New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, found that the biologic B-cell inhibitor belimumab was associated with a lower risk of severe infections and hospitalizations compared to nonbiologic immunosuppressants.
New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, demonstrated that withholding mycophenolate mofetil for 10 days significantly increased antibody response after 2 doses of COVID-19 vaccine, without a significant increase in flares.
New research presented this week at ACR Convergence 2022, the American College of Rheumatology’s annual meeting, demonstrated an association between age of diagnosis and clinical characteristics and treatments in Anti-neutrophil cytoplasmic antibody-associated vasculitis patients.
Using a novel systems biology approach, scientists at UC San Diego School of Medicine have further parsed the cellular players and roles involved in rheumatoid arthritis, a complex disease that affects more than one million Americans in ways that have defied development of uniform treatments.
Researchers at Washington University School of Medicine in St. Louis have identified a pathway in the brains of mice that is activated when the animals see other mice scratching, but that pathway does not run through the visual cortex.
A new study, led by researchers from the University of California, Irvine, reveals the unique cell-to-cell communication networks that can perpetuate inflammation and prevent repigmentation in patients with vitiligo disease.
Researchers from the Washington University Center for the Study of Itch and Sensory Disorders have identified a specific neuropeptide and a neural circuit that transmit pleasant touch from the skin to the brain. The findings eventually may help scientists better understand and treat disorders characterized by touch avoidance and impaired social development.
Tracing the impact of a single protein, Piezo1, Penn researchers found that restoring it in muscles affected by Duchenne muscular dystrophy could improve their ability to heal efficiently
A mutation in the gene that causes fibrodysplasia ossificans progressiva (FOP) doesn’t just cause extra bone growth but is tied to a problem in generating new muscle tissue after injury
The Icahn School of Medicine at Mount Sinai is establishing a Skin Biology and Diseases Resource-based Center (SBDRC), funded by a $4 million grant from the National Institutes of Health and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
Therapies that target aging cells early pave the way to easing back pain
Researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, deliver a biologic drug in response to inflammation.
The United States’ longest-running NIH-sponsored musculoskeletal research center will receive $4M to continue its studies of everything from ligament tears to osteoarthritis
In what turned out to be one of the most important accidents of all time, Scottish bacteriologist Alexander Fleming returned to his laboratory after a vacation in 1928 to find a clear zone surrounding a piece of mold that had infiltrated a petri dish full of Staphylococcus aureus (S. aureus), a common skin bacterium he was growing.
What exactly triggers a sneeze? A team led by researchers at Washington University School of Medicine in St. Louis has identified, in mice, specific cells and proteins that control the sneeze reflex. Better understanding of what causes us to sneeze — specifically how neurons behave in response to allergens and viruses — may point to treatments capable of slowing the spread of infectious respiratory diseases.
A UCLA-led research team has identified a chemical cocktail that enables the production of large numbers of muscle stem cells, which can self-renew and give rise to all types of skeletal muscle cells.
Researchers have developed new 4D hydrogels — 3D materials that have the ability to change shape over time in response to stimuli — that can morph multiple times in a preprogrammed or on-demand manner in response to external trigger signals.
New hydrogel-based materials that can change shape in response to psychological stimuli, such as water, could be the next generation of materials used to bioengineer tissues and organs, according to a team of researchers at the University of Illinois Chicago.
Researchers identified spinal cord neurons responsible for an itchy sensation after an epidural morphine injection and found a drug that may fix the problem without reducing morphine’s pain-killing effects.
For patients undergoing surgery for a hip fracture, there are still unknowns regarding the return to pre-facture level of function, specifically in regard to driving and mobility. However, a new article published in the January issue of the Journal of the American Academy of Orthopaedic Surgeons® (JAAOS®) further quantifies these outcomes. The study authors found that patients can expect to regain full functionality within two to three years after hip fracture surgery. The study also looked at the long-term psychosocial limitations of patients compared to peer groups and concluded that socialization may aid in recovery.
A novel drug called vamorolone may improve the efficacy of corticosteroid treatment for patients with Duchenne muscular dystrophy — a rare form of inherited and progressive muscular dystrophy, according findings from a clinical trial published in the journal PLOS Medicine.
Findings from a research study, led by scientists at Henry Ford, suggest an enzyme could play an important role in the treatment of cancer and autoimmune diseases in the airway.
A new study in mice at Washington University School of Medicine in St. Louis suggests gene therapy one day may help build muscle and relieve pain in overweight patients with osteoarthritis.
Studying eczema, researchers at Washington University School of Medicine in St. Louis have found that boosting the number of natural killer cells in the blood is a possible treatment strategy for the skin condition and also may help with related health problems, such as asthma.
Sticks and stones may break one’s bones, but healing them requires the production of a protein signal that stimulates the generation, growth and spread of vital nerve cells, or neurons, throughout the injured area. That’s the finding of a recent Johns Hopkins Medicine study that used mice to demonstrate what likely takes place during human fracture repair as well.
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