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New Mechanism Triggers Endothelial Permeability in vivo

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UAB discovery gives better understanding of and potential therapies for septic shock and reperfusion injuries.

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Long Lasting Anti-Hemophilia Factor Safe in Kids

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Children with hemophilia A require three to four infusions each week to prevent bleeding episodes, chronic pain and joint damage. A new, extended therapy combines recombinant factor VIII with a fusion protein that allows the molecule to remain in the circulation longer – translating into a need for less frequent treatment.

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Blood Disorder Study Illustrates the Challenges to Parsing Genetic Data

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Does a particular genetic variation translate into a predisposition to an illness, or is it simply a benign rearrangement of genetic code? Drawing upon genomic data from thousands of people, researchers attempted to answer this question by focusing on mutations in two genes associated with a key receptor in blood clotting.

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Molecular and Functional Basis Established for Nitric Oxide Joining Oxygen and Carbon Dioxide in Respiratory Cycle

Professor Jonathan Stamler’s latest findings regarding nitric oxide have the potential to reshape fundamentally the way we think about the respiratory system – and offer new avenues to save lives. His findings were recently published online in the Proceedings of the National Academy of Sciences.

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A Possible Novel Therapy for a Rare but Potentially Fatal Blood Disorder

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A transgenic mouse model is a proof-of-concept that platelet blood cells that are loaded with the enzyme ADAMTS13 can be an effective treatment in murine models of thrombotic thrombocytopenic purpura.

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Research Reveals High Prevalence of Sleep Disordered Breathing in Adults with Sickle Cell Disease

Adults with sickle cell disease who report trouble with sleep could actually have a clinical diagnosis of sleep disordered breathing which could lower their oxygen levels at night.

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TSRI Team Discovers Enzyme that Keeps Blood Stem Cells Functional to Prevent Anemia

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Scientists at The Scripps Research Institute have found a particular enzyme in blood stem cells that is key to maintaining healthy periods of cell inactivity; if these cells become too active and divide too often, they risk acquiring cell damage and mutations.

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Study Bolsters "Turbocharged" Protein as a Promising Tool in Hemophilia Gene Therapy

Using gene therapy to produce a mutant human protein with unusually high blood-clotting power, scientists successfully treated dogs with the bleeding disorder hemophlia, without triggering an unwanted immune response.

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New Gene Therapy for Hemophilia Shows Potential as Safe Treatment

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New Research from San Raffaele Telethon Institute for Gene Therapy and the University of North Carolina showed that a reprogrammed retrovirus could successfully transfer new clotting genes into animals with hemophilia B to safely and dramatically decrease spontaneous bleeding.

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Johns Hopkins Researchers Engineer Custom Blood Cells

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Researchers at Johns Hopkins have successfully corrected a genetic error in stem cells from patients with sickle cell disease, and then used those cells to grow mature red blood cells, they report. The study represents an important step toward more effectively treating certain patients with sickle cell disease who need frequent blood transfusions and currently have few options.