Cognitive changes following non-neurologic and non-cardiac surgery were not associated with changes in Alzheimer’s disease-related biomarkers in older patients, according to a study led by a team at Duke University School of Medicine.
A team of researchers from the University of Kentucky’s Sanders-Brown Center on Aging is working to identify new proteins that are destructive to the brain. They know that about 25% of individuals, and 50% of individuals with Alzheimer disease, have the genetic mutation APOE ε4 allele — a known risk factor for the disease. Through a recent study, researchers were surprised to find that even in the brains of patients without the disease-driving mutation, ApoE proteins were enhanced in dementia. Their findings appear in The American Journal of Pathology, published by Elsevier.
A new study has found that greater body fat is a risk factor for reduced cognitive function, such as processing speed, in adults. Even when the researchers took cardiovascular risk factors (such as diabetes or high blood pressure) or vascular brain injury into account, the association between body fat and lower cognitive scores remained. This suggests other not yet confirmed pathways that linked excess body fat to reduced cognitive function.
Researchers from Radboudumc have developed a set of growth charts for the brain.
Sanford Burnham Prebys professor Yu Yamaguchi has been awarded a $2.9 million grant from the National Institutes of Health to study the role of heparan sulfate (HS) in Alzheimer’s disease. HS is a structural molecule found in the scaffolding between cells that has been previously observed to influence the development of Alzheimer’s disease. However, the precise function it plays in the brain has not been studied closely.
University of Maryland School of Medicine researchers developed a technique in laboratory animals to consistently and reproducibly open the blood-brain barrier. Their paper essentially provides a roadmap for other researchers to develop and test new therapies for brain diseases.
Ten years ago, on Jan. 23, 2012, the brand-new University of Kansas Clinical Research Center opened its doors.
A cost analysis of the controversial new Alzheimer’s disease drug aducanumab shows that ancillary care services account for nearly 20% of total Medicare costs related to the drug, or $6,564 per patient per year.
The latest research news from the Health Disparities Channel.
Researchers from the Icahn School of Medicine at Mount Sinai have found that greater increases, decreases, or variability in body mass index (BMI) over time are associated with an accelerated rate of cognitive decline, irrespective of whether a person has normal, overweight or obese body mass index at baseline.
Researchers have determined the optimal number of intervention sessions needed to prevent cognitive decline in people at risk.
CLEVELAND: Cleveland Clinic has launched a landmark study to better understand why millions of people around the world suffer from brain diseases, with the goal of pinpointing disease biomarkers early, well before clinical symptoms present themselves. The new Cleveland Clinic Brain Study – the largest clinical study ever for brain disease – will collect data from up to 200,000 neurologically healthy individuals over a 20-year period to identify brain disease biomarkers and targets for preventing and curing neurological disorders.
Scientists have discovered that heart disease causes brain dysfunction that could lead to dementia before the buildup of plaque in blood vessels of the brain
Florida State University researchers have identified a link between two key parts of the brain that play significant roles in conditions such as Alzheimer’s disease, post-traumatic stress disorder, schizophrenia and depression.Associate Professor of Psychology and Neuroscience Wen Li and psychology doctoral candidate Kevin Clancy found that stimulating the system in the brain that deals with attention and imagery also enhances the efficiency of what’s called the default mode network, a key part of the brain’s functional organization.
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include an anti-CD19 chimeric antigen receptor (CAR) T cell therapy to treat follicular lymphoma, targeted therapies for urothelial cancers and advanced breast cancers, understanding the tumor microenvironment and immune landscape in pancreatic cancer, a link between depression risk and androgen deprivation for prostate cancer, and the discovery of new therapeutic targets for Alzheimer’s disease, liver cancer and aggressive breast cancer.
Following Medicare’s decision today about paying for a new Alzheimer’s disease treatment only in limited circumstances, Zaldy Tan, MD, MPH, a highly respected memory and geriatric medicine specialist at Cedars-Sinai, is available to comment.
As 2022 gets underway, experts in the Cedars-Sinai Departments of Neurology and Neurosurgery are monitoring new Alzheimer’s treatments, while also advancing Cedars-Sinai-led research in noninvasive diagnostic tools for the disease.
Increasing the expression of one gene in cells that assist the brain’s neurons protects neurons in mouse models of Alzheimer’s disease. These findings come from a new study published Jan. 10 in Nature Communications. High activity of the gene, Nrf2, slowed cognitive and physical decline in the mice and reduced the accumulation of sticky proteins in their brains, all key markers of the disease in humans.
A research team led by University of California, Irvine has discovered new neural circuits that regulate spatial learning and memory in the brain’s hippocampal formation. The team identified novel functional roles of new circuit connections between the venal CA1 region and dorsal CA3 regions of the hippocampus and demonstrated that genetic inactivation of this projection impairs object-related spatial learning and memory, but does not modulate anxiety-related behaviors.
First comprehensive analysis forecasts dementia prevalence in 195 countries and territories and examines the impact of expected trends in exposure to four important risk factors—smoking, obesity, high blood sugar, and low education.
When elderly people stay active, their brains have more of a class of proteins that enhances the connections between neurons to maintain healthy cognition, a UC San Francisco study has found.
