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A reporter's PressPass is required to access this story until the embargo expires on 20-Aug-2014 5:00 PM EDT

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A reporter's PressPass is required to access this story until the embargo expires on 20-Aug-2014 5:00 PM EDT

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Forcing Chromosomes into Loops May Switch Off Sickle Cell Disease

Scientists have altered key biological events in red blood cells, causing the cells to produce a form of hemoglobin normally absent after the newborn period. This approach may lead to a novel treatment for sickle cell disease.

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Drug Target Identified for Common Childhood Blood Cancer

In what is believed to be the largest genetic analysis of what triggers and propels progression of tumor growth in a common childhood blood cancer, researchers at NYU Langone Medical Center report that they have identified a possible new drug target for treating the disease.

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Scientists Discover Genetic Switch That Can Prevent Peripheral Vascular Disease in Mice

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Millions of people in the United States have a circulatory problem of the legs called peripheral vascular disease. It can be painful and may even require surgery in serious cases. This disease can lead to severe skeletal muscle wasting and, in turn, limb amputation.

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Liver Transplant Patients Who Receive Organs from Living Donors More Likely to Survive than Those Who Receive Organs from Deceased Donors

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Research derived from early national experience of liver transplantation has shown that deceased donor liver transplants offered recipients better survival rates than living donor liver transplants, making them the preferred method of transplantation for most physicians. Now, the first data-driven study in over a decade disputes this notion. Penn Medicine researchers found that living donor transplant outcomes are superior to those found with deceased donors with appropriate donor selection and when surgeries are performed at an experienced center. The research is published this week in the journal Hepatology.

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SLU Scientists Hit ‘Delete’: Removing Disordered Regions of Shape-Shifting Protein Explains How Blood Clots

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Researchers used x-ray crystallography to publish the first image of prothrombin. The protein’s flexible structure is key to the development of blood-clotting.

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Wisconsin Scientists Find Genetic Recipe to Turn Stem Cells to Blood

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The ability to reliably and safely make in the laboratory all of the different types of cells in human blood is one key step closer to reality.

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Biochemical Cascade Causes Bone Marrow Inflammation, Leading to Serious Blood Disorders

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Like a line of falling dominos, a cascade of molecular events in the bone marrow produces high levels of inflammation that disrupt normal blood formation and lead to potentially deadly disorders including leukemia, an Indiana University-led research team has reported.

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