Curated News: National Eye Institute (NEI)

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Embargo will expire: 11-Aug-2020 11:00 AM EDT Released to reporters: 6-Aug-2020 1:55 PM EDT

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Embargo will expire: 11-Aug-2020 11:00 AM EDT Released to reporters: 6-Aug-2020 1:55 PM EDT

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Released: 30-Jul-2020 4:20 PM EDT
Researchers Discover Stem Cells in Optic Nerve that Preserve Vision
University of Maryland Medical Center

Researchers at the University of Maryland School of Medicine (UMSOM) have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. The finding presents a new theory on why the most common form of glaucoma may develop and potential for new therapies.

Newswise: Dual role discovered for molecule involved in autoimmune eye disease
Released: 23-Jul-2020 11:00 AM EDT
Dual role discovered for molecule involved in autoimmune eye disease
NIH, National Eye Institute (NEI)

The inflammatory molecule interleukin-17A (IL-17A) triggers immune cells that in turn reduce IL-17A’s pro-inflammatory activity, according to a study by National Eye Institute (NEI) researchers.

Newswise: Dual role discovered for molecule involved in autoimmune eye disease
Released: 23-Jul-2020 11:00 AM EDT
Dual role discovered for molecule involved in autoimmune eye disease
NIH, National Eye Institute (NEI)

The inflammatory molecule interleukin-17A (IL-17A) triggers immune cells that in turn reduce IL-17A’s pro-inflammatory activity, according to a study by National Eye Institute (NEI) researchers.

Newswise: Vision loss in children whose eyesight may be 20/20 requires new diagnostic and teaching strategies
Released: 15-Jul-2020 11:20 AM EDT
Vision loss in children whose eyesight may be 20/20 requires new diagnostic and teaching strategies
NIH, National Eye Institute (NEI)

Cerebral (cortical) visual impairment (CVI) is a condition that interferes with the ability of the brain to process information from the eyes, and it has become a leading cause of visual impairment in the U.S.

Newswise: Vision loss in children whose eyesight may be 20/20 requires new diagnostic and teaching strategies
Released: 15-Jul-2020 11:20 AM EDT
Vision loss in children whose eyesight may be 20/20 requires new diagnostic and teaching strategies
NIH, National Eye Institute (NEI)

Cerebral (cortical) visual impairment (CVI) is a condition that interferes with the ability of the brain to process information from the eyes, and it has become a leading cause of visual impairment in the U.S.

Released: 10-Jul-2020 12:30 PM EDT
More Than Meets the Eye
Harvard Medical School

New findings reframe the traditional view of face blindness as a disorder arising strictly from deficits in visual perception of facial features Findings suggest prosopagnosia may be a more complex disorder rooted in multiple deficits Findings can help inform the design of tools to improve face recognition in those with the condition

Newswise: Scientists Use Nanoparticle-Delivered Gene Therapy to Inhibit Blinding Eye Disease in Rodents
Released: 7-Jul-2020 9:00 AM EDT
Scientists Use Nanoparticle-Delivered Gene Therapy to Inhibit Blinding Eye Disease in Rodents
Johns Hopkins Medicine

Scientists use nanoparticle-delivered gene therapy to limit blinding retinal disease in rodents.

Released: 24-Jun-2020 9:50 AM EDT
Dry Eye Awareness Month 2020 Focuses On How Lifestyle Changes During the COVID-19 Pandemic Can Affect Vision
Association for Research in Vision and Ophthalmology (ARVO)

On July 8, the Alliance for Eye and Vision Research (AEVR) in conjunction with the Tear Film & Ocular Surface Society (TFOS) will host the Fifth Annual Dry Eye Awareness Month Congressional Briefing entitled How Lifestyle Changes During the COVID-19 Pandemic Can Affect Vision.

Newswise: Researchers look to the eye for insights about the brain
Released: 23-Jun-2020 3:40 PM EDT
Researchers look to the eye for insights about the brain
NIH, National Eye Institute (NEI)

Researchers seeking to unravel the mysteries of how our amazingly complex brains do what they do, often start with the eye. An extension of neural tissue connecting the eye and brain, the retina, the light-sensing tissue at the back of the eye has long been a model for scientists to explore how the brain works.

Newswise: Researchers look to the eye for insights about the brain
Released: 23-Jun-2020 3:40 PM EDT
Researchers look to the eye for insights about the brain
NIH, National Eye Institute (NEI)

Researchers seeking to unravel the mysteries of how our amazingly complex brains do what they do, often start with the eye. An extension of neural tissue connecting the eye and brain, the retina, the light-sensing tissue at the back of the eye has long been a model for scientists to explore how the brain works.

