Curated News: National Center for Advancing Translational Sciences (NCATS)

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14-Jun-2021 11:40 AM EDT
Study Finds Association Between Head Impacts and Imaging Changes in Youth Football Players Over Consecutive Seasons
Wake Forest Baptist Health

With preseason football training on the horizon, a new study shows that head impacts experienced during practice are associated with changes in brain imaging of young players over multiple seasons.

Released: 11-Jun-2021 11:15 AM EDT
Financial toxicity associated with cancer care impacts nearly 50% of women with gynecologic cancer
Beth Israel Deaconess Medical Center

Researchers report on how a diverse cohort of gynecologic cancer patients are affected by financial distress, also called “financial toxicity” in acknowledgment of the health hazards it can pose, in the International Journal of Gynecological Cancer.

Newswise: Same Difference: Two Halves of The Hippocampus Have Different Gene Activity
Released: 28-May-2021 1:45 PM EDT
Same Difference: Two Halves of The Hippocampus Have Different Gene Activity
UT Southwestern Medical Center

DALLAS – May 28, 2021 – A study of gene activity in the brain’s hippocampus, led by UT Southwestern researchers, has identified marked differences between the region’s anterior and posterior portions. The findings, published today in Neuron, could shed light on a variety of brain disorders that involve the hippocampus and may eventually help lead to new, targeted treatments.

Released: 26-Mar-2021 10:40 AM EDT
Research Group Identifies Potential Therapeutic Target for Lupus
Michigan Medicine - University of Michigan

Inhibiting IRE1α, a molecule activated by the endoplasmic reticulum in neutrophils, counters disease progression in lupus mice.

Newswise: Opioid overdose reduced in patients taking buprenorphine
1-Mar-2021 5:30 PM EST
Opioid overdose reduced in patients taking buprenorphine
Washington University in St. Louis

The drug buprenorphine is an effective treatment for opioid use disorder, but many who misuse opioids also take benzodiazepines — drugs that treat anxiety and similar conditions. Many treatment centers hesitate to treat patients addicted to opioids who also take benzodiazepines. Researchers at Washington University School of Medicine in St. Louis studied overdose risk in people taking buprenorphine and found that the drug lowered risk, even in people taking benzodiazepines.

Newswise: COVID-19 increases mortality rate among pregnant women
26-Jan-2021 5:00 PM EST
COVID-19 increases mortality rate among pregnant women
University of Washington School of Medicine

The study, which followed 240 pregnant women between March and June 2020, found that the COVID-19 mortality rate in the pregnant women was significantly higher when compared to the COVID-19 mortality rate in similarly aged individuals within Washington state.

Released: 12-Jan-2021 11:35 AM EST
Nature Article Highlights UAMS Effort to Share COVID-19 Images on National Cancer Database
University of Arkansas for Medical Sciences

Data experts with the University of Arkansas for Medical Sciences (UAMS) have uploaded clinical images of COVID-19 patients to a publically available national database that scientists can use in researching the disease and its impact in a global pandemic.

8-Jan-2021 9:55 AM EST
Nurse Involvement Promotes Discussion of Advanced Care Planning During Office Visits
Wake Forest Baptist Health

Most doctors would agree that advanced care planning (ACP) for patients, especially older adults, is important in providing the best and most appropriate health care over the course of a patient’s life.

Newswise: Cancer cases are rising in adolescents and young adults
30-Nov-2020 10:55 AM EST
Cancer cases are rising in adolescents and young adults
Penn State College of Medicine

Cancer cases in adolescents and young adults have risen by 30% during the last four decades, with kidney cancer rising at the greatest rate, according to researchers at Penn State College of Medicine.

Newswise: Linking medically complex children’s outpatient team with hospitalists improved care
Released: 30-Nov-2020 12:05 PM EST
Linking medically complex children’s outpatient team with hospitalists improved care
University of Texas Health Science Center at Houston

When medically complex children are hospitalized, linking hospitalists to their regular outpatient providers through an inpatient consultation service were more likely to improve outcomes, according to researchers at The University of Texas Health Science Center at Houston (UTHealth).

Released: 17-Nov-2020 9:55 AM EST
Study explores sleep apnea, autoimmune disease link
University of Georgia

New research by University of Georgia scientists sheds light on why people with obstructive sleep apnea may have associated autoimmune disorders. The results could lead to better approaches to treatment and possibly new drug therapies.

Released: 2-Nov-2020 12:45 PM EST
Early UAMS Study Results Show 3.5% of Arkansans Infected by Coronavirus
University of Arkansas for Medical Sciences

Early results from a University of Arkansas for Medical Sciences (UAMS)-led COVID-19 antibody study show that 3.5% of Arkansans have been infected with the novel coronavirus.

