Curated News: National Eye Institute (NEI)

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Newswise: Scientists Uncover How Decisions About What We See Are Relayed Back Through the Brain
Released: 27-Jul-2021 9:30 AM EDT
Scientists Uncover How Decisions About What We See Are Relayed Back Through the Brain
NIH, National Eye Institute (NEI)

Researchers at the National Institutes of Health have discovered that decisions based on visual information, which involve a complex stream of data flowing forward and backwards along the brain’s visual pathways, is broadcast widely to neurons in the visual system, including to those that are not being used to make the decision.

Newswise: Scientists Uncover How Decisions About What We See Are Relayed Back Through the Brain
Released: 27-Jul-2021 9:30 AM EDT
Scientists Uncover How Decisions About What We See Are Relayed Back Through the Brain
NIH, National Eye Institute (NEI)

Researchers at the National Institutes of Health have discovered that decisions based on visual information, which involve a complex stream of data flowing forward and backwards along the brain’s visual pathways, is broadcast widely to neurons in the visual system, including to those that are not being used to make the decision.

19-Jul-2021 9:25 AM EDT
Gene Therapy May Preserve Vision in Retinal Disease and Serious Retinal Injury
Mount Sinai Health System

Mount Sinai researchers uncover a potential pathway for treatment that can prevent blindness

Newswise: Scientists Discover Gene Therapy Provides Neuroprotection to Prevent Glaucoma Vision Loss
19-Jul-2021 2:35 PM EDT
Scientists Discover Gene Therapy Provides Neuroprotection to Prevent Glaucoma Vision Loss
NIH, National Eye Institute (NEI)

A form of gene therapy protects optic nerve cells and preserves vision in mouse models of glaucoma, according to research supported by NIH’s National Eye Institute. The findings suggest a way forward for developing neuroprotective therapies for glaucoma, a leading cause of visual impairment and blindness.

Newswise: Scientists Discover Gene Therapy Provides Neuroprotection to Prevent Glaucoma Vision Loss
19-Jul-2021 2:35 PM EDT
Scientists Discover Gene Therapy Provides Neuroprotection to Prevent Glaucoma Vision Loss
NIH, National Eye Institute (NEI)

A form of gene therapy protects optic nerve cells and preserves vision in mouse models of glaucoma, according to research supported by NIH’s National Eye Institute. The findings suggest a way forward for developing neuroprotective therapies for glaucoma, a leading cause of visual impairment and blindness.

Released: 30-Jun-2021 11:55 AM EDT
Dry Eye Awareness Month 2021 Focuses on a Looming Lifestyle Epidemic—Ocular Surface Disease
Association for Research in Vision and Ophthalmology (ARVO)

The vision community and its coalition partners announce awareness and educational activities in July 2021 around the annual recognition of Dry Eye Awareness Month.

Newswise: NIH-Funded Study Shows Children Recycle Brain Regions When Acquiring New Skills
Released: 21-Jun-2021 9:45 AM EDT
NIH-Funded Study Shows Children Recycle Brain Regions When Acquiring New Skills
NIH, National Eye Institute (NEI)

Scientists studied the brain activity of school-aged children during development and found that regions that activated upon seeing limbs (hands, legs, etc.) subsequently activated upon seeing faces or words when the children grew older. The research, by scientists at Stanford University, Palo Alto, California, reveals new insights about vision development in the brain and could help inform prevention and treatment strategies for learning disorders. The study was funded by the National Eye Institute and is published in Nature Human Behaviour.

Newswise: NIH-Funded Study Shows Children Recycle Brain Regions When Acquiring New Skills
Released: 21-Jun-2021 9:45 AM EDT
NIH-Funded Study Shows Children Recycle Brain Regions When Acquiring New Skills
NIH, National Eye Institute (NEI)

Scientists studied the brain activity of school-aged children during development and found that regions that activated upon seeing limbs (hands, legs, etc.) subsequently activated upon seeing faces or words when the children grew older. The research, by scientists at Stanford University, Palo Alto, California, reveals new insights about vision development in the brain and could help inform prevention and treatment strategies for learning disorders. The study was funded by the National Eye Institute and is published in Nature Human Behaviour.

