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2-Dec-2018 12:30 PM EST
Dana-Farber Researchers Report Clinical Trial Results in Treatment of Leukemia and Lymphoma
Dana-Farber Cancer Institute

New results from clinical trials of immunotherapy and experimental targeted agents for patients with leukemia and lymphoma are being presented by Dana-Farber Cancer Institute researchers at the ASH Annual Meeting.

Released: 2-Dec-2018 12:05 PM EST
New Two-year Data Show 39 Percent of Non-Hodgkin Lymphoma Patients Treated with CAR T-cell Therapy Remain in Remission
Moffitt Cancer Center

A new article published today in The Lancet Oncology shows 39 percent of large B cell lymphoma patients treated with the chimeric antigen receptor T-cell therapy (CAR T) Yescarta® (axicabtagene ciloleucel) remained in remission more than two years (27.1 months median follow up) following therapy, and more than half of the patients treated remain alive. The new long-term safety and activity results of the ZUMA-1 clinical trial were also presented Sunday, Dec. 2 at the American Society of Hematology Annual Meeting in San Diego.

1-Dec-2018 12:05 PM EST
More than half of patients alive two years after receiving CAR-T therapy for diffuse large B-cell lymphoma in ZUMA-1 trial
University of Texas MD Anderson Cancer Center

A follow-up analysis of patients enrolled in a Phase I/II multi-center trial for diffuse large B-cell lymphoma (DLBCL) reported 51 percent of patients receiving an anti-CD19 chimeric antigen receptor (CAR T) called axi-cel were still alive two years post-treatment. The study, co-led by Sattva Neelapu, M.D., professor of Lymphoma & Myeloma at The University of Texas MD Anderson Cancer Center, reported its findings in the Dec. 2 online issue of The Lancet Oncology and during a presentation at the 60th American Society of Hematology Annual Meeting & Exposition in San Diego.

27-Nov-2018 2:45 PM EST
Studies Suggest that Immunotherapy Adds Punch to Earlier Attempts to Treat Recurrent Non-Hodgkin and Hodgkin Lymphoma
NYU Langone Health

New drugs that harness the body’s immune system to destroy cancer cells appear to increase the effectiveness of later drug therapies for non-Hodgkin and Hodgkin lymphoma patients, new research suggests. This happens, scientists say, even for repeat drug therapies whose initial attempts failed to stop or reverse the disease.

Released: 1-Dec-2018 3:00 PM EST
New Study Highlights CAR T-cell Therapy Success for Lymphoma When Used as Standard of Care
Moffitt Cancer Center

Moffitt Cancer Center partnered with 16 academic cancer centers to analyze real world data of 274 patients treated commercially with Yescarta® (axicabtagene ciloleucel), one of two CAR T products that is now standard of care for patients with diffuse large B cell lymphoma (DLBCL) who have not responded to two or more therapies. The researchers then compared those figures with results from the pivotal ZUMA-1 trial, which included 101 patients.

28-Nov-2018 9:00 AM EST
Calcium Signaling May Play Role in Addressing Drug Resistance to Non-Hodgkin Lymphoma Treatment
Rutgers Cancer Institute

Systems biology analyses by Rutgers Cancer Institute of New Jersey researchers examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma suggest calcium signaling may have an influence in addressing this treatment obstacle.

30-Nov-2018 4:00 PM EST
CAR-T cell update: therapy improves outcomes for patients with B-cell lymphoma
University of Chicago Medical Center

An international phase-2 trial of a CAR-T cell therapy—to be published on-line Dec. 1 in the New England Journal of Medicine (and presented at the ASH annual meeting in San Diego)—found that 52% of patients responded favorably to the therapy; 40% had a complete response and 12% had a partial response. One year later, 65% of those patients were relapse-free, including 79% of complete responders. The median progression-free survival “has not been reached.”

29-Nov-2018 1:00 PM EST
Sickle Cell Anemia Treatment Safely Lowers Disease Burden in African Children
Cincinnati Children's Hospital Medical Center

A daily hydroxyurea pill may bring relief for children living with the painful and deadly blood disease sickle cell anemia (SCA) in resource-challenged sub-Saharan Africa, where the disease is prevalent and health care is suboptimal. This is what a multinational clinical trial called REACH discovered when it tested daily hydroxyurea treatment in 606 children between the ages of 1 and 10 years old. Study data are published in the New England Journal of Medicine.

