Colliding ribosomes activate RNA repair
Ludwig-Maximilians-Universität München (Munich)LMU researchers discover how ribosomes contribute to the recognition and removal of RNA crosslinking damage
LMU researchers discover how ribosomes contribute to the recognition and removal of RNA crosslinking damage
Findings will help scientists understand how microgravity impacts the ability of human heart cells to withstand the stresses of space travel
Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.
Chulalongkorn University and the International Peace Foundation will co-host the JAPAN-ASEAN BRIDGES event series, which is open and free to the public. BRIDGES will bring the brightest minds of the world – Nobel Laureates in Physics, Economics, Medicine and Finance – to both Japan and Thailand from November 2023 to March 2024 to stimulate exchange and enhance further development through education.
Michigan State University researchers have solved the mystery of a poorly understood sperm structure called the cytoplasmic droplet, or CD. The CD is an expanded cytoplasm — watery, gel-like cell contents enclosed by cell membrane — found close to the head, at the neck of the sperm, in all mammals, including humans. This new genetic model is the first of its kind.
New device could improve the outcomes of cell-based therapies
UT Southwestern Medical Center will lead a multi-institution effort to gather and assimilate information on the billions of sequences employed by immune receptors of the adaptive immune system. The project, funded by the National Institutes of Health, aims to improve the understanding of immunity and help facilitate the development of improved vaccines and treatments for many diseases.
Rather than a slow, gradual process as Darwin envisioned, biologists can now see how evolutionary changes unfold on accelerated timescales. Using an arms race between bacteria and viruses, researchers are documenting complex evolutionary processes in simple laboratory flasks in only three weeks.
Jennifer Oyler-Yaniv is studying human diseases to learn about the immune system. She hopes that diseases such as cancer will reveal fundamental principles of how immune cells communicate
A multicenter study led by researchers at Sylvester Comprehensive Cancer Center shows how interactions between tumor cells and immune components of the microenvironment can impact treatment responses and outcomes in patients newly diagnosed with multiple myeloma who undergo combination treatments that include targeted immunotherapy.
While we all aspire for a long lifespan, what is most coveted is a long period of vigor and health, or “healthspan,” that precedes the inevitable decline of advancing age.
Research consortium investigators analyzed over 314,000 cells from rheumatoid arthritis tissue, defining six types of inflammation involving diverse cell types and disease pathways
New hope for other nervous system disorders like ALS
UCLA scientists have developed a new method to engineer more powerful immune cells that can potentially be used for “off-the-shelf” cell therapy to treat challenging cancers.
Researchers found that by restricting glucose in lung cancer cells, it caused the cells to lose their specialized features, making them more aggressive. This change was linked to alteration in certain molecules and how they modify DNA structure.
Rakuten Medical, Inc., a global biotechnology company developing and commercializing precision, cell-targeted therapies based on its proprietary Alluminox™ platform today announced the presentation of two posters of AI-based analyses at the 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), held November 3-5, 2023, in San Diego, CA (SITC 2023).
Plants avoid the buildup of mutational damage by spreading out the damage they inherit, so that while some offspring inherit lots of mutations, others inherit far fewer.
Researchers have sequenced the genome of the fungus causing tar spot on corn and identified key genes involved in disease development. This information will help researchers develop better disease management strategies.
In October 2023, the Advanced Photon Source (APS), a U.S. Department of Energy (DOE) Office of Science user facility at DOE’s Argonne National Laboratory, officially launched a new initiative to expand biological and environmental research at the world leading X-ray and analysis facility.
Largest study of children with sickle cell disease finds one in three had retinopathy.
An investigational treatment shows promise as a non-surgical option for corneal edema.
In order to survive, organisms must control the pressure inside them, from the single-cell level to tissues and organs. Measuring these pressures in living cells and tissues in physiological conditions is a challenge.
Research in mice shows that the anti-inflammatory properties of exercise may arise from immune cells mobilized to counter exercise-induced inflammation. Immune cells prevent muscle damage by lowering levels of interferon, a key driver of chronic inflammation, inflammatory diseases, and aging.
Antibiotic-resistant bacteria pose a major challenge to healthcare systems worldwide. Due to numerous resistance mechanisms, infections with the pathogen Pseudomonas aeruginosa are particularly feared. Researchers at the German Center for Infection Research (DZIF), the University Hospital Cologne, the Helmholtz Centre for Infection Research in Braunschweig and the University Medical Center Hamburg-Eppendorf have now discovered antibodies that could lead to a highly potent treatment option of acute and chronic infections with P. aeruginosa. The study was published in the prestigious scientific journal Cell.