Newswise: Scientists unravel the function of a sight-saving growth factor
Released: 16-Jun-2021 4:05 PM EDT
Scientists unravel the function of a sight-saving growth factor
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) have determined how certain short protein fragments, called peptides, can protect neuronal cells found in the light-sensing retina layer at the back of the eye. The peptides might someday be used to treat degenerative retinal diseases, such as age-related macular degeneration (AMD).

Newswise: Scientists unravel the function of a sight-saving growth factor
Released: 16-Jun-2021 4:05 PM EDT
Scientists unravel the function of a sight-saving growth factor
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) have determined how certain short protein fragments, called peptides, can protect neuronal cells found in the light-sensing retina layer at the back of the eye. The peptides might someday be used to treat degenerative retinal diseases, such as age-related macular degeneration (AMD).

Newswise:Video Embedded what-makes-us-sneeze
VIDEO
14-Jun-2021 5:20 PM EDT
What makes us sneeze?
Washington University in St. Louis

What exactly triggers a sneeze? A team led by researchers at Washington University School of Medicine in St. Louis has identified, in mice, specific cells and proteins that control the sneeze reflex. Better understanding of what causes us to sneeze — specifically how neurons behave in response to allergens and viruses — may point to treatments capable of slowing the spread of infectious respiratory diseases.

Newswise: Case Western Reserve-led research team aims to determine which diabetic individuals can successfully donate corneas for transplant (and which should not)
Released: 25-May-2021 9:20 AM EDT
Case Western Reserve-led research team aims to determine which diabetic individuals can successfully donate corneas for transplant (and which should not)
Case Western Reserve University

In a new study, supported by a five-year, $6.4 million grant from the National Eye Institute of the National Institutes of Health, researchers from Case Western Reserve University, University Hospitals and the Jaeb Center for Health Research, aim to finally determine which diabetic individuals can successfully donate their corneas for keratoplasty (and which should not).

Newswise:Video Embedded audacious-projects-develop-imaging-technology-to-aid-eye-tissue-regeneration2
VIDEO
Released: 22-Apr-2021 2:15 PM EDT
Audacious projects develop imaging technology to aid eye tissue regeneration
NIH, National Eye Institute (NEI)

As regenerative therapies for blinding diseases move closer to clinical trials, the National Eye Institute’s functional imaging consortium, a part of the NEI Audacious Goals Initiative (AGI), is pioneering noninvasive technologies to monitor the function of the retina’s light-sensing neurons and their connections to the brain.

Newswise:Video Embedded an-artificial-retina-engineered-from-ancient-protein-heads-to-space
VIDEO
Released: 13-Apr-2021 1:15 PM EDT
An Artificial Retina Engineered From Ancient Protein Heads to Space
NIH, National Eye Institute (NEI)

NIH supported early testing of the artificial retina. Now, scientists are testing whether manufacturing it on the International Space Station results in a viable treatment for people with blinding eye diseases.

Newswise: Preventive treatment reduces diabetic retinopathy complications
26-Mar-2021 12:00 PM EDT
Preventive treatment reduces diabetic retinopathy complications
NIH, National Eye Institute (NEI)

Early treatment with anti-VEGF injections slowed diabetic retinopathy in a clinical study from the DRCR Retina Network (DRCR.net). However, two years into the four-year study its effect on vision was similar to standard treatment, which usually begins at the onset of late disease.

Newswise: Preventive treatment reduces diabetic retinopathy complications
26-Mar-2021 12:00 PM EDT
Preventive treatment reduces diabetic retinopathy complications
NIH, National Eye Institute (NEI)

Early treatment with anti-VEGF injections slowed diabetic retinopathy in a clinical study from the DRCR Retina Network (DRCR.net). However, two years into the four-year study its effect on vision was similar to standard treatment, which usually begins at the onset of late disease.