Newswise: National Eye Institute establishes office of regenerative medicine
Released: 18-Jun-2020 10:20 AM EDT
National Eye Institute establishes office of regenerative medicine
NIH, National Eye Institute (NEI)

The National Eye Institute (NEI) has established an office to accelerate progress in regenerative medicine for eye disease and vision disorders.

Newswise: National Eye Institute establishes office of regenerative medicine
Released: 18-Jun-2020 10:20 AM EDT
National Eye Institute establishes office of regenerative medicine
NIH, National Eye Institute (NEI)

The National Eye Institute (NEI) has established an office to accelerate progress in regenerative medicine for eye disease and vision disorders.

Newswise:Video Embedded new-research-on-marfan-syndrome-focuses-on-eyes
VIDEO
Released: 16-Jun-2020 1:35 PM EDT
New research on Marfan syndrome focuses on eyes
NIH, National Eye Institute (NEI)

New NEI-supported research provides insight into the eye conditions associated with Marfan syndrome, where weakened zonule fibers cause vision problems.

Newswise: Vision screening device improves detection of “lazy eye”
Released: 3-Jun-2020 1:05 PM EDT
Vision screening device improves detection of “lazy eye”
NIH, National Eye Institute (NEI)

The National Eye Institute (NEI) has funded development of a handheld pediatric vision scanner that easily and accurately screens for amblyopia, or “lazy eye.” The device could facilitate earlier identification of children who need vision-saving treatment when therapy is likely to be more effective. It also could reduce unnecessary referrals to ophthalmologists.

Newswise: Vision screening device improves detection of “lazy eye”
Released: 3-Jun-2020 1:05 PM EDT
Vision screening device improves detection of “lazy eye”
NIH, National Eye Institute (NEI)

The National Eye Institute (NEI) has funded development of a handheld pediatric vision scanner that easily and accurately screens for amblyopia, or “lazy eye.” The device could facilitate earlier identification of children who need vision-saving treatment when therapy is likely to be more effective. It also could reduce unnecessary referrals to ophthalmologists.

Newswise: Very low-dose Avastin effective for preventing blindness in preterm infants
21-Apr-2020 12:05 PM EDT
Very low-dose Avastin effective for preventing blindness in preterm infants
NIH, National Eye Institute (NEI)

Babies born prematurely who require treatment to prevent blindness from retinopathy of prematurity (ROP) could be treated with a dose of Avastin (bevacizumab) that is a fraction of the dose commonly used for ROP currently. Results from the dose-finding study were published April 23 in JAMA Ophthalmology. The study was conducted by the Pediatric Eye Disease Investigator Group (PEDIG) and supported by the National Eye Institute (NEI), part of the National Institutes of Health.

Newswise: NEI researchers link age-related DNA modifications to susceptibility to eye disease
20-Apr-2020 12:05 PM EDT
NEI researchers link age-related DNA modifications to susceptibility to eye disease
NIH, National Eye Institute (NEI)

National Eye Institute (NEI) researchers profiling epigenomic changes in light-sensing mouse photoreceptors have a clearer picture of how age-related eye diseases may be linked to age-related changes in the regulation of gene expression. The findings, published online April 21 in Cell Reports, suggest that the epigenome could be targeted as a therapeutic strategy to prevent leading causes of vision loss, such as age-related macular degeneration (AMD).

Newswise: Researchers restore sight in mice by turning skin cells into light-sensing eye cells
14-Apr-2020 6:25 PM EDT
Researchers restore sight in mice by turning skin cells into light-sensing eye cells
NIH, National Eye Institute (NEI)

Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision, sidestepping the need for stem cells. The lab-made rods enabled blind mice to detect light after the cells were transplanted into the animals’ eyes.

9-Apr-2020 4:55 PM EDT
Diet May Help Preserve Cognitive Function
NIH, National Eye Institute (NEI)

According to a recent analysis of data from two major eye disease studies, adherence to the Mediterranean diet – high in vegetables, whole grains, fish, and olive oil – correlates with higher cognitive function.

Newswise: It’s now or never: Visual events have 100 milliseconds to hit brain target or go unnoticed
Released: 7-Apr-2020 4:40 PM EDT
It’s now or never: Visual events have 100 milliseconds to hit brain target or go unnoticed
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) have defined a crucial window of time that mice need to key in on visual events.

Newswise: It’s now or never: Visual events have 100 milliseconds to hit brain target or go unnoticed
Released: 7-Apr-2020 4:40 PM EDT
It’s now or never: Visual events have 100 milliseconds to hit brain target or go unnoticed
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute (NEI) have defined a crucial window of time that mice need to key in on visual events.

