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Newswise: Technology that simulates complex molecular interactions could lead to better treatments for diseases like cancer and COVID-19
5-Sep-2022 9:00 AM EDT
Technology that simulates complex molecular interactions could lead to better treatments for diseases like cancer and COVID-19
University of Minnesota College of Science and Engineering

A team led by University of Minnesota Twin Cities biomedical engineers has developed a universally accessible application that can simulate complex molecular interactions, which will allow researchers to design better treatments for diseases like cancer and COVID-19.

   
Released: 5-Sep-2022 12:00 PM EDT
Efficient repair of human homozygous genetic mutation by CRISPR/Cas9 mediated interlocus gene conversion
Preprints

Fei Yang, Jingtao Pang, Guolong Liu, Yang Yang, Shenguang Qin, Ying Zhang, Yongrong Lai, Dan Liang, Yuxuan Wu

Released: 5-Sep-2022 12:00 PM EDT
Gene interaction perturbation network deciphers a high-resolution taxonomy in colorectal cancer
Preprints

Zaoqu Liu, Siyuan Weng, Qin Dang, Hui Xu, Yuqing Ren, Chunguang Guo, Zhe Xing, Zhenqiang Sun, Xinwei Han

Released: 4-Sep-2022 12:00 PM EDT
PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling
Preprints

Jodie Hay, Anuradha Tarafdar, Ailsa Holroyd, Hothri A Moka, Karen M Dunn, Alzahra Alshayeb, Bryony H Lloyd, Jennifer Cassels, Natasha Malik, Ashfia F Khan, IengFong Sou, Jamie Lees, Hassan Nb Almuhanna, Nagesh Kalakonda,

Released: 4-Sep-2022 12:00 PM EDT
The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load and total HIV-1 DNA in HIV-1 infected humanized mice
Preprints

Mathieu Amand, Philipp Adams, Rafaela Schober, Gilles Iserentant, Jean-Yves Servais, Michel Moutschen, Carole Seguin-Devaux

Released: 4-Sep-2022 12:00 PM EDT
Aquaporin regulates cell rounding through vacuole formation during endothelial-to-hematopoietic transition
Preprints

Yuki Sato, Mugiho Shigematsu, Maria Shibata-Kanno, Sho Maejima, Chie Tamura, Hirotaka Sakamoto

Released: 4-Sep-2022 12:00 PM EDT
A Beefy-R culture medium: replacing albumin with rapeseed protein isolates
Preprints

Andrew J. Stout, Miriam L. Rittenberg, Michelle Shub, Michael K. Saad, Addison B. Mirliani, David L. Kaplan

Released: 3-Sep-2022 12:00 PM EDT
Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle.
Preprints

James W McNamara, Ben L Parker, Holly K Voges, Neda Rahmani R Mehdiabadi, Francesca Bolk, Dylan D Chung, Natalie Charitakis, Jeff Molendijk, Sean Lal, Mirana Ramialison, Kathy Karavendzas, Hayley L Pointer, Petros Syrris, Luis R Lope

Released: 3-Sep-2022 12:00 PM EDT
Salinomycin disturbs Golgi apparatus function and specifically affects cells in epithelial-to-mesenchymal transition
Preprints

Marko Marjanovic, Ana-Matea Mikecin Drazic, Marija Mioc, Filip Klicek, Mislav Novokmet, Gordan Lauc, Marijeta Kralj

Released: 3-Sep-2022 12:00 PM EDT
Decoding spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin
Preprints

Xiaofei Li, Zaneta Andrusivova, Paulo Czarnewski, Christoffer Mattsson Langseth, Alma Andersson, Yang Liu, Daniel Gyllborg, Emelie Braun, Ludvig Larsson, Lijuan Hu, Zhanna Alekseenko, Hower Lee, Christophe Avenel, Helena Kopp Kallner

Released: 3-Sep-2022 12:00 PM EDT
Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis
Preprints

Yiming Chao, Yang Xiang, Jiashun Xiao, Shihui Zhang, Weizhong Zheng, Xiaomeng Wan, Zhuoxuan Li, Mingze Gao, Gefei Wang, Zhilin Chen, Mo Ebrahimkhani, Can Yang, Angela Ruohao Wu, Pentao Liu,

Released: 3-Sep-2022 12:00 PM EDT
MAM-STAT3-induced upregulation of mitochondrial Ca+2 causes immunosenescence in patients with type A mandibuloacral dysplasia
Preprints

Arshad Ahmed Padhiar, Xiaohong Yang, Zhu Li, Jinqi Liao, İlyas Ali, Wei Shu, Arif Ali Chishti, Liangge He, Gulzar Alam, Abdullah Faqeer, Yan Zhou, Shuai Zhang, Ting Wang, Tao Liu,

Released: 2-Sep-2022 1:55 PM EDT
Water-based gel to be tested as dressing for diabetic wounds
Washington University in St. Louis

In early experiments, Jianjun Guan and his team found that after applying a single dose of their wound dressing into wounds in young diabetic mice, the wounds completely closed at day 14. Wounds that were treated only with the hydrogel or were untreated were reduced to roughly half of their original size.

