Jing et al. combine a stroma-free differentiation system with EZH1-repression-mediated epigenetic reprogramming to generate developmentally mature iPSC-derived CAR T cells with enhanced antitumor activities.
Talbott et al. discuss the current state of knowledge in fibroblast biology and heterogeneity, primarily focusing on fibroblasts in skin wound repair. They also consider emerging techniques in the field and evaluate limitations of existing methodolo
In this issue of Cell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer’s disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importan
In the current issue of Cell Stem Cell, Bogeska et al. demonstrate that repeated exposures to inflammation cause indelible and specific functional compromise and accelerated aging of long-term hematopoietic stem cells (LT-HSCs). This study proposes
In this issue of Cell Stem Cell, Jing et al. inhibit EZH1 expression in a system that supports mature T cell development from iPSCs in vitro. The authors efficiently generate T cells that are highly functional against tumors.
I Gde Rurus Suryawan, Andrianto Andrianto, Arisya Agita, Anudya Kartika Ratri, Ricardo Adrian Nugraha
The entire virus detection process is executed inside a uniquely designed, portable, inexpensive, disposable, and self-driven microfluidic chip. The fully automated sample-in–answer-out molecular diagnostic set-up rapidly detects Hepatitis C virus in about 45 minutes and uses relatively inexpensive and reusable equipment costing about $50 for sample processing and disease detection. The disposable microfluidic chip also offers shorter times for a reliable diagnosis and costs about $2.
During the annual ACA meeting, David Goodsell, of Scripps Research and RCSB Protein Data Bank, will discuss his use of artistic methods to visualize biological data. His presentation, "Art as a Tool for Structural Biology," takes place Tuesday. Traditional artistic mediums, like painting, provide the freedom necessary to illustrate cells, and Goodsell is using illustrations to lay the foundation for computational modeling of whole cells. He also creates brightly colored, cartoonlike graphics with nonphotorealistic computer graphics methods to highlight the overall shape of molecules and how they assemble and interact.
For the first time, plant biologists have defined the high-efficiency “hacks” that cannabis cells use to make cannabinoids (THC/CBD).
Mayo Clinic is using 3D printing as a new option to heal the larynx after cancer or traumatic injury.
Researchers report that a gene therapy approach, developed at UC San Diego measurably delayed disease onset in humanized mouse and rat models of familial ALS, an inherited form of the disease that runs in families.
By creating a new framework for using mechanical energetics as a measurement for stability, Georgia Tech researchers have gained deeper insights into how and why we fall.
Researchers at the McKelvey School of Engineering at Washington University in St. Louis have developed a synthetic chemistry approach to polymerize proteins inside of engineered microbes.
Yoshimitsu Shimomura, Masashi Nishikubo, Hayato Maruoka, Seiko Nasu, Tomomi Nishioka, Kenji Sakizono, Satoshi Mitsuyuki, Tomoyo Kubo, Naoki Okada, Daishi Nakagawa, Kimimori Kamijo, Hiroharu Imoto, Ryusuke Yamamoto, Yuya Nagai,
JMIR Publications recently published "Nonfungible Tokens as a Blockchain Solution to Ethical Challenges for the Secondary Use of Biospecimens: Viewpoint" in JMIR Bioinformatics and Biotechnology in which the authors discuss how current practices of de-identifying human samples for research is reminiscent of the treatment of Henrietta Lacks’s tissue in 1951. They highlight how current standards continue to release researchers and health systems from obligations to promote respect, beneficence, and justice for patients.
Michael Herriges, Maria Yampolskaya, Bibek R Thapa, Jonathan Lindstrom-Vautrin, Feiya Wang, Cheng-Lun Na, Liang Ma, McKenna M Montminy, Jessie Huang, Carlos Villacorta-Martin, Pankaj Mehta, Darrell N. Kotton
Raly James Custodio, Hee Jin Kim, Jiyeon Kim, Darlene Mae Ortiz, Mikyung Kim, Danilo Buctot, Leandro Val Sayson, Hyun Jun Lee, Bung-Nyun Kim, Eugene Yi, Jae Hoon Cheong
Adam Stabell, Shuxiong Wang, Grace Lee, Ji Ling, Sandrine Nguyen, George Sen, Qing Nie, Scott Atwood
Helena G Asenjo, Maria Alcazar-Fabra, Mencia Espinosa, Lourdes Lopez-Onieva, Amador Gallardo, Emilia Dimitrova, Angelika Feldmann, Tomas Pachano, Jordi Martorell-Marugan, Pedro Carmona-Saez, Antonio Sanchez-Pozo, Alvaro Rada-Iglesias, Robert J Klose, David
Chunbo Li, Luopei Guo, Keqin Hua
Risa Sugiura, Sayuri Hamano, Atsushi Tomokiyo, Daigaku Hasegawa, Shinichiro Yoshida, Hideki Sugii, Shoko Fujino, Orie Adachi, Masataka Kadowaki, Daiki Yamashita, Hidefumi Maeda
CHICAGO, July 26, 2022 /PRNewswire/ -- AACC 2022 Open Lab Solutions, Inc., is announcing the formation of a new division, AMCAR Scientific, that will focus on an expanding product line of plastic consumables used in the medical industry. OLS is exhibiting within booth #3257 at the 74th American Association for Clinical Chemistry Annual Scientific Meeting and Clinical Laboratory Exposition (AACC 2022) at the McCormick Place Convention Center in Chicago, July 24 – 28th.
