A fatty membrane in the belly called the omentum appears to play an important role in regulating the immune system. The finding could lead to new drugs for organ transplant patients and patients with auto-immune diseases.
New research proposes novel therapeutic targets for treating Huntington’s disease. A new study found the toxic effects of the huntingtin protein on cells may not be driven exclusively by the length of the protein’s expansion, but also by which other proteins are present in the cell.
UT Southwestern Medical Center researchers have taken a major step toward understanding the cellular clock, mapping for the first time the atomic-level architecture of a key component of the timekeeper that governs the body’s daily rhythms.
Mayo Clinic researchers have identified an immune system deficiency whose presence shows someone is up to four times likelier to die than a person without it. The glitch involves an antibody molecule called a free light chain; people whose immune systems produce too much of the molecule are far more likely to die of a life-threatening illness such as cancer, diabetes and cardiac and respiratory disease than those whose bodies make normal levels. The study is published in the June issue of Mayo Clinic Proceedings.
Developmental biologists are investigating craniofacial development in a frog model to better understand genetic control of cell migration. The work is expected to advance knowledge of how cancer cells migrate away from primary tumors to cause metastatic disease in new sites, among other processes.
Researchers from UCLA’s Jonsson Comprehensive Cancer Center have shown for the first time that the mechanical force produced by cell-cell interactions is critical for programming by the Notch signaling system.
Researchers at Dana-Farber/Children’s Hospital Cancer Center have devised a strategy to directly activate a natural “death” protein, triggering the self-destruction of cells--which could lead to new possibilities for designing cancer drugs.
An immune-system receptor plays an unexpected but crucially important role in keeping stem cells from differentiating and in helping blood cancer cells grow, researchers at UT Southwestern Medical Center report today in the journal Nature.
Johns Hopkins scientists have engineered cells that behave like AND and OR Boolean logic gates, producing an output based on one or more unique inputs. This feat, published in the May issue of Nature Chemical Biology, could eventually help researchers create computers that use cells as tiny circuits.
A new method for rapidly solving the three-dimensional structures of a special group of proteins, known as integral membrane proteins, may speed drug discovery by providing scientists with precise targets for new therapies, according to a paper published May 20 in Nature Methods.
A protein produced by the central nervous system’s support cells seems to play two opposing roles in protecting nerve cells from damage, an animal study by Johns Hopkins researchers suggests: Decreasing its activity seems to trigger support cells to gear up their protective powers, but increasing its activity appears to be key to actually use those powers to defend cells from harm.
Cardiomyocytes, the workhorse cells that make up the beating heart, can now be made cheaply and abundantly in the laboratory.
Scientists believe they've pinpointed the last crucial piece of the 80-year-old puzzle of how plants "know" when to flower.
E3 ligase’s role makes it target for defeating Herceptin resistance, stifling cancer’s preferred diet.
Researchers at NYU School of Medicine have, for the first time, identified a single gene that simultaneously controls inflammation, accelerated aging and cancer.
A team of scientists at McMaster University has discovered a drug, thioridazine, successfully kills cancer stem cells in the human while avoiding the toxic side-effects of conventional cancer treatments. To test more than a dozen different compounds, McMaster researchers pioneered a fully automated robotic system to identify several drugs, including thioridazine.
Blocking a protein in the heart that is produced under stressful conditions could be a strategy to prevent cardiac damage that results from chemotherapy, a new study suggests.
Johns Hopkins scientists have discovered a protein that appears to play an important regulatory role in deciding whether stem cells differentiate into the cells that make up the brain, as well as countless other tissues. This finding, published in the April Developmental Cell, could eventually shed light on developmental disorders as well as a variety of conditions that involve the generation of new neurons into adulthood, including depression, stroke, and posttraumatic stress disorder.
Scientists at Children’s Hospital Oakland Research Institute (CHORI) led by Vladimir Serikov, MD, PhD, and Frans Kuypers, PhD, report in the current Epub issue of Stem Cells Translational Medicine that placental stem cells with important therapeutic properties can be harvested in large quantities from the fetal side of human term placentas (called the chorion). The chorion is a part of the afterbirth and is normally discarded after delivery, but it contains stem cells of fetal origin that appear to be pluripotent -- i.e., they can differentiate into different types of human cells, such as lung, liver, or brain cells. Since these functional placental stem cells can be isolated from either fresh or frozen term human placentas, this implies that if each individual’s placenta is stored at birth instead of thrown away, these cells can be harvested in the future if therapeutic need arises. This potential represents a major breakthrough in the stem cell field.
Extended daily fasting overrides harmful effects of a high-fat diet.
Researchers at NYU School of Medicine have identified a target for slowing the progression of multiple myeloma by using currently available drugs.
Researchers from Iowa State University and the Salk Institute for Biological Studies have found three proteins involved in the accumulation of fatty acids in plants. The finding could help plant scientists boost production of biorenewable products.
Salk and Iowa State researchers identify three proteins involved in plant fatty acids, the key components of seed oils.
Scientists at Weill Cornell Medical College have discovered that the single protein -- alpha 2 delta -- exerts a spigot-like function, controlling the volume of neurotransmitters and other chemicals that flow between the synapses of brain neurons. The study, published online in Nature, shows how brain cells talk to each other through these signals, relaying thoughts, feelings and action, and this powerful molecule plays a crucial role in regulating effective communication.
The human body does a great job of generating new cells to replace dead ones but it is not perfect. Cells need to communicate with or signal to each other to decide when to generate new cells. Communication or signaling errors in cells lead to uncontrolled cell growth and are the basis of many cancers. At The University of Texas Health Science Center at Houston (UTHealth) Medical School, scientists have made a key discovery in cell signaling that is relevant to the fight against melanoma skin cancer and certain other fast-spreading tumors.
