Kidney transplant recipients are now benefiting from donor organs that do not match their blood type but are compatible and just as safe, according to a Vanderbilt University Medical Center study in the Journal of the American College of Surgeons.
Xenotransplantation—transplanting organs from animals into humans—is one step closer to becoming a possibility for infants awaiting human heart transplantation.
Pig heart transplants could potentially save the lives of infants with life-threatening heart diseases.
A new study in the journal Gastroenterology reveals that the standard method for ranking patients on the waitlist for lifesaving liver transplantation may not prioritize some of the sickest candidates for the top of the list.
Patients and providers now have instant access to Tennessee’s only full-service transplant center on their smartphones and mobile devices.
The proportion of liver transplants in the United States for alcohol-associated liver disease increased between 2002 and 2016, with much of the increase associated with a decrease in liver transplant for hepatitis C virus infection because of antiviral therapy. This observational study used data from the United Network for Organ Sharing for all liver transplants during the 15-year period and the national study group consisted of nearly 33,000 patients, including 9,438 patients with a diagnosis of alcohol-associated liver disease. Study findings suggest five-year survival after transplant was lower in patients with alcohol-associated liver disease.
The American Society of Transplant Surgeons (ASTS) has accredited Loyola Medicine to offer a prestigious two-year fellowship in liver and kidney transplant surgery.
Study led by St. Jude Children’s Research Hospital found treatment guided by measuring minimal residual disease was associated with better outcomes for hypodiploid acute lymphoblastic leukemia patients
• Whole-exome sequencing of blood or saliva revealed a genetic diagnosis of kidney disease in 32.7% of pediatric kidney transplant recipients. • The findings indicate that such a sequencing strategy may help individualize pre- and post-transplant care for many young kidney transplant recipients.
The American Society of Transplant Surgeons (ASTS) has accredited Loyola Medicine to offer a prestigious two-year fellowship in liver and kidney transplant surgery. The first fellow will begin in July, 2020.
A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells — which can give rise to every cell type in the body and which can be grown indefinitely in the lab — into becoming mature T cells capable of killing tumor cells.
Organ transplant rejection is a major problem in transplantation medicine. Suppressing the immune system to prevent organ rejection, however, opens the door to life-threatening infections. Researchers at the University of Basel's Biozentrum have now discovered a molecular approach preventing rejection of the transplanted graft while simultaneously maintaining the ability to fight against infections.
In a randomized clinical trial, researchers compared the effect of a stem cell transplant using a non-myeloablative regimen (a lower-dose, short course of more tolerable immune specific chemotherapy and antibodies to suppress the immune system) versus continuing disease-modifying therapy in 110 patients with relapsing-remitting multiple sclerosis.
Poo transplant or “Faecal microbiota transplantation” (FMT) can successfully treat patients with ulcerative colitis, new research from the University of Adelaide shows.
Vanderbilt University Medical Center (VUMC) set a new record for total transplants among its five organ specialties in 2018 with more than 500 transplants.
Liver transplant patients over time experience an increasing trend toward colon cancer and non-Hodgkin lymphoma, according to a study led by a Loyola Medicine gastroenterologist. The study also found that lung and heart transplant patients have a higher trend toward non-melanoma skin cancer.
FDA approves first U.S. clinical trial of an intravenously administered bacteriophage-based therapy to treat resistant bacterial infections.
Two 29-year-old patients from Michigan and Illinois are recovering following back-to-back triple-organ transplants to replace their failing hearts, livers and kidneys, marking a first in U.S. health care history.
The Fred Hutch Bone Marrow Transplant (BMT) Program at Seattle Cancer Care Alliance (SCCA) has once again earned national recognition for outperforming expected one-year survival rates, for the sixth consecutive year.
In a review of registry data for more than 5,300 liver transplants performed in children nationwide, Johns Hopkins Medicine researchers identify the type of patient who is most likely to survive a split liver transplant—receiving only part of a donor’s liver—with no additional long-term health risks, which could allow for an increase in the availability of organs. A report on the new study is published in the December issue of the journal Liver Transplantation.
