Curated News: National Institute of Dental and Craniofacial Research (NIDCR)

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Embargo will expire: 26-Feb-2020 11:00 AM EST Released to reporters: 19-Feb-2020 1:10 PM EST

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Released: 18-Feb-2020 8:00 AM EST
Study Reveals How Too Much Fluoride Causes Defects in Tooth Enamel
New York University

Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel—a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises. The study, led by researchers at NYU College of Dentistry, is published in Science Signaling.

Released: 11-Feb-2020 2:15 PM EST
Absent p53, oral cancers recruit and reprogram nerves to fuel tumor growth
University of Texas M. D. Anderson Cancer Center

Loss of an important tumor-suppressing gene allows head and neck cancer to spin off signals to nearby nerves, changing their function and recruiting them to the tumor, where they fuel growth and cancer progress.

Newswise: Mouse Study Shows Nerve Signaling Pathway Critical to Healing Fractures
Released: 5-Dec-2019 11:00 AM EST
Mouse Study Shows Nerve Signaling Pathway Critical to Healing Fractures
Johns Hopkins Medicine

Sticks and stones may break one’s bones, but healing them requires the production of a protein signal that stimulates the generation, growth and spread of vital nerve cells, or neurons, throughout the injured area. That’s the finding of a recent Johns Hopkins Medicine study that used mice to demonstrate what likely takes place during human fracture repair as well.

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