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Study Finds Improvements in Warfarin Use for Atrial Fibrillation Treatment Necessary to Protect Kidney Function and Heart Health

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Atrial fibrillation patients taking warfarin, a popular anticoagulation drug, are at higher risk of developing kidney failure if anticoagulation levels are not properly managed, according to a new study from researchers at the Intermountain Medical Center Heart Institute.

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Common Supplement Boosts Kidney Cancer Therapy

Researchers at UC Davis have shown that docosahexaenoic acid (DHA), a fatty acid commonly found in fish and fish oil supplements, reduces renal cell carcinoma invasiveness, growth rate, and blood vessel growth when combined with the anti-cancer therapy regorafenib. The study was published in the May issue of the journal Molecular Cancer Therapeutics.

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Loyola Liver/Kidney Transplant Patient Celebrates 1st Anniversary

A Loyola University Medical Center patient underwent a successful liver/kidney transplant to treat nonalcoholic steatohepatitis (fatty liver disease).

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 5-May-2016 5:00 PM EDT

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Female Hormones May Make Women Less Susceptible to Kidney Failure Than Men

• Researchers detected transient increases in enzymes indicative of kidney health that correlated with specific phases of the female reproductive hormone cycle. • The findings indicate that nonreproductive organs may undergo periodical adaptations phased by menstrual cycle–driven hormone changes.

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Blood Pressure Targets for Individuals with Kidney Disease Should Consider Patients’ Age

• Systolic blood pressure levels above 140 mmHg were linked with higher risks of coronary heart disease, stroke, kidney failure, and death in patients with chronic kidney disease of all ages, but the magnitude of these associations diminished with more advanced age. • Diastolic blood pressure levels below 70 mmHg were associated with a higher risk of death, but otherwise they showed no association with cardiovascular outcomes

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Kidney Health Advocacy Day 2016: ASN Urges Lawmakers Advance Living Organ Donation

The American Society of Nephrology (ASN) is one of two leading kidney health organizations participating in Kidney Health Advocacy Day 2016 in Washington, DC. Advocates from ASN and the American Association of Kidney Patients (AAKP) will meet with Congressional offices to call for lawmakers’ support of the Living Donor Protection Act of 2016. Kidney health providers and patients will urge passage of the legislation that would eliminate barriers to living donation and help increase access to lifesaving transplants.

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Penn Researchers Find Females More Resistant to Organ Damage Following Kidney Transplant

After a kidney transplant, women may experience decreased kidney damage from ischemia reperfusion injury compared to men due to the impact of gender-specific hormones, suggests a new preclinical study and an analysis of patient data published online in the Journal of Clinical Investigation from researchers at the Perelman School of Medicine at the University of Pennsylvania.

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Commonly Used Reflux and Ulcer Medication May Cause Serious Kidney Damage

• Patients who took proton pump inhibitors for heartburn, acid reflux, or ulcers had an increased risk of kidney function decline, chronic kidney disease, and kidney failure. • The longer patients took the drugs, the greater their risk.

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Study Suggests Link Between Obesity and Kidney Cancer

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Receptors for leptin, a protein hormone, may be associated with tumor recurrence in patients with renal cell carcinoma (RCC), providing further understanding about molecular links between obesity and RCC tumor formation and prognosis, according to a study at The University of Texas MD Anderson Cancer Center.

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Kidneys Have an Innate Clock That Affects Many Metabolic Processes in the Body

• Daily fluctuations caused by the kidney’s circadian clock have an important effect on the levels of various amino acids, lipids, and other components of blood in the body. • In individuals who take medications, the kidney’s circadian clock controls drug elimination from the body and therefore can influence the duration of a drug’s action and the effectiveness of the therapy.

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HPV Vaccine May Be Effective in Adolescents with Kidney Disease, but Less So in Those with a Kidney Transplant

• Following vaccination against human papillomavirus, girls and young women with chronic kidney disease and those on dialysis had antibody levels above the threshold that indicates protection from infection. • A significant proportion of patients with kidney transplants showed evidence of an inadequate antibody response to the vaccine.

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The Down Side of Your Sweet and Salty Addiction: Rapid Onset High Blood Pressure?

High levels of fructose similar to amounts consumed within the American diet may predispose individuals to fast-onset, salt-sensitive hypertension, according to New research presented at the Experimental Biology 2016 meeting in San Diego.

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Kidney Disease: Report Assesses Mammoth Problem for the United States

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A sweeping new report assessing chronic kidney disease in the United States offers startling statistics about a condition that affects almost 14 percent of the U.S. population and costs billions in Medicare spending each year. “This report is a one-stop shop to try to understand the prevalence of kidney disease, how it’s being treated and how the burden affects various populations,” said researcher Rajesh Balkrishnan, PhD, of the School of Medicine.

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Most Kidney Transplant Recipients Visit the Emergency Department After Discharge

• Among 10,533 kidney transplant recipients, 57% visited an emergency department within 2 years after transplantation. • Risk factors for emergency department visits included younger age, females, black and Hispanic race/ethnicity, public insurance, depression, diabetes, peripheral vascular disease, and use of emergency departments prior to transplantation.

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Tissue Imaging Mass Spectrometry detects early lipid changes in acute kidney injury

Researchers made a microscopic snapshot of the early renal lipid changes in acute kidney injury, using a laser-scanning method called MALDI tissue imaging to localize the changes.

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U of S Researchers Improve Kidney Diagnostics

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Researchers have devised a simple method to determine split renal function— critical knowledge for anyone planning to donate a kidney or to guide doctors’ decisions for surgery and other medical treatments.

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Conservative Care May Be a Reasonable Option for Elderly Kidney Failure Patients

• Among kidney failure patients aged ≥80 years, there was no statistically significant survival advantage for those who chose dialysis over conservative management.

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Mitochondrial Metabolism Linked to Acute Kidney Injury

Scientists from Beth Israel Deaconess Medical Center show that PGC1 alpha works through the NAD "aging molecule" to guard against stress; research offers new therapeutic target for acute kidney injury, a widespread problem for hospitalized patients

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Tips on Seeking a Thyroid Surgeon, How to Improve Cancer Immunotherapy, Drug Combination Shuts Down Tumor Growth in Aggressive Lung Cancer, and more in the Cancer News Source

Tips on Seeking a Thyroid Surgeon, How to Improve Cancer Immunotherapy, Drug Combination Shuts Down Tumor Growth in Aggressive Lung Cancer, and more in the Newswise Cancer News Source