Curated News: National Eye Institute (NEI)

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Newswise:Video Embedded babies-attend-to-clues-of-meaning-as-they-take-in-complex-visual-world
VIDEO
Released: 27-Mar-2024 11:05 AM EDT
Babies Attend to Clues of Meaning as They Take in Complex Visual World
NIH, National Eye Institute (NEI)

Findings from a National Eye Institute-supported study show for the first time that when babies look at photos of unfamiliar everyday scenes, such as an office or a lab, they tend to fixate on the same regions where adults find meaning. This inclination to home in on what’s interesting or meaningful grows more pronounced as babies age. The findings, published in Infancy, provide a more nuanced understanding of visual development, which may lead to earlier detection of brain-based causes of vision problems, such as cerebral/cortical visual impairment.

Newswise: NEI Study Points to ‘Ground Zero’ for AMD Development
Released: 27-Mar-2024 10:05 AM EDT
NEI Study Points to ‘Ground Zero’ for AMD Development
NIH, National Eye Institute (NEI)

National Eye Institute researchers studying human retinas discovered 87 target genes where a mix of environmental factors likely influence one’s risk of developing age-related macular degeneration (AMD), a leading cause of vision loss in people ages 65 and older.

Newswise: Inflammation-Reducing Drug Shows No Benefit for Dry Age-Related Macular Degeneration in Nih Trial
Released: 21-Mar-2024 11:30 AM EDT
Inflammation-Reducing Drug Shows No Benefit for Dry Age-Related Macular Degeneration in Nih Trial
NIH, National Eye Institute (NEI)

The drug minocycline, an antibiotic that also decreases inflammation, failed to slow vision loss or expansion of geographic atrophy in people with dry age-related macular degeneration (AMD), according to a phase II clinical study at the National Eye Institute (NEI), part of the National Institutes of Health.

Newswise: New technique enhances quality control of lab-grown cells for AMD treatment
Released: 18-Jan-2024 3:05 PM EST
New technique enhances quality control of lab-grown cells for AMD treatment
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) have improved a crucial step in the production of retinal pigment epithelium (RPE), a tissue they grow in the lab from patient blood cells and are testing in a clinical trial as treatment for age-related macular degeneration (AMD).

Newswise: Metabolomics: A New Approach to Understanding Glaucoma
Released: 14-Nov-2023 6:05 PM EST
Metabolomics: A New Approach to Understanding Glaucoma
NIH, National Eye Institute (NEI)

Glaucoma remains one of the most common causes of vision loss and blindness in the U.S. and much of the world, disproportionately affecting older people, African Americans, and Hispanics and Latinos.

Newswise: Scientists discover external protein network can help stabilize neural connections
10-Aug-2023 2:05 PM EDT
Scientists discover external protein network can help stabilize neural connections
NIH, National Eye Institute (NEI)

The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, according to a study in mice from the National Eye Institute (NEI) and the University of Freiberg, Germany.

Newswise: Gene that regulates immune activity in the retina identified
Released: 11-Jul-2023 11:25 AM EDT
Gene that regulates immune activity in the retina identified
UT Southwestern Medical Center

UT Southwestern Medical Center researchers have identified a gene called Lipe that appears to be pivotal to retinal health, with mutations spurring immune activation and retinal degeneration. This is important because the retina is responsible for detecting the light that is transformed into vision. The findings, published in Communications Biology, provide clues about the mechanisms behind a variety of disorders affecting the retina, including macular degeneration and diabetic retinopathy.

Newswise: Intraocular corticosteroids best for treating complications of chronic inflammatory eye condition
8-Jun-2023 9:00 AM EDT
Intraocular corticosteroids best for treating complications of chronic inflammatory eye condition
NIH, National Eye Institute (NEI)

Repeat treatment with corticosteroid injections improved vision in people with persistent or recurrent uveitis-related macular edema better than two other therapies, according to results from a clinical trial funded by the National Eye Institute (NEI).

Newswise: Intraocular corticosteroids best for treating complications of chronic inflammatory eye condition
8-Jun-2023 9:00 AM EDT
Intraocular corticosteroids best for treating complications of chronic inflammatory eye condition
NIH, National Eye Institute (NEI)

Repeat treatment with corticosteroid injections improved vision in people with persistent or recurrent uveitis-related macular edema better than two other therapies, according to results from a clinical trial funded by the National Eye Institute (NEI).