In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore,
BACKGROUNDDermal papillae (DP) and outer root sheath (ORS) cells play important roles in hair growth and regeneration by regulating the activity of hair follicle (HF) cells. AIMTo investigate the effects of human mesenchymal stem cell-derived
Mesenchymal stem cells (MSCs) have gained wide-ranging reputation in the medical research community due to their promising regenerative abilities. MSCs can be isolated from various resources mostly bone marrow, Adipose tissues and Umbilical cor
For more than 20 years, researchers have isolated and identified postnatal dental pulp stem cells (DPSCs) from different teeth, including natal teeth, exfoliated deciduous teeth, healthy teeth, and diseased teeth. Their mesenchymal stem cell (M
BACKGROUNDBronchopulmonary dysplasia (BPD) is not merely a chronic lung disease, but a systemic condition with multiple organs implications predominantly associated with hyperoxia exposure. Despite advances in current management strategies, lim
Stem cell fate determination is one of the central questions in stem cell biology, and although its regulation has been studied at genomic and proteomic levels, a variety of biological activities in cells occur at the metabolic level. Metabolom
The use of mesenchymal stem-cells (MSC) in cell therapy has received considerable attention because of their properties. These properties include high expansion and differentiation in vitro, low immunogenicity, and modulation of biological proc
With advances in the fields of regenerative medicine, cell-free therapy has received increased attention. Exosomes have a variety of endogenous properties that provide stability for molecular transport across biological barriers to cells, as a
In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore,
Kazuhiko Ikeda, Keiji Minakawa, Satoshi Ono, Mao Watanabe, Yuka Sato, Saki Takahashi, Sho Odawara, Kinuyo Kawabata, Koki Ueda, Kenneth Nollet, Hideki Sano, Takayuki Ikezoe, Atsushi Kikuta
Khosrow Rezvani, Sanam Sane, Rekha Sriniva, Rashaun Potts, Morgan Eikanger, Diana Zagirova, Jessica Freeling, Casey Reihe, Ryan Antony, Brij Gupta, Douglas Lynch, Jonathan Bleeker, Hassan Turaihi, Angela Pillatzki,
Wejdan Salem AlQurashi, Naif I. AlJohani
Afsane Soleimani, Mirsepehr Pedram, Fatemeh Saadinam, Mohammad Javad Rasaee, Saeed Oraee Yazdani, Masoud Soleimani
Huanping An, Yue Yu, Xuming Ren, Minghua Zeng, Yu Bai, Tao Liu, Huimei Zheng, Rong Sang, Fan Zhang, Yu Cai, YongMei Xi
Paul Wilmes, Jean-Pierre Trezzi, Velma Aho, Christian Jäger, Sebastian Schade, Annette Janzen, Oskar Hickl, Benoit Kunath, Mélanie Thomas, Kristopher Schmit, Pierre Garcia, Alessia Sciortino, Camille Martin-Gallausiaux, Rashi Halder,
BACKGROUNDCancer stem cells (CSCs) have been implicated in tumorigenesis and tumor recurrence and metastasis are key therapeutic targets in cancer treatment. MicroRNAs display therapeutic potential by controlling the properties of CSCs; however
Biochips (microarrays) are modern analytical tools that allow thousands of individual detections to be performed simultaneously in a small amount of sample material. A team led by Mark Somoza from the Faculty of Chemistry at the University of Vienna has now presented a new method in "Nature Communications". With this method, commercially available DNA chips can be quickly and easily converted into RNA chips, which are otherwise much more difficult to produce. Such RNA microarrays help to elucidate the still unknown functions of RNA molecules in cells - an important prerequisite for advancing the diagnosis and treatment of diseases such as cancer.
Larger organic farms operate more like conventional farms and use fewer sustainable practices than smaller organic farms, according to a new Cornell University study that also provides insight into how to increase adoption of sustainable practices.
Today, Gilson announced a new UV-VIS detector to its VERITY® line of purification systems. The VERITY® 1741 UV-VIS Detector is specifically designed with the needs of semi-preparative and preparative HPLC customers in mind.
A sustainable chemical separation method that uses membranes, microalgae and artificial intelligence has been developed by a team drawn from different KAUST groups whose members have diverse specialties in bioengineering, membranes and water reuse and recycling.
LumiraDx, a next-generation point of care diagnostics company will be hosting an industry workshop at this week’s American Association for Clinical Chemistry (AACC) Annual Conference in Chicago. The workshop, held on July 27th, will include data-backed insights on the impact of LumiraDx’s advanced microfluidic technology over lateral flow point-of-care antigen tests, and the role of these rapid immunoassays in response to the COVID-19 pandemic.
Madeleine Berendsen, Diede van Bladel, Eva Hesius, Fleur de Groot, Leonie Kroeze, Jos Rijntjes, Jeroen Luijks, Brigiet Hoevenaars, Altuna Halilovic, Peet Nooijen, Ellen van der Spek, Joost Vermaat, Corine Hess, Konnie Hebeda,
Marija Zivaljic, Mathieu Hubert, Ludivine Grzelak, Giulia Sansone, Uwe Maskos, Olivier Schwartz
Kotaro Sasaki, Yasunari Seita, Keren Cheng, John McCarrey, Nomesh Yadu, Ian Cheeseman, Alec Bagwell, Corinna N Ross, Isamar Santana-Toro, Li-Hua Yen, Sean Vargas, Christopher S Navara, Brian P Hermann
Tobias Däbritz, Sabine Tschiedel, Michael Cross, Dietger Niederwieser
Hamid Aria, Mahdieh Azizi, Shima Nazem, Maryam Bahmanyar, Ali Moravej, Mohammad Hosein Pourjafarian, Babak Pezeshki, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori
Phoonsuk Limraksasin, Praphawi Nattasit, Jeeranan Manokawinchoke, Watcharaphol Tiskratok, Naruephorn Vinaikosol, Hiroko Okawa, Chalida Nakalekha Limjeerajarus, Nuttapol Limjeerajarus, Prasit Pavasant, Thanaphum Osathanon, Hiroshi Egusa
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