GW Experts Available to Speak During Kidney Health Month
George Washington University
Highlights • Between 2005 and 2015, the unadjusted rate of living kidney donation in the United States was 30.1 and 19.3 per million population in women and men, respectively. • After adjusting for differences in age, race, the incidence of kidney failure, and geographic factors, the incidence of donation was 44% higher in women. • Over time, the incidence of donation was stable in women but declined in men. The decline was most marked in men from lower income groups.
In a small study, doctors at Johns Hopkins have successfully transplanted 10 hepatitis C-infected kidneys into patients without hepatitis C and prevented the patients from becoming infected by hepatitis C. The success of these transplants could mean more organs being available for the nearly 100,000 people in the U.S. currently waiting for a kidney transplant.
In celebration of the World Kidney Day 2018’s theme of "Kidneys & Women’s Health: Include, Value, Empower," the American Society of Nephrology (ASN) is highlighting several articles in its journals, Clinical Journal of the American Society of Nephrology (CJASN) and Journal of the American Society of Nephrology (JASN), that are focused on women's kidney health.
Vanderbilt University Medical Center is encouraging its medical providers to stop using saline as intravenous fluid therapy for most patients, a change provoked by two companion landmark studies released today that are anticipated to improve survival and decrease kidney complications.
• An analysis of published studies indicates that children with chronic kidney disease may have lower intellectual functioning compared than children in the general population. • Compared with children with mild-to-moderate stage kidney disease and with kidney transplants, children on dialysis had the lowest IQ scores. • Deficits were evident for attention, memory, and executive function domains.
Researchers at Washington University School of Medicine in St. Louis have found that when mature cells transition to begin dividing again, they all seem to do it the same way, regardless of what organ those cells come from.
Lingering inflammation after heart attack can lead heart failure. It can also claim another victim — the kidneys. New research shows that a bioactive compound called resolvin D-1, injected as a therapeutic dose, is able to limit this collateral damage in the kidneys, as tested in an animal model.
• Three new research articles compare human and mouse kidney development to identify shared and novel features. • The studies provide new detailed molecular data to guide future research. • The studies revealed deep conservation of certain processes, but also significant differences in gene expression during kidney development, as well as in the timing, scale, organization, and molecular profile of key cell types and cell structures.
New guidelines developed collaboratively by the American Society of Clinical Oncology (ASCO) and the National Comprehensive Cancer Network® (NCCN®) offer clinicians much needed recommendations for assessment and management of side effects related to immune checkpoint inhibitors.
肾结石(Kidney stones)是十分痛苦的,而其治疗也往往需要多个令病人很不舒服的治疗程序。 越来越多的证据表明,肾结石的发病率在稳步上升,特别是在女性中。 使用罗切斯特流行病学项目(Rochester Epidemiology Project)的数据,Mayo Clinic的研究人员调查了结石患者的增加情况,以确定这是一个新的趋势或者仅仅是由于肾结石检测手段改善而造成的患者增加。 他们的发现发表在Mayo Clinic Proceedings上。
Los cálculos renales son dolorosos y generalmente requieren de varios procedimientos muy molestos para los pacientes. Cada vez hay más pruebas acerca de que la incidencia de los cálculos renales aumenta continuamente, sobre todo entre las mujeres.
Kidney stones are a painful health condition, often requiring multiple procedures at great discomfort to the patient. Growing evidence suggests that the incidence of kidney stones is increasing steadily, especially in women. Using data from the Rochester Epidemiology Project, Mayo Clinic researchers investigated the rise in stone formers to determine if this is a new trend, or simply an improvement in the way kidney stones are detected. Their findings appear in the March issue of Mayo Clinic Proceedings.
Creating an artificial implantable kidney would be an epic advance in medicine and could address a chronic shortage of donor kidneys needed for transplant. Researchers who have been at this quest for the past 15 years face the challenge of how to keep the blood flowing smoothly through the artificial device without clotting. They are combining expertise in artificial kidney development and in computer simulation of blood flow to surmount the problem.