Newswise: AI Used to Advance Drug Delivery System for Glaucoma and Other Chronic Diseases
Released: 24-May-2023 9:00 AM EDT
AI Used to Advance Drug Delivery System for Glaucoma and Other Chronic Diseases
Johns Hopkins Medicine

Wilmer Eye Institute, Johns Hopkins Medicine researchers say they have used artificial intelligence models and machine-learning algorithms to successfully predict which components of amino acids that make up therapeutic proteins are most likely to safely deliver therapeutic drugs to animal eye cells.

   
Newswise: Study: Blood Vessel Damage Could Be an Alzheimer’s Driver
Released: 19-May-2023 8:05 PM EDT
Study: Blood Vessel Damage Could Be an Alzheimer’s Driver
Cedars-Sinai

Blood vessel abnormalities in the eye are a major factor in the progression of Alzheimer’s disease, according to research from Cedars-Sinai investigators published in the peer-reviewed journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

Newswise:Video Embedded nei-scientists-publish-recipe-for-making-blood-vessel-cells-from-patient-stem-cells
VIDEO
Released: 16-May-2023 9:30 AM EDT
NEI Scientists publish recipe for making blood vessel cells from patient stem cells
NIH, National Eye Institute (NEI)

Researchers at NIH’s National Eye Institute have published a detailed protocol for making three cell types that are key components to form blood vessels and capillaries.

Newswise:Video Embedded nei-scientists-publish-recipe-for-making-blood-vessel-cells-from-patient-stem-cells
VIDEO
Released: 16-May-2023 9:30 AM EDT
NEI Scientists publish recipe for making blood vessel cells from patient stem cells
NIH, National Eye Institute (NEI)

Researchers at NIH’s National Eye Institute have published a detailed protocol for making three cell types that are key components to form blood vessels and capillaries.

Released: 1-May-2023 6:05 PM EDT
Scientists discover anatomical changes in the brains of the newly sighted
Massachusetts Institute of Technology (MIT)

In a new study, Sinha and his colleagues have now discovered anatomical changes that occur in the brains of these patients after their sight is restored. These changes, seen in the structure and organization of the brain’s white matter, appear to underlie some of the visual improvements that the researchers also observed in these patients.

Newswise: Herpes study adds to understanding of viral reinfections, how to potentially prevent them
Released: 1-May-2023 10:25 AM EDT
Herpes study adds to understanding of viral reinfections, how to potentially prevent them
University of Illinois Chicago

A new study on herpes infections of the eye helps shed light on the question of viral reinfections by identifying a key protein involved in viral reinfections that could be targeted by antiviral drugs.

Newswise: Extremely rare gene variants point to a potential cause of age-related macular degeneration
29-Mar-2023 2:00 PM EDT
Extremely rare gene variants point to a potential cause of age-related macular degeneration
NIH, National Eye Institute (NEI)

A study from the National Eye Institute (NEI) identified rare genetic variants that could point to one of the general mechanisms driving age-related macular degeneration (AMD), a common cause of vision loss in older adults.

Newswise: Extremely rare gene variants point to a potential cause of age-related macular degeneration
29-Mar-2023 2:00 PM EDT
Extremely rare gene variants point to a potential cause of age-related macular degeneration
NIH, National Eye Institute (NEI)

A study from the National Eye Institute (NEI) identified rare genetic variants that could point to one of the general mechanisms driving age-related macular degeneration (AMD), a common cause of vision loss in older adults.

Newswise: FDA-approved drug shows promise in lab models for blinding childhood disease 
Released: 29-Mar-2023 12:05 PM EDT
FDA-approved drug shows promise in lab models for blinding childhood disease 
NIH, National Eye Institute (NEI)

A National Eye Institute-led team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.

Newswise: FDA-approved drug shows promise in lab models for blinding childhood disease 
Released: 29-Mar-2023 12:05 PM EDT
FDA-approved drug shows promise in lab models for blinding childhood disease 
NIH, National Eye Institute (NEI)

A National Eye Institute-led team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.

Newswise: Early study shows cones in retinal degeneration, thought to be dormant, may retain visual function
Released: 27-Mar-2023 5:40 PM EDT
Early study shows cones in retinal degeneration, thought to be dormant, may retain visual function
University of California, Los Angeles (UCLA), Health Sciences

New UCLA research in mice suggests that “dormant” cone photoreceptors in the degenerating retina are not dormant at all, but continue to function, producing responses to light and driving retinal activity for vision.

Newswise: Tiny nanoparticle could have big impact on patients receiving corneal transplants
Released: 24-Mar-2023 3:25 PM EDT
Tiny nanoparticle could have big impact on patients receiving corneal transplants
Virginia Commonwealth University (VCU)

Corneal transplants can be the last step to returning clear vision to many patients suffering from eye disease. Each year, approximately 80,000 corneal transplantations take place in the U.S. Worldwide, more than 184,000 corneal transplantation surgeries are performed annually.

