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Quick Antibiotics Reduce PICU Needs and Mortality of Pediatric Cancer Patients

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A University of Colorado Cancer Center study published in the journal Pediatric Blood & Cancer shows that pediatric cancer patients who receive antibiotics within 60 minutes of reporting fever and showing neutropenia (low neutrophil count), go on to have decreased intensive care needs and lower mortality compared with patients who receive antibiotics outside the 60-minute window.

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The Immune System May Play a Key Role in Viral Therapy’s Effectiveness Against Tumors

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Viral therapy for childhood cancer could possibly improve if treatments such as chemotherapy do not first suppress patients’ immune systems, according to findings published today in the journal Molecular Therapy—Oncolytics.

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Platelet Transfusions Increase Death Rate in Some Blood Cell Disorders

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People hospitalized with certain rare blood cell disorders frequently receive a treatment that is associated with a two- to fivefold increase in death, according to a new study that reviewed hospital records nationwide. The study authors recommend that for these rare disorders, doctors should administer the treatment, a platelet transfusion, only in exceptional circumstances.

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New Test Helps Guide Treatment for Bone Marrow Transplant Patients with Graft vs. Host Disease

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Innovative scoring system uses “Ann Arbor GVHD score” to better predict how patients will respond, minimize side effects

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Targeting Fatty Acids May Be Treatment Strategy for Arthritis, Leukemia

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Enzymes linked to diabetes and obesity appear to play key roles in arthritis and leukemia, potentially opening up new avenues for treating these diverse diseases, according to researchers at Washington University School of Medicine in St. Louis.

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Test Predicts Response to Early Treatment for Dangerous Complication of Stem Cells Transplants Used in Leukemia Patients

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A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD).

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Top Blood Transfusion-Related Complication More Common Than Previously Reported

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Two studies published in the January issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists® (ASA®), shed new light on the prevalence of transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO), the number one and two leading causes of blood transfusion-related deaths in the United States.

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Experts in Leukemia and Bone Marrow Transplant Prepare for Upcoming Pivotal Trial of Innovative Targeted Payload Immunotherapy

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If approved, Iomab-B should increase the number of patients eligible for curative bone marrow transplant (BMT, also known as HSCT) and improve clinical outcomes.

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Experts in Leukemia Treatment Support Ongoing Trials for Novel Alpha-Radiolabeled Antibody Treatment

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Since intensive chemotherapy is associated with a high mortality rate and limited benefits to high risk patients, low intensity treatments such as Actimab-A could potentially extend overall survival in elderly patients while significantly decreasing traditional chemotherapy related toxicities, including treatment related early mortality.

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PRM-151 Therapy Well Tolerated in Patients with Advanced Myelofibrosis

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A study that investigated the potential of the compound PRM-151 (PRM) for reducing progressive bone marrow fibrosis (scarring) in patients with advanced myelofibrosis has shown initial positive results. Myelofibrosis is a life-threatening bone marrow cancer.