A paper published today in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, researchers at Beth Israel Deaconess Medical Center (BIDMC) shed new light on a genetic risk factor for Alzheimer’s disease that may indirectly influence patients’ risk of postoperative delirium.
Israeli researchers have developed new technology for transporting drugs within silicon nanostructures to the brain. These nanostructures release an essential protein, which can inhibit the development of Alzheimer's disease, and provide targeted delivery in the brain with the use of a “gene gun.”
Scientists at the University of Birmingham in collaboration with the University of Amsterdam have uncovered a possible explanation for the mental sluggishness that often accompanies illness.
Nearly half of Americans in their 50s and early 60s think they’re likely to develop dementia as they grow older, but only 5% of them have actually talked with a doctor about what they could do to reduce their risk, a new study finds. Meanwhile, a third or more say they’re trying to stave off dementia by taking supplements or doing crossword puzzles – despite the lack of proof that such tactics work.
A gene called apolipoprotein E (APOE), long implicated in Alzheimer’s disease, has two variants that act differently among Caribbean Hispanics depending on the ancestral origin, according to a study published in Alzheimer’s and Dementia, the journal of the Alzheimer’s Association.
Researchers identified non-coding regions of the human genome that control the development and function of four brain cell types and mapped genetic risk variants for psychiatric diseases. They found that risk variants for Alzheimer’s disease were enriched in microglia-specific regulatory elements.
A new study finds that cognitive impairment begins in the earliest stages of age-related hearing loss—when hearing is still considered normal.
Endocytosis, a fundamental process that cells use to take in macromolecules, functions a lot like an airlock on a spaceship – but squishier, says Dr. Gunther Hollopeter, assistant professor of molecular medicine at the Cornell University College of Veterinary Medicine.
New research has found that people who are illiterate, meaning they never learned to read or write, may have nearly three times greater risk of developing dementia than people who can read and write. The study is published in the November 13, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The advisory council is made up of federal and non-federal members who serve overlapping four-year terms. As a new member, Ordóñez brings the perspectives of Hispanic and Latino Americans and providers of long-term services and support.
Columbia neuroengineers have found the first evidence that individual neurons in the human brain target specific memories during recall. They studied recordings in neurosurgical patients who had electrodes implanted in their brains and examined how the patients’ brain signals corresponded to their behavior while performing a virtual-reality object–location memory task. The researchers identified “memory-trace cells” whose activity was spatially tuned to the location where subjects remembered encountering specific objects.
A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer’s and Parkinson’s diseases and other neurological disorders. The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the fate of stem cells by detecting genetic material (RNA) involved in turning such cells into brain cells (neurons), according to a study in the journal Nano Letters.
People who have trouble sleeping may be more likely to have a stroke, heart attack or other cerebrovascular or cardiovascular diseases, according to a study published in the November 6, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.
By: Kara Irby | Published: November 6, 2019 | 10:10 am | SHARE: November is nationally recognized as Alzheimer’s Awareness month. President Ronald Reagan made the designation in 1983 and today more than 50 million people are living with Alzheimer’s disease and other forms of dementia worldwide.These Florida State University experts are available to comment on a variety of topics related to Alzheimer’s disease.
A new test agent can easily and efficiently detect the misfolded protein aggregates that cause devastating neurological diseases in blood samples. The technology could lead to early diagnosis of prion, Alzheimer's, and Parkinson's diseases for the first time.
على الرغم من الفحص العلمي الممتد لعقود، لم ينجح باحثو داء الزهايمر حتى الآن في اكتشاف أو معالجة سببه أو علاجه. ويُعتبر فهم ما يكمن وراء ثلاثة أنواع فرعية متميزة وسيلة بحثية جديدة واعدة.
Malgré des décennies d'examen scientifique, les chercheurs qui se consacrent à la maladie d’Alzheimer doivent encore en déterminer la cause ou le traitement. En comprenant les éléments sous-jacents de ses trois sous-types différents, une nouvelle perspective de recherche prometteuse semble se dessiner.
Apesar de décadas de escrutínio científico, os pesquisadores da doença de Alzheimerainda não descobriram sua causa ou tratamento. Compreender no que se baseiam os seus três subtipos distintos é considerado uma nova e promissora via de investigação.
Trotz jahrzehntelanger wissenschaftlicher Untersuchungen haben die Erforscher der Alzheimer-Krankheit deren Ursache und Behandlungsmethoden noch nicht klären können. Zu verstehen, was den drei verschiedenen Subtypen der Krankheit zugrunde liegt, gilt als vielversprechender neuer Forschungsansatz.
Pese a décadas de escrutinio científico, a los investigadores sobre la enfermedad de Alzheimer todavía les queda por resolver su causa y tratamiento. No obstante, se cree que al entender lo que subyace bajo los tres subtipos distintos, las nuevas investigaciones se enrumbarán por un camino esperanzador.
How well eight-year-olds score on a test of thinking skills may be a predictor of how they will perform on tests of thinking and memory skills when they are 70 years old, according to a study published in the October 30, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that education level and socioeconomic status were also predictors of thinking and memory performance. Socioeconomic status was determined by people’s occupation at age 53.
A new study from Columbia University found that a higher level of education protected against cognitive decline in black people with a gene linked to Alzheimer’s disease.
The human brain can recognise a familiar song within 100 to 300 milliseconds, highlighting the deep hold favourite tunes have on our memory, a UCL study finds.
Although there’s no cure for dementia, there are therapies that impact how people can continue to function well and lead good lives.