At three-years-old, Kyle Lugo is one of the youngest patients to undergo a kidney transplant at Hackensack Meridian Health Hackensack University Medical Center. Kyle’s kidney transplant was performed on Christmas Eve.
• A new method is useful for assessing how well individual dialysis facilities are referring patients for kidney transplantation. • When the method was applied to dialysis facilities in Georgia, researchers found that most of the variation in referrals for transplantation were due to characteristics within the dialysis facilities rather than patient characteristics.
Holly Kramer, MD, MPH, a kidney specialist and nationally known kidney disease researcher at Loyola University Chicago and Loyola Medicine, has been named president-elect of the National Kidney Foundation, Inc.
• Among working-aged adults who started dialysis between 1996 and 2013, employment was low throughout the study period at 23-24%, and 38% of patients who were employed 6 months prior to being diagnosed with kidney failure stopped working by the time they initiated dialysis. After accounting for differences in patients over time, the probability of employment in kidney failure patients increased slightly over time.
Female kidney donors who are overweight may be at a greater risk for preeclampsia during pregnancy than those with normal body weight, according to a new study. The increased risk is due to a reduction in a type of kidney function called renal functional reserve (RFR).
Kidney specialists face increasing work demands, high rates of burnout, and declining interest in nephrology as a career. A group of articles publishing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN) sheds light on how that these factors threaten to reduce job satisfaction and impair the delivery of high-quality care to patients with kidney diseases.
The most common type of tumor found in the kidney is generally quite small (less than 1.5 in). These tumors are usually found by accident when CAT scans are performed for other reasons and the serendipitous finding poses a problem for doctors.
Researchers have applied Nobel prize-winning microscope technology to uncover an ion channel structure that could lead to new treatments for kidney stones. In a recent study published in Nature Structural and Molecular Biology, researchers revealed atomic-level details of the protein that serves as a passageway for calcium across kidney cell membranes.
The proteasome inhibitor carfilzomib has taken on an increasing role in the treatment of multiple myeloma, but new research from the Abramson Cancer Center of the University of Pennsylvania shows the therapy comes with the risk of cardiovascular problems in a higher than expected percentage of patients.
Tyler Williamson went to TEDx Birmingham’s 2017 event in March expecting to be inspired and to network and make new connections with fellow attendees. What the 27-year-old did not anticipate was that inspiration would lead him to volunteer to become a living kidney donor just seven months later.
Three months after receiving a kidney transplant, Holly Miyagawa was back on the beach playing volleyball. That was 17 years ago. Since then, the Hermosa Beach, CA, resident has gone on to medal in volleyball at the World Transplant Games and the Transplant Games of America. This New Year's Day, she'll accompany the Donate Life float in the Tournament of Roses Parade, representing Cedars-Sinai, where she received her transplant.
In an effort to provide patients the opportunity to share practical health consumer perspectives, the Clinical Journal of the American Society of Nephrology (CJASN) is including Patient Voice editorials that will accompany certain journal articles. In the first editorial, Paul T. Conway, a past recipient of the ASN President’s medal, highlights 2 CJASN articles that focus on patient comprehension of how treatments align with their individual interests.
A study published in the Journal of Clinical Oncology reports initial findings with a novel drug belonging to a new class of medicines called HIF-2a inhibitors that show promise in treating metastatic kidney cancer.
An interdisciplinary research team led by the National University of Singapore (NUS) has recently discovered a unique panel of urine biomarkers that could accurately diagnose nephrolithiasis, also commonly known as kidney stone.
Researchers have demonstrated for the first time that extracellular vesicles – tiny protein-filled structures – isolated from amniotic fluid stem cells (AFSCs) can be used to effectively slow the progression of kidney damage in mice with a type of chronic kidney disease.