Techniques used by researchers from the Department of Energy’s Oak Ridge National Laboratory to analyze a simple marine worm and its resident bacteria could accelerate efforts to understand more complex microbial communities such as those found in humans.
For the first time, scientists at Fred Hutchinson Cancer Research Center have transplanted brain cancer patients’ own gene-modified blood stem cells in order to protect their bone marrow against the toxic side effects of chemotherapy. Initial results of the ongoing, small clinical trial of three patients with glioblastoma showed that two patients survived longer than predicted if they had not been given the transplants, and a third patient remains alive with no disease progression almost three years after treatment.
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, report that significant numbers of myofibroblasts – cells that produce the fibrous scarring in chronic liver injury – revert to an inactive phenotype as the liver heals. The discovery in mouse models could ultimately help lead to new human therapies for reversing fibrosis in the liver, and in other organs like the lungs and kidneys.
New research may help explain what’s going on in the lungs of people with treatment-resistant asthma -- and aid the development of new treatment options and better ways to identify people at risk.
Scientists at the Research Institute of Molecular Pathology in Vienna discover and elucidate the function of conserved cell division proteins in yeast.
In an effort to identify the underlying causes of neurological disorders that impair motor functions such as walking and breathing, UCLA researchers have developed a novel system to measure the communication between stem cell-derived motor neurons and muscle cells in a Petri dish.
Cells resist hormone inhibition and chemotherapy; video captures production of other cell types.
New discovery of a genetic mutation in congenital asplenia may lead to genetic prenatal screening in patients with the rare, but deadly, disorder.
Embryonic stem cells are primed to kill themselves if damage to their DNA makes them a threat to the developing embryo. University of North Carolina at Chapel Hill researchers reveal how they do it.
Mayo Clinic dermatologists struck by the beauty they see in the cellular have started a competition to celebrate art in medicine. The winning entries appear in the May issue of the Journal of Cutaneous Pathology.
Johns Hopkins researchers have discovered that a protein that transports sodium, potassium and chloride may hold clues to how glioblastoma, the most common and deadliest type of brain cancer, moves and invades nearby healthy brain tissue.
Scientists now have a better understanding of how precise memories are formed thanks to research led by Prof. Jean-Claude Lacaille of the University of Montreal’s Department of Physiology. “In terms of human applications, these findings could help us to better understand memory impairments in neurodegenerative disorders like Alzheimer's disease,” Lacaille said. The study looks at the cells in our brains, or neurons, and how they work together as a group to form memories.
Scientists at Joslin Diabetes Center have identified a key mechanism of action for the TOR (target of rapamycin) protein kinase, a critical regulator of cell growth which plays a major role in illness and aging. This finding not only illuminates the physiology of aging but could lead to new treatments to increase lifespan and control age-related conditions, such as cancer, type 2 diabetes, and neurodegeneration.
A team of Stowers scientists defines biochemical crosstalk between DNA interacting proteins and their modifications.
Stowers scientists use fruit flies to reveal unknown function of a transcriptional regulator of development and cancer
Research led by St. Jude Children’s Research Hospital investigators suggests that safeguarding cell survival and maintaining a balanced immune system is just the start of the myeloid cell leukemia sequence 1 (MCL1) protein’s work.
The cells that line the pipes leading to the heart pull more tightly together in areas of fast-flowing blood. The discovery could help to reduce vascular leakage and better treat heart disease.
In a study published in Science, researchers at Case Western Reserve University School of Medicine have now discovered that, the gas nitric oxide (NO), produced in all cells of the human body for natural purposes, plays a fundamental regulatory role in controlling bacterial function, via a signaling mechanism called S-nitrosylation (SNO), which binds NO to protein molecules.
A "self-repair" mechanism has been found by which developing organisms recognize and correct facial defects. A tadpole model showed organisms aren't genetically hard-wired with cell movements that result in normal facial features. Cell groups instead measure shape and position and move and remodel to fix abnormalities.
Johns Hopkins and Yale scientists have found that melanoma cells use a cloaking protein to hide from immune cells poised to attack the cancer. Nearly 40 percent of their sampling of melanoma tissues contained the B7-H1 protein, also called PD-L1, and scientists say it could be used as a target for new therapies.
In a study in PLoS Computational Biology, two Santa Fe Institute researchers trace the development of life-sustaining chemistry to the earliest forms of life on Earth.
Researchers have identified molecular probes capable of selectively attaching to fibronectin fibers under different strain states, enabling the detection and examination of fibronectin strain events that have been linked to pathological conditions including cancer and fibrosis.
Researchers have advanced the ability to view a clear picture of a single cellular structure in motion. By identifying molecules using compressed sensing, this new method provides needed spatial resolution plus a faster temporal resolution.
Researchers at Columbia University Medical Center have identified a molecular pathway that controls the retention and release of the brain’s stem cells. The discovery offers new insights into normal and abnormal neurologic development and could eventually lead to regenerative therapies for neurologic disease and injury. The findings, from a collaborative effort of the laboratories of Drs. Anna Lasorella and Antonio Iavarone, were published today in the online edition of Nature Cell Biology.
Researchers have demonstrated that two related enzymes — phosphoinositide-3 kinase (PI3K) gamma and delta — play a key role in the development of T-cell acute lymphoblastic leukemia (T-ALL), a highly aggressive childhood leukemia that is difficult to treat. The study also showed that a dual PI3K gamma/delta inhibitor can significantly prolong survival in a mouse model of the disease.
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