Curated News: The Lancet

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Brexanolone, an IV infusion comprised of a derivative of progesterone, was approved by the U.S. Food and Drug Administration for the treatment of PPD in 2019. The fast-acting medication significantly reduces depression symptoms and provides effects for up to 90 days. However, exactly how the drug provides these therapeutic effects has remained a mystery – until now.

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This study shows vaccination against COVID-19 is an essential strategy to improve outcomes in this high-risk population. The results support guidelines that patients with cancer should receive at least 3 COVID-19 vaccine doses.

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A recent study performed in Zambia by University of Maryland School of Medicine’s (UMSOM) Institute of Human Virology researchers found that high uptake of HIV preventative medicine, known as pre-exposure prophylaxis (PrEP), is possible in prison populations with adequate resources and support from the criminal justice health system.

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At least 830 men, women and children were coercively sterilized in Utah, approximately 54 of whom may still be alive. They were victims of a sterilization program that lasted for fifty years in the state and targeted people confined to state institutions. Many were teenagers or younger when operated upon; at least one child was under the age of ten.

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This is amongst the findings of the 2023 Lancet Series on Breastfeeding, which comprises three papers launched in South Africa on 10 February and in the UK on 8 February.

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Extreme heat and humidity and other climate-related events have an alarming impact on mental health outcomes in terms of depression and anxiety in Bangladesh, the world’s seventh most vulnerable country to climate change.

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Over four percent of deaths in cities during the summer months are due to urban heat islands, and one third of these deaths could be prevented by reaching a tree cover of 30%, according to a modelling study published in The Lancet and led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by “la Caixa” Foundation.

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Patients with myelofibrosis had clinically significant improvement in disease-related symptoms, including anemia and spleen enlargement, when treated with the targeted therapy momelotinib, according to results from the international Phase III MOMENTUM trial led by researchers at The University of Texas MD Anderson Cancer Center.

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The main point of the study, which was completed before other variants came on the scene, is for pregnant women to get vaccinated and receive all their boosters, including the bivalent booster.

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An increase in "deaths of despair" in recent decades has been frequently portrayed as a phenomenon affecting white communities, but a new analysis in The Lancet shows the toll has been greater on Native Americans.

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monoclonal antibody treatment was found to be safe, well tolerated, and effective in protecting against malaria in a small group of healthy volunteers who were exposed to malaria in a challenge study, according to new research published in The Lancet Infectious Diseases by researchers at the University of Maryland School of Medicine (UMSOM).

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Promising results from an ongoing clinical trial a three-drug treatment may improve survival in patients with newly diagnosed multiple myeloma who have undergone preliminary treatment followed by a stem cell transplant.

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Results of the 18-month study, published in Lancet Regional Health - Americas and led by Amit Bahl, M.D., M.P.H., emergency medicine with Corewell Health East, formerly Beaumont Health, showed that while omicron cases had the highest hospital admission rates among children ages 0 to 17, serious, even deadly, cases of illness were less likely during omicron than during the delta and alpha variants. In fact, the odds of severe disease were 65% lower during omicron compared to alpha.

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Get more exercise. Eat right. Make new friends.

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Moderate levels of two outdoor air pollutants, ozone and fine particulate matter, are associated with non-viral asthma attacks in children and adolescents who live in low-income urban areas, a study funded by the National Institutes of Health has found.