• In a trial of kidney transplant recipients with late antibody-mediated rejection, treatment with bortezomib, a type of proteasome inhibitor, failed to improve the function of transplanted kidneys and prevent immunologic tissue injury. • Bortezomib treatment was also linked with gastrointestinal and hematologic toxicity.
• In the United States, the excess risk of kidney failure–related death decreased by 12% to 27% over any 5-year interval between 1995 and 2013. • Decreases in excess mortality over time were observed for all ages and both during treatment with dialysis and during time with a functioning kidney transplant.
Around 17% of American adults have chronic kidney disease (CKD), and the rate of prevalence is higher for US Veterans. CKD, if not treated appropriately, can ultimately lead to kidney failure requiring either dialysis or a transplant.
Diabetes is known to increase a person’s risk of kidney disease. Now, a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true: Kidney dysfunction increases the risk of diabetes. Further, the researchers deduced that a likely culprit of the two-way relationship between kidney disease and diabetes is urea. The findings are significant because urea levels can be lowered through medication and diet, thereby allowing for improved treatment and possible prevention of diabetes.
The hope given from a deceased donor, and a sibling, give two kidney transplant recipients a chance to live
• New research indicates that the role of dendritic cells in kidney inflammation is more complex than previously thought. Different types of dendritic cells communicate with each other to control the magnitude of the immune response. • The findings may lead to a better understanding of various types of kidney disease.
• In an analysis of pairs of kidneys from the same donor in which 1 kidney was used but the other was discarded, the kidneys that were used tended to perform well. • The majority of discarded kidneys could have potentially been transplanted with good outcomes.
Sunitinib (marketed as Sutent) a drug that has already proven highly effective as first-line treatment for people with metastatic renal cell carcinoma, was recently approved by the U.S. Food and Drug Administration to also treat patients with the disease who are at high risk for tumor recurrence.
Stress in early life may change the immune response in the kidneys, increasing the risk of heart disease later in life, according to a new study.
DNA sequences between mitochondria within a single cell are vastly different, found researchers. This knowledge will help to better illuminate the underlying mechanisms of many disorders that start with accumulated mutations in individual mitochondria and provide clues about how patients might respond to specific therapies.
In a new study of kidney disease patients, researchers used DNA sequencing to identify the underlying genetic cause of disease, improving diagnosis and treatment.
Iowa State's Robbyn Annand is studying how a hybrid of electrochemical and microfluidic technologies could be used to improve the dialysis equipment that cleans salt, waste and water from blood. That technology could enable a wearable, artificial kidney.
• In tissue samples from patients who received kidney transplants without the need for chronic immunosuppression, researchers found increased expression of many genes associated with the regulation of certain immune cells. • The findings provide an improved understanding of transplant organ acceptance and rejection.
Social media is a powerful tool that can help people facing health challenges, such as Native Americans on kidney dialysis.
Three Loyola Medicine kidney transplant patients received kidneys from three living donors on the same day in a transplant chain.
Los investigadores de Mayo Clinic demostraron una vinculación entre el tipo de anticoagulante que toma el paciente para evitar un accidente cerebrovascular y más riesgo de deterioro de la función renal o de insuficiencia renal.
Mayo Clinic researchers have shown a link between which type of oral anticoagulant (blood-thinning medication) a patient takes to prevent a stroke and increased risks of kidney function decline or failure.
Slight changes to the system for allocating deceased-donor kidneys could result in higher rates of organ procurement and lead to more kidney transplants across the country, according to new research co-authored by an Indiana University Kelley School of Business professor.
A novel computational method allows researchers to parse how multiple organs contribute to a disease over time, giving a more holistic view of disease and potentially revealing new avenues for intervention.
Michigan Medicine enters drug discovery collaboration with AstraZeneca in Chronic Kidney Disease
Rural counties continue to rank lowest among counties across the U.S., in terms of health outcomes. A group of national organizations including the Robert Wood Johnson Foundation and the National 4-H Council are leading the way to close the rural health gap.