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Released: 13-Dec-2017 2:00 PM EST
Genomic Blood Test Predicts Survival Rates After Surgery for Advanced Heart Failure
University of California, Los Angeles (UCLA), Health Sciences

An experimental blood test developed at UCLA that uses gene activity data from immune cells was 93 percent accurate in predicting survival rates for people with advanced heart failure who had surgery to implant mechanical circulatory support devices.

Released: 13-Dec-2017 1:00 PM EST
1 in 5 Young Colon Cancer Patients Have Genetic Link
Michigan Medicine - University of Michigan

A new study indicates a benefit for all young colon cancer patients to have genetic testing. But with more than half exhibiting no family history, will insurers cover the tests? As doctors grapple with increasing rates of colorectal cancers in young people, new research from the University of Michigan may offer some insight into how the disease developed and how to prevent further cancers.

Released: 13-Dec-2017 12:05 PM EST
Combination Immunotherapy Shown to Be Effective Initial Treatment for Relapsed or Refractory Hodgkin Lymphoma
City of Hope

For many people with classical Hodgkin lymphoma, the disease is one of the most curable forms of cancer with standard chemotherapy or chemo plus radiotherapy. But for the 10 to 30 percent of patients whose cancer relapses, or doesn’t respond to initial therapy, secondary treatment often involves harsher chemotherapies followed by an autologous stem cell transplant, which uses a patient’s own stem cells.

Released: 13-Dec-2017 12:05 PM EST
Immunotherapy, Gene Editing Advances Extend to Type 1 Diabetes
Seattle Children's Hospital

Advances in engineering T cells to treat cancer are paving the way for new immunotherapies targeted at autoimmune diseases, including type 1 diabetes. Now, researchers are also investigating therapies that reprogram T cells to “turn down” an immune response, which may hold promise for curing type 1 diabetes, as well as a number of diseases where overactive T cells attack a person’s healthy cells and organs.

Released: 13-Dec-2017 10:05 AM EST
UTHealth Study Finds That Male Virgins Can Still Acquire HPV
University of Texas Health Science Center at Houston

Men who have never engaged in sexual intercourse are still at risk for acquiring HPV, according to a study published recently in the Journal of Infectious Diseases by researchers at The University of Texas Health Science Center at Houston (UTHealth) School of Public Health.

Released: 13-Dec-2017 9:05 AM EST
New Ultra-Thin Diamond Membrane Is a Radiobiologist’s Best Friend
American Institute of Physics (AIP)

Measuring dosage of radiation can be challenging, especially when working with low-energy protons, but researchers have now developed an ultra-thin diamond membrane that can measure the number of protons in a dose of radiation with almost perfect accuracy. The detector attaches to a charged-particle microbeam and enables the delivery of radiation to an area less than 2 micrometers wide. The study, published this week in Applied Physics Letters, represents a valuable technological advance for radiation biology.

   
Released: 13-Dec-2017 9:05 AM EST
Lyme Study Uses Drug Discovery Methods That Have Fueled Cancer Breakthroughs
Duke Health

Researchers at Duke Health are working to expand the medical toolkit for treating Lyme disease by identifying vulnerable areas of the disease-causing bacterium that could lead to innovative therapies.

Released: 13-Dec-2017 9:05 AM EST
A $1.8 Million NIH Grant to Help Tiny Gene Regulator Research at Kansas State University
Kansas State University

A teeny, tiny worm and a $1.8 million National Institutes of Health grant may help a Kansas State University researcher understand how the smallest molecules can have big effects on gene expression. Using microscopic worms as a model system, Anna Zinovyeva, assistant professor in the Division of Biology, is researching how small bits of non-coding RNA, called microRNAs, decrease gene activity in animals.

