its historic support of research funding for the National Institutes of Health (NIH) and to cosponsor and pass the Living Donor Protection Act (H.R. 1270), no-cost legislation to eliminate barriers to living donation and increase access to transplants.
A team led by University of Iowa researchers has identified a gene linked to rare kidney-related birth defects. When working properly, a gene called GREB1L activates a cascade of signals that ultimately tells other genes what they need to do to create a kidney. Results published in the journal Genetics.
People with chronic kidney disease may be especially vulnerable to the deleterious effects of poor sleep, according to a new paper published in the Journal of the American Society of Nephrology.
• In individuals with chronic kidney disease, high sleep fragmentation was associated with an elevated risk of developing kidney failure. • Higher sleep fragmentation and shorter sleep duration were each linked with steeper declines in kidney function over time. • Subjectively measured daytime sleepiness was associated with an increased risk of early death from any cause.
Nisanne Ghonemi's research seeks to address a universal problem in kidney transplant surgery that can result in failure of the organ graft. Her research will explore the use of a class of drugs known as prostacyclins to reduce ischemia-reperfusion injury to a transplanted kidney from a deceased patient that can result in failure of the organ graft.
Waking up in the morning with the joint pain, swelling and stiffness that accompanies lupus doesn’t exactly inspire a workout. But research in mice and a related pilot study in humans are showing how regular activity and stress reduction could lead to better health in the long run.
Not all kidney cancers are killers, and many small tumors can be left alone or watched over time because there is a low risk they will become dangerous, according to Dr. Brian Shuch at the Yale School of Medicine.
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