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Potential New Therapy Approaches to Reverse Kidney Damage Identified

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Study shows that cell plasticity program resulting from kidney damage can be targeted to reverse disease and fibrosis.

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Key Gene Found to Drive Kidney Disease Severity

Patients with higher levels of a key protein are at greater risk for severe kidney disease

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 6-Aug-2015 5:00 PM EDT

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Byproduct of Intestinal Bacteria May Jeopardize Heart Health in Patients with Kidney Disease

• Blood levels of TMAO, a byproduct generated from intestinal bacterial as they metabolize dietary nutrients, progressively increase with advancing severity of kidney disease. • TMAO levels are dramatically reduced when kidney function is restored following kidney transplantation. • High TMAO levels are linked with an increased risk of atherosclerosis and premature death in patients with chronic kidney disease.

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Mild Hypothermia in Deceased Organ Donors Significantly Improves Organ Function in Kidney Transplant Recipients

Mild hypothermia in deceased organ donors significantly reduces delayed graft function in kidney transplant recipients when compared to normal body temperature, according to UCSF researchers and collaborators, a finding that could lead to an increase in the availability of kidneys for transplant.

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Tailored Mobile Health Technologies May Help Patients Take Their Medications Appropriately

• There was only a 5% error rate when patients with chronic kidney disease used mobile health technologies designed to help them use medications appropriately.

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A New Litmus Test for Chaos?

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Researchers from the University of Maryland have come up with a new definition of chaos that applies more broadly than Lyapunov exponents and other previous definitions of chaos. The new definition fits on a few lines, can be easily approximated by numerical methods, and works for a wide variety of chaotic systems.

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Researchers Identify Potential New Targets for Treating Kidney Disease

• Proteins in the Wnt signaling pathway help drive kidney scarring that can lead to chronic kidney disease.

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Researchers Find Key Player in Diabetic Kidney Disease Through Power of Metabolomics

Tapping the potential of metabolomics, an emerging field focused on the chemical processes of metabolism, researchers at University of California, San Diego School of Medicine have identified a new and pivotal player in diabetic kidney disease.

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Investigational Drug Prevents Life-Threatening Side Effects of Kidney Disease Treatment

The investigational drug patiromer quickly reduced elevated blood-potassium levels—a common life-threatening side effect of treatment for chronic diabetic kidney disease. In this year-long study of more than 300 patients, patiromer kept potassium levels under control for the length of the trial.