   
Newswise: Visually navigating on foot uses unique brain region
Released: 15-Mar-2023 8:45 AM EDT
Visually navigating on foot uses unique brain region
NIH, National Eye Institute (NEI)

Using vision to efficiently move through an area by foot uses a unique region of the brain’s cortex, according to a small study funded by the National Eye Institute (NEI).

Newswise: AI-based systems can help identify rapidly advancing age-related macular degeneration
Released: 14-Mar-2023 3:35 PM EDT
AI-based systems can help identify rapidly advancing age-related macular degeneration
NIH, National Eye Institute (NEI)

Researchers supported by the National Eye Institute are developing artificial intelligence/machine learning (AI/ML)-based systems that not only screen for AMD but also predict which patients will likely progress to late within two years. The systems also evaluate separately one’s risk for developing late wet (neovascular) AMD from one’s risk for late dry (geographic atrophy) AMD.

Newswise: AI-based systems can help identify rapidly advancing age-related macular degeneration
Released: 14-Mar-2023 3:35 PM EDT
AI-based systems can help identify rapidly advancing age-related macular degeneration
NIH, National Eye Institute (NEI)

Researchers supported by the National Eye Institute are developing artificial intelligence/machine learning (AI/ML)-based systems that not only screen for AMD but also predict which patients will likely progress to late within two years. The systems also evaluate separately one’s risk for developing late wet (neovascular) AMD from one’s risk for late dry (geographic atrophy) AMD.

Newswise: New Insights: Eye Damage in Alzheimer’s Disease Patients
Released: 3-Mar-2023 10:05 AM EST
New Insights: Eye Damage in Alzheimer’s Disease Patients
Cedars-Sinai

Cedars-Sinai investigators have produced the most extensive analysis to date of changes in the retina—a layer of tissue at the back of the eye where visual information originates—and how those retinal changes correspond to brain and cognitive changes in Alzheimer’s disease patients.

Newswise: Eye experts weigh in on artificial tears in midst of infectious outbreak
Released: 2-Mar-2023 1:15 PM EST
Eye experts weigh in on artificial tears in midst of infectious outbreak
NIH, National Eye Institute (NEI)

Questions remain about artificial tears linked to an outbreak of Pseudomonas aeruginosa infections involving 64 people in 13 states, including 8 cases of vision loss, as well as lung and urinary tract infections, and one death. Federal agencies warned people to stop using EzriCare and Delsam Pharma artificial tears after tests of opened bottles used by those affected found a rare, extensively drug-resistant strain of P. aeruginosa. The strain had never been reported in the United States.What is clear is that eye health experts have advice for people using artificial tears, which are sold over the counter and widely used for eye irritation associated with dry eye disease, contact lens use, and refractive surgery, as well among those using other eye drops regularly, such as for glaucoma.

Newswise: Eye experts weigh in on artificial tears in midst of infectious outbreak
Released: 2-Mar-2023 1:15 PM EST
Eye experts weigh in on artificial tears in midst of infectious outbreak
NIH, National Eye Institute (NEI)

Questions remain about artificial tears linked to an outbreak of Pseudomonas aeruginosa infections involving 64 people in 13 states, including 8 cases of vision loss, as well as lung and urinary tract infections, and one death. Federal agencies warned people to stop using EzriCare and Delsam Pharma artificial tears after tests of opened bottles used by those affected found a rare, extensively drug-resistant strain of P. aeruginosa. The strain had never been reported in the United States.What is clear is that eye health experts have advice for people using artificial tears, which are sold over the counter and widely used for eye irritation associated with dry eye disease, contact lens use, and refractive surgery, as well among those using other eye drops regularly, such as for glaucoma.

Newswise: How Common is Face Blindness?
Released: 27-Feb-2023 12:05 PM EST
How Common is Face Blindness?
Harvard Medical School

Face blindness, a mystifying condition that can trick us into believing we recognize people we’ve never met or make us fail to recognize those we have, has been previously estimated to affect between 2 and 2.5 percent of people in the world. Now, a new study by researchers at Harvard Medical School (HMS) and the VA Boston Healthcare System is providing fresh insights into the disorder, suggesting it may be more common than currently believed.

Newswise: Early anti-VEGF treatment of diabetic retinopathy yields no benefit to visual acuity
2-Feb-2023 11:05 AM EST
Early anti-VEGF treatment of diabetic retinopathy yields no benefit to visual acuity
NIH, National Eye Institute (NEI)

While early treatment of diabetes-related eye disease slowed progression to severe disease, it did not improve visual acuity compared with treating more severe disease once it developed, according to a clinical study from the DRCR Retina Network.

