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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 8-Feb-2016 3:00 PM EST

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Study Identifies New Class of Anticancer Compounds for Possible Targeted Therapy in Blood Cancers

A research team from the Department of Pharmacology and Therapeutics at Roswell Park Cancer Institute (RPCI) has discovered a new class of small-molecule compounds that are good candidates for development of novel targeted therapies in the treatment of leukemia and lymphoma. This new class of compounds drives cancer cells to suicide, the researchers report in the peer-reviewed journal Cell Death and Disease.

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New Gene Therapy Treatment Proves Effective for Rare Blood Disorder

A single injection. That’s all someone with a factor VII deficiency would need for a life-long cure, thanks to a new gene therapy treatment developed in a collaboration of researchers at the University of North Carolina (UNC) and The Children’s Hospital of Philadelphia (CHOP).

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New Guidelines Reverse Previous Recommendations on Gluten Introduction to Prevent Celiac Disease

Based on new evidence, the age of introduction of gluten into the infant diet—or the practice of introducing gluten during breast-feeding—does not reduce the risk of celiac disease in infants at risk, according to a Position Paper of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). The statement appears in the Journal of Pediatric Gastroenterology and Nutrition (JPGN), official journal of ESPGHAN and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, published by Wolters Kluwer.

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Link Found Between Obesity and Blood Clots in Pediatric Patients

Researchers at Wake Forest Baptist Medical Center have found an association between obesity and the formation of blood clots in the veins of children and adolescents.

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New Pathway to Differentiation Found, Shedding Light on Some Cancers

UAB researchers have discovered a new mechanism of differentiation, as studied in megakaryocytes, the blood cells responsible for platelet production. The ultimate effect of this new pathway is an alternative splicing of messenger RNAs.

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McMaster Researchers Reveal Predictive Staircase to Leukemia

Researchers detail how they have been able to fingerprint myelodysplastic syndromes (MDS), a state for blood cells that turns into acute myeloid leukemia (AML) cancer in approximately 30% of patients

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Mines Researchers Develop Injectable Microwheels to Deliver Fast, Effective Treatment for Blood Clots

Research conducted by members of the Colorado School of Mines Department of Chemical and Biological Engineering demonstrates microscale biomedical devices shaped like wheels can be injected into the body and effectively “roll” to treat areas in need – such as arterial blockages.

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Novel RNA Delivery System May Treat Incurable Blood Cancers

Tel Aviv University researchers develop unique system to deliver therapy at site of Mantle Cell Lymphoma.

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New Funding Allows for the Clinical Development of Novel Cell Based Hemophilia Therapy

A new $8.5M (CAD) grant award by the European commission via its Horizon 2020 program will be used for the treatment of hemophilia A, also called factor VIII (FVIII) deficiency, the most common form of hemophilia A. The genetic disorder is caused by missing or defective factor VIII, a blood clotting protein. The grant was awarded to the HemAcure consortium consisting of Canadian- based Sernova Corp and five European academic and private partners to advance development of a GMP clinical grade Factor VIII releasing therapeutic cell product in combination with Sernova's Cell Pouch™ for the treatment of severe hemophilia A.

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Nutritional Vitamin D Supplements Do Not Help Treat Anemia in Dialysis Patients

Vitamin D2 supplements taken for 6 months did not reduce dialysis patients’ need for anemia drugs that stimulate red blood cell production.

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The Leonard C. Goodman Institute for Investigative Reporting Is Now Accepting Submissions

The deadline for this round of proposals is January 15, 2016. Candidates will be notified of decisions by the end of February 2016. The Institute pays a competitive rate--and covers expenses--for investigative reporting that advances social and economic justice. All stories are published in In These Times magazine and on InTheseTimes.com.

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Top Stories 11 Dec 2015; New Forensic Science Breakthroughs, Breast Cancer Treatment Difference by Age, Racial Disparities in Dialysis, and More...

Click to view today's top stories.

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An International Randomized Controlled Study Reports a Higher Incidence of Inhibitors with Recombinant Factor VIII than Plasma-derived Factor VIII Containing Von Willebrand Factor in Previously Untreated Patients with Hemophilia A

The Angelo Bianchi Bonomi Foundation is pleased to announce that the SIPPET (Survey of Inhibitors in Plasma-Products Exposed Toddlers), the first randomized and controlled study on hemophilia and inhibitors designed to answer a key clinical question regarding the role that the product source plays in the development of inhibitors, has been completed.

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NUS Scientists Discover New Cellular Mechanism for Potential Target Protein for Acute Myeloid Leukemia

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A team of researchers from the National University of Singapore has found a new significant correlation between the protein nucleophosmin and the development of an aggressive form of blood cancer called acute myeloid leukemia (AML). The team, led by Professor Lim Tit Meng from the Department of Biological Sciences at the NUS Faculty of Science, explained the puzzling phenomenon of AML cells appearing like normal cells even though they are cancerous. The team discovered that the mutated form of the protein which is found in about one-third of AML cases, is associated with a novel cellular mechanism that develops AML cells containing normal chromosomes.

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Montefiore-Einstein Investigators Present Research at 2015 American Society of Hematology Annual Meeting

Montefiore Einstein Center for Cancer Care, Albert Einstein Cancer Center and The Children’s Hospital at Montefiore present research at the American Society of Hematology’s annual meeting. Presentations include the first report on a genetic risk factor for avascular necrosis associated with treatment of acute lymphoblastic leukemia (ALL) in children.

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Protein Biomarker Identifies Damaged Brain Wiring After Concussion

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A brain protein called SNTF, which rises in the blood after some concussions, signals the type of brain damage that is thought to be the source of these cognitive impairments.

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Treatment for Sickle Cell Disease May Help Protect Patients’ Kidney Function

• After 6 months of treatment with hydroxyurea, sickle cell disease patients’ kidney function, as measured by the urinary albumin/creatine ratio, improved significantly.

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Research Yields Potential Treatment Approach for Glycogen Storage Disease

Researchers from the Duke-NUS Graduate Medical School Singapore (Duke-NUS) and Duke Medicine have identified a potential treatment strategy for an often-fatal inherited glycogen storage disease.

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Thrombosis During Sepsis Is a Consequence of Protective Host Immune Responses

Researchers from the University of Birmingham have, for the first time, identified how Salmonella infections that have spread to our blood and organs can lead to life-threatening thrombosis.