Released: 2-Sep-2022 12:00 PM EDT
Exploration of HSPC aging mechanism based upon in vitro cell modeling and MDS clinical sampling
Preprints

Haiyan Hu, Xiangrong Song, Lin Zhao, Lanyue Hu, Chu Xu, Yanjuan Lin, Manying Zhou, Xiaolan Lian, Lina Zhang

Released: 2-Sep-2022 12:00 PM EDT
Computational Modeling of the Chlamydial Developmental Cycle Reveals a Potential Role for Asymmetric Division
Preprints

Travis J Cherelli, Nicole Grieshaber, Cody Appa, Scott S Grieshaber

Released: 2-Sep-2022 12:00 PM EDT
LGR5 targeting molecules as therapeutic agents for multiple cancer types
Preprints

Hung-Chang Chen, Nico Mueller, Katherine Stott, Eilidh Rivers, Chrysa Kapeni, Carolin M Sauer, Flavio Beke, Stephen Walsh, Nicola Ashman, Louise M O'Brien, Amir Rafati Fard, Arman Godsinia, Fadwa Joud, Olivier Giger,

Released: 2-Sep-2022 12:00 PM EDT
Local induction of IAA5 and IAA29 promotes DNA damage-triggered stem cell death in Arabidopsis roots
Preprints

Naoki Takahashi, Nobuo Ogita, Toshiya Koike, Kohei Nishimura, Soichi Inagaki, Masaaki Umeda

Released: 1-Sep-2022 12:00 PM EDT
Potential Mechanisms for Human Genome Integration of Genetic Code from SARS-CoV-2 mRNA Vaccination
Preprints

Anthony M Kyriakopoulos, Peter A Mccullough, Greg Nigh, Stephanie Seneff

Released: 1-Sep-2022 12:00 PM EDT
Mesenchymal stem cell culture within perfusion bioreactors incorporating 3D-printed scaffolds enables improved extracellular vesicle yield with preserved bioactivity
Preprints

Stephanie M Kronstadt, Divya B Patel, Louis J Born, Daniel Levy, Max J Lerman, Bhushan Mahadik, Shannon T McLoughlin, Arafat Fasuyi, Lauren Fowlkes, Lauren Hoorens van Heyningen, Amaya Aranda, Sanaz Nourmohammadi Abadchi, Kai-Hua Chang,

Released: 1-Sep-2022 12:00 PM EDT
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Protect Bone against Ovariectomy‑Induced Osteoporosis through ERK Signaling by Estrogen Receptor α
Preprints

Hui Qi, Enpu Shen, Beibei Li, Zhiwen Wu, Yongsheng Jie, Rui Zheng, Xiong Shu, Lei Chen, Danping Liu, Cheng'ai Wu

Released: 1-Sep-2022 12:00 PM EDT
Intestinal stem cell aging at single-cell resolution: functional perturbations alter cell developmental trajectory reversed by gerotherapeutics
Preprints

Jiahn Choi, Michele Houston, Ruixuan Wang, Kenny Ye, Wenge Li, Xusheng Zhang, Derek M Huffman, Leonard H Augenlicht

Released: 1-Sep-2022 12:00 PM EDT
Nogo-A regulates the fate of human dental pulp stem cells towards osteogenic, adipogenic, and neurogenic differentiation
Preprints

Juliet Shen, Chai Foong Lai, Anamaria Balic, Pierfrancesco Pagella, Martin E. Schwab, Thimios Mitsiadis

Released: 1-Sep-2022 12:00 PM EDT
X chromosome dosage drives statin–induced dysglycemia and mitochondrial dysfunction
Preprints

Peixiang Zhang, Joseph J Munier, Laurent Vergnes, Carrie B Wiese, Jenny C Link, Fahim Abbasi, Emilio Ronquillo, Antonio Munoz, Yu-Lin Kuang, Meng Liu, Gabriela Sanchez, Akinyemi Oni-Orisan, Carlos Iribarren, Michael J. McPhaul,

