Value in Health, the official journal of ISPOR—the professional society for health economics and outcomes research, announced today the publication of research demonstrating that discrete choice experiments are able to predict real-world healthcare choices.
Pathologists are increasingly optimistic about the potential of the human microbiome to help guide diagnosis and monitoring of chronic diseases.
New research led by the University of South Australia shows just how effective bowel cancer screening is in helping to reduce the number of bowel cancer deaths by up to 45 per cent.
Certain human gut microbes with links to health thrive when fed specific types of ingredients in dietary fibers, according to a new study from Washington University School of Medicine in St. Louis. The work — conducted in mice colonized with human gut bacteria and using new technologies for measuring nutrient processing — is a step toward developing more nutritious foods based on a strategy of targeted enrichment of key members of gut microbial communities.
Researchers at Beth Israel Deaconess Medical Center demonstrated for the first time that a strong association between obesity and chronic diarrhea is not driven by diet or physical activity. The findings could have important implications for how physicians might approach and treat symptoms of diarrhea in patients with obesity differently.
Pancreatic adenocarcinoma (PDAC) is a lethal malignancy that most often is resistant to chemotherapy. Researchers have been searching for ways to increase the sensitivity of the tumors to cancer-fighting drugs. A Mayo Clinic-led study published today opens a promising new front in that battle.
In early test tube and mouse studies, investigators at Johns Hopkins Medicine and the Johns Hopkins Kimmel Cancer Center have found that nonmuscle myosin IIC (MYH14), a protein activated in response to mechanical stress, helps promote metastatic behavior in pancreatic cancer cells, and that the compound 4-hydroxyacetophenone (4-HAP), known to stiffen myosin IIC-containing cells, can send it into overdrive, overwhelming the ability of cells to invade nearby tissue.
The American College of Radiology (ACR) has acquired the My CT Colonography center online locator, a patient-friendly online tool to find a computed tomography (CT) colonography screening center near you. The ACR will now work with stakeholders to explore ways to achieve the goal of having all facilities that perform CTC registered on a center locator.
A source of embarrassment to some, or pure comedy to others, flatulence and the gases of the intestines are increasingly seen as playing an important role in our digestive health.
The Icahn School of Medicine at Mount Sinai has been awarded nearly $1.7 million in grant funding from the U.S. Department of Defense to study how bladder cancer affects certain types of white blood cells called “natural killer” cells, or NK cells, which control and limit tumor growth. A clinical and research team of investigators with expertise in bladder cancer and immunotherapy will also design interventions to reverse NK cell dysfunction. According to the U.S. Department of Veterans Affairs, bladder cancer is the fourth most common cancer among veterans. Smoking and exposure to industrial chemicals are the leading causes.
George Washington University researchers published a comprehensive list of the types and ratios of microbes that inhabit the healthy human gut in PLOS ONE, supporting growing research in the field.
If a woodrat is in captivity and is eating an artificial diet, that finely tuned gut microbiome changes. In a paper published in the International Society for Microbial Ecology Journal
A University of Florida microbiologist's latest research found that disease-causing bacteria are competing with their human hosts for a key micronutrient.
An oncogene, UPS21, has been confirmed as a frequently amplified gene in pancreatic ductal adenocarcinoma, the most common and often lethal form of pancreatic cancer. The discovery could lead to new treatment options.
A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides recommendations on the use of radiation therapy to treat patients diagnosed with pancreatic cancer
A drug developed by researchers at the Renaissance School of Medicine at Stony Brook University that targets enzymes involved in the development of pancreatic cancer cells is showing promise for improved treatment of metastatic pancreatic cancer.
Les résultats des traitements du cancer colorectal pourraient être améliorés en modifiant génétiquement une protéine immunorégulatrice située dans les cellules cancéreuses, en rendant les cellules plus vulnérables à la chimiothérapie. C’est que révèlent les recherches menées par Mayo Clinic.
Os resultados do câncer colorretal podem ser aprimorados por meio da alteração de uma proteína imunorreguladora nas células cancerígenas, tornando essas células mais vulneráveis à quimioterapia. Isso de acordo com uma nova pesquisa da Mayo Clinic.
While weeding in her north Seattle garden, Miggie Olsson discusses how she, as a patient, became a unicorn.
Los resultados del cáncer colorrectal pueden mejorar cuando se altera genéticamente una proteína que regula la inmunidad de las células cancerosas con el fin de volverlas más vulnerables a la quimioterapia, dice un nuevo estudio de Mayo Clinic.
Finding May Create Opportunity to Test Patients to Avoid Ineffective Drugs
Mayo Clinic的一项研究发现，乳糜泻患者的父母、兄弟姐妹和子女具有患此疾病的高风险。该研究建议此疾病患者所有一级亲属均进行筛查，而不仅是已表现出症状的亲属。
A couple of molecules that nerve cells use to grow during development could help explain why the most common pancreatic cancers are so difficult to contain and for patients to survive
Les parents, les frères et sœurs et les enfants de personnes atteintes de la maladie cœliaque présentent un risque élevé d’être également atteints de la maladie, selon une étude de Mayo Clinic. Cette étude exige le dépistage de tous les parents au premier degré des patients, et non pas uniquement les personnes présentant des symptômes.
Eltern, Geschwister und Kinder von Menschen mit Zöliakie sind mit einem hohen Risiko auch mit der Krankheit, nach einer Mayo Clinic Studie. Diese Studie fordert ein Screening aller Angehörigen ersten Grades von Patienten
Attend press conferences live – online at http://bit.ly/acs2019sandiego or in person - at the American Chemical Society Fall 2019 National Meeting & Exposition. Press conferences will be held Monday, Aug. 26 and Tuesday, Aug. 27, 2019.
