Announcement of national and international nominations being sought for the 2021 Harrington Prize for Innovation in Medicine, which honors a physician-scientist who has moved science forward with achievements notable for innovation, creativity and the potential for clinical application.
Most patients hospitalized with COVID-19 (coronavirus) pneumonia experienced improvement after receiving a Food and Drug Administration-approved drug normally given for rheumatoid arthritis, according to an observational study at Cedars-Sinai. Outcomes for patients who received the drug, tocilizumab, included reduced inflammation, oxygen requirements, blood pressure support and risk of death, compared with published reports of illness and death associated with severely ill COVID-19 patients.
Diseases of the Colon and Rectum Journal August 2020 Video Abstracts and Editor Picks
UC Davis researchers have found that combining a Western-style high-fat diet with antibiotic use significantly increases the risk of developing pre- inflammatory bowel disease. This combination shuts down the mitochondria in cells of the colon lining, leading to gut inflammation. Mesalazine can help restart the mitochondria and treat pre-IBD condition.
Physicians are studying whether vadadustat, an investigational therapy, could protect the lungs of COVID-19 patients by triggering the body’s protective response to low oxygen levels in a randomized Phase II clinical trial at UTHealth.
The CDI will work with Merck to identify candidate treatments for the still-spreading pandemic.
The University of Texas MD Anderson Cancer Center and Sanofi today announced a five-year strategic collaboration to accelerate the development of investigational treatments, including targeted and immune therapies, for patients with cancer.
Moffitt Cancer Center researchers want to learn more about how PI3K inhibitor therapy works with the body’s immune system to determine if there are ways to predict or mitigate associated adverse effects. Their findings were published in the July 14 issue of Blood Advances, a journal of the American Society of Hematology.
Keck Medicine of USC physicians are enrolling patients as part of an international clinical trial to evaluate the safety and efficacy of an antiviral drug, DAS181, as a possible treatment for hospitalized patients with severe COVID-19.
The mechanisms of action of acalabrutinib led to the hypothesis it might be effective in reducing the massive inflammatory response seen severe forms of COVID19. Indeed, it did provide clinical benefit in a small group of patients by reducing their inflammatory parameters and improving their oxygenation.
The individual mix of microorganisms in the human gastrointestinal tract provides vital clues as to how any future incidence of type 2 diabetes can be predicted, prevented and treated.
A drug used to treat systemic lupus erythematosus (SLE) significantly reduces the incidence of a rare and sometimes fatal heart condition in newborn babies, a new study from NYU Grossman School of Medicine researchers shows.
Only 1.9% of uninfected household contacts who took a single dose of baloxavir marboxil came down with the flu.
An interventional therapy aimed at improving survival chances and reducing the need for critical care treatment due to COVID-19 is being investigated by physicians at The University of Texas Health Science Center at Houston (UTHealth). The clinical trial is underway at Memorial Hermann and Harris Health System’s Lyndon B. Johnson Hospital.
A study from Hospital for Special Surgery (HSS) finds that topical steroids administered during anterior cervical discectomy and fusion (ACDF) surgery help reduce swallowing difficulties following the procedure. This study is available online as part of the AAOS 2020 Virtual Education Experience. The results were also published in The Spine Journal in September 2019.
Critically ill COVID-19 patients who received a single dose of a drug that calms an overreacting immune system were 45% less likely to die overall, and more likely to be out of the hospital or off a ventilator one month after treatment, compared with those who didn’t receive the drug, according to a new observational study.
A Keck Medicine of USC study reveals that kappa opioids, a significantly less addictive opioid, may preserve cartilage in joints and ease pain
One of the fastest-growing pharmaceuticals companies in the country, headquartered in Lexington County, today announced several major expansion and investment projects.
Scientists at USC Dornsife College of Letters, Arts and Sciences may have found the beginnings of a path toward increasing human lifespan.
Fueling transformative research through collaboration, the San Antonio Partnership for Precision Therapeutics (SAPPT) announces the funding of three more collaborative COVID-19 research efforts in San Antonio. SAPPT has awarded more than $600,000 to fund these projects, following the funding of a SARS CoV-2 vaccine project announced in April of this year.
A clinical trial conducted at Washington University School of Medicine in St. Louis and other sites has found evidence that the experimental drug tofersen lowers levels of a disease-causing protein in people with an inherited form of amyotrophic lateral sclerosis, or ALS, caused by mutations in the gene SOD1.
The study will aim to understand whether systemic medications and biologics, such as dupilumab—a monoclonal antibody that binds to an inflammatory molecule, IL-4 receptor alfa, and inhibits the inflammatory response that leads to rashes and itching from atopic dermatitis/eczema—may have a positive or negative impact on COVID-19 responses in patients who have the disease.
As Americans have the highest opioid use rates, leading to abuse, the orthopaedic community has committed itself to studying prescription methods and patient populations to help mitigate potential addiction. A new scientific review article titled, “Ninety-day Postoperative Narcotic Use After Hospitalization for Orthopaedic Trauma,” published in the July issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS), found a correlation between patient-reported pain at discharge from inpatient surgery and the number of opioids prescribed during the 90-day postoperative period.
Researchers fear that widespread use of antibiotics during the coronavirus pandemic will add fuel to the fire, making more common infections that were once treatable possibly life threatening.