Released: 12-Dec-2017 6:05 PM EST
Estudio De Mayo Clinic Descubre en Emoticones Un Medio Esperanzador Para Seguir La Calidad De Vida De Los Pacientes OncolóGicos
Mayo Clinic

En los resultados presentados ante la Sociedad Americana de Hematología, los investigadores de Mayo Clinic descubrieron que los emoticones, en lugar de las tradicionales escalas de emociones, sirven para evaluar la calidad de vida física, emocional y general de los pacientes.

Released: 12-Dec-2017 5:05 PM EST
Roswell Park Research Suggests New Strategy for Unleashing Cancer-Fighting Power of p53 Gene
Roswell Park Comprehensive Cancer Center

In a new study in the journal Nature Communications, a research team from Roswell Park Cancer Institute reports their discovery of a major mechanism by which cells regulate the tumor suppressor p53, opening up new avenues for cancer research and treatment.

Released: 12-Dec-2017 3:00 PM EST
UCLA Study Finds Link Between Breast Cancer Treatments and Cellular Markers of Aging
University of California, Los Angeles (UCLA), Health Sciences

A new study has found that women who had received chemotherapy and/or radiation to treat breast cancer were more likely to have high levels of DNA damage and reduced activity of an enzyme involved in chromosome healing, compared to women who underwent surgery alone. The results suggest that some breast cancer survivors may be more vulnerable to biological changes associated with accelerated aging because of their prior treatment.

Released: 12-Dec-2017 2:05 PM EST
Equipo Investigativo Internacional Descubre Modelo GenéTico Para Predecir Resultados en Mielofibrosis Primaria
Mayo Clinic

Un grupo de investigadores de Mayo Clinic y de varios otros centros docentes de investigación en Italia descubrieron un modelo genético para predecir resultados en pacientes con mielofibrosis primaria, de 70 años o menos y candidatos a trasplante de células madre como tratamiento para su enfermedad.

Released: 12-Dec-2017 11:05 AM EST
Jeffery Kelly Elected to National Academy of Inventors
Scripps Research Institute

Jeffery Kelly, Ph.D., co-chair of the Department of Molecular Medicine at The Scripps Research Institute (TSRI), has been named a fellow of the esteemed National Academy of Inventors (NAI), the organization announced today.

Released: 12-Dec-2017 11:05 AM EST
Researchers Develop Test That Can Diagnose Two Cancer Types
Georgia State University

A blood test using infrared spectroscopy can be used to diagnose two types of cancer, lymphoma and melanoma, according to a study led by Georgia State University.

7-Dec-2017 2:30 PM EST
Dana-Farber/Brigham and Women’s physician wins prestigious 2017 William Dameshek Prize from the American Society of Hematology
Dana-Farber Cancer Institute

• Benjamin Ebert, MD, PhD, current chair of Medical Oncology, was presented with recognition at annual American Society of Hematology meeting • Ebert is notable for his leadership in describing the genomic landscape of adult myelodysplastic syndromes (MDS)

Released: 12-Dec-2017 9:05 AM EST
Research Reveals How Diabetes in Pregnancy Affects Baby’s Heart
University of California, Los Angeles (UCLA), Health Sciences

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have discovered how high glucose levels - whether caused by diabetes or other factors - keep heart cells from maturing normally. Their findings help explain why babies born to women with diabetes are more likely to develop congenital heart disease.

Released: 12-Dec-2017 9:00 AM EST
Clinicians Who Ignore Nitric Oxide (NO) Function Put Their Patients at Risk
Strategic Communications, LLC

Dr. Nathan Bryan, Baylor College of Medicine and one of the leading experts in nitric oxide biochemistry and physiology said today, “healthcare providers, especially those helping patients with cardiovascular issues and age-related disease, are not using perhaps the most important ‘tool’ in their ‘toolbox,’ restoring nitric oxide function. Bryan organized and chaired a full day workshop on the Clinical Applications of Nitric Oxide held during the 25th American Academy of Anti-Aging Medicine World Congress.