Newswise: Early anti-VEGF treatment of diabetic retinopathy yields no benefit to visual acuity
2-Feb-2023 11:05 AM EST
Early anti-VEGF treatment of diabetic retinopathy yields no benefit to visual acuity
NIH, National Eye Institute (NEI)

While early treatment of diabetes-related eye disease slowed progression to severe disease, it did not improve visual acuity compared with treating more severe disease once it developed, according to a clinical study from the DRCR Retina Network.

Newswise: Researchers Unravel Why Episodes of Low Blood Sugar Worsen Eye Disease in People with Diabetes
Released: 26-Jan-2023 9:00 AM EST
Researchers Unravel Why Episodes of Low Blood Sugar Worsen Eye Disease in People with Diabetes
Johns Hopkins Medicine

People with diabetes who experience periods of low blood sugar — a common occurrence in those new to blood sugar management — are more likely to have worsening diabetic eye disease. Now, researchers at Johns Hopkins Medicine say they have linked such low blood sugar levels with a molecular pathway that is turned on in oxygen-starved cells in the eye.

Newswise: Zebrafish model helps explain eye development
Released: 12-Jan-2023 1:30 PM EST
Zebrafish model helps explain eye development
NIH, National Eye Institute (NEI)

Scientists at the National Eye Institute (NEI) have developed a zebrafish model of NEDBEH—a rare genetic disorder that can cause coloboma, where parts of the eye are missing due to developmental defects. The model provides a new tool for understanding the eye's embryonic development. The NEI is part of the National Institutes of Health.

Newswise: Zebrafish model helps explain eye development
Released: 12-Jan-2023 1:30 PM EST
Zebrafish model helps explain eye development
NIH, National Eye Institute (NEI)

Scientists at the National Eye Institute (NEI) have developed a zebrafish model of NEDBEH—a rare genetic disorder that can cause coloboma, where parts of the eye are missing due to developmental defects. The model provides a new tool for understanding the eye's embryonic development. The NEI is part of the National Institutes of Health.

Newswise: Dry eye disease alters how the eye’s cornea heals itself after injury
29-Dec-2022 3:15 PM EST
Dry eye disease alters how the eye’s cornea heals itself after injury
Washington University in St. Louis

Studying mice, researchers at Washington University School of Medicine in St. Louis have found that proteins made by stem cells to help regenerate the cornea may become new targets for treating and preventing injuries to the cornea related to dry eye disease. When eyes are dry, the cornea is more susceptible to injury.

Newswise:Video Embedded nih-researchers-use-3d-bioprinting-to-create-eye-tissue
VIDEO
20-Dec-2022 3:15 PM EST
NIH researchers use 3D bioprinting to create eye tissue
NIH, National Eye Institute (NEI)

Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases. The research team from the National Eye Institute (NEI), part of the National Institutes of Health, printed a combination of cells that form the outer blood-retina barrier—eye tissue that supports the retina's light-sensing photoreceptors. The technique provides a theoretically unlimited supply of patient-derived tissue to study degenerative retinal diseases such as age-related macular degeneration (AMD).

   
Newswise:Video Embedded nih-researchers-use-3d-bioprinting-to-create-eye-tissue
VIDEO
20-Dec-2022 3:15 PM EST
NIH researchers use 3D bioprinting to create eye tissue
NIH, National Eye Institute (NEI)

Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases. The research team from the National Eye Institute (NEI), part of the National Institutes of Health, printed a combination of cells that form the outer blood-retina barrier—eye tissue that supports the retina's light-sensing photoreceptors. The technique provides a theoretically unlimited supply of patient-derived tissue to study degenerative retinal diseases such as age-related macular degeneration (AMD).

   
Newswise: National Institutes of Health awards Case Western Reserve University $7.3M for eye research
Released: 9-Nov-2022 12:45 PM EST
National Institutes of Health awards Case Western Reserve University $7.3M for eye research
Case Western Reserve University

The National Institutes of Health (NIH) has awarded the Case Western Reserve University (CWRU) School of Medicine a five-year, $7.3 million grant to identify new technology, methods and models to study the impact of inflammation and pain on eye health, specifically the surface.

Newswise: NIH researchers home in on a new cause of Stargardt disease
Released: 27-Oct-2022 11:30 AM EDT
NIH researchers home in on a new cause of Stargardt disease
NIH, National Eye Institute (NEI)

Using a new stem-cell based model made from skin cells, scientists found the first direct evidence that Stargardt-related ABCA4 gene mutations affect a layer of cells in the eye called the retinal pigment epithelium (RPE).