Every human being has the right to health and new initiatives should be put in place to encourage pharmaceutical companies to ensure that everyone has access to essential medicine, according to a new book from Nicole Hassoun, professor of philosophy at Binghamton University, State University of New York.
Simpler phenolic compounds, known as hydroxybenzoic acids, that result when the gut bacteria break down aspirin and flavonoids from fruits and vegetables may contribute to colorectal cancer prevention.
Only 10.1% of Los Angeles County pharmacies provided this service and 77.4% imposed age-restrictions at 18 years or older, including in neighborhoods with the highest rates of unintended pregnancies and teen births.
Findings from an online survey of more than 53,000 American adults suggest that using heartburn medications known as proton pump inhibitors (PPIs) once or twice daily significantly increases the odds of a positive test for COVID-19 compared to those who do not take PPIs. This research appeared online July 7, 2020 in pre-print format in The American Journal of Gastroenterology.
Researchers at the Seaver Autism Center for Research and Treatment at Mount Sinai have started recruiting participants for a new clinical trial to evaluate the safety, tolerability, and efficacy of a low dose of ketamine in children diagnosed with ADNP syndrome (also known as Helsmoortel-VanDerAa syndrome), a rare neurodevelopmental disorder caused by mutations in the activity dependent neuroprotective protein (ADNP) gene.
Amid news that the United States has bought up virtually the entire global supply of remdesivir, a new Boston University School of Public Health (BUSPH) study outlines how the drug could save lives in countries with less hospital capacity, such as South Africa, where COVID-19 is beginning to overwhelm intensive care units (ICUs).
A team of UD engineers has uncovered the role of surface diffusion in protein transport, which could aid biopharmaceutical processing. This work will lead to the creation of new ways to reduce waste during the expensive drug manufacturing process, enabling more efficient ways of designing and developing manufacturing techniques.
Milestone for therapeutic development of peptides against gastrointestinal disordersThe fascinating family of trefoil factor peptides brings hope to both research and industry to improve the treatment of chronic disorders such as Crohn’s disease. For the first time, a team led by ERC awardee Markus Muttenthaler from the Faculty of Chemistry of the University of Vienna succeeded in the synthesis and folding of the peptide TFF1, a key player in mucosal protection and repair.
What The Study Did: How the prescription of hydroxychloroquine and chloroquine to outpatients has changed in the United States during the COVID-19 pandemic is examined in this study.
Health care providers may unintentionally expose patients to endocrine- disrupting chemicals (EDCs) by prescribing certain medications and using medical supplies, according to a perspective published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
A new study reveals that the common asthma drug salbutamol may offer potential as a treatment for Alzheimer's disease.
Many studies published by major spinal surgery journals do not include full disclosure of researchers’ financial conflicts of interest (COIs), reports a study in Spine. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Mice that received an injection of a new experimental drug, TAT-DP-2, after a stroke had smaller areas of damage, and their long-term neurological function was better than that of untreated animals.
Choice and control are important factors for ensuring a positive childbirth experience, yet until recently, little was known about the impact of alternative administrations of fentanyl – one of the pain relief drugs used during labour– on both mother and baby.
Jianjun Sun, Ph.D., associate professor in UTEP’s Department of Biological Sciences, led the research on Mycobacterium tuberculosis (Mtb). Sun’s lab has been investigating the mechanisms of Mtb pathogenesis for more than 10 years at UTEP with a specific focus on EsxA, which is a virulence factor essential for Mtb virulence and a preferred target for developing novel anti-TB drugs and vaccines.
A Cornell-led collaboration is flipping the switch on traditional synthetic chemistry by using electricity to drive a new chemical reaction that previously stumped chemists who rely on conventional methods.
Researchers at Columbia Engineering and the University of Wisconsin-Madison have identified a library of molecules that shut down the SARS-CoV-2 polymerase reaction, a key step that establishes the potential of these molecules as lead compounds to be further modified for the development of COVID-19 therapeutics. Five of these molecules are already FDA-approved for use in the treatment of other viral infections including HIV/AIDS, cytomegalovirus, and hepatitis B.
USC Norris Comprehensive Cancer Center receives $5 million for cancer drug discoveries
UC San Diego and Deerfield Management created Poseidon Innovation to support researchers working to advance disease-curing therapeutics by funding early stage projects and expediting the drug-development cycle. Poseidon announces it is funding three researchers.
The Biocodex Microbiota Foundation, an organization founded by Biocodex and committed to inspiring scientific projects that investigate the implication of microbiota in human health, has announced the open call for applications for its annual US research grant, now in its fourth year.
The Wake Forest Institute for Regenerative Medicine (WFIRM) and Oracle Health Sciences have teamed as part of the Innovation Quarter’s iQ Healthtech Labs™ to develop a consortium of industry, government, and academic members that will study novel approaches to establishing the safety of new drugs that are nearing clinical investigation in humans and FDA approval.
Historically, half or more of people with type 1 diabetes develop kidney disease, which frequently progresses to kidney failure requiring hemodialysis or a kidney transplant for survival. Progression of kidney disease in type 1 diabetes is correlated with increased amounts of uric acid. A multi-institution randomized clinical trial of a drug used to control uric acid did not show the desired clinical benefits, but did give a very clear answer to an important scientific question.
omen with premature ovarian insufficiency (POI) become estrogen deficient at an early age, which makes them more vulnerable to the loss of bone mineral density.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right