Released: 1-Sep-2022 12:00 PM EDT
Label-free imaging of 3D pluripotent stem cell differentiation dynamics on chip
Preprints

Scott Atwell, Dominik J. E. Waibel, Sayedali Shetab Boushehri, Carsten Marr, Matthias Meier

Released: 1-Sep-2022 5:00 AM EDT
Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development
Cell Stem Cell

Fu and colleagues profiled a stem cell-derived microfluidic amniotic sac embryoid (μPASE) using single-cell RNA sequencing. Molecular maps of lineage diversifications from the pluripotent human epiblast toward the amniotic ectoderm, primitive streak

Released: 1-Sep-2022 5:00 AM EDT
Modeling human multi-lineage heart field development with pluripotent stem cells
Cell Stem Cell

We describe hPSC-derived models of FHF, aSHF, and pSHF development spanning the mesoderm, progenitor, and cardiomyocyte stages. Comparison between the hPSC-derived and the corresponding mouse populations revealed conserved developmental trajectories

Released: 1-Sep-2022 5:00 AM EDT
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal
Cell Stem Cell

Xie and colleagues propose a regulatory mechanism of hepatic bile acid metabolism in colitis pathogenesis. They find that the hepatic CYP8B1-cholic acid metabolic axis impairs Lgr5+ intestinal stem cell renewal by repressing PPARα, thus exacerbating

Released: 1-Sep-2022 5:00 AM EDT
Current status of cell-based interventions in Japan
Cell Stem Cell

The Act on the Safety of Regenerative Medicine regulates cell-based interventions in Japan. Recent revisions to the law require disclosure of explanatory and consent materials for interventions seeking approval. In this Forum, we present an updated a

Released: 1-Sep-2022 5:00 AM EDT
Lymphatic endothelia stakeout cryptic stem cells
Cell Stem Cell

A trio of studies in this issue of Cell Stem Cell catalogs the anatomical and functional relationship of intestinal lymphatics with epithelial stem cells, defining an important niche role for the lymphatic endothelium.

Released: 1-Sep-2022 5:00 AM EDT
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells
Cell Stem Cell

In this issue of Cell Stem Cell, Pham et al. report that naive human pluripotent stem cells can be differentiated into extraembryonic mesoderm cells (EXMCs). EXMCs are maintained for up to 70 days, resemble human and monkey extraembryonic mesoderm,

Released: 1-Sep-2022 5:00 AM EDT
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates
Cell Stem Cell

Muscle stem cells (MuSCs) exhibit different metabolic profiles depending on their activity, however the mechanisms by which mitochondria affect MuSC fate has been understudied. In this issue of Cell Stem Cell, Hong et al. (2022) and Baker et al. (2

Released: 1-Sep-2022 5:00 AM EDT
Uncovering the origins and lineage markers of human heart fields
Cell Stem Cell

In this issue of Cell Stem Cell, Yang et al. devise a protocol for induction and differentiation of human heart-field precursors, drawing on inspiration from in vivo development. Intricate computational analyses uncovered conserved factors governin

Newswise: New Technology Offers Pathways to Finding Treatments for Kidney Disease
Released: 31-Aug-2022 5:10 PM EDT
New Technology Offers Pathways to Finding Treatments for Kidney Disease
Washington University in St. Louis

McKelvey Engineering, School of Medicine collaborate to develop hydrogel system that preserves the biochemistry and mechanical environments of cultured podocyte cells

   
Released: 31-Aug-2022 1:50 PM EDT
New algorithm uncovers the secrets of cell factories
Chalmers University of Technology

Drug molecules and biofuels can be made to order by living cell factories, where biological enzymes do the job.

   
Released: 31-Aug-2022 1:25 PM EDT
Department of Energy Announces $5 Million for Research to Develop New Models for Bio-Preparedness
Department of Energy, Office of Science

The U.S. Department of Energy (DOE) announced $5 million in funding for research to advance the development of tools that effectively use real-world data—disparate data that is often difficult to readily integrate—into new models (e.g., epidemiology or therapeutic development) in support of bio-preparedness and response studies.

Newswise: Bar-Ilan University researchers produce nanodiamonds capable of delivering medicinal and cosmetic remedies through the skin
Released: 30-Aug-2022 11:25 AM EDT
Bar-Ilan University researchers produce nanodiamonds capable of delivering medicinal and cosmetic remedies through the skin
Bar-Ilan University

Combining techniques in nanotechnology and optics, researchers produced tiny (nanometric) diamond particles so small that they are capable of penetrating skin to deliver medicinal and cosmetic remedies. In addition, they created a safe, laser-based optical method that quantifies nanodiamond penetration into the various layers of the skin and determines their location and concentration within body tissue in a non-invasive manner – eliminating the need for a biopsy.