Released: 30-Nov-2018 4:05 PM EST
Bloodstream Infection Rates as a Measure of Quality in Hemodialysis Facilities
Beth Israel Lahey Health

A new study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) investigated rates of bloodstream infection among patients with or without catheters in outpatient hemodialysis facilities in New England.

Released: 30-Nov-2018 2:05 PM EST
BIDMC Research & Health News Digest: November 2018
Beth Israel Lahey Health

A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

Released: 30-Nov-2018 2:05 PM EST
PhRMA Foundation Releases Highlights of its 2018 Funding Efforts
PhRMA Foundation

The PhRMA Foundation awarded more than $6 million over the last two years to more than 100 leaders in scientific research in the United States. The Foundation is proud to announce another successful year supporting innovative research efforts in areas of great importance: Alzheimer’s Disease, Melanoma, Parkinson’s Disease, Schizophrenia, Breast Cancer, Lung Cancer, Leukemia, Ulcerative Colitis, Vascular Disease, and Colorectal Cancer. This year the Foundation also funded two Centers of Excellence in Value Assessment.

Released: 30-Nov-2018 1:05 PM EST
Experts Present New Recommendations on 'Overlapping' Type of Leukemia
Wolters Kluwer Health: Lippincott

Chronic myelomonocytic leukemia (CMML) is a rare disease with overlapping features of two categories of bone marrow and blood cell disorders that poses challenges in clinical management. Joint recommendations on diagnosis and treatment of CMML from two European specialty societies were published today in HemaSphere, the official journal of the European Hematology Association (EHA). The journal is published in the Lippincott portfolio by Wolters Kluwer.

Released: 29-Nov-2018 10:05 AM EST
Brooklyn Native and Orthopedic Spine Surgeon Gives Back to His Community
NYU Langone Hospital - Brooklyn

Kola Jegede, MD, a Brooklyn native, has joined NYU Langone Hospital–Brooklyn with the hope of giving back to his home borough as an orthopedic spine surgeon who can relieve pain and improve his patients’ quality of life.

Released: 29-Nov-2018 9:00 AM EST
Venetoclax Combination Approved for Elderly AML
Dana-Farber Cancer Institute

A new option – a combination of a standard drug and the novel agent venetoclax – has been granted accelerated approval by the Food and Drug Administration for certain AML patients after a large, multicenter phase 1 clinical trial showed the combination had “promising efficacy” and was well tolerated in older AML patients.

Released: 28-Nov-2018 3:00 PM EST
FDA Approves New Targeted Drug for Leukemia Tested at University of Pennsylvania
Perelman School of Medicine at the University of Pennsylvania

The U.S. Food and Drug Administration (FDA) has approved the first ever inhibitor drug specifically approved for treating patients with relapsed or refractory acute myeloid leukemia (AML) with a mutation in the Fms-like tyrosine kinase 3 (FLT3) gene.

Released: 28-Nov-2018 10:05 AM EST
New Study Finds Racial Disparities in Oral Anticoagulant Use
Health Sciences at the University of Pittsburgh

Black patients with atrial fibrillation are significantly less likely to receive oral anticoagulants--particularly newer, more effective versions-- than white and Hispanic patients.

Released: 28-Nov-2018 10:05 AM EST
Umbilical Cord Blood Cells Studied for Preserving Brain Function in Infants with Congenital Diaphragm Disease
University of Texas Health Science Center at Houston

A new clinical trial at The University of Texas Health Science Center at Houston (UTHealth) is the first in the world to investigate whether infusing an infant’s own umbilical cord blood cells, or autologous cells, can protect the brain, mitigating the risk of neurodevelopmental challenges in babies with severe congenital diaphragmatic hernia (CDH).

Released: 27-Nov-2018 9:00 AM EST
Study Affirms Challenges in Managing Severe Pain of Sickle Cell Disease
Johns Hopkins Medicine

In a study tracking the severe crisis pain of sickle cell disease and its management in 73 adults over a period of a year, Johns Hopkins researchers found that even among those on high doses of daily at-home opioids, a persistent subset was more likely to seek emergency hospital care for crisis pain and was less likely to have the pain controlled by intensive treatment.