Despite decades of scientific scrutiny, Alzheimer's disease researchers have yet to work out its cause or treatment. Understanding what underlies its three distinct subtypes is thought to be a promising new research avenue. In a new study in JAMA Neurology, a team of neuroscientists at Mayo Clinic in Florida led by Melissa Murray, Ph.D., examined a key region of the brain and found that patterns of Alzheimer's-related damage differed by subtype and age of onset.
Early retirement can accelerate cognitive decline among the elderly, according to research conducted by faculty at Binghamton University, State University of New York.
The way people walk is an indicator of how much their brains, as well as their bodies, are aging. Scientists reporting in a special supplement to the Journal of Alzheimer's Disease (JAD) say that gait disorders
A new study of 3,000 people in Wisconsin aged 21 and older with Down syndrome, published today [Monday, Oct. 28, 2019] in JAMA Neurology by researchers at the University of Wisconsin–Madison, shows that by age 55, three in five will be diagnosed with Alzheimer’s disease or a similar neurodegenerative condition. Meanwhile, people without Down syndrome are rarely diagnosed with dementia before age 65.
What can reading 26,000 books tell researchers about how language environment affects language behavior? Brendan T. Johns, an assistant professor of communicative disorders and sciences at UB has published a computational modeling study that suggests our experience and interaction with specific learning environments, like the characteristics of what we read, leads to differences in language behavior that were once attributed to differences in cognition.
Prior to an Alzheimer’s diagnosis, a person in the early stages of the disease faces a heightened risk of adverse financial outcomes — a likely consequence of compromised decision making when managing money, in addition to exploitation and fraud by others.
Investigators at the University of Alabama at Birmingham and Stanford University want to learn more about silent strokes and their role in brain health, cognitive decline and dementia.
This two-part event on Alzheimer’s disease will focus largely on a novel approach involving autophagy, a cellular mechanism that only recently has been linked to the disease’s development. During the first part, a workshop, scholars, students, and professionals will exchange their ideas and research topics scientifically. In the second part, a panel discussion, experts will discuss and explain key results to the public.
Prof. Dr. Christian Behl is a Professor of Pathobiochemistry and Chair and Director of the Institute of Pathobiochemistry at the University Medical Center of the Johannes Gutenberg University Mainz in Germany. His research expertise is on neurodegeneration, the cause of a number of diseases linked to old age like Alzheimer’s, Parkinson’s and ALS, and on ways of preventing novel concepts based on basic molecular mechanisms, for instance autophagy.
Since its inception in 1995, the mission for A Woman’s Journey has remained the same: to empower women to make the right health care decisions for their families and themselves.
A UCLA-led study finds that, with the use of MRI scans, it is possible to distinguish between memory loss caused by Alzheimer’s disease and traumatic brain injury.
A new study from Washington University School of Medicine in St. Louis indicates that people with dementia – whose parents also had dementia – develop symptoms an average of six years earlier than their parents.
Older people who experienced more hospitalizations and also had more Alzheimer’s pathology in their brain experienced the fastest rates of cognitive decline, according to study results published in the October 15 online issue of the Annals of Neurology.
Neuroscientists at Georgetown University Medical Center say they have developed and tested an agent that reduces the buildup of toxic proteins in animal models of both Parkinson’s and Alzheimer’s diseases, and improves cognitive and motor behavior.
The memory of specific episodes is the base of autobiographical memory, but we do not know how the brain structures the experience to remember it in the long run.
A new multisite study funded by the National Institute on Aging will examine whether co-occurring Alzheimer’s disease and stage 4 breast or prostate cancer alters pain perception, potentially leading to undertreated cancer pain.
Value in Health, the official journal of ISPOR, announced today the publication of an analysis showing that direct medical costs are the major cost driver of Alzheimer’s disease care in Thailand, a finding distinct from other countries across the world.
Rush is part of national study to test effects of lifestyle intervention on older adults at risk for dementia.
A new study examining the role that star-shaped brain cells called astrocytes play in Huntington’s disease has identified a potential strategy that may halt the disease and repair some of the damage it causes.
The National Institutes of Health has awarded a five-year, multi-investigator research grant expected to total more than $63 million to Mayo Clinic and the University of California, San Francisco (UCSF), to advance treatments for frontotemporal lobar degeneration (FTLD).
A new Stony Brook University-led study, to be published in PNAS, provides a biophysical model that reveals how damage accumulates in proteins with age and is a trigger to death. The finding opens a door to a better understanding of the molecular origins of age-related neurodegenerative diseases.
In a new study, UC San Francisco scientists used maps of brain connections to predict how brain atrophy would spread in individual patients with frontotemporal dementia (FTD)
At the American Neurological Association's 2019 Annual Meeting, Kim Campbell, Alzheimer’s disease (AD) advocate and widow of Grammy Hall of Fame and Award-winning music legend Glen Campbell, recounted both the toll that Alzheimer's disease took on her husband and their family, and the musical talent that sustained him.
Researchers at the University of Toronto (U of T) specializing in language variation and change have identified a specific relationship between an individual's use of language
In a media roundtable at 11 a.m. U.S. Central on Tuesday, October 15, leading neuroscientists will summarize key science being presented at the American Neurological Association’s 2019 Annual Meeting (ANA2019). Reporters may attend in person or dial in.
Everybody knows sleep is good for your body. It may be good for your mind, too. That’s what scientists at Wake Forest School of Medicine will attempt to determine thanks to a $5.3 million grant from the National Institute on Aging, part of the National Institutes of Health.
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