Harnessing a probe used to image the brain in diagnosing Alzheimer's disease and related forms of dementia, scientists at Dana-Farber Cancer Institute and Massachusetts General Hospital (MGH) have successfully cleared patient-derived brain cells of an abnormal protein associated with dementia and other neurogenerative disorders.
Researchers have provided a crucial first step towards understanding how computing technology could be used to help people with depression remember happy memories.
Stony Brook University's Liliana Dávalos, PhD, is studying the phenomenal capabilities of the shrew, which shrinks up to 20 percent during winter months without hibernating. The research may shed light on the processes of neurological degeneration and regeneration in mammals.
Nursing researchers have developed a novel tool called the “Basic Knowledge of Alzheimer’s Disease,” to measure and assess Alzheimer’s knowledge in rural and underserved communities, in a way that matches their socioeconomic, educational and cultural needs. They put the survey to a test at senior centers in the Florida Glades and Appalachian Virginia, West Virginia, Alabama and North Carolina.
Consuming garlic helps counteract age-related changes in gut bacteria associated with memory problems, according to a new study conducted with mice. The benefit comes from allyl sulfide, a compound in garlic known for its health benefits.
Researchers are reporting new findings on how bacteria involved in gum disease can travel throughout the body, exuding toxins connected with Alzheimer’s disease, rheumatoid arthritis and aspiration pneumonia.
A new study provides critical insight into a little-known, yet relatively common, inherited neurological condition called Charcot-Marie-Tooth disease. The findings point to a pathway to possible treatments for this disease and better understanding of other neurodegenerative disorders, including Alzheimer's disease, that affect millions.
The eyes may be the window to the soul, but to scientists, they are also the window to the brain. In particular, the retina, a delicate light-sensing neural network with specialized cells at the back of the eyeball, is linked directly to the brain via the optic nerve and is considered by some to be part of the brain itself. Now, researchers at the University of Illinois at Chicago are developing imaging techniques that will allow them to study minute changes in the retina that indicate the early stages of brain diseases like Alzheimer’s disease and Parkinson’s disease.
As part of its Diagnostics Accelerator research program, the Alzheimer's Drug Discovery Foundation (ADDF) announced today a new initiative that aims to fast-track the development of digital tools for Alzheimer's disease and related dementias.
Researchers at the University of Minnesota have developed a unique 3D-printed transparent skull implant for mice that provides an opportunity to watch activity of the entire brain surface in real time. The device allows fundamental brain research that could provide new insight for human brain conditions such as concussions, Alzheimer’s and Parkinson’s disease.
Alzheimer's disease wreaks emotional havoc on patients, who are robbed of their memories, their dignity, and their lives. To date, there have been very few successes in the pursuit of a treatment. But one drug that looks at AD from a different angle is now ready for its first round of testing in humans.
Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, report on a novel four-year, randomized clinical trial evaluating different home-based methods to assess cognitive function and decline in participants over the age of 75.
Women who start their period later, go through menopause earlier or have a hysterectomy may have a greater risk of developing dementia, according to a new study published in the March 27, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study found a link between increased risk of dementia and fewer total reproductive years when women are exposed to higher levels of estrogen hormones.
To function properly, proteins must morph into specific 3D shapes through a biophysical phenomenon called protein folding. Researchers at ORNL are using various deep-learning techniques to study the intermediate protein stages between the initial unfolded state and the final folded state, which are notoriously difficult to characterize. These methods could also help identify factors that cause proteins to “misfold” into dysfunctional shapes, a phenomenon often attributed as a leading factor in the development of diseases including Alzheimer’s, cardiovascular disorders, and diabetes.
Working with mice, a team of Johns Hopkins Medicine researchers has developed a relatively inexpensive, portable mini microscope that could improve scientists’ ability to image the effects of cancer, stroke, Alzheimer’s disease and other conditions in the brains of living and active mice over time. The device, which measures less than 5 cubic centimeters, is docked onto animals’ heads and gathers real-time images from the active brains of mice moving naturally around their environments.
