Feature Channels: Heart Disease

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The study found that ‘silent’ covert strokes are actually more common than overt strokes in people aged 65 or older who have surgery

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MyoKardia, Inc. today announced the launch of the 2nd Annual MyoSeeds™ Research Grants Program, an initiative to support original, independent research in the biology and underlying mechanisms of cardiomyopathies and precision heart disease treatment.

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Castleman Disease patients who do not respond to the only drug currently approved by the FDA may have another option that targets a specific pathway called PI3K/Akt/mTOR

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Hui Yang, Harold and Inge Marcus Career Associate Professor of Industrial and Manufacturing Engineering at Penn State, was awarded a $320,625 grant from the National Science Foundation (NSF) to study exactly how a process called glycosylation can cause proteins to disrupt the harmony of cell activity.

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The human heart’s energy needs and functions are difficult to reproduce in other animals; one new system looks to circumvent these issues and provide a functional view of how different treatments can help ailing cells in the heart following oxygen and nutrient deprivations. Researchers have unveiled a new silicon chip that holds human lab-grown heart muscle cells for assessing the effectiveness of new drugs. They discuss their work in this week’s APL Bioengineering.

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Consuming flavonoid-rich items such as apples and tea protects against cancer and heart disease, particularly for smokers and heavy drinkers, according to new research from Edith Cowan University (ECU).

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Common prostate cancer therapy may increase short-term risk of death in patients with pre-existing cardiovascular conditions.

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A new grant will study why the newborn mammalian heart can repair itself, an ability that vanishes a few days after birth. Aims are to decipher mechanisms that govern that neonatal regenerative potential, and see if those mechanisms can be manipulated to remuscularize hearts after heart attack.

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Most people with a medical condition called long QT syndrome have a mutation in a gene that causes bouts of fast, chaotic heartbeats. They also experience fainting spells and seizures. The clinical approach has largely assumed that when the heart beats erratically, the brain eventually does not get enough oxygen — which in turn causes the seizures.

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The Cardiovascular Research Foundation (CRF) has announced the 12 late-breaking trials and 16 late-breaking science presentations that will be reported at the Transcatheter Cardiovascular Therapeutics (TCT) 2019 scientific symposium. TCT, the world’s premier educational meeting specializing in interventional cardiovascular medicine, will take place September 25 – 29, 2019 at The Moscone Center in San Francisco, California.

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The numerous insights and resources gained by health care providers, stroke survivors, and their caregivers during the COMPASS post-acute stroke services study are available to anyone online through the COMPASS study website.

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In a Phase III clinical trial, the drug volanesorsen significantly reduced blood fat (triglyceride) levels in participants with a rare disease called familial chylomicronemia syndrome; finding could also help inform better prevention methods and treatments for many types of heart disease.

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The heart cannot regenerate muscle after a heart attack. Injecting heart muscle cells grown in vitro could help the failing heart, but engraftment rates are low. A new and simple method to improve the quality of the delivered cells has now been tested in mice, and it doubles the engraftment rate.

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One of the most common problems cardiologists handle is atrial fibrillation, an abnormal or irregular heartbeat that can lead to blood clots, stroke, heart failure and other heart-related complications.

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The heart transplant program at UC San Diego Health has demonstrated the best one-year survival rate for patients in the United States among health care providers with a volume of more than 50 heart transplants per year, according to the Scientific Registry of Transplant Recipients.

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On August 4, a special session at the 71st AACC Annual Scientific Meeting & Clinical Lab Expo will shed much-needed light on the nuances of direct-to-consumer genetic testing.

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Una nueva investigación de Mayo Clinic muestra que la inteligencia artificial puede detectar en un electrocardiograma (ECG) las señales de la arritmia cardíaca llamada fibrilación auricular, aunque el ritmo cardíaco sea normal en el momento del examen. Es decir, el ECG mediante inteligencia artificial puede detectar una fibrilación auricular que ocurrió recién y sin síntomas o que es inminente, lo cual mejoraría las alternativas terapéuticas. Con este estudio, puede aumentar la eficacia del ECG.

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A new Mayo Clinic research study shows that artificial intelligence (AI) can detect the signs of an irregular heart rhythm — atrial fibrillation (AF) — in an EKG, even if the heart is in normal rhythm at the time of a test. In other words, the AI-enabled EKG can detect recent atrial fibrillation that occurred without symptoms or that is impending, potentially improving treatment options. This research could improve the efficiency of the EKG, a noninvasive and widely available method of heart disease screening. The findings and an accompanying commentary are published in The Lancet.

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一项I期临床试验表明，通过采集和处理婴儿自体干细胞并在手术时直接将其注入心脏，有望对左心发育不良综合征(HLHS)进行再生治疗。该研究是美国食品药品监督管理局监测的首项同类研究。The Journal of Thoracic and Cardiovascular Surgery（《胸心血管外科杂志》）上发表了一篇详细介绍该临床试验的论文。

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A study from the University of Pittsburgh Graduate School of Public Health shows that using an estradiol patch was associated with accumulation of fat around the heart and worsening of coronary artery calcification.

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A newly developed technique that shows artery clogging fat-and-protein complexes in live fish gave investigators from Carnegie

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Researchers at Iowa State University have developed a model to test how shading and air flow can improve indoor temperatures during the sweltering heat of Midwest summers.

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Measuring waistline, blood pressure, cholesterol, blood fats, and blood sugar during doctor visits can detect heart disease and diabetes earlier, according to a Clinical Practice Guideline issued today by the Endocrine Society.