Newswise: shipra-gandhi-landscape.jpg
Released: 30-Oct-2020 2:05 PM EDT
Roswell Park Sees Suggestion of Benefit in First Clinical Trial to Combine Beta-Blocker and Checkpoint Inhibitor
Roswell Park Comprehensive Cancer Center

The same biochemical triggers that spur a “fight or flight” response when we encounter threats may help tumor cells to thrive. A team of researchers from Roswell Park Comprehensive Cancer Center is looking at ways to disrupt that dynamic so that cancer treatments can be more effective. Their latest work, published today in Clinical Cancer Research, a journal of the American Association for Cancer Research, suggests that a drug widely prescribed to control blood pressure may improve patients’ response to cancer immunotherapy.

Newswise: HSS Researchers Launch Study Using Novel MRI Techniques to Find a Biomarker for Parsonage-Turner Syndrome, A Nerve Disorder
Released: 21-Sep-2020 6:05 PM EDT
HSS Researchers Launch Study Using Novel MRI Techniques to Find a Biomarker for Parsonage-Turner Syndrome, A Nerve Disorder
Hospital for Special Surgery

Researchers at Hospital for Special Surgery (HSS) are using a novel MRI technique known as magnetic resonance neurography, or MRN, to study Parsonage-Turner Syndrome (PTS), a painful nerve disorder that can lead to severe weakness and paralysis.

Released: 10-Sep-2020 2:55 PM EDT
Seven in 10 Americans willing to get COVID-19 vaccine, survey finds
Ohio State University

Almost seven in 10 Americans would be interested in receiving a COVID-19 vaccine when one becomes available, according to a new study. But researchers say there are concerning gaps in interest, particularly among Black Americans, who suffer disproportionately from the virus.

Newswise: Deep Look at Immune Cells in Patients’ Tumors Reveals Insights on Timing for Treatment Combinations
Released: 8-Sep-2020 2:00 PM EDT
Deep Look at Immune Cells in Patients’ Tumors Reveals Insights on Timing for Treatment Combinations
Roswell Park Comprehensive Cancer Center

It’s clear that radiation therapy, or radiotherapy, an approach used to treat cancer since the early 20th century, can be an effective companion to newer, immune-stimulating approaches known as immunotherapy. Research from a team from Roswell Park Comprehensive Cancer Center explains how radiation helps boost the immune system’s ability to fight cancer in combination with immune checkpoint inhibitors — and provides new evidence that the timing of these therapies can make a big difference in how effectively they work together.

Newswise: New computational tool allows researchers to predict key functional sites in proteins
Released: 3-Sep-2020 8:35 AM EDT
New computational tool allows researchers to predict key functional sites in proteins
Penn State College of Medicine

A new technology that uses a protein’s structure to predict the inner wiring that controls the protein’s function and dynamics is now available for scientists to utilize. The tool, developed by researchers at Penn State, may be useful for protein engineering and drug design.

Newswise: To Improve Research in Underserved Communities, Train Community Health Workers
Released: 27-Aug-2020 4:30 PM EDT
To Improve Research in Underserved Communities, Train Community Health Workers
Michigan Medicine - University of Michigan

New grant allows for improved training of community health workers to engage minority populations in research where they are often underrepresented and health disparities exist.

25-Aug-2020 11:50 AM EDT
Genetic Causes of Severe Childhood Brain Disorders Found Using New Computational Methods that Process Clinical Features at Scale
Children's Hospital of Philadelphia

A team of researchers have combined clinical information with large-scale genomic data to successfully link characteristic presentations of childhood epilepsies with specific genetic variants.

Newswise: VUMC Awarded $34 Million to Lead Nationwide Convalescent Plasma Study
Released: 21-Aug-2020 9:55 AM EDT
VUMC Awarded $34 Million to Lead Nationwide Convalescent Plasma Study
Vanderbilt University Medical Center

Vanderbilt University Medical Center (VUMC) has been awarded a one-year, $34-million grant by the National Center for Advancing Translational Sciences, part of the National Institutes of Health, to conduct a nationwide study of “convalescent plasma” as a treatment for COVID-19.

Newswise: Scan For Arterial Plaque is Better At Predicting Heart Attack Than Stroke
Released: 18-Aug-2020 9:00 AM EDT
Scan For Arterial Plaque is Better At Predicting Heart Attack Than Stroke
UT Southwestern Medical Center

DALLAS – Aug. 18, 2020 – The amount of calcified plaque in the heart’s arteries is a better predictor of future heart attacks than of strokes, with similar findings across sex and racial groups, according to new research from UT Southwestern.