Released: 18-Mar-2021 9:35 AM EDT
National Eye Institute launches data portal for macular degeneration research
NIH, National Eye Institute (NEI)

The National Eye Institute (NEI) Data Commons now enables researchers to access data from patients with macular degeneration who participated in the Age-related Eye Disease Study 2 (AREDS2). The database complements newly available stem cell lines created by the New York Stem Cell Foundation Research Institute (NYSCF) from blood cells of AREDS2 study participants.

22-Feb-2021 3:20 PM EST
International Team Identifies 127 Glaucoma Genes in Largest Study of Its Kind
Massachusetts Eye and Ear

In the largest genome-wide association study of glaucoma to date, an international team of researchers compared the genes of 34,179 people with the disease to 349,321 control subjects. They identified 127 genes linked to glaucoma, including 44 new gene loci and confirmed 83 previously reported loci.

Newswise:Video Embedded johns-hopkins-scientists-find-mammals-share-gene-pathways-that-allow-zebrafish-to-grow-new-eyes
VIDEO
Released: 11-Feb-2021 1:45 PM EST
Johns Hopkins Scientists Find Mammals Share Gene Pathways That Allow Zebrafish To Grow New Eyes
Johns Hopkins Medicine

Working with fish, birds and mice, Johns Hopkins Medicine researchers report new evidence that some animals’ natural capacity to regrow neurons is not missing, but is instead inactivated in mammals. Specifically, the researchers found that some genetic pathways that allow many fish and other cold-blooded animals to repair specialized eye neurons after injury remain present in mammals as well, but are turned off, blocking regeneration and healing.

Newswise: Cold sores: Discovery reveals how stress, illness and even sunburn trigger flareups
Released: 11-Feb-2021 8:05 AM EST
Cold sores: Discovery reveals how stress, illness and even sunburn trigger flareups
University of Virginia Health System

The finding could lead to new ways to prevent cold sores and herpes-related eye disease from reoccurring, the researchers report.

Newswise: Researchers use patients’ cells to test gene therapy for rare eye disease
25-Jan-2021 4:10 PM EST
Researchers use patients’ cells to test gene therapy for rare eye disease
NIH, National Eye Institute (NEI)

Scientists at the National Eye Institute (NEI) have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood. A form of Leber congenital amaurosis, the disease is caused by autosomal-dominant mutations in the CRX gene, which are challenging to treat with gene therapy.

Newswise: Researchers use patients’ cells to test gene therapy for rare eye disease
25-Jan-2021 4:10 PM EST
Researchers use patients’ cells to test gene therapy for rare eye disease
NIH, National Eye Institute (NEI)

Scientists at the National Eye Institute (NEI) have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood. A form of Leber congenital amaurosis, the disease is caused by autosomal-dominant mutations in the CRX gene, which are challenging to treat with gene therapy.

Released: 21-Jan-2021 12:00 PM EST
ARVO Foundation Announces 2021 Mallinckrodt Uveitis Research Fellowship Recipient
Association for Research in Vision and Ophthalmology (ARVO)

The Association for Research in Vision and Ophthalmology (ARVO) today announced the recipient of the Mallinckrodt Uveitis Research Fellowship, generously funded by Mallinckrodt Pharmaceuticals. The award, funded through the ARVO Foundation, supports an early career investigator with a one-year grant of $45,000 to study an aspect of uveitis or other inflammatory conditions of the eye. The 2021 awardee is Shilpa Kodati, MD of the National Eye Institute (NEI) at the National Institutes of Health (NIH).

Newswise: A Rift in the Retina May Help Repair the Optic Nerve
Released: 14-Jan-2021 9:00 AM EST
A Rift in the Retina May Help Repair the Optic Nerve
Johns Hopkins Medicine

In experiments in mouse tissues and human cells, Johns Hopkins Medicine researchers say they have found that removing a membrane that lines the back of the eye may improve the success rate for regrowing nerve cells damaged by blinding diseases. The findings are specifically aimed at discovering new ways to reverse vision loss caused by glaucoma and other diseases that affect the optic nerve, the information highway from the eye to the brain.

