- In hemodialysis patients, hypothyroidism was linked with impairments across multiple areas of health-related quality of life, including lower energy and greater fatigue, poorer physical function, and greater pain.
Many patients with advanced chronic kidney disease have thyroid disease.
Newswise — Washington, DC (July 13, 2017) — A new study indicates that impaired thyroid function may have detrimental effects on dialysis patients’ health and well-being. The findings appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).
Although hypothyroidism—a condition in which the thyroid gland does not produce enough thyroid hormone—is common in hemodialysis patients, it’s unclear how it affects their health and quality of life.
To investigate, Connie M. Rhee, MD, MSc (University of California Irvine) and her colleagues examined information from 450 hemodialysis patients from 17 outpatient dialysis facilities who completed questionnaires every 6 months. To assess thyroid function, the team measured patients’ blood levels of thyrotropin, which is elevated in patients with hypothyroidism.
Higher thyrotropin levels were associated with impairments across multiple areas of health-related quality of life, including energy/fatigue, physical function, and pain.
“Given the high prevalence of thyroid dysfunction and low levels of quality of life in dialysis patients, future research is needed to determine the underlying mechanisms of these associations, and whether thyroid hormone replacement can improve the health-related quality of life of this population,” said Dr. Rhee. “In addition, as the first study in dialysis patients to document an association between higher thyrotropin levels and low levels of physical function, a strong predictor of death, future studies are needed to determine whether correction of thyroid status with exogenous thyroid hormone can improve physical function in this population.”
Study co-authors include, Yanjun Chen, MS, Amy S. You, MS, Steven M. Brunelli, MD, MSCE, Csaba P. Kovesdy, MD, Matthew J. Budoff, MD, Gregory A. Brent, MD, Kamyar Kalantar-Zadeh, MD, MPH, PhD, and Danh V. Nguyen, MS, PhD.
Disclosures: The authors reported no financial disclosures.
The article, entitled “Thyroid Status, Quality of Life, and Mental Health in Hemodialysis Patients,” will appear online at http://cjasn.asnjournals.org/ on July 13, 2017, doi: 10.2215/CJN.13211216.
The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.
Since 1966, ASN has been leading the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients. ASN has nearly 17,000 members representing 112 countries. For more information, please visit www.asn-online.org or contact the society at 202-640-4660.
# # #