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regenerative med

Penn Study on Super-Silenced DNA Hints at New Ways to Reprogram Cells

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Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity to use in regenerative medicine studies and one day in the clinic.

Medicine

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St. Jude Children's Research Hospital, Acute Lymphoblastic Leukemia, High-Risk Leukemia, Journal Of Clinical Oncology, Leukemia germline variations, TP53 tumor suppressor gene , second cancers

Tumor Suppressor Gene Variants Identified as Cancer ‘Double Whammy’ for Leukemia Patients

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A study led by St. Jude Children’s Research Hospital found germline variations in a key tumor suppressor gene that may prompt changes in treatment and follow-up care for certain high-risk leukemia patients

Medicine

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Oncology, Hematology, clinical trial, Clinical & Translational Research, Dna Sequencing, Dna Profiling

Christiana Care to Offer No Cost Tumor Profiling and DNA Sequencing to Patients with Advanced or Rare Cancers

Christiana Care Health System is joining the Strata Precision Oncology Network to offer next-generation tumor profiling at no cost to patients with advanced or rare cancers. Based on the results, eligible patients will be matched to the best available clinical trials or most innovative therapy. The project begins on Feb. 1, 2018.

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Mechanism for Resistance to Immunotherapy Treatment Discovered

Two research groups from Dana-Farber Cancer Institute have independently discovered a genetic mechanism in cancer cells that influences whether they resist or respond to immunotherapy drugs known as checkpoint inhibitors. The scientists say the findings reveal potential new drug targets and might aid efforts to extend the benefits of immunotherapy treatment to more patients and additional types of cancer.

Medicine

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MD Anderson Cancer Center, Breast Cancer, Dcis

New Cancer Model Shows Genomic Link Between Early-Stage and Invasive Breast Cancer Types

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A new genetic-based model may explain how a common form of early-stage breast cancer known as ductal carcinoma in situ (DCIS) progresses to a more invasive form of cancer say researchers at The University of Texas MD Anderson Cancer Center.

Medicine

Science

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Genetic Changes Help Mosquitoes Survive Pesticide Attacks

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UCR study shows how intensive pesticide use is driving mosquito evolution at the genetic level

Medicine

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Genetic Testing, Family Health History, Seattle Cancer Care Alliance, Philippines, Professional Society of Genetic Counselors, Asia Pacific Society of Human Genetics

Seattle Cancer Care Alliance Genetic Counselor Available for Interview

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Medicine

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HIV, AIDS, CAR T cell, Stem Cells, chimeric antigen receptor, Chimeric antigen receptor T-cell, Immunity, HSPC, hematopoietic stem/progenitor cells, Gene Therapy

Gene Therapy Using CAR T-Cells Could Provide Long-Term Protection Against HIV

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Through gene therapy, researchers engineered blood-forming stem cells (hematopoietic stem/progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV-infected cells. These engineered cells persisted for more than two years

Medicine

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Genetic Disease, Neurofibromatosis 1, NF1

A Cluster of Mutations in Neurofibromatosis Is an Important Risk Factor for Severe Symptoms

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Research shows that missense mutations in a cluster of just five codons in the NF1 gene are an important risk factor for severe symptoms of the genetic disease neurofibromatosis type 1. Such information is vital to help guide clinical management and genetic counseling in this complex disease.

Medicine

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Multiple Sclerosis (MS), Gene Expression, Neuroprotective

Researchers Find Potential Path to Repair MS-Damaged Nerves

Gene expression in specific cells and in specific regions can provide a more precise, neuroprotective approach than traditional treatments







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