Released: 17-Dec-2020 1:25 PM EST
Study in mice shows genes may be altered through drug repurposing
University of Illinois Chicago

Researchers at the University of Illinois Chicago have published a study showing a promising approach to using drug repurposing to treat genetic diseases. A team from the UIC Department of Ophthalmology and Visual Sciences published the article, “Gene dosage manipulation alleviates manifestations of hereditary PAX6 haploinsufficiency in mice” in the journal Science Translational Medicine.

Newswise: NIH researchers discover brain area crucial for recognizing visual events
Released: 17-Dec-2020 11:00 AM EST
NIH researchers discover brain area crucial for recognizing visual events
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) report that a brain region in the superior temporal sulcus (fSTS) is crucial for processing and making decisions about visual information.

Newswise: NIH researchers discover brain area crucial for recognizing visual events
Released: 17-Dec-2020 11:00 AM EST
NIH researchers discover brain area crucial for recognizing visual events
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) report that a brain region in the superior temporal sulcus (fSTS) is crucial for processing and making decisions about visual information.

Newswise: Surgical and drug treatment options lead to similar outcomes for diabetic eye disease
10-Dec-2020 4:20 PM EST
Surgical and drug treatment options lead to similar outcomes for diabetic eye disease
NIH, National Eye Institute (NEI)

Surgical and injectable drug approaches are equally effective for treatment of bleeding inside the eye from proliferative diabetic retinopathy (PDR), according to a National Eye Institute (NEI)-supported clinical study from the DRCR Retina Network (DRCR.net).

Newswise: Study suggests sugary diet endangers waste-eating protein crucial to cellular repair
Released: 15-Dec-2020 9:20 AM EST
Study suggests sugary diet endangers waste-eating protein crucial to cellular repair
Tufts University

A high-sugar diet creates a ‘double jeopardy’ impact for a protein crucial to cellular housekeeping, a new study suggests. The protein offsets cell damage from sugar, but too much sugar renders it ineffective. The results may offer insight for reducing age-related degenerative disease.

Newswise: Envision color: Activity patterns in the brain are specific to the color you see
12-Nov-2020 12:00 PM EST
Envision color: Activity patterns in the brain are specific to the color you see
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) have decoded brain maps of human color perception. The findings, published today in Current Biology, open a window into how color processing is organized in the brain, and how the brain recognizes and groups colors in the environment. The study may have implications for the development of machine-brain interfaces for visual prosthetics. NEI is part of the National Institutes of Health.

Newswise: Envision color: Activity patterns in the brain are specific to the color you see
12-Nov-2020 12:00 PM EST
Envision color: Activity patterns in the brain are specific to the color you see
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) have decoded brain maps of human color perception. The findings, published today in Current Biology, open a window into how color processing is organized in the brain, and how the brain recognizes and groups colors in the environment. The study may have implications for the development of machine-brain interfaces for visual prosthetics. NEI is part of the National Institutes of Health.

Newswise: Biologists Create “Atlas” of Gene Expression in Neurons, Documenting the Diversity of Brain Cells
29-Oct-2020 12:55 PM EDT
Biologists Create “Atlas” of Gene Expression in Neurons, Documenting the Diversity of Brain Cells
New York University

New York University researchers have created a “developmental atlas” of gene expression in neurons, using gene sequencing and machine learning to categorize more than 250,000 neurons in the brains of fruit flies. Their study, published in Nature, finds that neurons exhibit the most molecular diversity during development and reveals a previously unknown type of neurons only present before flies hatch.

Newswise: Cornea appears to resist infection from novel coronavirus
2-Nov-2020 4:30 PM EST
Cornea appears to resist infection from novel coronavirus
Washington University in St. Louis

Although viruses such as herpes simplex can infect the eye's cornea and Zika virus has been found in corneal tissue and tears, new research from Washington University School of Medicine in St. Louis suggests the cornea can resist infection from the novel coronavirus.

Newswise: Scientists use gene therapy and a novel light-sensing protein to restore vision in mice
20-Oct-2020 8:30 AM EDT
Scientists use gene therapy and a novel light-sensing protein to restore vision in mice
NIH, National Eye Institute (NEI)

A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to Nanoscope, LLC for development of MCO1. The company is planning a U.S. clinical trial for later this year.