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A wireless, wearable monitor built with stretchable electronics could allow comfortable, long-term health monitoring of adults, babies and small children without concern for skin injury or allergic reactions caused by conventional adhesive sensors with conductive gels.

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For a third consecutive year, UT Southwestern Medical Center is the No. 1 hospital in Dallas-Fort Worth and No. 2 in Texas, according to U.S. News & World Report’s annual Best Hospitals listings released today. UT Southwestern also ranked nationally in seven specialties including heart and neurological care.

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The chances of patients experiencing complications after having a cardiac device implanted vary according to where they have the procedure.

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The pivotal trial to determine the safety and effectiveness of a modular device designed to be the first completely off-the-shelf endovascular solution for aortic aneurysms involving the visceral branch vessels is successfully underway with its first surgery at UNC Hospitals in Chapel Hill, NC.

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Researchers at Beth Israel Deaconess Medical Center (BIDMC) have developed a novel imaging approach that has the potential to identify patients with coronary disease without administration of drugs or contrast dye and within a short 15 minute exam protocol.

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The notion that more medical errors occur in July compared to other months due to an influx of new medical school graduates starting their in-hospital training does not apply to heart surgery.

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Um estudo clínico de fase 1 é a primeira pesquisa monitorada pela Food and Drug Administration (Agência Americana de Controle de Alimentos e Medicamentos) que demonstra o potencial da terapia regenerativa para a síndrome da hipoplasia do coração esquerdo (SHCE) por meio de coleta, processamento e introdução das próprias células tronco da criança no coração durante o momento da cirurgia.

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Un ensayo clínico de fase I es el primer estudio controlado por la Administración de Alimentos y Medicamentos de Estados Unidos que demuestra el potencial de la terapia regenerativa para el síndrome de hipoplasia del ventrículo izquierdo (HLHS, por sus siglas en inglés), mediante la recolección y el procesamiento de las propias células madre del recién nacido y de la inyección de las mismas directamente en el corazón durante una intervención quirúrgica.

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A new study out of Beth Israel Deaconess Medical Center, published in the Annals of Internal Medicine, finds widespread aspirin use among Americans 40 years old and above, despite few benefits and high risks.

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A phase I clinical trial is the first research monitored by the Food and Drug Administration that demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome (HLHS) through collecting, processing and injecting an infant's own stem cells directly into the heart at the time of surgery.

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University of California San Diego School of Medicine scientists say the loss of a single gene two to three million years ago in our ancestors may have resulted in a heightened risk of cardiovascular disease in all humans as a species, while also setting up a further risk for red meat-eating humans.

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The agenda is now available online for TCT 2019 (Transcatheter Cardiovascular Therapeutics), the annual scientific symposium of the Cardiovascular Research Foundation. TCT is the world’s premier educational meeting specializing in interventional cardiovascular medicine. Every year, TCT features major medical research breakthroughs and gathers leading researchers and clinicians from around the globe to present and discuss the latest evidence-based research in the field.

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Runner required almost 50 minutes of CPR on the way to the hospital.

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Hot weather is here. Before lathering on the sunscreen and heading outdoors, it’s important to know the signs of heat-related injuries and how to stay cool when the temperatures soar.

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With the 50th anniversary of the Apollo 11 moon landing approaching, UT Southwestern Medical Center researchers are publishing heart-related space research that helps us to understand the problem of low blood pressure.

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On an ice hockey team, the players all start off with identical uniforms, skates and a stick. But if you take one of them, add padding, a glove, and a mask; and switch the stick to one with a larger blade, then you get a goalie. Now, the player has morphed — or differentiated — into a one with a specific function: protect the goal from invading pucks.

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Upon uncovering that inadequate blood flow can be a more imminent, life-threatening problem than aortic rupture for some patients, doctors emerge with a new procedural method.

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Biomedical engineers at Penn State have developed a process to build protective, synthetic plant cell walls around animal cells. The work, published in Nature Communications, could hold significant potential for a variety of medical and biomanufacturing applications for human health.

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In a massive new analysis of findings from 277 clinical trials using 24 different interventions, Johns Hopkins Medicine researchers say they have found that almost all vitamin, mineral and other nutrient supplements or diets cannot be linked to longer life or protection from heart disease.

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A highly competitive $4.5 million grant from the National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) will support Keck School of Medicine of USC efforts to recruit patients from underrepresented populations into cardiac surgery clinical trials.

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The link between obesity and cardiovascular disease is well-known but in what is believed to be the first study of its kind, an international team has found even restricting calorie intake moderately, by people only marginally overweight, can significantly reduce the risk of heart attack.

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In adults already at a healthy weight or carrying just a few extra pounds, cutting around 300 calories a day significantly improved already good levels of cholesterol, blood pressure, blood sugar and other markers.

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The ACC/AHA published new heart disease prevention guidelines for primary care providers to use when treating patients with heart disease or who are at risk for heart disease. The guidelines recommend for primary care providers to go beyond medical intervention, and consider the patient’s socioeconomic challenges when it comes to accessing care and making lifestyle changes to improve his or her condition. The guidelines include a new recommendation that low-dose aspirin should not be administered on a routine basis for primary prevention of heart disease among adults 70 years of age or older, or at any age who are at increased bleeding risk.

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When multidisciplinary health care teams were engaged in caring for patients suffering from refractory cardiogenic shock, a severe condition that can occur after a heart attack, the likelihood of survival increased significantly, by approximately 50 percent. The study was published online in the July issue of Circulation.