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Anti-Cancer Drug Effective Against Common Stem Cell Transplant Complication

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Researchers at UC Davis have found that the drug bortezomib effectively treats chronic graft-versus-host disease (GVHD), a common and debilitating side effect from allogeneic hematopoietic stem cell transplants. The trial showed that bortezomib provides better outcomes than existing treatments and does not impair the immune response against residual cancer cells, or the graft-versus-tumor effect (GVT).

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“JAKing” Up Blood Cancers, One Cell at a Time

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A solitary cell containing a unique abnormality can result in certain types of blood cancers known as myeloproliferative neoplasms (MPN), according to researchers in Switzerland. The results open new opportunities to examine single mutant cells and follow tumor initiation and progression of human MPN cancers.

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New Ways to Treat Anemia Could Evolve From UT Southwestern Research Showing That Acetate Supplements Speed Up Red Blood Cell Production

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UT Southwestern Medical Center researchers seeking novel treatments for anemia found that giving acetate, the major component of household vinegar, to anemic mice stimulated the formation of new red blood cells.

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Gene Mutation Discovered in Blood Disorder

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An international team of scientists has identified a gene mutation that causes aplastic anemia, a serious blood disorder in which the bone marrow fails to produce normal amounts of blood cells. The gene regulates telomeres on the ends of chromosomes.

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World Breakthrough: A New Molecule Allows for an Increase in Stem Cell Transplants

A new molecule, the first of its kind, allows for the multiplication of stem cells in a unit of cord blood. Umbilical cord stem cells are used for transplants aimed at curing a number of blood-related diseases, including leukemia, myeloma and lymphoma. For many patients this therapy comprises a treatment of last resort.

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Study Compares Effectiveness of Treatments for Blood Clots

In an analysis of the results of nearly 50 randomized trials that examined treatments of venous thromboembolisms (blood clot in a vein), there were no significant differences in clinical and safety outcomes associated with most treatment strategies when compared with the low-molecular-weight heparin-vitamin K antagonist combination, according to a study in the September 17 issue of JAMA.

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Sickle Cell Disease: Saving a Generation

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Sickle cell disease had been considered a pediatric ailment since people with it generally didn’t live to adulthood. As pediatricians, we’ve done a good job caring for our patients – 95% now live to their 20th birthday. Unfortunately, when our patients prepare to leave the pediatric system, a smooth transition to adult healthcare is lacking.

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One-Minute Point-of-Care Anemia Test Shows Promise in New Study

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A simple point-of-care testing device for anemia could provide more rapid diagnosis of the common blood disorder and allow inexpensive at-home self-monitoring of persons with chronic forms of the disease.

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Genomic Analysis Reveals That a High-Risk Leukemia Subtype Becomes More Common with Age

More than one-quarter of young adults with the most common form of acute lymphoblastic leukemia (ALL) have a high-risk subtype with a poor prognosis and may benefit from drugs widely used to treat other types of leukemia that are more common in adults, according to multi-institutional research led by St. Jude Children’s Research Hospital investigators.

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Sickle Cell Disease Patients Are Less Likely to Follow Physician Recommendations When They Perceive Discrimination, Study Finds

A Johns Hopkins Sickle Cell Disease researcher and patient led a study of other Sickle Cell patients and the connection between their adherence to medical advice and their perceived discrimination by the healthcare system.

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