Released: 26-Nov-2018 3:05 PM EST
Fred Hutch at ASH: Press briefing on a combination CAR T-cell therapy, other CAR T insights, CRISPR for blood disorders, and more
Fred Hutchinson Cancer Center

Fred Hutchinson Cancer Research Center’s latest findings on cancer immunotherapies, CRISPR for blood disorders, stem cell transplantation and insights on the immune system and cancer will be featured at the 60th annual meeting of the American Society of Hematology, which will be held Dec. 1–4 in San Diego.

Released: 26-Nov-2018 1:05 PM EST
Brain Responses to Language in Toddlers with Autism Linked to Altered Gene Expression
UC San Diego Health

An international team of scientists, led by researchers at the University of Cyprus and University of California San Diego School of Medicine, have identified a previously unknown, large-scale association between molecular gene expression activity in blood leukocyte cells and altered neural responses to speech in toddlers with autism as measured with functional magnetic resonance imaging.

Released: 26-Nov-2018 10:05 AM EST
Screening Tools Can Miss Sepsis in Pregnancy; Study Urges Action
Michigan Medicine - University of Michigan

New research reveals a need for better tools for catching severe infections in pregnant women and simple early interventions clinicians can take now to save lives.

Released: 26-Nov-2018 9:00 AM EST
CAR T Studies Highlight Abramson Cancer Center Research at ASH Annual Meeting
Perelman School of Medicine at the University of Pennsylvania

Penn researchers will present findings at the 60th American Society of Hematology Annual Meeting and Exposition in San Diego, including studies that evaluate CAR T combinations, how the timing of CAR T therapy may impact its effectiveness, and which patients who currently aren’t eligible for CAR T therapy should have greater access.

Released: 26-Nov-2018 7:00 AM EST
Fear A Major Factor in Reduced Quality Life for Young Adults with Type 1 Diabetes
Association of Diabetes Care & Education Specialists (ADCES)

Talking with young adults who have Type 1 diabetes about their fears could greatly impact overall quality of life.

15-Nov-2018 10:05 AM EST
Breast Cancers Enhance Their Growth by Recruiting Cells From Bone Marrow
The Rockefeller University Press

Researchers in Israel have discovered that breast tumors can boost their growth by recruiting stromal cells originally formed in the bone marrow. The study, which will be published November 23 in the Journal of Experimental Medicine, reveals that the recruitment of bone marrow–derived fibroblasts lowers the odds of surviving breast cancer, but suggests that targeting these cells could be an effective way of treating the disease.

16-Nov-2018 10:05 AM EST
New Blood Pressure Guideline Could Prevent 3 Million Cardiovascular Events Over 10 Years
University of Utah Health

In 2017, the American College of Cardiology and the American Heart Association released new blood pressure guidelines, lowering hypertension threshold to 130/80 mm Hg from the previous 140/90 mm Hg. A new study predicts that achieving and maintaining the 2017 guideline blood pressure goals could prevent more than 3 million cardiovascular disease events over ten years.

13-Nov-2018 1:00 PM EST
Rapid Response Inpatient Education Boosts Use of Needed Blood-Thinning Drugs
Johns Hopkins Medicine

A new study designed to reach hospitalized patients at risk shows that a “real-time” educational conversation, video or leaflet can lower the missed dose rates of drugs that can prevent potentially lethal blood clots in their veins.

13-Nov-2018 12:05 PM EST
Anti-Malaria Drugs Have Shown Promise in Treating Cancer, and Now Researchers Know Why
Perelman School of Medicine at the University of Pennsylvania

Anti-malaria drugs known as chloroquines have been repurposed to treat cancer for decades, but until now no one knew exactly what the chloroquines were targeting when they attack a tumor. Now, researchers from the Abramson Cancer Center of the University of Pennsylvania say they have identified that target – an enzyme called PPT1.

Released: 15-Nov-2018 7:00 AM EST
Can’t Exercise? A Hot Bath May Help Improve Inflammation, Metabolism, Study Suggests
American Physiological Society (APS)

Hot water treatment may help improve inflammation and blood sugar (glucose) levels in people who are unable to exercise, according to a new study. The findings are published ahead of print in the Journal of Applied Physiology.

