In this issue of Cell Stem Cell, Tran and colleagues develop a platform for differentiating thousands of miniature kidney organoids consisting of one or two nephron-like structures each. They use this platform to identify a potent new inhibitor of cy
Cell competition is a fitness quality control that eliminates cells that are less fit than their neighbors. Nichols, Lima, and Rodríguez review the importance of cell competition in the early mammalian embryo for the elimination of abnormal cells, f
Niec et al. integrate spatial and single-cell transcriptomics data and develop computational approaches to finely map the cellular and transcriptional landscape of the intestinal crypt-villus axis. Combining these results with functional experiments
Duffy antigen receptor for chemokines (DARC)/CD234, also known as atypical chemokine receptor 1 (ACKR1), is a seven-transmembrane domain protein expressed on erythrocytes, vascular endothelium, and a subset of epithelial cells (Peiper et al., 1995).
In this issue of Cell Stem Cell, Xu et al. and Yu et al. use low-input epigenetic profiling techniques to map H3K9me3 deposition in early human development. They reveal stage-specific H3K9me3 deposition on retrotransposons, which may play crucial c
Wang and colleagues comprehensively compare the landscapes of H3K9me3 between human and mouse early embryos and reveal the roles of hominoid-specific retrotransposons in H3K9me3-dependent heterochromatin remodeling during early human development. The
Xu et al. profiled the genome-wide H3K9me3 distribution in human oocytes and early embryos. They found the function and mechanism of H3K9me3 modification on long terminal repeat (LTR) regulation and provide a detailed map of the sequential reprogram
One often thinks that the early embryo is fragile and needs support. However, at the earliest stages of development, it has the power to feed the future placenta and instructs the uterus so that it can nest. Using ‘blastoids’, in vitro embryo models formed with stem cells, the Lab of Nicolas Rivron at IMBA showed that the earliest molecular signals that induce placental development and prepare the uterus come from the embryo itself. The findings, now published in Cell Stem Cell, could contribute to a better understanding of human fertility.
UC San Diego researchers say they may have found the reason why multiple human clinical trials of staphylococcus vaccines have failed: the bacteria knows us too well.
The eye’s light-sensing retina taps different circuits depending on whether it is generating image-forming vision or carrying out a non-vision function such as regulating pupil size or sleep/wake cycles, according to a new mouse study from the National Eye Institute (NEI) and the National Institute of Mental Health (NIMH).
Researchers have solved a medical mystery in a poorly understood disease by uncovering which cells cause tumours in patients with tuberous sclerosis complex (TSC).
UC San Diego researchers found that in mice how much they ate and when altered the nature of their gut microbiome: too much food too frequently resulted in poorer microbial and metabolic health.
Could the SARS-CoV-2 vaccine reawaken previous antibody responses and point the way to a universal coronavirus vaccine? A new analysis of the antibody response to a COVID-19 vaccine suggests the immune system’s history with other coronaviruses, including those behind the common cold, shapes the patient’s response, according to a recently published study published in Cell Reports.
Mount Sinai-led researchers have shown that tiny, robust immune particles derived from the blood of a llama could provide strong protection against every COVID-19 variant, including Omicron, and 18 similar viruses.
Researchers at Ruhr-Universität Bochum have been studying the role of the two proteins tenascin C and tenascin R in multiple sclerosis. In this disease, cells of the immune system destroy the myelin sheaths, i.e. the sheaths of the nerve cells.
University of Sheffield research collaboration with Stanford University reveals why some healthy adults with the COVID-19 infection become seriously ill, whilst others have few symptoms
Researchers have uncovered a new function for alpha-synuclein, a well-known protein marker of Parkinson’s, with relevance toward treatment for the disease
A new tool can quickly and reliably identify the presence of Ebola virus in blood samples, according to a study by researchers at Washington University School of Medicine in St. Louis and colleagues at other institutions.
The interest of scientists in adult stem cells resides in their ability to self-renew indefinitely and differentiate into all cell types making up the organ where they reside.
Researchers from the Icahn School of Medicine at Mount Sinai have applied a novel stem cell model to map disease risk variants in human neurons, which could help provide insights into the biological mechanisms that underlie neuropsychiatric disorders such as autism and schizophrenia.
According to a new University of Kentucky College of Medicine study, asymptomatic COVID-19 infection during pregnancy could still have potential long-term consequences for a developing baby.