Newswise: NIH researchers discover tooth-enamel protein in eyes with dry AMD
Released: 13-Mar-2020 12:45 PM EDT
NIH researchers discover tooth-enamel protein in eyes with dry AMD
NIH, National Eye Institute (NEI)

A protein that normally deposits mineralized calcium in tooth enamel may also be responsible for calcium deposits in the back of the eye in people with dry age-related macular degeneration (AMD), according to a study from researchers at the National Eye Institute (NEI).

Newswise: ‘Primitive’ Stem Cells Shown to Regenerate Blood Vessels in The Eye
Released: 9-Mar-2020 9:00 AM EDT
‘Primitive’ Stem Cells Shown to Regenerate Blood Vessels in The Eye
Johns Hopkins Medicine

Johns Hopkins Medicine scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes. The findings from this experimental study, they say, advance regenerative medicine techniques aimed at reversing the course of diabetic retinopathy and other blinding eye diseases.

Newswise: AI may help spot newborns at risk for most severe form of blinding disease
Released: 4-Mar-2020 12:05 PM EST
AI may help spot newborns at risk for most severe form of blinding disease
NIH, National Eye Institute (NEI)

An artificial intelligence (AI) device that has been fast-tracked for approval by the Food and Drug Administration may help identify newborns at risk for aggressive posterior retinopathy of prematurity (AP-ROP). AP-ROP is the most severe form of ROP and can be difficult to diagnose in time to save vision.

Newswise: Tiny containers transport targeted treatments
Released: 27-Jan-2020 12:35 PM EST
Tiny containers transport targeted treatments
National Institute of Biomedical Imaging and Bioengineering

Promising intracellular protein-based therapeutics have been of limited use due to the difficulty of delivery into diseased cells. Now bioengineers have developed nanoparticles that can deliver these therapeutics to their targets—avoiding degradation and toxic interactions with healthy tissues.

Released: 10-Dec-2019 2:10 PM EST
'Ojos' study to examine eye disease in Latino communities
University of Illinois at Chicago

With $9.7 million in funding from the National Eye Institute, researchers at the University of Illinois at Chicago will study the impact of chronic eye disease among Latinos.

Newswise: Helper Protein Worsens Diabetic Eye Disease
Released: 27-Nov-2019 8:00 AM EST
Helper Protein Worsens Diabetic Eye Disease
Johns Hopkins Medicine

In a recent study using mice, lab-grown human retinal cells and patient samples, Johns Hopkins Medicine scientists say they found evidence of a new pathway that may contribute to degeneration of the light sensitive tissue at the back of the eye. The findings, they conclude, bring scientists a step closer to developing new drugs for a central vision-destroying complication of diabetes that affects an estimated 750,000 Americans.

Newswise: NIH, NIST researchers use artificial intelligence for quality control of stem cell-derived tissues
Released: 14-Nov-2019 4:05 PM EST
NIH, NIST researchers use artificial intelligence for quality control of stem cell-derived tissues
NIH, National Eye Institute (NEI)

Researchers at the National Eye Institute used artificial intelligence to evaluate stem cell-derived “patches” of retinal pigment epithelium tissue for implanting into the eyes of patients with age-related macular degeneration, a leading cause of blindness.

Newswise: Treatment for common vision disorder does not improve children’s reading skills
18-Oct-2019 3:05 AM EDT
Treatment for common vision disorder does not improve children’s reading skills
NIH, National Eye Institute (NEI)

Results from a clinical trial funded by the National Eye Institute (NEI) show that while vision therapy can successfully treat convergence insufficiency (CI) in children, it fails to improve their reading test scores.

Newswise: Antibody-based eye drops show promise for treating dry eye disease
Released: 11-Oct-2019 4:05 PM EDT
Antibody-based eye drops show promise for treating dry eye disease
University of Illinois at Chicago

Researchers at the University of Illinois at Chicago are the first to identify the presence of a specific type of antibody, called anti-citrullinated protein autoantibodies, or ACPAs, in human tear fluid. They are also the first to demonstrate that patients with dry eye disease experienced reduced signs and symptoms of the condition in response to a new eye drop treatment -- made from pooled human antibodies -- that targets ACPAs.