Results of a medical records study of more than 7,000 patients awaiting a lung transplant in the United States affirm the basis of a court filing in 2017 that called the organ allocation system geographically “rigged” in some regions of the nation.
Here's a great holiday story about a 20-year-old Reno, NV, man whose mother saved his life. Harley Brackney's snowboarding accident and subsequent trip to the emergency room led to the shocking discovery that he had a life-altering condition - stage 5 renal failure - and needed a kidney transplant. Fortunately for Harley Brackney, his mom was a perfect match and instead of waiting 7 to 10 years for a donor organ -- as many people must -- he was able to have a transplant in just a matter of months.
In medical chart reviews of 2,430 kidneys transplanted from 1,298 donors—585 (24 percent) of them with AKI—researchers say they found no significant differences in rates of organ rejection among kidneys from deceased donors with or without AKI. They also report they found no evidence that factors such as the amount of time an organ is chilled and left without blood supply before transplantation had any impact on recipient outcomes for those who received AKI kidneys.
Currently, uterus donation is only available for women with family members who are willing to donate. With live donors in short supply, the new technique might help to increase availability and give more women the option of pregnancy. The first baby has been born following a uterus transplantation from a deceased donor, according to a case study from Brazil published in The Lancet. The study is also the first uterine transplantation in Latin America.
Scientists at Washington University School of Medicine in St. Louis have developed a new tool described as a “flight data recorder” for developing cells, illuminating the paths cells take as they progress from one type to another. This cellular tracking device could one day help scientists guide cells along the right paths to regenerate certain tissues or organs, or help study the origins of cancer.
Growing functional blood vessel networks is no easy task. Previously, other groups have made networks that span millimeters in size. But now, a University of Delaware team has grown a self-assembling, functional network of blood vessels across centimeter scales, a size relevant for human use. With continued development and refinement, the microfluidic system could be used to grow blood vessels for human tissue and organ transplants.
In this five-day fellowship program sponsored by the Mayo Foundation for Medical Education and Research, journalists will receive a behind-the-scenes, in-depth look at what’s new and what’s next in several medical specialties. Topics will include aging, cancer, brain injuries and diseases, transplant medicine, vaccines and developing technologies such as regenerative medicine, telemedicine and simulation-based medical training. The program will include hands-on activities. In addition to group sessions, journalists can personalize part of the program.
The FDA has approved an investigational new drug clinical trial that will start shortly at MedStar Heart & Vascular Institute, to determine whether stem cell therapy improves myocardial function in patients with severe heart failure—severe enough to require the implantation of a left ventricular assist device, or LVAD.
Improving outcomes for patients with myeloid cancers who undergo stem cell transplantation is a focus of several studies to be presented by Dana-Farber Cancer Institute scientists at the ASH Annual Meeting.
Following the Food and Drug Administration’s approval of chimeric antigen receptor (CAR) T-cell therapies for the treatment of certain types of non-Hodgkin lymphomas, UC San Diego Health was the first medical center in San Diego to be certified to offer this type of immunotherapy outside of a clinical trial.
Researchers at Memorial Sloan Kettering Cancer Center (MSK) reported results from a new study that looks at the likelihood of complications for people undergoing bone marrow transplants (BMTs). The observational study found that people with lower gut microbiota diversity before having a transplant appear to be at higher risk for developing complications. These findings further support evidence that the connection between microbiota and outcomes starts before people begin the transplantation process. These findings were presented as part of the 2018 annual meeting of the American Society of Hematology (ASH) press program.
Parkinson's disease, osteoarthritis, rheumatic diseases, alcoholism and mental health disorders increase the risk of surgical complications after a hip fracture surgery, a new Finnish study analysing nationwide registers finds. 4.6% of all hip surgery patients and 10% of total hip replacement surgery patients experienced surgical complications within three months following their surgery.
MSK experts in CAR-T therapy, immunotherapy, leukemia, lymphoma, blood and marrow stem cell transplantation, and more, are also available to comment on meeting news.