Released: 15-Nov-2018 6:00 AM EST
Treating the "bubble babies"
Universite de Montreal

A new study shows that the genotype of a child with severe combined immune deficiency (SCID) affects his survival rate after stem cell transplantation from an unrelated donor.

Released: 15-Nov-2018 5:00 AM EST
National study testing drug to treat graft-versus-host disease after stem cell transplants
University of Nebraska Medical Center (UNMC)

University of Nebraska Medical Center leading national team to determine if ruxolitinib is effective for treating a certain type of graft versus host disease (GVHD) called sclerotic. The grant is funded by Incyte, a global biopharmaceutical company.

Released: 14-Nov-2018 3:30 PM EST
St. Jude Announces Extensive Resource to Advance Leukemia Research
St. Jude Children's Research Hospital

The Public Resource of Patient-derived and Expanded Leukemias (PROPEL) offers patient-derived xenograft samples free of charge for researchers worldwide.

14-Nov-2018 2:00 PM EST
Streamlined method helps people with diabetes act on CGM data
Endocrine Society

Endocrine Society experts have expanded their efforts to develop streamlined methods for continuous glucose monitor (CGM) users to better manage their blood sugar levels.

14-Nov-2018 11:00 AM EST
A New Approach to Detecting Cancer Earlier From Blood Tests: Study
University Health Network (UHN)

Cancer scientists led by principal investigator Dr. Daniel De Carvalho at Princess Margaret Cancer Centre have combined “liquid biopsy”, epigenetic alterations and machine learning to develop a blood test to detect and classify cancer at its earliest stages.

Released: 14-Nov-2018 10:05 AM EST
Investigational Drug Shows Promising Results in Phase II Study of Aggressive, Often Fatal Blood Disorder with No Approved Therapies
University of Texas MD Anderson Cancer Center

A Phase I/II study, led by investigators at The University of Texas MD Anderson Cancer Center, reports an investigational drug called tagraxofusp has demonstrated high response rates in patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare but highly aggressive – and often fatal bone marrow and blood disorder – for which there are no existing approved therapies.

Released: 13-Nov-2018 10:05 AM EST
Immunotherapy combination and chemotherapy show encouraging results in Phase II acute myeloid leukemia study
University of Texas MD Anderson Cancer Center

A triple therapy combining two immune checkpoint inhibitors (ICPIs) with the standard-of-care chemotherapy, a hypomethylating agent called azacitidine, has shown promising results for treatment of relapsed or refractory acute myeloid leukemia (AML), according to findings from a Phase II study at The University of Texas MD Anderson Cancer Center.

Released: 13-Nov-2018 7:05 AM EST
Fat fundamentals: Scientists uncover crucial biological circuits that regulate lipids and their role in overall health
McMaster University

Tiny microscopic worms, invisible to the naked eye, are helping scientists to better understand an extraordinarily complex biological pathway that connects fat to overall health and aging in humans.

6-Nov-2018 6:00 PM EST
Hepatitis C Treatment Can Be Shortened in 50 Percent of Patients, Study Finds
Loyola Medicine

Hepatitis C drugs cure more than 90 percent of patients, but can cost more than $50,000 per patient. Findings from a new study could lead to big cost savings. In 50 percent of patients, the standard 12-week treatment regimen could be shortened to as little as six weeks without compromising efficacy.

7-Nov-2018 9:00 AM EST
Combination chemotherapy and immunotherapy effective in Phase II leukemia study
University of Texas MD Anderson Cancer Center

A combination of the standard-of-care chemotherapy drug known as azacitidine, with nivolumab, an immune checkpoint inhibitor, demonstrated an encouraging response rate and overall survival in patients with relapsed or refractory acute myeloid leukemia (AML) according to findings from a Phase II study at The University of Texas MD Anderson Cancer Center.

7-Nov-2018 9:00 AM EST
Call for Nominations: The Endocrine Society’s Award for Excellence in Science and Medical Journalism
Endocrine Society

The Endocrine Society is calling for nominations for the 12th annual Award for Excellence in Science and Medical Journalism. The award recognizes outstanding reporting that enhances public understanding of health issues pertaining to the field of endocrinology.

