The National Institutes of Health (NIH) has awarded researchers at Case Western Reserve University a grant to begin studying the possible long-term health effects of exposure to hazardous chemicals from the East Palestine, Ohio, train derailment.
A passionate plea for the re-establishment of Canada's health coalition focused on hypertension prevention and control appears as an editorial in the Canadian Journal of Cardiology, published by Elsevier.
Cedars-Sinai investigators have detailed a new way that bacteria use iron to cooperate and resist antibiotic treatment. The study, led by the Cedars-Sinai departments of Biomedical Sciences and Pathology and Laboratory Medicine, is published in the peer-reviewed journal Nature Microbiology and is the first to show this type of antibiotic cross-protection.
Blood vessels constitute a closed pipe system distributed throughout the body, transporting blood from the heart to other organs and delivering metabolic waste products back to the lungs and kidneys. Changes in blood vessels are related to
BACKGROUNDIn vitro expansion to increase numbers of hematopoietic stem cells (HSCs) in cord blood could improve clinical efficacy of this vital resource. Nicotinamide (NAM) can promote HSC expansion ex vivo, but its effect on hematopoietic
About eight million people live with Type 1 diabetes (T1D) worldwide, a chronic autoimmune condition in which the body attacks and destroys its own insulin-producing β-cells (pronounced “beta”) in the pancreas, leading to a lack of insulin and inability to regulate blood sugar. It’s not known why the body suddenly perceives its own β-cells as the enemy; some lines of evidence suggest environmental factors such as viral infections may trigger the onset of T1D, others suggest genetics may also play some role.
Groundbreaking research by investigators at Joslin Diabetes Center sheds new light on the specific changes β-cells go through at the onset of T1D. Their findings—published in Nature Cell Biology—offer new avenues for targeted interventions for the chronic autoimmune condition.
A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis -- the formation of blood clots – researchers report February 23rd in the journal Cell Metabolism.
Certain genes associated with hypertension affect blood pressure from early in life, and they increase the risk of cardiovascular disease as you get older. However, you can do something about it.
SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in Long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies.
A new analysis method can detect pathogens in blood samples faster and more accurately than blood cultures, which are the current state of the art for infection diagnosis. The new method, called digital DNA melting analysis, can produce results in under six hours, whereas culture typically requires 15 hours to several days, depending on the pathogen.
Siteman Cancer Center, based at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis, is one of the first centers nationwide to offer a newly approved cell-based immunotherapy that targets melanoma.
A first-of-its-kind cellular immunotherapy pioneered at Moffitt Cancer Center has received approval from the Food and Drug Administration and is now available for patients with advanced melanoma. Lifileucel is the first tumor-infiltrating lymphocyte therapy, or TIL, approved for solid tumors.
The qualities of flowing blood, or hemodynamics, hold important insights into vascular diseases, but technological limitations have largely kept measurements of these properties out of reach in the clinic. Now, there may be a potential solution on the horizon.
A new study published by Nutrients reports that consuming 100% orange juice prior to a meal, when compared to sugar-sweetened, orange-flavored drinks, suppresses food intake at the next meal and results in lower daily blood glucose concentrations in healthy, normal-weight adults.1
The discovery of a pair of genes that work in perfect harmony to protect male fertility, could provide new insights into some unexplained cases of the most severe form of infertility, research suggests.
White blood cells known as neutrophils feature a nucleus that is structured strikingly different than most nuclei. These unique shapes permit neutrophils to travel all over the body to combat invading pathogens.
A group of international mycology experts led by Professor Dr Oliver A. Cornely at the University of Cologne has jointly drafted a guideline for the diagnosis and treatment of cryptococcosis, which aims at improving infection management and thus the survival rate of patients.
Chula researchers have developed a remarkable wireless hepatitis B virus test kit to screen for infection and collect data for an online database that’s fast and complete in one step.
Using the results of a standard blood test and an online tool, you can find out if you are at increased risk of having a heart attack within six months.
