Researchers at the University of Maryland School of Medicine and the University of Southern California have discovered a genetic biomarker that may help doctors to better diagnose and treat cancer of the esophagus. (Journal of the National Cancer Institute, 11-15-00)
If mouse studies hold true for humans, a daily cup of yogurt or dose of antibiotics may become the first effective treatments for a common and sometimes fatal obesity-related liver disorder, Hopkins scientists report. (Gastroenterology, 11-00)
The diet drug combination fen-phen was removed from the market in 1997 because of its association with heart valve abnormalities. New research reveals cellular events, apparently triggered by the neurotransmitter serotonin, that may explain the disease mechanisms.
A new study reports that sildenafil citrate (Viagra), when combined with nitrates, can cause serious and prolonged decreases in blood flow through critically narrowed coronary arteries. (Circulation, 11-14-00)
A new Mayo Clinic study shows that the same underlying factors that cause people to seek out the behaviors of coffee or alcohol consumption or smoking may also make them less likely to develop ParkinsonÃs disease. The findings may point to a new, underlying risk factor that could be helpful in diagnosing and treating the disease. (Neurology, 11-14-00)
A new website, www.thebrainmatters.org, focuses on the personal and societal impacts of neurological diseases, providing profiles of seven people living with neurological diseases and resources for others seeking help and information. The website goes online, Friday, Nov. 10.
Parkinson's disease occurs in men two times more frequently than in women, according to a study in the November 14 issue of Neurology, the scientific journal of the American Academy of Neurology.
Drinking coffee may reduce the risk of ParkinsonÃs disease, according to a study published in the November 14 issue of Neurology, the scientific journal of the American Academy of Neurology.
Smoking and having low levels of "good" cholesterol can be extra risky in people who've already had a heart attack, said researchers from Wake Forest University Baptist Medical Center (WFUBMC) today at the American Heart Association's annual fall conference.
In cell biology studies, researchers report "strong evidence" that a molecule called ubiquilin controls levels of certain proteins that are central to the early development of Alzheimer's disease. (Journal of Cell Biology 11-00)
Diabetes is a known risk factor for mortality in patients with heart disease. Now a major new study by cardiac researchers at Intermountan Health Care's LDS Hospital has found heart disease patients who are not diabetic, but who have moderately elevated blood glucose levels, are also at significantly higher risk for death.
Sexual dysfunction in men with high blood pressure may be aided by the newest type of hypertension drug, reported a Wake Forest University Baptist Medical Center researcher at the American Heart Association's annual conference.
Reducing the number of medications taken by heart transplant patients can eliminate unpleasant and unhealthy side effects without increasing the risk of organ rejection, reported a Wake Forest University Baptist Medical Center researcher at the Southern Thoracic Surgical Association meeting.
A Johns Hopkins study of Korean Americans found that they have hypertension at rates much higher than other Americans or their counterparts in Korea.
An examination of two rare, very different and hereditary bone disorders has revealed clues about the common genetic switches controlling normal bone development, according to new research guided by a Johns Hopkins Children's Center endocrinologist.
AHRQ today announced funding for a major new research initiative, called the EXCEED (Excellence Centers to Eliminate Ethnic/Racial Disparities) Initiative, intended to improve knowledge of the factors underlying ethnic and racial inequities in health care.
People diagnosed with depression during the 1996 Depression Screening Day were more likely to follow treatment recommendations if they had health insurance. (American Journal of Psychiatry, 11-00)
A new study of twin and nontwin sibling pairs reinforces the theory that sexual orientation is significantly influenced by one's genes. The study is the only one known to have used a large national probability sample. (American Journal of Psychiatry, 11-00)
Researchers from Lawrence Livermore National Laboratory and the UC Davis Cancer Center have agreed to collaborate on an integrated cancer program. Some 10-12 projects are already underway.
A new international, multicenter study has confirmed that perfectionism is inherent in individuals with the eating disorder anorexia nervosa. (American Journal of Psychiatry, 11-00)
Americans who get hands-on help from others so that they can accomplish life's basic daily activities are not necessarily elderly nor do they all live in nursing homes, according to a new report by AHRQ. Roughly 79 percent live in places other than institutions, and almost half are under 65 years of age.
Metabolism of nicotine products produces a substance that is a direct precursor to the tobacco-specific lung carcinogen NNK. (Proceedings of the National Academy of Sciences, 10-24-00)
Ninety-seven percent of pregnant women fail to sleep through the night by the end of their pregnancy, according to a new study by researchers at Saint Joseph's University and Delaware County (Pa.) Memorial Hospital. (Journal of Obstetric, Gynecologic, and Neonatal Nursing, 10-00)
For 7-year-old Kyle Schepens - near death due to a virulent form of heart disease - a new and surprisingly hopeful treatment allowed him to celebrate his eighth birthday. (Heart and Lung Transplantation, 11-00)
The following tip sheet reports works-in-progress on the newest approaches to Alzheimer's disease, epilepsy, stem cell therapy and seasonality from Hopkins' neuroscientists attending this month's meeting in New Orleans, November 4 to 9.