Newswise: Two commonly used uveitis drugs perform similarly in NIH-funded clinical trial
6-Sep-2019 2:00 PM EDT
Two commonly used uveitis drugs perform similarly in NIH-funded clinical trial
NIH, National Eye Institute (NEI)

Methotrexate and the more expensive mycophenolate mofetil performed similarly in a head-to-head clinical trial that compared the two drugs for treating noninfectious uveitis

Newswise: Rosy health and sickly green: color associations play robust role in reading faces
Released: 8-Jul-2019 1:05 PM EDT
Rosy health and sickly green: color associations play robust role in reading faces
NIH, National Eye Institute (NEI)

Anyone who has ever sensed that a person is sick simply by looking at their face has experienced the wealth of information conveyed by face color. A new study by the National Eye Institute (NEI), part of the National Institutes of Health, provides evidence that the human brain’s visual system is especially sensitive to the color of faces compared to the colors of other objects or things. Study results were published today in Nature Communications.

Newswise: Children’s Brains Reorganize After Epilepsy Surgery to Retain Visual Perception
31-May-2019 2:05 PM EDT
Children’s Brains Reorganize After Epilepsy Surgery to Retain Visual Perception
NIH, National Eye Institute (NEI)

Children can keep full visual perception – the ability to process and understand visual information – after brain surgery for severe epilepsy, according to a study funded by the National Eye Institute (NEI), part of the National Institutes of Health. A new report by Carnegie Mellon University, Pittsburgh, researchers from a study of children who had undergone epilepsy surgery suggests that the lasting effects on visual perception can be minimal, even among children who lost tissue in the brain’s visual centers.

Released: 7-May-2019 11:05 AM EDT
New Treatment for Severe Dry Eye Disease Promising in Early Clinical Trials
University of Illinois at Chicago

Participants in a phase I/II clinical trial of a new enzyme-based treatment for severe dry eye disease experienced reduced signs of disease and discomfort, according to a paper in Translational Vision Science and Technology.The trial compared eye drops containing a biosynthetic form of an enzyme called DNase with eye drops without the enzyme.

Newswise:Video Embedded nih-study-finds-no-evidence-that-calcium-increases-risk-of-amd
VIDEO
19-Mar-2019 4:05 PM EDT
NIH Study Finds No Evidence That Calcium Increases Risk of AMD
NIH, National Eye Institute (NEI)

Eating a calcium-rich diet or taking calcium supplements does not appear to increase the risk of age-related macular degeneration (AMD), according to the findings of a study by scientists at the National Eye Institute (NEI). AMD is a leading cause of vision loss and blindness among people age 65 and older in the United States. The study findings are published in JAMA Ophthalmology.

Newswise:Video Embedded imaging-method-reveals-long-lived-patterns-in-cells-of-the-eye
VIDEO
14-Mar-2019 2:30 PM EDT
Imaging Method Reveals Long-Lived Patterns in Cells of the Eye
NIH, National Eye Institute (NEI)

Cells of the retinal pigment epithelium (RPE) form unique patterns that can be used to track changes in this important layer of tissue in the back of the eye, researchers at the National Eye Institute (NEI) have found. Using a combination of adaptive optics imaging and a fluorescent dye, the researchers used the RPE patterns to track individual cells in healthy volunteers and people with retinal disease. The new finding could provide a way to study the progression and treatment of blinding diseases that affect the RPE.

Newswise: Nitisinone Increases Melanin in People with Albinism
Released: 20-Feb-2019 11:00 AM EST
Nitisinone Increases Melanin in People with Albinism
NIH, National Eye Institute (NEI)

A small pilot clinical study at the National Eye Institute (NEI) suggests that the drug nitisinone increases melanin production in some people with oculocutaneous albinism type 1B (OCA-1B), a rare genetic disease that causes pale skin and hair and poor vision. Increased melanin could help protect people with the condition against the sun’s UV rays and promote the development of normal vision.

Newswise: Glaucoma detection gets potential boost from virtual reality, brain-based device
Released: 29-Jan-2019 1:05 PM EST
Glaucoma detection gets potential boost from virtual reality, brain-based device
NIH, National Eye Institute (NEI)

A wearable brain-based device called NGoggle that incorporates virtual reality could help improve glaucoma diagnosis and prevent vision loss. Duke University researchers funded by the National Eye Institute (NEI) have launched a clinical study testing the device in hopes that it could decrease the burden of glaucoma, a major cause of blindness in the U.S.

Newswise: Faulty molecular master switch may contribute to AMD
Released: 22-Jan-2019 8:00 AM EST
Faulty molecular master switch may contribute to AMD
NIH, National Eye Institute (NEI)

A signaling pathway controlled by transforming growth factor beta (TGF-beta) could be involved in the progression of age-related macular degeneration (AMD).