Researchers funded by NIBIB have designed neuron-like probes that can be implanted and remain viable for long-term use to study and treat the brain.
A recent study has demonstrated that smoking is not associated with a higher risk of dementia.
A new review article explores the pathophysiological factors that link sleep disturbances and Alzheimer’s disease. Better understanding of this connection may lead to potential diagnostic and therapeutics for Alzheimer’s disease, and other neurodegenerative diseases and dementia. The article is published ahead of print in the Journal of Neurophysiology (JNP).
Seemingly harmless fluid-filled spaces around the cerebral small vessels, commonly seen on brain MRIs in older adults, are now thought to be associated with more compromised cognitive skills, according to a Vanderbilt University Medical Centerstudy published in Neurology.
Using strong and targeted but noninvasive magnets at specific sites in the brains of people with and without mild learning and memory problems, Johns Hopkins researchers report they were able to detect differences in the concentrations of brain chemicals that transmit messages between neurons. The strength of these magnetic fields allows the researchers to measure tiny amounts and compare multiple brain metabolite levels at the same time. These studies may ultimately help to reveal what initiates memory decline and may, perhaps, even predict dementia risk. The researchers believe that measuring such data over time will allow them to more accurately detect and describe changes in metabolism in the brain as a person progresses from healthy to mild cognitive impairment and to dementia.
Long-term, high nut consumption could be the key to better cognitive health in older people according to new research from the University of South Australia.
The game isn’t about talking robots or colorful books. It’s about getting seniors in the early stages of dementia out of their rooms, moving their bodies and, most importantly, working together.
Mild cognitive impairment (MCI) refers to having problems with your memory and decision-making abilities.
A team of scientists spent six months co-designing robots with informal caregivers for people with dementia, such as family members. They found that caregivers wanted the robots to fulfill two major roles: support positive moments shared by caregivers and their loved ones; and lessen caregivers’ emotional stress by taking on difficult tasks, such as answering repeated questions and restricting unhealthy food.
Mayo Clinic 研究者已识别出一个叫做 “UCP-1”的基因，该基因或可预测 2 型糖尿病患者是否会患上胰腺癌。研究结果发表于《Gastroenterology》。
Researchers at UAB show that a new screening instrument, the Alabama Brief Cognitive Screen, is an effective and useful tool for clinicians to assess the severity of cognitive deficits.
Having a parent with Alzheimer’s disease has been known to raise a person’s risk of developing the disease, but new research suggests that having second- and third-degree relatives who have had Alzheimer’s may also increase risk. The study is published in the March 13, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Scientists continue to find evidence linking Type 2 diabetes with Alzheimer’s disease, the most common form of dementia and the seventh leading cause of death in the United States. However, little is understood about the mechanism by which the two are connected.Now, researchers at Joslin Diabetes Center, an affiliate of Harvard Medical School, have demonstrated that impaired insulin signaling in the brain negatively affects cognition, mood and metabolism, all components of Alzheimer’s Disease.
Researchers from the National University of Singapore found that seniors who consume more than two standard portions of mushrooms weekly may have 50 per cent reduced odds of having mild cognitive impairment.
A major new study from the UC Davis Alzheimer’s Center has uncovered dramatic differences in the brains of Hispanics with a dementia diagnosis compared with those of non-Hispanic whites and of African Americans.
Persons with Alzheimer's disease have approximately 30% higher risk of head injuries, and 50% higher risk of traumatic brain injuries than persons without Alzheimer's disease, a recent study from University of Eastern Finland shows. The results were published in Journal of Epidemiology and Community Health.
A study of more than 200 people at the Duke Eye Center suggests the loss of blood vessels in the retina could signal Alzheimer’s disease.
Researchers from the Duke Eye Center have shown that a new, non-invasive imaging device can see signs of Alzheimer’s disease in a matter of seconds.