Mount Sinai researchers analyzed thousands of microglia from different brain regions of deceased patients who had been diagnosed with a variety of neuropsychiatric and neurodegenerative disorders. Their results, published in Nature Genetics, support the idea that microglia may play critical roles in some cases of brain disease while also providing a potentially valuable guide for future studies.
There has yet been no plausible theory to explain Alzheimer's disease arising among Down syndrome young adults. A microbe is proposed for that role.
Washington University School of Medicine in St. Louis is launching an international clinical trial aimed at preventing Alzheimer’s disease in people genetically destined to develop the illness at a young age. Unlike most other Alzheimer’s prevention trials, this one will enroll people before the disease has taken hold – up to 25 years before the expected onset of dementia.
Using new methodology, University of Kentucky researchers have mapped the variations in sugar chains attached to brain proteins from deceased healthy individuals or individuals with Alzheimer’s disease. Thus far, no effective treatments for Alzheimer’s disease (AD) are available. New approaches to preventing the progression of this devastating neurological disease are desperately needed.
Researchers at Vanderbilt University Medical Center have discovered a nanoparticle released from cells, called a “supermere,” which contains enzymes, proteins and RNA associated with multiple cancers, cardiovascular disease, Alzheimer’s disease and even COVID-19.
For the first time, scientists have identified a rare population of potentially toxic senescent cells in human brains that can serve as a target for a new Alzheimer’s disease treatment.
“A Caring Science Model of Specialized Dementia Care for Transforming Practice and Advancing Health Equity,” has been designated as an “Edge Runner” by the American Academy of Nursing.
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Damage to a part of the brain that regulates hyperactivity can contribute to both memory problems and seizures in the most common form of epilepsy, according to research at the University of Wisconsin–Madison. The study, published recently in the Journal of Neuroscience, may lead to earlier diagnosis of epilepsy and possibly new ways to treat epilepsy and other disorders that share symptoms, like Alzheimer’s disease, traumatic brain injury and autism spectrum disorder.
A new study finds that a simple, self-administered test developed by researchers at The Ohio State University Wexner Medical Center, College of Medicine and College of Public Health can identify the early, subtle signs of dementia sooner than the most commonly used office-based standard cognitive test.
In a discovery that could one day benefit people suffering from traumatic brain injury, Alzheimer’s disease, and schizophrenia, UT Southwestern researchers have identified the characteristics of more than 100 memory-sensitive neurons that play a central role in how memories are recalled in the brain.
A new Cleveland Clinic-led study has identified sildenafil – an FDA-approved therapy for erectile dysfunction (Viagra) and pulmonary hypertension (Revatio) – as a promising drug candidate to help prevent and treat Alzheimer’s disease.
In this study of 3,000 adults with cataracts, the risk of developing dementia was lower in participants who underwent cataract removal compared with those who didn’t.
Having an elevated resting heart rate in old age may be an independent risk factor of dementia, according to a study at Karolinska Institutet in Sweden published in the journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.
Perturbing the gut microbiome with antibiotics during early life leads to a reduction in amyloid plaques in male mice in adulthood — and microglia are a critical component of the effect.
Difficulty in understanding speech, especially in background noise, is a common concern for older adults. Using a word identification task in quiet and noisy conditions, researchers examined the impact of mild dementia on speech perception. They tested individuals with and without mild dementia and found that word identification scores of those without dementia were significantly better in all conditions, meaning people with mild dementia symptoms recalled fewer words in both quiet and noisy situations.
USC study published in the Journal of Experimental Medicine shows that experimental drug protects against injury caused by tiny blood clots in the brain’s white matter, which can accumulate over time and lead to cognitive decline
A clutter-free environment may not help people with dementia carry out daily tasks – according to a new study from the University of East Anglia.
Isaacson will lead an academic clinical research program aimed at reducing the risk of Alzheimer’s disease (AD), Parkinson’s disease, and Lewy body dementia in individuals with a family history of these diseases who do not yet have any cognitive decline or other clinical complaints.
Good news for those of us who can’t face the day without their morning flat white: a long-term study has revealed drinking higher amounts of coffee may make you less likely to develop Alzheimer’s disease.
The Institute for Molecular Medicine will advance the manufacturing of Duvax for the first clinical trials of a dual vaccine for Alzheimer's disease to begin in 2023
Among the many devastating impacts of Alzheimer’s disease and other types of dementia is the risk that patients will wander and become lost. Indeed, according to the Alzheimer’s Association, six in 10 people with the disease will wander at least once over the course of their illness — and many do so repeatedly.
Using a new model of brain activity, Indiana University computational neuroscientists are exploring striking bursts of activity in the human brain that may have potential to serve as biomarkers for brain disease and conditions such as depression, schizophrenia, dementia, and ADHD.
Intake of 4-6 total cups daily was associated with lowest risks.
In recent studies, researchers find 1) Few people get a timely diagnosis of dementia, especially if they are of color with no college degree. 2) No dementia risk in members of military over 65. 3) Link to hearing and dementia.
Over the last decade, the publications of Jerold Chun and Randal J. Kaufman are among the top 1% in the world for number of citations
New research from Sanford Burnham Prebys has revealed features of the aging Down syndrome brain that could help explain why people with Down syndrome almost inevitably get Alzheimer's later in life.
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