The study led by Ilhem Messoudi, Ph.D., chair of the Department of Microbiology, Immunology and Molecular Genetics, was published in Cell Reports May 25.
The research shows that COVID-19 infection in pregnant mothers who were asymptomatic or had mild symptoms still triggered immune responses causing inflammation in the placenta.
A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response.
Processes in the human body could turn groups of harmless immune cells into ruthless killers, capable of attacking other cells infected with viruses or parasites, and potentially tumour cells, a new study reveals.
New research from Ann & Robert H. Lurie Children’s Hospital of Chicago and collaborators from other institutions provides insights into some of the genetic characteristics resulting in the development of relapse in patients with Wilms tumor (nephroblastoma), the most common type of pediatric cancer of the kidney.
The cornea - the transparent protective outer layer of the eye critical to helping us see – produces a delicate and limited immune response to fight infections without damaging our vision, according to a ground-breaking new study from the Peter Doherty Institute for Infection and Immunity (Doherty Institute).
Researchers at Washington University School of Medicine in St. Louis have identified a previously unknown function for the fragile X protein, the loss of which is the leading inherited cause of intellectual disability. The researchers showed that the protein modulates how neurons in the brain’s memory center process information, a central part of learning and memory.
New research describes a “chaperone” protein that delivers zinc, a trace element essential for survival in all living things, to where it’s needed. The chaperone could be especially important when access to zinc is limited—for example in nutrient deficient diets and for growing crops on depleted soils.
New research from scientists at UC Davis Health provides clues for how friendly bacteria in the gut — probiotics — may help eradicate bacterial pathogens like Salmonella by being able to compete with them for needed resources.
… Given the important function of PTBP1 in directing lineage choice in diverse stem
cell systems and the overall relevance of mRNA splicing in hematopoiesis, we
hypothesized that PTBP1 might play a role as a regulator of posttranscriptional …
A study led by UC Davis Cancer Center identified a binding protein in cancer cell’s nucleus, known as CHD4, as a critical agent keeping Kaposi's sarcoma-associated herpesvirus (KSHV) dormant and undetected by the body’s immune system. CHD4 is linked to cancer cell growth in many types of cancers.
Researchers from the Girona Biomedical Research Institute (IDIBGI) and Pompeu Fabra University (UPF) in Barcelona, Spain, have identified the role of an amino acid in humans, mice and flies suffering depression.
In a new study published in the journal Cell Reports, Moffitt Cancer Center researchers show that cancer cells in an acidic environment undergo lipid synthesis and accumulation. The team identified the key signaling molecules responsible for these changes and discovered that these alterations are associated with poor outcomes and disease progression among breast cancer patients.
This Backstory describes the development of a research article published in Cell Stem Cell that was originally submitted to Community Review, a program wherein a manuscript is simultaneously considered at multiple Cell Press journals. The article, a
… stem cell … stem cell state, accompanied by altered niche requirements and a
mature chief cell/secretory phenotype. Following the constitutive expression of p57
in vivo, chief cells showed an impaired injury response. Thus, p57 is a gatekeeper …
… In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the
nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation
status of hepatocyte-like cells derived from human pluripotent stem cells. … In this …
… programs maintaining stem cell integrity have been identified, safety mechanisms
eliminating malignant HSPCs from the stem cell pool … HSPCs and antigen-specific
CD4 + T cells, causing stem cell proliferation, differentiation, and specific exhaustion …
… In this study, we demonstrated that TET2 deficiency impaired muscle stem cell
proliferation and differentiation, leading to notable changes in mouse body weight
and muscle morphology during development. We further assayed the genome-wide …
Using second-long electrical shocks, UC San Diego scientists discovered they could control the types of cells in a community of bacteria. Being able to direct the ratio of cells holds implications for settings spanning agriculture to health care, where antibiotic resistance is a significant threat.
A planetary scientist worked with engineers to measure the physical limits of a liquid for salty water under high pressure. Results suggest where robotic missions should look for life on the ice-covered oceans of Jupiter’s moon Europa and Saturn’s moon Titan.
Too many women are getting unnecessary mastectomies and other invasive procedures because of a knowledge gap about differences in cancer genes. A new study offers a path to closing the gap.
Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer’s disease. Research led by UC San Diego has consistently found high levels of PHGDH expression in brain tissue and blood samples of older adults with different stages of the disease.