   
Newswise: White, red, and blue signals alert you to dangerous germs!
Released: 29-Aug-2022 1:30 PM EDT
White, red, and blue signals alert you to dangerous germs!
Osaka Metropolitan University

Osaka Metropolitan University scientists have developed a simple, rapid method to simultaneously identify multiple food poisoning bacteria, based on color differences in the scattered light by nanometer-scaled organic metal nanohybrid structures (NHs) that bind via antibodies to those bacteria.

   
Released: 29-Aug-2022 12:00 PM EDT
Genetic contribution to microglial activation in schizophrenia
Preprints

Jari Koistinaho, Marja Koskuvi, Elina Pörsti, Ying Chieh Wu, Kalevi Trontti, Amanda McQuade, Ilkka Ojansuu, Tyrone Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta,

Released: 29-Aug-2022 12:00 PM EDT
Cancer stem-like cells of nasopharyngeal carcinoma express CXCR4 and display highly invasive activity
Preprints

Zhenwei Zhu, Jingyu Li, Jingxian Liu, Yuan He, Yan Xue, Xiangchan Hong, Zeying Jiang, Dangu Luo, Pei Guo, Kaitai Yao, Lin Chen

Released: 29-Aug-2022 12:00 PM EDT
Risk factors of primary poor graft function after allogeneic hematopoietic stem cell transplantation in patients with myeloid tumors
Preprints

Lin-Yi Zhang, Yi-Ying Xiong, Ming-Yan Liao, Xiao Qing, Xiao-Qiong Tang, Luo Xiao-Hua, Hong-Bin Zhang, Wang Li, Liu Lin

Released: 29-Aug-2022 12:00 PM EDT
BAIAP2L2 is activated by NFκB1 and promotes the malignancy of hepatocellular carcinoma by suppressing the ubiquitin-mediated degradation of GABPB1 to activate TRET transcription
Preprints

Wenbo Jia, Liang Yu, Bin Xu, Yanzhi Feng, Jinyi Wang, Jian Chu, Deming Zhu, Chao Xu, Yongping Zhou, Lianbao Kong, Wenzhou Ding

Released: 29-Aug-2022 12:00 PM EDT
ALK signaling drives tumorigenicity and chemoresistance of pancreatic ductal adenocarcinoma cells
Preprints

Beatriz Parejo-Alonso, Alba Royo-Garcia, Pilar Espiau-Romera, Sarah Courtois, Alvaro Curiel-Garcia, Sladjana Zagorac, Isabel Villaoslada, Kenneth P. Olive, Christopher Heeschen, Patricia Sancho

Released: 29-Aug-2022 12:00 PM EDT
hBMSC-derived Exosomes Mitigate Th17/Treg Homeostasis in Periodontitis via miR-1246
Preprints

Yuxing Xia, Tianfan Cheng, Min Zhou, Feiwu Kang, Chongshan Liao

Released: 29-Aug-2022 12:00 PM EDT
Gli2 and Gli3 Regulate Horizontal Basal Cell-Mediated Regeneration of the Olfactory Epithelium
Preprints

Anna Shirazyan, Haeyoung Park, Ariell M Joiner, Justine Ra, Melissa S Kim, Archana Kumari, Nicole E Franks, Tien Peng, Robert M Bradley, Charlotte M Mistretta, Andrzej A Dlugosz, Benjamin L Allen

Released: 27-Aug-2022 12:00 PM EDT
SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammation
Preprints

Michael D Moore, Errin Johnson, Chloe Jacklin, Stephen Johnson, Owen Green, William S James

Released: 26-Aug-2022 12:00 PM EDT
SEC-seq: Association of molecular signatures with antibody secretion in thousands of single human plasma cells
Preprints

Rene Yu-Hong Cheng, Joseph de Rutte, Andee R Ott, Lucienne Bosler, Wei-Ying Kuo, Jesse Liang, Brian E Hall, David J Rawlings, Dino Di Carlo, Richard G James

Released: 26-Aug-2022 12:00 PM EDT
Pancreatic transplant surgery and stem cell therapy: Finding the balance between therapeutic advances and ethical principles
World Journal of Stem Cells

The latest achievements in the field of pancreas transplantation and stem cell therapy require an effort by the scientific community to clarify the ethical implications of pioneering treatments, often characterized by high complexity from a sur



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