Released: 12-Dec-2017 7:05 AM EST
Marijuana May Help HIV Patients Keep Mental Stamina Longer
Michigan State University

A chemical found in marijuana, known as tetrahydrocannabinol, or THC, has been found to potentially slow the process in which mental decline can occur in up to 50 percent of HIV patients, says a new Michigan State University study.

10-Dec-2017 11:00 PM EST
Study Identifies Barriers to Transplant Therapy to Treat Multiple Myeloma Among Racial Minority Groups
Mayo Clinic

A study by researchers at Mayo Clinic’s campus in Jacksonville, Florida has found that barriers to patients receiving stem cell therapy as part of their treatment for multiple myeloma include income, education, insurance status and access to care at an academic center or facility that treats a high volume of patients.

7-Dec-2017 2:30 PM EST
Study Identifies Agent That Can Reverse Resistance to Targeted Drug in Some Leukemia Cell Types
Dana-Farber Cancer Institute

• Azacitidine reverses resistance to SL-401 in AML and BPDCN cell lines, researchers find • Results prompt clinical trial of SL-401 and azacitidine in AML and MDS patients

Released: 11-Dec-2017 4:05 PM EST
Drug Suppresses Spread of Breast Cancer Caused by Stem-Like Cells
UC San Diego Health

Rare stem-like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.

Released: 11-Dec-2017 3:00 PM EST
Scientists Identify Promising New Approach forImmune System Defense Against Cancer
University of California San Diego

Researchers have identified a promising new strategy to fight infections and cancer. They uncovered a novel function for a protein known as “Runx3” that is key to the development of killer T cells—immune cells important for fighting infections and cancer.

11-Dec-2017 1:05 PM EST
Blueprints for Anti-Cancer Drugs Discovered in Bacterial Genomes
Scripps Research Institute

New research suggests these hidden genes hold the blueprints for designing new, even more effective cancer-targeting compounds.

Released: 11-Dec-2017 2:05 PM EST
Updated Brain Cell Map Connects Various Brain Diseases to Specific Cell Types
University of California San Diego

Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer’s, Parkinson’s, schizophrenia and bipolar disorder. By analyzing individual nuclei of cells from adult human brains, researchers have identified 35 different subtypes of neurons and glial cells and discovered which of these subtypes are most susceptible to common risk factors for different brain diseases.

   
Released: 11-Dec-2017 12:05 PM EST
Typhoid Fever Toxin Has a Sweet Tooth
Cornell University

Although the insidious bacterium Salmonella typhi has been around for centuries, very little is actually known about its molecular mechanisms. A new study from researchers at the College of Veterinary Medicine addresses this knowledge gap and may lead to novel, targeted treatments.

Released: 11-Dec-2017 12:05 PM EST
Scientists Discover Possible Master Switch for Programming Cancer Immunotherapy
Scripps Research Institute

How do killer T cells “learn” to leave their home base and amass within specific tissues like the skin, gut, and lung, or solid tumors?

Released: 11-Dec-2017 11:05 AM EST
Report: New System for More Accurate Cancer Staging to Aid Precision Medicine
Atrium Health Wake Forest Baptist

Adding a blood test called liquid biopsy to a standard tissue biopsy could significantly improve the accuracy of diagnosis and treatment for patients with cancer, according to researchers at Wake Forest Baptist Medical Center.

Released: 11-Dec-2017 11:00 AM EST
Researchers at Mount Sinai and Sema4 Develop Powerful New Method for Microbiome Analysis
Mount Sinai Health System

Approach can identify antibiotic resistance and virulence markers missed by conventional techniques

6-Dec-2017 11:05 AM EST
One in the Hand Worth Two in the Bush? Tendency to Undervalue Future Rewards Linked to ADHD, Obesity
UC San Diego Health

Researchers at University of California San Diego School of Medicine have found a genetic signature for delay discounting — the tendency to undervalue future rewards — that overlaps with attention-deficit/hyperactivity disorder (ADHD), smoking and weight.