Newswise: Scientists use gene therapy and a novel light-sensing protein to restore vision in mice
20-Oct-2020 8:30 AM EDT
Scientists use gene therapy and a novel light-sensing protein to restore vision in mice
NIH, National Eye Institute (NEI)

A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to Nanoscope, LLC for development of MCO1. The company is planning a U.S. clinical trial for later this year.

Newswise: FAU Researchers Receive $1.3 Million NIH Grant for Stem Cell Research
Released: 14-Oct-2020 8:30 AM EDT
FAU Researchers Receive $1.3 Million NIH Grant for Stem Cell Research
Florida Atlantic University

The NIH grant will enable FAU scientists to identify the gene regulation pathways activated to program immature stem-like cells of the eye lens to attain their mature form and transparent function. The research team plans to explore the genetic and cellular mechanisms controlling developmental DNA conformational changes and will identify the transcription factors needed for eye lens formation.

Newswise:Video Embedded could-a-tiny-fish-hold-the-key-to-curing-blindness
VIDEO
Released: 25-Sep-2020 6:05 PM EDT
Could a tiny fish hold the key to curing blindness?
NIH, National Eye Institute (NEI)

Imagine this: A patient learns that they are losing their sight because an eye disease has damaged crucial cells in their retina. Then, under the care of their doctor, they simply grow some new retinal cells, restoring their vision. Although science hasn’t yet delivered this happy ending, researchers are working on it – with help from the humble zebrafish. When a zebrafish loses its retinal cells, it grows new ones. This observation has encouraged scientists to try hacking the zebrafish’s innate regenerative capacity to learn how to treat human disease. That is why among the National Eye Institute’s 1,200 active research projects, nearly 80 incorporate zebrafish.

Newswise:Video Embedded could-a-tiny-fish-hold-the-key-to-curing-blindness
VIDEO
Released: 25-Sep-2020 6:05 PM EDT
Could a tiny fish hold the key to curing blindness?
NIH, National Eye Institute (NEI)

Imagine this: A patient learns that they are losing their sight because an eye disease has damaged crucial cells in their retina. Then, under the care of their doctor, they simply grow some new retinal cells, restoring their vision. Although science hasn’t yet delivered this happy ending, researchers are working on it – with help from the humble zebrafish. When a zebrafish loses its retinal cells, it grows new ones. This observation has encouraged scientists to try hacking the zebrafish’s innate regenerative capacity to learn how to treat human disease. That is why among the National Eye Institute’s 1,200 active research projects, nearly 80 incorporate zebrafish.

Released: 25-Aug-2020 3:05 PM EDT
Why We Distort Probability
New York University

A team of scientists , using experimental research, has concluded that our cognitive limitations lead to probability distortions and to subsequent errors in decision-making.

Newswise: American Cleaning Institute Partners with NIH’s National Eye Institute on Ocular Safety
Released: 20-Aug-2020 4:15 PM EDT
American Cleaning Institute Partners with NIH’s National Eye Institute on Ocular Safety
American Cleaning Institute

The American Cleaning Institute launched a partnership with the National Institutes of Health’s (NIH) National Eye Institute (NEI) as part of the Packets Up! campaign to help educate families on the simple steps to prevent accidental eye exposures among children in the laundry room.

Newswise: Nanoparticles enhance gene therapies for eye disease
Released: 14-Aug-2020 4:35 PM EDT
Nanoparticles enhance gene therapies for eye disease
National Institute of Biomedical Imaging and Bioengineering

NIBIB-funded researchers have created nanoparticles for successful gene therapy of a mouse model of macular degeneration. The nanoparticle carriers have the potential to significantly expand the effectiveness of gene therapies for human eye diseases, including blindness.

