A two-year study found that spikes of post-vaccination SARS-CoV-2 viral infections (commonly known as COVID-19 breakthrough cases) remain common, yet hospitalization rates have dramatically dropped following the first wave of the virus’ omicron subvariant.
A new study finds that the longer a person has type 2 diabetes, the more likely they may be to experience changes in brain structure. MRI results, researchers say, indicate the negative effects longstanding diabetes may have on brain health outcomes and emphasize the importance of preventing early onset type 2 diabetes.
Researchers at Vanderbilt University Medical Center have received a four-year, $28 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, to study the relationship between COVID-19 and diabetes.
New insights into the underlying mechanisms of Type 2 diabetes and novel potential therapeutic targets for the disease were revealed in a recent study.
Conventional wisdom holds that storing fat around your belly puts you at increased risk for type 2 diabetes. But surprising new findings from the University of Virginia School of Medicine suggest that naturally occurring variations in our genes can lead some people to store fat at the waist but also protect them from diabetes.
People who carry the gene variant associated with the strongest risk for Alzheimer’s disease may lose their ability to detect odors earlier than people who do not carry the gene variant, which may be an early sign of future memory and thinking problems, according to a study published in the July 26, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. The gene variant associated with this increased risk of Alzheimer’s is called APOE e4.
Understanding how this blood-sugar detection system works and how these neurocircuits operate would give researchers and doctors greater insights into how our brains regulate our blood sugar and, perhaps, how to target them therapeutically to treat metabolic diseases like diabetes and obesity, according to the study authors.
In a study led by Johns Hopkins Medicine, in collaboration with Yale School of Medicine, researchers have identified a biomarker found via a simple urine test that can be used to diagnose acute tubulointerstitial nephritis (AIN), a medical condition that causes inflammation of the kidneys and can lead to acute kidney injury (AKI) — a sudden loss of kidney function. Experts say a kidney biopsy is often required to diagnose AIN because there are no disease-specific signs or symptoms.
Scientists have taken an important step forward in predicting who will develop Type 1 diabetes months before symptoms appear.
Researchers with UC San Diego School of Medicine identified a potential new drug that improved liver fibrosis in patients with NASH by 27%.
Results from a new study of diabetic foot ulcers and the risk of wound recurrence show that a new approach can help health care workers measure the likelihood that the wound will reopen in the future.
Monthly cash payments to eligible families under the temporary pandemic-era expansion of the federal Child Tax Credit led to better adult health and food security, new UCLA-led research suggests.
Stella Hoft, a M.D./Ph.D. student at Saint Louis University’s School of Medicine, was recently awarded a F30 Grant through the National Institute of Diabetes & Digestive & Kidney Diseases.
Rich DiPaolo, Ph.D., professor and interim chair in the Department of Molecular Microbiology and Immunology, warns that patients with gastritis caused by autoimmunity as well as Helicobacter pylori, a type of bacteria that infects your stomach, may benefit from routine screenings to identify patients with a high risk of progressing to gastric cancer.
Unfortunately, effective medical therapies do not exist for this population of patients, Dr. Pavan Bhatraju said. In their paper, the investigators proposed a way to classify subpopulations of AKI patients with the aim of identifying therapies specific patient populations.
Researchers from Sanford Burnham Prebys and the Chinese University of Hong Kong have developed a computational approach to predict whether a person with type 2 diabetes will develop kidney disease. The findings could help doctors prevent or better manage kidney disease in people with type 2 diabetes.
Sian Piret, PhD, in the Renaissance School of Medicine at Stony Brook University, has received a $1.4 million grant from the National Institute of Health’s National Institute of Diabetes and Digestive and Kidney Diseases to investigate a certain metabolic process called BCAA catabolism that is known to occur with acute kidney injury, but its exact role remains unknown.
Researchers at Washington University School of Medicine in St. Louis have identified four important signs and symptoms that signal an elevated risk of early-onset colorectal cancer. The incidence of colorectal cancer is rising in people under 50, making it important to recognize such signs.
If more people have access to health insurance, we have to be sure the death rates of those with certain chronic conditions are decreasing.
Type 2 diabetes (T2D) is surging among U.S. children. The number of youths under age 20 living with the disease has nearly doubled between 2001 and 2017, and yet—aside from increases in childhood obesity—the reasons for this disturbing increase are not clear. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH), has awarded the Children’s Hospital at Montefiore (CHAM) and Albert Einstein College of Medicine a six-year, $4.1 million grant to identify the biological and social factors that cause children and adolescents to develop the condition.
New UCLA research suggests that a novel machine-learning technique known as "causal forest" was about five times more efficient than the current clinical practice of treating patients with high blood pressure.
Chronic kidney disease is a strong cardiovascular risk factor and is often accompanied by hypertension and diabetes. A new risk model for cardiovascular disease, developed by Penn, was found to be more accurate than existing clinical models.
As jobless rates rose during the COVID-19 pandemic, millions more Americans experienced food insecurity because they lacked consistent access to food. National health organizations recommend primary care providers screen patients for food insecurity, since not having access to enough food can lead to chronic diseases.
All racial/ethnic minority groups develop diabetes at lower weights than white adults
Northwestern University researchers have developed a first-of-its-kind small, flexible, stretchable bandage that accelerates healing by delivering electrotherapy directly to the wound site.
Analyzing the most extensive datasets in the U.S., researchers from the Icahn School of Medicine at Mount Sinai have revealed that vaccination against COVID-19 is associated with fewer heart attacks, strokes, and other cardiovascular issues among people who were infected with SARS-CoV-2, the virus that causes COVID-19. The research letter, “Impact of Vaccination on Major Adverse Cardiovascular Events in Patients with COVID-19 Infection,” was published in the Journal of the American College of Cardiology on February 20. The research will also be presented on March 5, 2023 in a poster session in New Orleans, LA, at the American College of Cardiology’s 72nd Annual Scientific Session Together With World Heart Federation’s World Congress of Cardiology.