Released: 14-Aug-2020 11:55 AM EDT
Convalescent Plasma Associated with Reduced COVID-19 Mortality in 35,000-Plus Hospitalized Patients
Mayo Clinic

Mayo Clinic and collaborators have published a preprint that identifies two main signals of efficacy that can inform future clinical trials on plasma therapy on COVID-19 patients. The data are extracted from the Mayo-led national Expanded Access Program (EAP) for convalescent plasma for the treatment of hospitalized patients with COVID-19.

Newswise: Fat-Based Molecules are Key to Zika Virus Infection
Released: 31-Jul-2020 9:00 AM EDT
Fat-Based Molecules are Key to Zika Virus Infection
Pacific Northwest National Laboratory

Researchers from PNNL have helped colleagues at OHSU identify lipid molecules required for Zika infection in human cells. The specific lipids involved could also be a clue to why the virus primarily infects brain tissue.

Newswise: Better Measure of ‘Good Cholesterol’ Can Gauge Heart Attack And Stroke Risk in Some Populations
Released: 27-Jul-2020 11:00 AM EDT
Better Measure of ‘Good Cholesterol’ Can Gauge Heart Attack And Stroke Risk in Some Populations
UT Southwestern Medical Center

DALLAS – June 22, 2020 – For decades, high-density lipoprotein (HDL) cholesterol has been dubbed “good cholesterol” because of its role in moving fats and other cholesterol molecules out of artery walls. People with higher HDL cholesterol levels tend to have lower rates of cardiovascular disease, studies have shown.

Newswise: Better Measure of ‘Good Cholesterol’ Can Gauge Heart Attack And Stroke Risk in Some Populations
Released: 22-Jun-2020 8:00 AM EDT
Better Measure of ‘Good Cholesterol’ Can Gauge Heart Attack And Stroke Risk in Some Populations
UT Southwestern Medical Center

DALLAS – June 22, 2020 – For decades, high-density lipoprotein (HDL) cholesterol has been dubbed “good cholesterol” because of its role in moving fats and other cholesterol molecules out of artery walls. People with higher HDL cholesterol levels tend to have lower rates of cardiovascular disease, studies have shown.

Newswise: Diabetes reversed in mice with genetically edited stem cells derived from patients
21-Apr-2020 8:50 AM EDT
Diabetes reversed in mice with genetically edited stem cells derived from patients
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have used induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes, transformed the stem cells into insulin-producing cells, used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals.

Released: 19-Mar-2020 9:55 AM EDT
E-cigarette users had substances linked to bladder cancer in urine
University of North Carolina Health Care System

In the review published in the journal European Urology Oncology, researchers compiled the results of 22 different studies that analyzed the urine of people who used e-cigarettes or other tobacco products, including cigarettes, to check for evidence of cancer-linked compounds or biomarkers of those compounds. They found six biomarkers or compounds with a strong link to bladder cancer.

Newswise:Video Embedded little-tissue-big-mission-beating-heart-tissues-to-ride-aboard-the-iss
VIDEO
Released: 4-Mar-2020 1:45 PM EST
Little Tissue, Big Mission: Beating Heart Tissues to Ride Aboard The ISS
Johns Hopkins University

Launching no earlier than March 6 at 11:50 PM EST, the Johns Hopkins University will send heart muscle tissues, contained in a specially-designed tissue chip the size of a small cellphone, up to the microgravity environment of the International Space Station (ISS) for one month of observation.

Newswise:Video Embedded revving-up-immune-system-may-help-treat-eczema
VIDEO
Released: 26-Feb-2020 12:15 PM EST
Revving up immune system may help treat eczema
Washington University in St. Louis

Studying eczema, researchers at Washington University School of Medicine in St. Louis have found that boosting the number of natural killer cells in the blood is a possible treatment strategy for the skin condition and also may help with related health problems, such as asthma.

Newswise: Barbershops Targeted to Improve Health of Black Men
Released: 18-Feb-2020 9:40 AM EST
Barbershops Targeted to Improve Health of Black Men
Vanderbilt University Medical Center

Black men with high blood pressure could benefit from a research study beginning this month to check their vitals while they are getting a haircut at a barbershop.

Released: 23-Jan-2020 12:05 PM EST
Adrenaline Handbrake
Harvard Medical School

Researchers have solved the long-standing mystery of how adrenaline regulates a key class of membrane proteins that are responsible for initiating the contraction of heart cells. The findings provide a mechanistic description of how adrenaline stimulates the heart and present new targets for cardiovascular drug discovery, including the potential development of alternative therapeutics to beta-blockers.


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