Newswise:Video Embedded multifocal-contact-lenses-slow-myopia-progression-in-children
VIDEO
6-Aug-2020 1:55 PM EDT
Multifocal contact lenses slow myopia progression in children
NIH, National Eye Institute (NEI)

Children wearing multifocal contact lenses had slower progression of their myopia, according to results from a clinical trial funded by the National Eye Institute, part of the National Institutes of Health. The findings support an option for controlling the condition, also called nearsightedness, which increases the risk of cataracts, glaucoma and retinal detachment later in life. Investigators of the Bifocal Lenses In Nearsighted Kids (BLINK) Study published the results August 11 in the Journal of the American Medical Association.

Newswise:Video Embedded multifocal-contact-lenses-slow-myopia-progression-in-children
VIDEO
6-Aug-2020 1:55 PM EDT
Multifocal contact lenses slow myopia progression in children
NIH, National Eye Institute (NEI)

Children wearing multifocal contact lenses had slower progression of their myopia, according to results from a clinical trial funded by the National Eye Institute, part of the National Institutes of Health. The findings support an option for controlling the condition, also called nearsightedness, which increases the risk of cataracts, glaucoma and retinal detachment later in life. Investigators of the Bifocal Lenses In Nearsighted Kids (BLINK) Study published the results August 11 in the Journal of the American Medical Association.

Released: 30-Jul-2020 4:20 PM EDT
Researchers Discover Stem Cells in Optic Nerve that Preserve Vision
University of Maryland Medical Center

Researchers at the University of Maryland School of Medicine (UMSOM) have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. The finding presents a new theory on why the most common form of glaucoma may develop and potential for new therapies.

Newswise: Dual role discovered for molecule involved in autoimmune eye disease
Released: 23-Jul-2020 11:00 AM EDT
Dual role discovered for molecule involved in autoimmune eye disease
NIH, National Eye Institute (NEI)

The inflammatory molecule interleukin-17A (IL-17A) triggers immune cells that in turn reduce IL-17A’s pro-inflammatory activity, according to a study by National Eye Institute (NEI) researchers.

Newswise: Dual role discovered for molecule involved in autoimmune eye disease
Released: 23-Jul-2020 11:00 AM EDT
Dual role discovered for molecule involved in autoimmune eye disease
NIH, National Eye Institute (NEI)

The inflammatory molecule interleukin-17A (IL-17A) triggers immune cells that in turn reduce IL-17A’s pro-inflammatory activity, according to a study by National Eye Institute (NEI) researchers.

Newswise: Vision loss in children whose eyesight may be 20/20 requires new diagnostic and teaching strategies
Released: 15-Jul-2020 11:20 AM EDT
Vision loss in children whose eyesight may be 20/20 requires new diagnostic and teaching strategies
NIH, National Eye Institute (NEI)

Cerebral (cortical) visual impairment (CVI) is a condition that interferes with the ability of the brain to process information from the eyes, and it has become a leading cause of visual impairment in the U.S.

Newswise: Vision loss in children whose eyesight may be 20/20 requires new diagnostic and teaching strategies
Released: 15-Jul-2020 11:20 AM EDT
Vision loss in children whose eyesight may be 20/20 requires new diagnostic and teaching strategies
NIH, National Eye Institute (NEI)

Cerebral (cortical) visual impairment (CVI) is a condition that interferes with the ability of the brain to process information from the eyes, and it has become a leading cause of visual impairment in the U.S.

Released: 10-Jul-2020 12:30 PM EDT
More Than Meets the Eye
Harvard Medical School

New findings reframe the traditional view of face blindness as a disorder arising strictly from deficits in visual perception of facial features Findings suggest prosopagnosia may be a more complex disorder rooted in multiple deficits Findings can help inform the design of tools to improve face recognition in those with the condition

Newswise: Scientists Use Nanoparticle-Delivered Gene Therapy to Inhibit Blinding Eye Disease in Rodents
Released: 7-Jul-2020 9:00 AM EDT
Scientists Use Nanoparticle-Delivered Gene Therapy to Inhibit Blinding Eye Disease in Rodents
Johns Hopkins Medicine

Scientists use nanoparticle-delivered gene therapy to limit blinding retinal disease in rodents.


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