Labeling cancer cells with genetic barcodes
“In ReSisTrace, we label cancer cells uniquely with genetic barcodes and allow them to divide once, so that we get two identical sister cells that share the same barcode.
Findings from St. Jude Children’s Research Hospital showed a novel dual targeting approach, where a single molecule can recognize two potential cancer-related proteins, is more effective than the single targeting approach, preventing immune escape.
Black women in the U.S were, on average, six times more likely to be murdered than their white peers for the years 1999 through 2020, according to an analysis of racial disparities in U.S. homicide rates released by Columbia University Irving Medical Center and Columbia’s Mailman School of Public Health.
Over 100,000 individuals in the United States are currently in need of organ transplants. The demand for organs, such as hearts, kidneys, and livers, far exceeds the available supply and people sometimes wait years to receive a donated organ.
In a major, international study, named SELECT2, a University Hospitals (UH) research team found that patients with large strokes had a dramatically better recovery after endovascular thrombectomy plus medical management at long-term follow-up, than patients who only received standard medical management.
Scientists hope to advance precision medicine through the discovery of a gene variant that leads to the same phenotype in separate high-dwelling populations while taking a different evolutionary path.
In a new article published in the Journal of Clinical Oncology, Moffitt Cancer Center researchers in collaboration with Sylvester Comprehensive Cancer Center and groups around the world share results from a novel model that can provide tailored predictions of how individual patients respond to different therapies.
Regular erections could be important for maintaining erectile function, according to a new study on mice published in Science by researchers at Karolinska Institutet.
Up to 30% of patients newly diagnosed with acute myeloid leukemia (AML) have an FLT3 gene mutation, which is associated with a high risk of relapse and a very poor prognosis.
Team of researchers led by Indiana University School of Medicine faculty have developed a breakthrough new blood test for schizophrenia, a psychiatric disorder that includes hallucinations and delusions.
Cedars-Sinai Cancer investigators have discovered a protein expressed on multiple myeloma cancer cells that drives disease growth and development. The new study found that blocking part of the protein’s unique signaling pathway stops myeloma growth in culture and in laboratory mice.
Researchers in a Johns Hopkins Children’s Center-led study say they have made progress in developing a blood test to identify disease-associated changes in the brain specifically linked to postpartum depression and other psychiatric and neurological disorders.
Montefiore Health System and Albert Einstein College of Medicine have been awarded a $1.5 million National Institutes of Health grant to provide advanced research training to post-graduate trainees from groups that are underrepresented in medicine and have research interests in heart, lung, blood, and sleep disorders. Over five years, nine researchers will receive intense research training and robust mentorship from almost 30 established, senior investigators across Montefiore and Einstein.
Daniel Herranz Benito, PhD, PharmD, resident researcher at Rutgers Cancer Institute of New Jersey, the state’s leading cancer program and only NCI-designated Comprehensive Cancer Center together with RWJBarnabas Health, and associate professor of pharmacology and pediatrics at Rutgers Robert Wood Johnson Medical School, has received a total of $2.6M to support his research on acute lymphoblastic leukemia (ALL), an aggressive type of leukemia that affects both children and adults.
Empa researchers have observed living red blood cells transforming into spiky "echinocytes" in real time when treated with high concentrations of ibuprofen using holotomographic microscopy and displayed them in 3D renderings.
Retroviruses are viruses that multiply by incorporating their genes into the genome of a host cell. If the infected cell is a germ cell, the retrovirus can then be passed on to the next generation as an “endogenous” retrovirus (ERV) and spread as part of the host genome in that host species.
Russell DeBose-Boyd, Ph.D., Professor of Molecular Genetics at UT Southwestern Medical Center, has been awarded the Hill Prize in Biological Sciences from the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST) in recognition of his long-standing research into a key mechanism necessary for cholesterol control.
As new cancer treatments become available, some of the most important ongoing research must look at ways to optimize those new approaches so that more patients can benefit from groundbreaking therapies.