People with Type 2 Diabetes Have More Lipid Droplets and Changes to Muscle Mitochondria, Independent of Obesity
American Physiological Society (APS)
Insulin is an essential hormone for humans and many other living creatures. Its best-known task is to regulate sugar metabolism. How it does this job is well understood.
Obesity and metabolic diseases, such as diabetes, are extremely common in the United States.
Recent evidence has emerged to suggest that age-related macular degeneration (AMD) is a clinical risk factor for increased risk for infection and mortality.
New research published in Developmental Medicine & Child Neurology has revealed a link between maternal diabetes during pregnancy and a range of neurodevelopmental conditions in children—including autism, attention-deficit/hyperactivity disorder (ADHD), developmental delay, intellectual disability, cerebral palsy, and epilepsy.
Drinking two or more cups of coffee a day was associated with twice the risk of death from cardiovascular disease among people with severe hypertension compared to non-coffee drinkers, in a study of more than 18,600 men and women in Japan.
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Algal blooms or cylindrospermopsin, exacerbated by climate change, shown to have a connection with several adverse health effects.
Diabetes is a leading cause of death in the United States. In 2020, Healthy Paso Del Norte reported that in El Paso, where nearly 82% of the population is Hispanic or Latino, 16.9% were diagnosed with diabetes. According to the U.S. Department of Health and Human Services Office of Minority Health, Hispanics were 1.3 times more likely than non-Hispanic whites to die from diabetes in 2018, and Hispanic adults are 70 percent more likely than non-Hispanic white adults to be diagnosed with diabetes.
For the first time in Thailand, a research team from Chula’s Faculty of Veterinary Science (CUVET) is the first to have successfully developed a method to culture dog pancreatic cells from stem cells and cell transplantation technology. They aim to test the method in the lab and sick animals suffering from diabetes.
Metformin, the most prescribed drug for treating diabetes mellitus, known as type 2 diabetes, requires the presence of the growth differentiation factor 15 (GDF15) —a protein whose expression increases in response to cellular stress— to present its antidiabetic effects.
Researchers have uncovered a protein produced by the immune system, suPAR, that causes atherosclerosis. Investigators say it's the first immune target to treat cardiovascular disease, which affects over 1 billion people worldwide. Researchers believe treatment could be developed within five years.
Wearable fitness devices offer new insights into the relationship between physical activity and type 2 diabetes, according to a new analysis of the National Institutes of Health’s All of Us Research Program data published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
A randomized controlled trial of more than 100 persons with type 2 diabetes found that a low-carbohydrate, high-fat, calorie unrestricted diet helped patients achieve better weight loss and glucose control over a 6-month intervention compared to a high-carb, low-fat diet. The changes were not sustained 3 months after the intervention, suggesting a need for long-term dietary changes to maintain meaningful health benefits. The findings are published in Annals of Internal Medicine.
New research suggests that former professional football players may face accelerated aging, despite past research showing they have life spans similar or longer than the general population In the new study, retired football players reported shorter health spans — defined as years free of disease – than men in the general population Two age-related diseases — arthritis and dementia — were found more commonly among former football players, compared with men of the same age in the general population Additionally, hypertension and diabetes were more common among younger former players, those ages 25 to 29, compared with same-age men from the general population. The results warrant further study to define the biochemical, cellular, and physiologic mechanisms behind premature aging in former football players
Researchers from the Liston lab, at the Babraham Institute, have recently published a preventative therapeutic for diabetes in mice.
While use of insulin pumps to manage type 1 diabetes has grown over 20 years, there has been no improvement in racial, ethnic, and socioeconomic disparities in their use.
“Horror story” should spark state response, but does not amputations jumped 84 percent in decade leading up to the pandemic, jumped even more since cases of diabetes-linked blindness, dialysis soar as well state refuses to fund evidence-based self-care programs proven to lower diabetes risks, which would save thousands of lives and billions of tax dollars
A largescale new study offers a new approach to treating in type 2 diabetes - that puts patients in charge of their own medication.
Teens with Type 1 diabetes (T1D) who took bromocriptine, a medication used to treat Parkinson’s disease and Type 2 diabetes, had lower blood pressure and less stiff arteries after one month of treatment compared to those who did not take the medicine, according to a small study published today in Hypertension, an American Heart Association journal.
Regenstrief Institute Research Scientist April Savoy, PhD, a human factors engineer and health services researcher, is developing and testing user-friendly health information tools and technology designed to enhance accessibility and value to older adults with both diabetes and Alzheimer’s disease, and their caregivers.
With low or no-carbohydrate diets rising in popularity in recent times, the humble potato is now regularly overlooked in favour of other vegetables.