Newswise: NIH researchers home in on a new cause of Stargardt disease
Released: 27-Oct-2022 11:30 AM EDT
NIH researchers home in on a new cause of Stargardt disease
NIH, National Eye Institute (NEI)

Using a new stem-cell based model made from skin cells, scientists found the first direct evidence that Stargardt-related ABCA4 gene mutations affect a layer of cells in the eye called the retinal pigment epithelium (RPE).

Newswise:Video Embedded nih-scientists-discover-essential-step-in-recharging-the-eye-s-light-sensing-retina
VIDEO
Released: 26-Oct-2022 1:30 PM EDT
NIH Scientists Discover Essential Step in Recharging the Eye’s Light-Sensing Retina
NIH, National Eye Institute (NEI)

Scientists have discovered a mechanism by which an area of a protein shape-shifts to convert vitamin A into a form usable by the eye’s light-sensing photoreceptor cells.

Newswise:Video Embedded nih-scientists-discover-essential-step-in-recharging-the-eye-s-light-sensing-retina
VIDEO
Released: 26-Oct-2022 1:30 PM EDT
NIH Scientists Discover Essential Step in Recharging the Eye’s Light-Sensing Retina
NIH, National Eye Institute (NEI)

Scientists have discovered a mechanism by which an area of a protein shape-shifts to convert vitamin A into a form usable by the eye’s light-sensing photoreceptor cells.

Newswise:Video Embedded 3d-map-reveals-dna-organization-within-human-retina-cells
VIDEO
4-Oct-2022 1:05 PM EDT
3D map reveals DNA organization within human retina cells
NIH, National Eye Institute (NEI)

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell’s nucleus. The resulting comprehensive gene regulatory network provides insights into regulation of gene expression in general, and in retinal function, in both rare and common eye diseases. The study published in Nature Communications.

Newswise:Video Embedded 3d-map-reveals-dna-organization-within-human-retina-cells
VIDEO
4-Oct-2022 1:05 PM EDT
3D map reveals DNA organization within human retina cells
NIH, National Eye Institute (NEI)

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell’s nucleus. The resulting comprehensive gene regulatory network provides insights into regulation of gene expression in general, and in retinal function, in both rare and common eye diseases. The study published in Nature Communications.

Newswise: NIH researchers develop gene therapy for rare ciliopathy
6-Sep-2022 8:05 AM EDT
NIH researchers develop gene therapy for rare ciliopathy
NIH, National Eye Institute (NEI)

Researchers from the National Eye Institute (NEI) have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Leber congenital amaurosis (LCA), a disease that causes blindness in early childhood.

Newswise: NIH researchers develop gene therapy for rare ciliopathy
6-Sep-2022 8:05 AM EDT
NIH researchers develop gene therapy for rare ciliopathy
NIH, National Eye Institute (NEI)

Researchers from the National Eye Institute (NEI) have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Leber congenital amaurosis (LCA), a disease that causes blindness in early childhood.

Newswise: High-Tech Imaging Reveals Details About Rare Eye Disorder
26-Jul-2022 10:05 PM EDT
High-Tech Imaging Reveals Details About Rare Eye Disorder
NIH, National Eye Institute (NEI)

Using a new imaging technique, researchers from the National Eye Institute have determined that retinal lesions from vitelliform macular dystrophy (VMD) vary by gene mutation. Addressing these differences may be key in designing effective treatments for this and other rare diseases. NEI is part of the National Institutes of Health.

Newswise: High-Tech Imaging Reveals Details About Rare Eye Disorder
26-Jul-2022 10:05 PM EDT
High-Tech Imaging Reveals Details About Rare Eye Disorder
NIH, National Eye Institute (NEI)

Using a new imaging technique, researchers from the National Eye Institute have determined that retinal lesions from vitelliform macular dystrophy (VMD) vary by gene mutation. Addressing these differences may be key in designing effective treatments for this and other rare diseases. NEI is part of the National Institutes of Health.

Newswise: Black Patients Found Six Times More Likely to Have Advanced Vision Loss After Glaucoma Diagnosis Than White Patients
20-Jul-2022 8:30 AM EDT
Black Patients Found Six Times More Likely to Have Advanced Vision Loss After Glaucoma Diagnosis Than White Patients
Mount Sinai Health System

Black patients have a dramatically higher risk of advanced vision loss after a new diagnosis of primary open angle glaucoma (POAG) when compared to white patients, according to a new study from New York Eye and Ear Infirmary of Mount Sinai (NYEE).


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