9-Dec-2017 3:30 AM EST
Hyperlens Crystal Capable of Viewing Living Cells in Unprecedented Detail
Vanderbilt University

A fundamental advance in the quality of an optical material used to make hyperlenses makes it possible to see features on the surface of living cells in greater detail than ever before.

6-Dec-2017 9:05 AM EST
Researchers Identify Epigenetic Orchestrator of Pancreatic Cancer Cells
The Rockefeller University Press

Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells’ chromatin. The study, which will be published December 11 in the Journal of Cell Biology, suggests that targeting this enzyme could make pancreatic cancer cells more vulnerable to existing therapies that currently have only limited effect against this deadly form of cancer.

7-Dec-2017 2:25 PM EST
Study Shows Combining Chemotherapy with Targeted Drug Boosts Response in Chronic Lymphocytic Leukemia
Dana-Farber Cancer Institute

Among younger patients newly diagnosed with chronic lymphocytic leukemia (CLL), treatment with a combination of chemotherapy and a molecularly targeted drug significantly improves response over what is typically seen with chemotherapy alone, according to an investigator-initiated multi-center phase II clinical trial.

9-Dec-2017 10:30 AM EST
Phase 2 CAR-T Study Reports Significant Remission Rates at 15-Month Follow Up
University of Texas MD Anderson Cancer Center

A study involving the recently approved CD19-targeting chimeric antigen receptor (CAR) T cell therapy shows that 42 percent of patients with aggressive large B-cell lymphoma remained in remission at 15 months following treatment with axi-cel (marketed as Yescarta™).

7-Dec-2017 2:05 PM EST
Global CAR T Therapy Trial Shows High Rates of Durable Remission for Non-Hodgkin’s Lymphoma
Perelman School of Medicine at the University of Pennsylvania

In a pair of clinical trials stretching from Philadelphia to Tokyo, the chimeric antigen receptor (CAR) T cell therapy Kymriah™ (formerly known as CTL019) demonstrated long-lasting remissions in non-Hodgkin’s lymphoma (NHL) patients. Results from a global, multisite trial will be presented today at the 59th American Society of Hematology Annual Meeting and Exposition in Atlanta (Abstract #577). Results from the single-site study, with follow-up extending past two years, will be published today in the New England Journal of Medicine.

7-Dec-2017 2:30 PM EST
Sequencing Offers Clues to Progression Toward Multiple Myeloma
Dana-Farber Cancer Institute

Researchers at Dana-Farber Cancer Institute have carried out the largest genomic analysis of patients with smoldering multiple myeloma (SMM), a precursor to full-blown blood cancer that doesn’t show outward symptoms.

7-Dec-2017 2:20 PM EST
Tracking How Multiple Myeloma Evolves by Sequencing DNA in the Blood
Dana-Farber Cancer Institute

Although people with multiple myeloma usually respond well to treatment, the blood cancer generally keeps coming back. Following genetic changes in how the disease evolves over time will help to understand the disease and, eventually, deliver more effective treatments.

7-Dec-2017 2:00 PM EST
Rapid Responses, Few Adverse Effects Seen with Targeted Agent in Phase 1 Trial in Rare Blood Disorder
Dana-Farber Cancer Institute

• Clinical Activity in a Phase 1 Study of BLU-285, a Potent, Highly-Selective Inhibitor of KIT D816V in Advanced Systemic Mastocytosis • Study shows one of multiple ways in which novel targeted cancer therapies are now being deployed to improve outcomes and quality of life for patients with rare, advanced, or difficult-to-treat blood malignancies.

7-Dec-2017 2:15 PM EST
Study Explores Use of Checkpoint Inhibitors After Relapse From Donor Stem Cell Transplant for Hematologic Cancers
Dana-Farber Cancer Institute

Immunotherapy agents known as checkpoint inhibitors have shown considerable promise in patients with hematologic cancers who relapse after a transplant with donor stem cells. Preliminary results from the first clinical trial in these patients of one such agent – nivolumab – indicate that along with signs of effectiveness, it also produced significant side effects at the dose initially studied. The findings indicate a need for further clinical trials in this group before being considered for off-label use with these patients, Dana-Farber Cancer Institute investigators report.