An international team of scientists led by researchers from the Department of Molecular Biosciences, The Wenner-Gren Institute, SciLifeLab, Stockholm University has published in PLoS Pathogens the first successful application of 2-photon intravital microscopy (IVM) to image the dynamics of fungal infections in the kidney of a living host.
Rakuten Medical, Inc., a global biotechnology company developing and commercializing precision, cell targeting therapies based on its proprietary Alluminox™ platform, today announced that the Company will present at the 14th Annual Jefferies London Healthcare Conference being held in London, UK, on November 14-16, 2023.
In research published in Nature Catalysis, scientists at Florida State University produced the first high-resolution, time-lapsed images showing magnesium ions interacting with the CRISPR-Cas9 enzyme while it cut strands of DNA, providing clear evidence that magnesium plays a role in both chemical bond breakage and near-simultaneous DNA cutting.
Findings from researchers at the University of Michigan Health Rogel Cancer Center, published in Cancer Discovery, show how a specific nucleotide metabolite called GTP controls responses to radiation and chemotherapy in an unexpected way.
University of Kentucky Markey Cancer Center researchers Ka-wing Fong, Ph.D., and Eric Rellinger, M.D., were named V Scholars by the V Foundation for Cancer Research. They will each receive $600,000 to fund their individual cancer research projects over three years.
Scientists at St. Jude Children’s Research Hospital determined structures of a transporter protein involved in the movement of neurochemicals such as serotonin and dopamine, unearthing multiple mechanisms that can guide drug development.
Researchers at the University of Wisconsin–Madison and Academia Sinica of Taiwan have harnessed a combination of lab-grown cells to regenerate damaged heart muscle.The study, published in Circulation — which addresses major challenges of using heart muscle cells, called cardiomyocytes, grown from stem cells — takes a crucial step toward future clinical applications.
Dendritic cells play a key role in the mammalian immune system. These cells are present throughout the human body and are known to capture foreign bodies, i.e., antigens, using extendable “arms” called dendrites
An enzyme that may help some breast cancers spread can be stopped with an antibody created in the lab of Cold Spring Harbor Laboratory Professor Nicholas Tonks.
Mature spermatozoa are characterized by an head, midpiece and a long tail for locomotion. Now, researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Unit "Life & Health" at the University of Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice.
Previously, touch was thought to be detected only by nerve endings present within the skin and surrounding hair follicles.
Researchers have discovered a protein that seals plant roots to regulate the uptake of nutrients and water from the soil, the discovery could help develop climate proof crops that require less water and chemical fertilizers
A novel replacement strategy termed GE x HDR 2.0: Find and Replace, developed by researchers from Bar-Ilan University and described in published today in Nature Communications, combines CRISPR-Cas9-mediated genome editing with recombinant adeno-associated serotype 6 (rAAV6) DNA donor vectors to precisely replace the RAG2 coding sequence while preserving regulatory elements.
Irvine, Calif., Oct. 26, 2023 — A study from the University of California, Irvine has revealed that in 2022, 38 North American businesses used direct-to-consumer advertising to promote unproven stem cell interventions and exosome products as purported treatments and preventatives for COVID-19. Collectively, these organizations operated or facilitated access to 60 clinics – with 24 in the U.
New WSU bioreactor rapidly grows cancer-killing cells for immunotherapy
Biological mechanisms found in fruit flies could inform efforts against disease-spreading mosquitos.
Harnessing new advances in genomic surveillance technology could help detect the rise of deadly ‘superbugs’
A research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.
The quintessential female sex hormone estrogen stimulates cells that line blood vessels to deliver insulin to muscles, lowering blood sugar and protecting against Type 2 diabetes, UT Southwestern Medical Center researchers report. The findings, published in Nature Communications, could eventually lead to new therapies for Type 2 diabetes, a disease that affects hundreds of millions of people around the globe and continues to grow more prevalent.
Stimulating muscle fibers with magnets causes them to grow in the same direction, aligning muscle cells within tissue, Massachusetts Institute of Technology (MIT) and Boston University investigators report October 20 in the journal Device.
A UC Davis study shows the first-in-human imaging of the body’s CD8 T cell immune response to COVID-19 infection in recovering patients.