Endostatin, a drug that seeks to reduce tumors by cutting off their blood supply, appears to be safe and well-tolerated, according to preliminary results on 19 people studied in Boston.
The upcoming winter holidays can be a painful reminder for those who have experienced the death of a loved one. A seminar on Monday, Nov. 13 in Rochester will address general issues of grief and identify specific issues of grief associated with the holidays.
University of Michigan scientists have identified genetic mutations that cause a serious medical condition called hereditary lymphedema-distichiasis or LD. (American Journal of Human Genetics, 12-00)
Mayo Clinic researchers have developed a new laboratory method for detecting recurring cancer of the bladder sooner and more accurately. (The Journal of Urology, 11-00)
A study concludes that a hip replacement device developed at Mayo Clinic is successful in conserving bone, making it an attractive choice for younger patients. (Journal of Bone and Joint Surgery, 9-00)
Researchers at the Johns Hopkins Oncology Center uncovered a genetic alteration that appears to predict how individuals with an aggressive type of brain cancer will respond to chemotherapy. (NEJM, 11-9-00)
Scientists from UCLA and the University of Cambridge, United Kingdom, report a revolutionary advance in pain medicine that promises to deliver painkillers directly to the affected area of the body, in smaller doses and with fewer side effects.
In animals with spinal cord injuries, cells bio-engineered to produce the neurotransmitter serotonin apparently can relieve chronic pain and clearly can increase mobility, researchers from the University of Texas Medical Branch at Galveston have found.
A study by cardiac researchers at Intermountain Health Care's LDS Hospital in Salt Lake City reveals that levels of a marker of inflammation called C-reactive protein actually do a better job of predicting who will benefit from medication and who will die among patients who already have coronary artery disease. (Journal of the American College of Cardiology, 11-00)
Heart disease patients may someday receive a dose of gene therapy that would protect injured coronary arteries from further damage and possibly even treat the underlying heart disease. (Nature Biotechnology, 11-00)
Joseph Cofrancesco Jr., M.D., M.P.H., assistant professor in the Department of Medicine at Johns Hopkins, was one of 47 physicians nationwide nominated for the Association of American Medical Colleges (AAMC) Humanism in Medicine Award for 2000.
Three studies provide new insight into the role of infections and inflammation in heart attacks. (Circulation 11-7-00)
Survival rates have been steadily improving for children who undergo surgery as infants for a life-threatening congenital condition called hypoplastic left heart syndrome. Researchers reported on 15 years of experience with the reconstructive, multistage surgery. (Circulation, 11-00)
Scientists at Johns Hopkins have demonstrated that a specific enzyme in the brain is essential for nerve cells to form a hallmark of Alzheimer's disease (AD) -- the so-called amyloid plaques that collect and surround brain cells.
Scientists at Johns Hopkins report they've restored movement to newly paralyzed rodents by injecting stem cells into the animals' spinal fluid. Results of their study were presented at the annual meeting of The Society for Neuroscience in New Orleans.
Individualized medical treatments for people diagnosed with heart disease may not be too far in the future with the expansion of genomic research at the University of Texas Southwestern Medical Center at Dallas. The expansion is being made possible by a $13.9 million federal grant.
A UT Southwestern Medical Center at Dallas doctor is performing a new procedure that can detect pre-malignant and malignant breast cells long before they become visible tumors.
The American Academy of Orthopaedic Surgeons, which will build a safe, wheelchair-accessible playground in San Mateo, Calif., is holding Playground Design Day in advance to get children's input on what playground features are most important to them.
Memorial Sloan-Kettering Cancer Center today launched a lay language database of high priority trials for its web site.
African Americans who undergo the most frequently performed blood vessel operation, carotid endarterectomy, have worse outcomes than whites, according to a new study by Johns Hopkins researchers. (Annals of Surgery, 11-00)
FDA has awarded a six-month $100,000 SBIR grant to MetaPhore Pharmaceuticals to study the dramatic and perplexing blood pressure drop that occurs during septic shock and leads to death in up to 50 percent of cases.
At University of Iowa Health Care pediatric specialty-based asthma care program, researchers see cause for revising asthma guidelines published and disseminated by the National Heart, Lung and Blood Institute within the National Institutes of Health.
The life you save may be your own - if you can react quickly to stroke warning signs. (Stroke: Journal of the American Heart Association, 11-00)
Both houseflies and filth flies can transmit cryptosporidiosis. Better fly control is one key to decreasing the risk of this disease, as reported at the annual meeting of the American Society of Tropical Medicine and Hygiene.
Researchers from California and London have identified a previously unknown mechanism that controls the storage capacity of the bladder and the frequency of urination. (Nature, 10-26-00)
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