A small pilot study shows for the first time that changes in diet, exercise, stress management and social support may result in longer telomeres, the parts of chromosomes that affect aging.
Roundup of what's new and what's news at the Center for Innovative Care in Aging at the Johns Hopkins University School of Nursing
Cornell University researchers have developed a reliable method to distinguish memory declines associated with healthy aging from the more-serious memory disorders years before obvious symptoms emerge. The method also allows research to accurately predict who is more likely to develop cognitive impairment without expensive tests or invasive procedures.
-Proteins are the chief actors in cells, carrying out the duties specified by information encoded in our genes. Most proteins live only two days or less, ensuring that those damaged by inevitable chemical modifications are replaced with new functional copies.
Among scientists, the role of proteins called sirtuins in enhancing longevity has been hotly debated, driven by contradictory results from many different scientists. But new research at Washington University School of Medicine in St. Louis may settle the dispute.
When the tiny roundworm C. elegans reaches middle age—at about 2 weeks old—it can't quite move like it did in the bloom of youth. But rather than imposing an exercise regimen to rebuild the worm's body-wall muscles, researchers can bring the wriggle back by stimulating the animal's neurons. And, they say, pharmaceuticals might have a similar effect in mammals.
Cell senescence, an irreversible arrest of proliferation, is thought to be associated with normal aging and is protective against cancer. Penn researchers found that senescent cells undergo changes in their chromatin, similar to changes in cells that are prematurely aging. When the nuclear protein lamin B1 is deleted in senescent cells, large-scale changes in gene expression occurred. This loss of lamin B1 may cause changes in chromatin architecture and add to premature cell aging.
Adults age 45 and older who engaged in moderate physical activity up to two and a half hours a week did not increase their risk of developing knee osteoarthritis over a 6-year follow-up period, a new study finds.
A team of Columbia University Medical Center researchers, led by Nobel laureate Eric R. Kandel, MD, has found that deficiency of a protein called RbAp48 in the hippocampus is a significant contributor to age-related memory loss and that this form of memory loss is reversible. The findings were published today in the online edition of Science Translational Medicine.
Beat the Blues, an inexpensive intervention, shows promise at easing depression among older African Americans in studies by faculty at the Johns Hopkins University School of Nursing.
A researcher at Michigan Technological University is looking into neural connections to high blood pressure and congestive heart failure.
If Popeye were to age naturally like the rest of us, he would need more than just big muscles to stay independent during his senior years. When it comes to muscles and aging, the important thing is quality, not quantity.
Scientists at Sanford-Burnham Medical Research Institute have identified a key factor that regulates the autophagy process, a kind of cleansing mechanism for cells in which waste material and cellular debris is gobbled up to protect cells from damage, and in turn, modulates aging.
Researchers at the University of California, San Diego School of Medicine offer an explanation for why we all don't get Alzheimer's disease (AD) - a trick of nature that in most people maintains critical separation between a protein and an enzyme that, when combined, trigger the progressive cell degeneration and death characteristic of AD.
A study by Valentina Moskvina, Ph.D., of the Cardiff University School of Medicine, Wales, United Kingdom, and colleagues, examined the genetic overlap between Parkinson disease (PD) and Alzheimer disease (AD).
In the past, the only treatment available for varicose veins was a type of surgery called vein stripping, which required general anesthesia and weeks of downtime. Now, dermatologists who have received additional training are using minimally invasive procedures to treat varicose veins, allowing patients to get back to their lives more quickly and resume activities that they may have avoided beforehand.
Johns Hopkins Nursing researchers focus on the discrimination-depression link, herpes tests for teens, the baby-mom bond, violence against women across the globe, and more in the July-August 2013 research news briefs.
In a first-of-its-kind clinical trial, physician-scientists at University Hospitals Case Medical Center found that sleep quality impacts skin function and aging. The study, commissioned by Estée Lauder, demonstrated that poor sleepers had increased signs of skin aging and slower recovery from a variety of environmental stressors, such as disruption of the skin barrier or ultraviolet (UV) radiation. Poor sleepers also had worse assessment of their own skin and facial appearance.
Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of developing cerebral microbleeds, according to a new study from researchers in the Netherlands.
Vitamin D-deficient older individuals are more likely to struggle with everyday tasks such as dressing or climbing stairs, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).
The trajectory of amyloid plaque buildup—clumps of abnormal proteins in the brain linked to Alzheimer’s disease—may serve as a more powerful biomarker for early detection of cognitive decline rather than using the total amount to gauge risk, researchers from Penn Medicine’s Department of Radiology suggest in a new study published online July 15 in Neurobiology of Aging.
An international group of scientists has shown that a drug candidate designed by scientists from the Florida campus of The Scripps Research Institute significantly increases exercise endurance in animal models.
Music – as poets have noted – has the power to wash away the dust of everyday life, and medical experts believe it may also imbue physical and social benefits. Now a new UC San Francisco research project is exploring whether singing in a community choir can provide tangible health advantages to older adults.