8-Dec-2017 9:30 AM EST
International Research Team Identifies Genetic-Based Model for Predicting Outcomes in Primary Myelofibrosis
Mayo Clinic

A group of investigators from Mayo Clinic and multiple academic research centers in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell transplant to treat their disease.

7-Dec-2017 2:00 PM EST
Immunotherapy Drug for Rheumatoid Arthritis Nearly Eliminates Severe Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplant
Seattle Children's Hospital

Results from a phase 2 clinical trial, presented by Seattle Children’s Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants.

9-Dec-2017 2:00 PM EST
Using Software, Researchers Predict Tumor Markers That Could Be Immune Targets
University of North Carolina Health Care System

Researchers report at the 59th Annual American Society for Hematology Annual Meeting in Atlanta on Saturday, Dec. 9, that they were able to validate their approach for predicting markers – called minor histocompatibility antigens – in a group of patients with blood cancers.

8-Dec-2017 12:05 PM EST
St. Jude Gene Therapy Improves Immunity in Babies with ‘Bubble Boy’ Disease
St. Jude Children's Research Hospital

Preliminary findings indicate gene therapy pioneered at St. Jude Children’s Research Hospital is safe and effective for babies with a devastating inherited disorder that leaves them with little or no immune protection

5-Dec-2017 9:05 PM EST
New Mediola and OlympiAD Trial Results Offer Another Boon for PARP Inhibitors in Treatment of Advanced BRCA-Related Breast Cancer
Perelman School of Medicine at the University of Pennsylvania

Patients with certain advanced hereditary breast cancers may have new treatments options on the horizon, according to two studies presented this week at the annual San Antonio Breast Cancer Symposium. Susan Domchek, MD, executive director of the Basser Center for BRCA at Penn’s Abramson Cancer Center, will present new results from the Mediola and OlympiAD trials showing continued success of treating BRCA-related metastatic breast cancer with the PARP inhibitor olaparib with limited side effects for patients.

8-Dec-2017 10:05 AM EST
For Women with Genetic Risk, Bi-Annual MRI Beats Mammograms
University of Chicago Medical Center

Intensive surveillance including a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) exam every six months was far more effective in detecting breast cancer in younger women with a high-risk genetic profile than an annual mammogram. DCE-MRI every six months performed well for early detection of invasive breast cancer in high-risk women.

Released: 8-Dec-2017 10:05 AM EST
New Online Database Brings the Genome Into Focus Using Molecular Structure
Iowa State University

An online database built by Iowa State University scientists provides a new tool with which researchers can study human biology. The database is freely accessible to anyone on the web, where it allows scientists to study the functions and structure of RNA with greater speed and ease than in the past.

Released: 8-Dec-2017 9:05 AM EST
PARP Inhibitor Improves Progression-Free Survival in Patients with Advanced Breast Cancers and BRCA Mutations
University of Texas MD Anderson Cancer Center

In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes.

6-Dec-2017 4:45 PM EST
How a Seahorse-Shaped Brain Structure May Help Us Recognize Others
Harvard Medical School

Study in mice reveals a brain circuit that regulates social memory formation and recognition. Results shed light on brain’s ability to reconcile conflicting social stimuli, and shed light on anomalies in social behavior seen in neurodevelopmental, neurologic and psychiatric disorders

   
8-Dec-2017 5:00 AM EST
Study Finds Genetic Mutation Causes ‘Vicious Cycle’ in Most Common Form of ALS
Michigan Medicine - University of Michigan

University of Michigan-led research brings scientists one step closer to understanding the development of neurodegenerative disorders such as ALS. A study published today in Nature Communications details what the researchers describe as a vicious cycle of toxic protein production set in motion by cell stress.



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