睡眠过程中出现呼吸暂停症状的患者在其大脑管理记忆、方向感和时间感知的部位可能会累积更多的毒性蛋白质tau，该蛋白质是阿尔茨海默症的一个生物学标志。Mayo Clinic于 3 月 3 日星期日发布的一项初步研究将在 5 月 4 日至 10 日期间于费城举行的美国神经病学学会第 71 届年会上发表。
Pessoas que param de respirar durante o sono podem ter um alto acúmulo da proteína tóxica tau, uma marca biológica da doença de Alzheimer, na parte do cérebro que administra a memória, a navegação e percepção do tempo.
University of Minnesota engineering researchers have developed a unique new device that provides the first step toward ultrasensitive biosensors to better detect diseases like Alzheimer’s disease and Chronic Wasting Disease at the molecular level.
Las personas que dejan de respirar mientras duermen pueden acumular más proteína tóxica tau (uno de los distintivos biológicos de la enfermedad de Alzheimer) en la zona cerebral que controla la memoria, la orientación espacial y la percepción del tiempo.
Scientists at Wake Forest Baptist Health have been awarded $3.9 million from the National Institutes of Health to determine if a procedure used to treat Parkinson’s patients can improve age-related cognitive abilities and counteract the effects of Alzheimer’s and other types of dementia.
A new pilot study led by researchers at Stony Brook University and the Stony Brook World Trade Center Health and Wellness Program suggests that there may be a link between chronic PTSD in responders and neurodegeneration.
The science of sleep, and how to get people to do it better, is getting attention from policymakers to researchers who are trying to understand how sleep impacts performance and health.
A Michigan State University researcher will use a five-year, $5 million grant from the National Institutes for Health to investigate the role pesticides might play in olfactory impairment and their relevance to diseases such as Alzheimer's and Parkinson's.
A grant from The Harry T. Mangurian, Jr. Foundation will expand FAU’s Dementia Prevention Initiative, a large longitudinal study of brain aging and dementia. Using genetics, biology and the molecular bases of disease, the program incorporates personalized evaluation and prevention plans to reduce risk. Researchers are examining novel biomarkers and peripheral predictors of disease like physical performance, retinal imaging, and gait analyses, and are working with companies to develop novel blood tests to improve diagnosis and prediction.
Researchers have developed an artificial intelligence platform to detect a range of neurodegenerative disease in human brain tissue samples, including Alzheimer’s disease and chronic traumatic encephalopathy.
Cognitive impairment affects more than 50 million people worldwide. In the United States alone, one in three seniors dies with some type of dementia. This creates a critical clinical need for safe and effective therapies for the treatment and prevention of cognitive impairment.
People who stop breathing during sleep may have higher accumulations of the toxic protein tau, a biological hallmark of Alzheimer's disease, in part of the brain that manages memory, navigation and perception of time.
People who are witnessed by a bed partner to have stopped breathing during sleep may have higher accumulations of an Alzheimer’s disease biomarker called tau in an area of the brain that helps with memory, according to a preliminary study released today that will be presented at the American Academy of Neurology’s 71st Annual Meeting in Philadelphia, May 4 to 10, 2019.
The Alzheimer’s Foundation of America (AFA) urged President Trump’s administration to continue funding the fight against Alzheimer’s disease by investing an additional $350 million in federal Alzheimer’s research funding for Fiscal Year (FY) 2020.
The vast majority of patients with neurodegenerative disorders do not have specific gene mutations, but a single misbehaving protein – called TDP-43 – seems to be at the heart of these diseases. Pitt researchers have found a way to recreate and rescue TDP-43 pathology in a dish.
A powerful tool is available to investigate brain development, memory and learning, and brain dysregulation in neuropsychiatric diseases like addiction, depression, schizophrenia and Alzheimer’s. This molecular biology tool can selectively and robustly turn on genes in brain neurons of living rats.
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