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Trending Stories Report for 21 May 2015

Trending news releases with the most views in a single day. Topics include: gun regulation, psychology and altruism, big data, threats to coral reefs, extra-terrestrial life, personalized diets, metabolic syndrome and heart health, new drug target to treat arthritis, and archeologists find oldest tools.

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Minimal Residual Disease Alone Not Predictive in T-Cell Leukemia

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Researchers found that the presence of a few remaining leukemia cells, called minimal residual disease (MRD), at the end of induction chemotherapy was not predictive of risk or outcome in children with T-cell acute lymphoblastic leukemia (ALL). This opens the possibility for patients with T-cell ALL who have MRD to achieve complete remission without undergoing intensified cancer treatments and their associated toxicities.

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Study May Suggest New Strategies for Myelodysplastic Syndromes Treatment

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A study revealing fresh insight about chromosome “tails” called telomeres may provide scientists with a new way to look at developing treatments or even preventing a group of blood cell disorders known as myelodysplastic syndromes (MDS).

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Repurposed Anti-Cholesterol Drug Could Improve Treatment-Resistant Anemias

Diamond Blackfan anemia (DBA), a rare inherited bone marrow failure syndrome is typically treated with glucocorticoids that cause a host of often dangerous side effects. Using a mouse model, Whitehead scientists have determined that combining the drug fenofibrate with glucocorticoids could allow for dramatically lower steroid doses in the treatment of DBA and other erythropoietin-resistant anemias. These promising results are the foundation for a clinical trial that will begin soon.

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Malaria's Doorway to Infect Blood Cells Identified; Potential to Close it, Lock it, Throw Away the Key

Scientists have identified a protein on the surface of human red blood cells that serves as an essential entry point for invasion by the malaria parasite. This discovery opens up a promising new avenue for the development of therapies to treat and prevent malaria.

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New Mechanism Triggers Endothelial Permeability in vivo

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UAB discovery gives better understanding of and potential therapies for septic shock and reperfusion injuries.

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Long Lasting Anti-Hemophilia Factor Safe in Kids

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Children with hemophilia A require three to four infusions each week to prevent bleeding episodes, chronic pain and joint damage. A new, extended therapy combines recombinant factor VIII with a fusion protein that allows the molecule to remain in the circulation longer – translating into a need for less frequent treatment.

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Blood Disorder Study Illustrates the Challenges to Parsing Genetic Data

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Does a particular genetic variation translate into a predisposition to an illness, or is it simply a benign rearrangement of genetic code? Drawing upon genomic data from thousands of people, researchers attempted to answer this question by focusing on mutations in two genes associated with a key receptor in blood clotting.

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Molecular and Functional Basis Established for Nitric Oxide Joining Oxygen and Carbon Dioxide in Respiratory Cycle

Professor Jonathan Stamler’s latest findings regarding nitric oxide have the potential to reshape fundamentally the way we think about the respiratory system – and offer new avenues to save lives. His findings were recently published online in the Proceedings of the National Academy of Sciences.

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A Possible Novel Therapy for a Rare but Potentially Fatal Blood Disorder

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A transgenic mouse model is a proof-of-concept that platelet blood cells that are loaded with the enzyme ADAMTS13 can be an effective treatment in murine models of thrombotic thrombocytopenic purpura.