New research suggests that reading books, writing and participating in brain-stimulating activities at any age may preserve memory. The study is published in the July 3, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Higher levels of omega-3 fatty acids in the blood may reduce the risk for hip fractures in postmenopausal women, recent research suggests.
UCLA researchers have found that older adults who regularly used a brain-fitness program on a computer demonstrated significantly improved memory and language skills.
A supplemental beverage used to treat muscle-wasting may help boost muscle mass among the elderly, according to a new study. The results were presented today at The Endocrine Society’s 95th Annual Meeting in San Francisco.
The ability to distinguish odors declines with age. A study shows that African-Americans have a greater decrease than Caucasians. This has serious consequences. Olfactory loss often leads to impaired nutrition. It can be an early warning sign of neurodegenerative diseases, and can predict death.
The more an older man walks, the better his physical and mental health and his quality of life are likely to be, finds a new study in the American Journal of Health Promotion.
Mice suffering from age-related heart disease saw a significant improvement in cardiac function after treatment with the FDA-approved drug rapamycin for just three months. Research at the Buck Institute shows how rapamycin impacts mammalian tissues, providing functional insights and possible benefits for a drug that can extend lifespan in mice as much as 14 percent. Researchers at the Mayo clinic are now recruiting seniors with cardiac artery disease for a clinical trial involving the drug.
An abnormal heartbeat, known as atrial fibrillation, is associated with memory and thinking problems, according to new published research.
For many older adults, the aging process seems to go hand-in-hand with an annoying increase in clumsiness. New research from Washington University in St. Louis suggests some of these reaching-and-grasping difficulties may be caused by changes in the mental frame of reference that older adults use to visualize nearby objects.
More than 55 Indiana U. researchers participated in ACSM. Here, researchers discuss findings involving elite athletes, arterial stiffening in young and older populations, and a simple program for losing weight and sitting less.
On May 22, JoVE will publish details of a technique to measure the health of human genetic material in relation to a patient’s age. The method is demonstrated by the laboratory of Dr. Gil Atzmon at New York’s Albert Einstein College of Medicine. Dr. Atzmon hopes that the dissemination of this technique will lead to the development of a “genetic thermometer” to assess a patient’s health in relation to other individuals of the same age.
Efforts to integrate health protection/promotion programs in the workplace are needed soon if the aging U.S. workforce is to remain competitive, according to recommendations from ACOEM and NIOSH. Recommendations in the May Journal of Occupational and Environmental Medicine summarize results of a 2-day national summit convened last year.
National Senior Health and Fitness Day on May 29 is opportunity for senior adults to get fit.
Gerontology and geriatrics education is a growing field as experts seek to train students, caregivers, and seniors themselves about healthy aging, vitality, and the new generation of active elderly people.
A mutant protein responsible for Hutchinson-Gilford Progeria syndrome (HGPS) bars large proteins from entering the nucleus, according to a study in The Journal of Cell Biology.
A University of Iowa study shows that older people can put off the aging of their minds by playing a simple game that primes their processing speed skills. The research showed participants' cognitive skills improved in a range of functions, from improving peripheral vision to problem solving. Results published in the journal PLOS One.
May is Older Americans Month. Every day more than 10,000 baby boomers turn 65 with expectations of living into their 80s. Their children can easily live to be 100. Geriatric Medicine Specialist Stephen Jones, MD, gives his Top 10 Tips for staying healthy to 100 years old.
While the search continues for the Fountain of Youth, researchers may have found the body’s “fountain of aging”: the brain region known as the hypothalamus. For the first time, scientists at Albert Einstein College of Medicine of Yeshiva University report that the hypothalamus of mice controls aging throughout the body. Their discovery of a specific age-related signaling pathway opens up new strategies for combating diseases of old age and extending lifespan. The paper was published today in the online edition of Nature.
Elderly patients who receive anesthesia are no more likely to develop long-term dementia or Alzheimer’s disease than other seniors, according to new Mayo Clinic research. The study analyzed thousands of patients using the Rochester Epidemiology Project -- which allows researchers access to medical records of nearly all residents of Olmsted County, Minn. -- and found that receiving general anesthesia for procedures after age 45 is not a risk factor for developing dementia. The findings were published Wednesday, May 1, online in Mayo Clinic Proceedings.
People born during 1945 through 1965 are five times more likely than other adults to be infected with hepatitis C. If you were born during these years, talk to your doctor about getting tested.
Research Identifies Potential Therapeutic Targets for Late Onset Alzheimer’s Disease (LOAD) By Revealing a Network of Genes Involved in the Inflammatory Response.
Financial exploitation, particularly thefts and scams, are increasing at an alarming rate, particularly in older adults. This study examined this population and their vulnerability for experiencing fraud.
Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts.
Older adults who are subject to elder abuse, neglect and exploitation face a greater risk of being hospitalized than other seniors, according to the results of a study published in the April 8 issue of JAMA Internal Medicine.
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