   
Released: 6-Nov-2018 11:00 AM EST
High Blood Pressure Poses Risk of Heart/Stroke Events for People Under Age 40
Duke Health

People younger than age 40 who have high blood pressure are at increased risk of heart failure, strokes and blood vessel blockages as they age, according to a study in JAMA led by Duke Health.

Released: 6-Nov-2018 10:05 AM EST
New Checkpoint Inhibitor Shows Promise in Clinical Trial for Non-Hodgkin’s Lymphoma
University of Chicago Medical Center

By combining the experimental anti-cancer antibody known as 5F9 with the anti-cancer antibody rituximab, researchers managing a phase 1b clinical trial were able to induce a positive response in 11 out of 22 people with relapsed/refractory non-Hodgkin’s lymphoma. Eight of the 22 patients went into complete remission from their cancers.

Released: 5-Nov-2018 5:05 PM EST
Yale Cancer Center investigators show recommended, but underused treatment for rare blood cancer saves lives
Yale Cancer Center/Smilow Cancer Hospital

U.S. and European guidelines on treating Polycythemia Vera (PV), a potentially deadly blood cancer, call for two treatments for patients with high-risk disease: therapeutic phlebotomy and cytoreductive therapy with a drug called hydroxyurea (HU). HU is the most commonly used option, but evidence for HU treatment is limited and both treatments are underused. Now, researchers at Yale Cancer Center have documented reduced risk of death and incidence of blood clots in patients receiving those therapies.

Released: 5-Nov-2018 11:00 AM EST
Mount Sinai Is First to Use FDA-Approved Drug-Eluting Stent That Treats Peripheral Artery Disease
Mount Sinai Health System

Vascular specialists at the Icahn School of Medicine at Mount Sinai are the first in the United States to use the Eluvia™, a drug-eluting vascular stent system for clinical treatment of peripheral artery disease (PAD), a circulatory condition that causes a narrowing of the blood vessels and a reduction of blood flow to the limbs.

Released: 1-Nov-2018 11:05 AM EDT
BIDMC Research & Health News Digest: October 2018
Beth Israel Lahey Health

A monthly roundup of research briefs showcasing recent scientific advances led by Beth Israel Deaconess Medical Center faculty.

Released: 31-Oct-2018 9:05 PM EDT
NUS study: RNA defects linked to multiple myeloma progression in high risk patients
National University of Singapore (NUS)

Researchers from the Cancer Institute of Singapore (CSI Singapore) at the National University of Singapore have uncovered an association between RNA abnormalities and MM progression.

30-Oct-2018 6:05 PM EDT
Relapsed leukemia flies under immune system’s radar
Washington University in St. Louis

A study from Washington University School of Medicine in St. Louis offers a potential explanation for why many AML patients experience a relapse after a stem cell transplant, and suggests a therapeutic approach that may help to place relapsed patients back into remission.

Released: 31-Oct-2018 9:15 AM EDT
Journal of Lipid Research names new editors-in-chief
American Society for Biochemistry and Molecular Biology (ASBMB)

The American Society for Biochemistry and Molecular Biology announced today that Kerry-Anne Rye of the University of New South Wales Sydney and Nicholas O. Davidson of Washington University in St. Louis will be the next editors-in-chief of the Journal of Lipid Research.

     
Released: 30-Oct-2018 9:00 AM EDT
Your blood pressure and heart rate change to meet physical and social demands throughout the day
Binghamton University, State University of New York

Blood pressure and heart rate are not fixed, but rather they adapt to meet physical and social demands placed on the body, according to new research from Binghamton University, State University at New York.

   
26-Oct-2018 1:05 PM EDT
Mass Shootings May Trigger Unnecessary Blood Donations
Vanderbilt University Medical Center

Mass shootings often trigger a sharp increase in blood donations for affected communities but more than 15 percent of the product intended to save lives could be discarded, according to a study released today in The Journal of Trauma and Acute Care Surgery.

25-Oct-2018 12:30 PM EDT
Following Las Vegas Mass Shooting, High Blood Transfusion Needs Were Met by Existing Supply at Local Hospitals and Blood Suppliers
Northwestern Medicine

A new Northwestern Medicine study published in the Journal of Trauma and Acute Care Surgery analyzed the blood resource needs and blood donations in Las Vegas compared to other mass shooting incidents offering insight into medical needs following a mass shooting incident, which may help guide preparedness for future events.



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