Colorectal cancer outcomes may improve by genetically altering an immune-regulatory protein in cancer cells, making the cells more vulnerable to chemotherapy.
As a disposable version of the instrument used in one of the most common medical procedures in the United States inches closer to widespread availability, a team of Johns Hopkins data researchers is studying the economic and safety implications associated with the devices used to perform colonoscopies.
For years, scientists have been trying to solve a medical mystery: Why do people with type 1 or type 2 diabetes have an increased risk of developing some forms of cancer? Today, researchers report a possible explanation for this double whammy.
Researchers have decoded a chain of molecules that are critical for the growth and survival of pancreatic ductal adenocarcinoma—the most common and also the most lethal form of pancreatic cancer.
Researchers at Washington University School of Medicine in St. Louis have discovered that an initial urinary tract infection (UTI) triggers changes to immune and other cells in the bladder that can prime the bladder to overreact to bacteria, worsening subsequent UTIs.
In an extensive “data mining” analysis of British medical records, researchers at the Johns Hopkins Kimmel Cancer Center conclude that taking even a single course of antibiotics might boost—albeit slightly—the risk of developing colon cancer—but not rectal cancer—a decade later. The findings, reported in the August 20 issue of the journal Gut, highlight the need for judicious use of this broad category of drugs, which are frequently improperly or overprescribed, the report authors say.
Scientists have analyzed the genetic repertoire of bacteria in the human mouth and gut The effort marks the first chapter in efforts to compile a compendium of all genes in the human microbiome Mapping the microbial genome can reveal links between bacterial genes and disease risk and could inform the development of precision therapies Analysis reveals staggering person-to-person variation in microbial gene content Unique microbial genes, specific to each person, have functions distinct from common, or shared, genes Unique genes may act as a microbe’s evolutionary organ Researchers have made the data publicly accessible at The Universe of Microbial Genes
A phase 1 clinical trial testing a new drug in pancreatic cancer had promising initial results, report researchers from the University of Michigan Rogel Cancer Center. The trial looked at AZD1775, an inhibitor designed to block an enzyme called Wee1, which plays a role in DNA damage repair.
Patients with metastatic colorectal cancer who engaged in moderate exercise while undergoing chemotherapy tended to have delayed progression of their disease and fewer severe side effects from treatment, according to the results of a new study.
Louis Battaglia's doctors initially could not determine the source of his pain, until he saw specialists at NYU Langone Hospital–Brooklyn, who found it was a rare form of stomach cancer.
The discovery of the previously unknown mutation, reported in Nature Genetics by investigators from Dana-Farber/Brigham and Women’s Cancer Center, could lead to routine testing of individuals with a strong family history of pancreatic cancer to determine if they carry the mutation, occurring in the gene known as RABL3.
Physicians have long suspected that red blood cell transfusions given to premature infants with anemia may put them in danger of developing necrotizing enterocolitis, or NEC, a potentially lethal inflammatory disease of the intestines. However, solid evidence for the connection has been difficult to obtain in part because of the lack of a practical animal model able to accurately represent what physically occurs when a baby gets NEC.
A new drug that penetrates the protective barrier around pancreatic cancers and accumulates in malignant cells may improve current chemotherapy, a study in mice suggests.
There is no cure for the more than 1.6 million people in the United States living with Crohn’s disease (CD) and its symptoms, including abdominal pain, intestinal distress and severe weight-loss. CD is a form of inflammatory bowel disease (IBD) in which the body’s own immune system attacks the gastrointestinal tract, and treatment is focused on controlling the symptoms of the disease in its acute phase and managing it in remission. But recently, researchers at Case Western Reserve University School of Medicine identified a pathway in the immune system activated in CD and which holds promise for investigating new treatments.
A rare, short-lived population of immune cells in the bloodstream may serve as ‘periscopes’ to monitor immune status via lymph nodes deep inside the body.
Newly published manuscript explores risk factors and etiology of sporadic colon and rectal (colorectal) cancer in young adults.
A newly developed technique that shows artery clogging fat-and-protein complexes in live fish gave investigators from Carnegie
A new study harnessed the unique genetic history of the people of Finland to identify variations in DNA that might predispose certain individuals to disease, whether or not they are Finnish themselves. The study was conducted by researchers at Washington University School of Medicine in St. Louis and collaborating institutions.
The much-talked-about "Coffee Study" is featured in the August 2019 issue of the medical journal Diseases of the Colon and Rectum.
A study of patients' gut bacteria highlights likely reasons behind the pandemic spread of resistant E. coli strains, and the need to re-think the clinical significance of bacteria in the urine without symptoms, because treatment-resistant strains can be highly pathogenic to the urinary system.
Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn’s disease (CD). But in 2016, Mahmoud A Ghannoum, PhD, FAAM, FIDSA, professor and director of the Center for Medical Mycology at Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center, was the first to identify a specific fungus in humans that interacted with bacteria in the development of the disease. Now, to learn precisely how that fungus interacts with bacteria to trigger CD, Ghannoum has received a five-year, $3M grant from the National Institutes of Health. His investigation will involve innovative molecular and cellular technologies, to delete specific genes in the fungus and note the effects on the inflammation that is a marker for CD using powerful microscopic analysis.
Targeting medical treatment to an ailing body part is a practice as old as medicine itself. A Band-Aid is placed on a skinned knee. Drops go into itchy eyes. A broken arm goes into a cast.
A specific class of bacteria from the gut prevents mice from becoming obese, suggesting these same microbes may similarly control weight in people, a new study reports. The beneficial bacteria, called Clostridia, are part of the microbiome — collectively trillions of bacteria and other microorganisms that inhabit the intestine. University of Utah Health investigators led the study which publishes online in the journal Science on July 25.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right