Newswise:Video Embedded nih-researchers-rescue-photoreceptors-prevent-blindness-in-animal-models-of-retinal-degeneration
VIDEO
Released: 16-Jan-2019 3:05 PM EST
NIH researchers rescue photoreceptors, prevent blindness in animal models of retinal degeneration
NIH, National Eye Institute (NEI)

Using a novel patient-specific stem cell-based therapy, researchers at the National Eye Institute (NEI) prevented blindness in animal models of geographic atrophy, the advanced “dry” form of age-related macular degeneration (AMD), which is a leading cause of vision loss among people age 65 and older. The protocols established by the animal study, published January 16 in Science Translational Medicine (STM), set the stage for a first-in-human clinical trial testing the therapy in people with geographic atrophy, for which there is currently no treatment.

Newswise: Researchers Design Technology That Sees Nerve Cells Fire
Released: 12-Dec-2018 4:50 PM EST
Researchers Design Technology That Sees Nerve Cells Fire
NIH, National Eye Institute (NEI)

Researchers at Stanford University, Palo Alto, California, have created a noninvasive technology that detects when nerve cells fire based on changes in shape. The method could be used to observe nerve activity in light-accessible parts of the body, such as the eye, which would allow physicians to quantitatively monitor visual function at the cellular level.

Newswise: NEI awards prize for progress toward developing lab-made retinas
Released: 4-Dec-2018 5:05 PM EST
NEI awards prize for progress toward developing lab-made retinas
NIH, National Eye Institute (NEI)

The National Eye Institute (NEI) awarded $25,000 to a team led by Wei Liu, Ph.D., Albert Einstein College of Medicine, for demonstrating progress toward the development of a living model of the human retina, the light-sensitive tissue at the back of the eye. The prize money was awarded for the first of two phases of the NEI 3-D Retina Organoid Challenge 2020 (3-D ROC 2020), a national initiative to generate human retina organoids from stem cells. NEI is part of the National Institutes of Health.

Newswise: NIH Researchers Discover Neural Code That Predicts Behavior
23-Nov-2018 6:00 PM EST
NIH Researchers Discover Neural Code That Predicts Behavior
NIH, National Eye Institute (NEI)

Scientists at the National Eye Institute (NEI) have found that neurons in the superior colliculus, an ancient midbrain structure found in all vertebrates, are key players in allowing us to detect visual objects and events.

Newswise:Video Embedded nih-scientists-combine-technologies-to-view-the-retina-in-unprecedented-detail
VIDEO
Released: 14-Nov-2018 4:30 PM EST
NIH Scientists Combine Technologies to View the Retina in Unprecedented Detail
NIH, National Eye Institute (NEI)

By combining two imaging modalities—adaptive optics and angiography—investigators at the National Eye Institute (NEI) can see live neurons, epithelial cells, and blood vessels deep in the eye’s light-sensing retina. Resolving these tissues and cells in the outermost region of the retina in such unprecedented detail promises to transform the detection and treatment of diseases such as age-related macular degeneration (AMD), a leading cause of blindness among the elderly.

Newswise: NIH-funded study proposes blurry vision in babies may guide brain development
Released: 5-Nov-2018 1:05 PM EST
NIH-funded study proposes blurry vision in babies may guide brain development
NIH, National Eye Institute (NEI)

Shortly after birth when the world is a blur, babies may be learning to identify patterns. According to a new study funded by the National Eye Institute (NEI), the initial phase of blurry vision may be fundamental to the development of normal visual processing.

Newswise: NEI Investigator Hikosaka Awarded Gruber Prize in Neuroscience
Released: 1-Nov-2018 1:00 PM EDT
NEI Investigator Hikosaka Awarded Gruber Prize in Neuroscience
NIH, National Eye Institute (NEI)

Dr. Okihide Hikosaka, senior investigator at the National Eye Institute (NEI) Laboratory of Sensorimotor Research, is a recipient of the 2018 Gruber Prize in Neuroscience.

25-Sep-2018 1:00 PM EDT
Therapy Applied Directly Inside the Eye Best for Treating Uveitic Macular Edema
NIH, National Eye Institute (NEI)

Delivery of corticosteroids directly into the eye is more effective than injections adjacent to the eye, according to results from a comparative clinical trial of macular edema in patients with noninfectious uveitis.

Newswise: Study suggests maintaining good vision may stave off cognitive decline
Released: 24-Sep-2018 1:00 PM EDT
Study suggests maintaining good vision may stave off cognitive decline
NIH, National Eye Institute (NEI)

During aging, loss of vision and cognition often coincide. In a new study, researchers funded by the National Eye Institute (NEI) and National Institute on Aging (NIA) have found that vision loss precedes loss of mental capacity. The findings suggest that maintaining eye health could help protect cognition in older adults.


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