Nutrition researchers studied 80 people with nonalcoholic fatty liver disease and found that those who followed an alternate-day fasting diet and exercised were able to improve their health. In Cell Metabolism, the researchers report that over a period of three months people in the intervention saw increased insulin sensitivity and decreased liver fat, weight and ALT, or alanine transaminase enzymes, which are markers for liver disease.
University of Virginia School of Medicine researchers have discovered a key trigger for non-alcoholic fatty liver disease, a mysterious condition that causes fat to build up in the liver for no clear reason.
In a new study led by Children’s Hospital of Philadelphia (CHOP) and Nemours Children’s Health, researchers have overcome the obstacle of scale by analyzing electronic health record data from PEDSnet, a national multicenter pediatric network, to identify a large cohort of children with CKD, evaluate CKD progression, and examine clinical risk factors for kidney function decline. The findings were published in the Clinical Journal of the American Society of Nephrology.
In the past decade, researchers have begun to appreciate the importance of a two-way communication that occurs between microbes in the gastrointestinal tract and the brain, known as the gut–brain axis.
Researchers at Washington University School of Medicine in St. Louis have found that a defect in an enzyme called APT1 interferes with the ability to secrete insulin, contributing to the development of Type 2 diabetes in people who are overweight or obese.
Studying mice, researchers at Washington University School of Medicine in St. Louis have found that proteins made by stem cells to help regenerate the cornea may become new targets for treating and preventing injuries to the cornea related to dry eye disease. When eyes are dry, the cornea is more susceptible to injury.
Youth who underwent metabolic and bariatric surgery as teenagers are at heightened risk for alcohol use, according to the first study to document long-term alcohol use and associated issues in this population. Researchers found that after eight years, nearly half of study participants had alcohol use disorders, symptoms of alcohol-related harm, or alcohol-related problems. Results were published in the journal Annals of Surgery.
While use of insulin pumps to manage type 1 diabetes has grown over 20 years, there has been no improvement in racial, ethnic, and socioeconomic disparities in their use.
Analysis shows steep increases in organ donations, transplantations during large motorcycle rallies. The increase in organ donations and transplantations appears to be driven by well-documented increases in crash-related deaths during large motorcycle rallies.
A new study by Cedars-Sinai investigators describes risk factors that could make it more likely for people who have chronic pancreatitis, an ongoing inflammation of the pancreas, to develop diabetes. The findings are published in Diabetes Care.
New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, demonstrated that withholding mycophenolate mofetil for 10 days significantly increased antibody response after 2 doses of COVID-19 vaccine, without a significant increase in flares.
In the battle of the sexes, women beat men in their ability to recover from kidney injury, but the reasons are not well understood. A study led by Duke Health researchers provides some insights: Females, it turns out, have an advantage at the molecular level that protects them from a form of cell death that occurs in injured kidneys. This protection could be exploited as a potential therapeutic.
New study identifies that first-degree relatives of patients with nonalcoholic fatty liver disease with advanced fibrosis (scarring of the liver) are at a 15% risk of developing the condition.
A device known as a bionic pancreas, which uses next-generation technology to automatically deliver insulin, was more effective at maintaining blood glucose (sugar) levels within normal range than standard-of-care management among people with type 1 diabetes, a new multicenter clinical trial has found.
In 2015, published findings from the landmark Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive blood pressure management reduced cardiovascular disease and lowered the risk of death. In 2019, results of the SPRINT MIND trial showed that lowering blood pressure also reduced the risk of mild cognitive impairment in older adults. Now, researchers from Wake Forest University School of Medicine have shown that while intensive blood pressure control was beneficial to SPRINT participants’ health during the trial, the benefits for cardiovascular mortality went away after approximately two years when protocols for blood pressure management were no longer being followed.
Multiple lipid biomarkers are linked to the development of neuropathy in patients with type 2 diabetes, a new study finds. Participants with high scores for diabetic neuropathy had changes in lipids reflecting impaired energy metabolism. Researchers say the findings bring potential to identify those with the highest risk of developing disease and facilitate more focused management.
Our guts, and all our organs, are arranged in left-right asymmetric patterns inside our bodies, so that everything may fit.
Scientists at Tufts University have discovered a pathway through which communications are regulated in the brain, and a misfire in the messaging can result in overeating, slower burning of calories, and other metabolic problems linked to obesity.
Analysis suggests undiagnosed diabetes is more prevalent in certain subgroups, including older and obese adults, racial/ethnic minorities, and those without health care access.
New research in rats finds a diet high in the fiber inulin offered a protective effect against the damage of a high-salt diet. The research will be presented this week at the American Physiological Society and American Society for Nephrology Control of Renal Function in Health and Disease conference
UC San Diego researchers describe connection between pediatric liver disease and increased risk of developing type 2 diabetes. Both rates are rising in children.
Scientists sought to determine whether high blood glucose blunts the body’s response to exercise and whether lowering it can restore the ability to improve aerobic capacity with training.
Joslin Diabetes Center, the preeminent institution for diabetes research and care, affiliated with Harvard Medical School and a part of Beth Israel Lahey Health, has again been awarded $8.5 million from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK) in continued support for Joslin’s Diabetes Research Center (DRC) program. The grant, which officially began April 1, 2022, marks the 36th continuous year of NIH investment in Joslin’s DRC.
Black kidney transplant recipients have a faster clearance rate of the immunosuppressive drug tacrolimus than white recipients, according to a new study led by the University at Buffalo. The study, published earlier this year in Pharmacotherapy, is one of the first to examine how both race and sex influence tacrolimus pharmacokinetics.
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