This past January 2018, a surgical team from NYU Langone Health performed its second face transplant, replacing much of the upper, mid, and lower face and jaws of a 26-year-old man from California. NYU Langone Health is one of only a handful of medical centers in the United States — and the only one in New York State — with a dedicated program for face transplantation.
Millions of Americans have no idea that they have fatty liver disease. This growing problem will soon be the number one reason for liver transplantation, overtaking hepatitis C. Holiday overindulgence in alcohol and food could make the problem dramatically worse.
According to a recently released national report the Cedars-Sinai Comprehensive Transplant Center's Liver Transplant Program had the best one-year survival outcome of all hospitals in California, with 96 percent of patients surviving beyond the one-year milestone. Kidney transplant and heart transplant patients also had excellent outcomes, with 97 percent of patients surviving past the one-year benchmark.
The UC San Diego Health Cardiovascular Institute performed its 50th heart transplant of the year. The heart transplant program at the Sulpizio Cardiovascular Center is now the largest in San Diego and the third largest in California, placing it among the nation’s top performing transplant centers.
A glucose-powered biofuel cell that uses electrodes made from cotton fiber could someday help power implantable medical devices such as pacemakers and sensors. The new fuel cell, which provides twice as much power as conventional biofuel cells, could be paired with batteries or supercapacitors to provide a hybrid power source for the medical devices.
University of Nebraska Medical Center leading national team to determine if ruxolitinib is effective for treating a certain type of graft versus host disease (GVHD) called sclerotic. The grant is funded by Incyte, a global biopharmaceutical company.
For the first time, transplanting gut bacteria from healthy donors was used to successfully treat patients suffering from severe colitis caused by treatment with immune checkpoint inhibitors. The study from The University of Texas MD Anderson Cancer Center, which includes two patients, suggests fecal microbiota transplantation is worth investigating in clinical trials as a therapy for this common side effect of immunotherapy.
SAN FRANCISCO – Data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found that using normothermic machine perfusion to preserve steatotic livers leads to altered lipid structure and metabolism and may result in more successful transplantation of these organs.
SAN FRANCISCO – Data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found that more than half of pediatric liver transplant recipients are under-immunized at the time of their transplant and are at increased risk for vaccine-preventable infections.
SAN FRANCISCO – Preliminary data from a new study presented this week at The Liver Meeting® – held by the American Association for the Study of Liver Diseases – found that pre-emptive administration of pan-genotypic, direct-acting antiviral therapy prevents chronic hepatitis C virus infection in hepatitis C-negative cardiac transplant patients who receive donor hearts infected with the virus.
Virginia Mason has earned its 14th straight “A” for patient safety from The Leapfrog Group, the national health care improvement advocacy organization that today announced its safety grades for more than 2,600 hospitals across the United States.
At-home blood sampling streamlines the process of therapeutic drug monitoring and creates comfort and emotional safety for children
Noviembre es el mes de concienciación sobre el Clostridium difficile (C. difficile), lo que brinda un momento para enfocarse en concienciar más a la gente acerca de la prevención y tratamiento de las infecciones por Clostridium difficile.
Study could transform care for organ transplant recipients
Research conducted at Hospital for Special Surgery and other joint replacement centers indicates that a newer “modular dual mobility” hip replacement could reduce the risk of dislocation in revision surgery patients. The study was presented at the annual meeting of the American Assoc. of Hip and Knee Surgeons.
Rutgers scientists have created a tiny, biodegradable scaffold to transplant stem cells and deliver drugs, which may help treat Alzheimer’s and Parkinson’s diseases, aging brain degeneration, spinal cord injuries and traumatic brain injuries. Stem cell transplantation, which shows promise as a treatment for central nervous system diseases, has been hampered by low cell survival rates, incomplete differentiation of cells and limited growth of neural connections.
The Mid-America Transplant Foundation has awarded a Clinical Innovation grant to Saint Louis University School of Medicine researchers to develop new methods for detecting rejection in liver transplant patients.
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