Compared with team-based care alone, the addition of a computerized clinical decision support system (CDSS) significantly reduced cardiovascular risk factors in patients with diabetes.
Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reduced the risk for hospitalization for any cause in patients with chronic kidney disease (CKD) with and without type 2 diabetes.
Renalytix plc (NASDAQ: RNLX) (LSE: RENX) announces the publication of new real-world evidence (RWE) in Primary Care and Community Health demonstrating the Company’s KidneyIntelX bioprognostic™ test resulted in changed clinical decision making for patients in the early-stage of diabetic kidney disease (DKD) being cared for within the Mount Sinai Health System’s Population Health Ambulatory Pharmacy and Condition Management programs.
Children living with type 1 diabetes miss an average of nine more sessions of school a year compared to children without the condition, a new study led by Cardiff University has found.
As the Christmas season starts to ramp up, University of South Australia researchers are reminding people to prioritise a good night’s sleep as new research shows that a troubled sleep may be associated with risk factors for type 2 diabetes.
The Icahn School of Medicine at Mount Sinai announced today the appointment of two new Laureates as part of its Biomedical Laureates Program, bringing the total to five appointments for this year and furthering its institutional commitment to broadening faculty diversity and mentorship opportunities.
A study is the first to use a large range of instruments/ tools and include older adults from many ethnic groups to determine factors affecting their physical activity. Results showed that age, education, social network, pain and depression accounted for a statistically significant proportion of unique variance in physical activity in this diverse older population living independently. Those who reported lower physical activity tended to be older, have less years of education and reported lower social engagement, networking, resilience, mental health, self-health rating, and higher levels of depression, anxiety, pain, and body mass index compared to the moderate to high physical activity groups.
A roundup of the latest research discoveries and faculty news at Cedars-Sinai.
About one third of patients with diabetes mellitus (DM) develop diabetic retinopathy (DR), a leading cause of blindness in working-age individuals.
November is National Diabetes Awareness Month. Youth onset type 2 diabetes is rising worldwide, and a recent study by researchers at Johns Hopkins Children’s Center, published in the Journal of Pediatrics, documented a steep rise in new diagnoses of type 2 diabetes among children during the early part of the COVID-19 pandemic
The same complex genetics that contribute to a higher risk of type 2 diabetes may also increase the risk of developing diabetes during pregnancy among women of South Asian descent, a study published today in eLife shows.
A recent analysis of clinical trial data estimates that treatment with the combination of angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers (ACE inhibitors/ARBs) and sodium-glucose cotransporter-2 (SGLT2) inhibitors can substantially increase the lifetime survival free of kidney failure for patients with albuminuric chronic kidney disease without diabetes.
A collaborative team of scientists from the Terasaki Institute for Biomedical Innovation and the University of Nebraska Medical Center has developed a fibrous aerogel that promotes faster and more effective healing of diabetic wounds.
The principal investigator in the Center for Endocrinology, Diabetes and Metabolism at Children’s Hospital Los Angeles is being honored at WRISG—the Western Region Islet Study Group’s beta cell research meeting. Senta Georgia, PhD, first attended the Western Region Islet Study Group (WRISG) meeting as a graduate student in 2004.
More than 20 UT Southwestern Medical Center scientists are among the 2022 Highly Cited Researchers listed in the top 1% of researchers from across the globe
A new study by Cedars-Sinai investigators describes risk factors that could make it more likely for people who have chronic pancreatitis, an ongoing inflammation of the pancreas, to develop diabetes. The findings are published in Diabetes Care.
Results of pancreas transplantation continue to improve and up to 90% of recipients with diabetes enjoy freedom from both insulin therapy and the need for close glucose monitoring following the procedure, according to a new paper published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
In a new ‘Ideas and Opinions,’ authors from Johns Hopkins Bloomberg School of Public Health analyze California’s newly announced effort to manufacture insulin for its residents. The commentary is published in Annals of Internal Medicine.
Scientists have used a proteomics approach to identify a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes.
Diabetes is a chronic health condition that impacts how the body turns food into energy. More than 37 million people in the United States have Type 2 diabetes, the most common form of the metabolic disorder, according to the Centers for Disease Control and Prevention. An additional 96 million adults have prediabetes and most of them are unaware they are developing a serious chronic disease.
Researchers at UC Riverside are paving the way for diabetes and cancer patients to forget needles and injections, and instead take pills to manage their conditions.
For the first time, researchers have assembled a high-quality reference genome for the Nile rat, a promising model organism for diabetes research.
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In Alzheimer's disease, the degeneration of brain cells is linked to formation of toxic protein aggregates and deposits known as amyloid plaques.