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World Breakthrough: A New Molecule Allows for an Increase in Stem Cell Transplants

A new molecule, the first of its kind, allows for the multiplication of stem cells in a unit of cord blood. Umbilical cord stem cells are used for transplants aimed at curing a number of blood-related diseases, including leukemia, myeloma and lymphoma. For many patients this therapy comprises a treatment of last resort.

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Study Compares Effectiveness of Treatments for Blood Clots

In an analysis of the results of nearly 50 randomized trials that examined treatments of venous thromboembolisms (blood clot in a vein), there were no significant differences in clinical and safety outcomes associated with most treatment strategies when compared with the low-molecular-weight heparin-vitamin K antagonist combination, according to a study in the September 17 issue of JAMA.

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Sickle Cell Disease: Saving a Generation

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Sickle cell disease had been considered a pediatric ailment since people with it generally didn’t live to adulthood. As pediatricians, we’ve done a good job caring for our patients – 95% now live to their 20th birthday. Unfortunately, when our patients prepare to leave the pediatric system, a smooth transition to adult healthcare is lacking.

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One-Minute Point-of-Care Anemia Test Shows Promise in New Study

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A simple point-of-care testing device for anemia could provide more rapid diagnosis of the common blood disorder and allow inexpensive at-home self-monitoring of persons with chronic forms of the disease.

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Genomic Analysis Reveals That a High-Risk Leukemia Subtype Becomes More Common with Age

More than one-quarter of young adults with the most common form of acute lymphoblastic leukemia (ALL) have a high-risk subtype with a poor prognosis and may benefit from drugs widely used to treat other types of leukemia that are more common in adults, according to multi-institutional research led by St. Jude Children’s Research Hospital investigators.

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Sickle Cell Disease Patients Are Less Likely to Follow Physician Recommendations When They Perceive Discrimination, Study Finds

A Johns Hopkins Sickle Cell Disease researcher and patient led a study of other Sickle Cell patients and the connection between their adherence to medical advice and their perceived discrimination by the healthcare system.

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UT Southwestern Expert Co-Chairs National Team to Develop First Comprehensive Guidelines for Management of Sickle Cell Disease

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The National Heart, Lung, and Blood Institute (NHLBI) has released the first comprehensive, evidence-based guidelines for management of sickle cell disease from birth to end of life.

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Novel Cancer Drug Proves Safe for Leukemia Patients in Phase I Clinical Trial

Results of a Phase I clinical trial showed that a new drug targeting mitochondrial function in human cancer cells was safe and showed some efficacy. The findings, reported by doctors at Wake Forest Baptist Medical Center, are published in the current online edition of the journal Clinical Cancer Research.

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Researchers Turn to Plants to Help Treat Hemophilia

Accidents as minor as a slip of the knife while chopping onions can turn dangerous for patients with hemophilia, who lack the necessary proteins in their blood to stem the flow from a wound.

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Football Season Brings Hidden Dangers of Sickle Cell Trait into the Spotlight

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John Wood, MD, PhD, and colleagues are looking into how the body regulates blood flow to the muscles and brain in patients with sickle cell trait (SCT). They hope to determine specific factors that put certain SCT athletes at risk for life-threatening complications during vigorous exercise.

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