Com o avanço da idade, as células podem sofrer envelhecimento, um estado no qual elas param de crescer, mas continuam liberando moléculas inflamatórias e tecido degradado.
مدينة روتشستر، ولاية مينيسوتا —مع تقدم السن، يمكن أن تتعرض الخلايا للشَيخُوخَة، وهي حالة تتوقف فيها عن النمو ولكنها تستمر في إطلاق جزيئات التهابية وجزيئات مدمرة للأنسجة. عندما يكون الشخص صغيرًا في السن، يستجيب الجهاز المناعي ويطرح الخلايا الهَرِمة، والتي يشار إليها غالبًا باسم الخلايا الزُومبيّ. ومع ذلك، تبقى خلايا الزُومبيّ باقية وتساهم في العديد من المشاكل والأمراض الصحية المرتبطة بالعمر. سلط الباحثون في مايو كلينك، في دراستين، الضوء على بَيولُوجْيا خلايا الشَيخُوخَة.
Scientists at the UC Davis School of Medicine may have figured out why some people have trouble digesting sorbitol, a sugar alcohol used in sugar-free gum, mints, candy and other products.
A Study by Politecnico di Milano and Istituto Mario Negri has been published in Advanced Materials.
One of the key goals of medical science is to speed up the healing of tissue injuries in a way that would not enable the forming of less functional scar tissue in the affected areas.
Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been uncovered.
Scientists at Cold Spring Harbor Laboratory (CSHL) and the University of California, Davis have reached a new breakthrough in pancreatic cancer research—eight years in the making.
From lab-grown chicken to cricket-derived protein, these innovative alternatives offer hope for a planet struggling with the environmental and ethical impacts of industrial agriculture.
The discovery of a pair of genes that work in perfect harmony to protect male fertility, could provide new insights into some unexplained cases of the most severe form of infertility, research suggests.
Scientists unveil 145 genes vital for genome health, and possible strategies to curb progression of human genomic disorders.
A collaborative effort led by Stuti Sharma, PhD, Assistant Professor in the Department of Biochemistry & Cell Biology at Stony Brook University, resulted in a promising study toward a better understanding of mitochondrial adenosine triphosphate (ATP) synthase.
Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field. The findings were published in the February 14 online issue of Cell. Utilizing data from more than 1,000 tumors across 10 different cancers, the study is the first to integrate DNA, RNA, and proteomics (the study of proteins), revealing the complex interplay of immune cells in tumors. The data came from the Clinical Proteomic Tumor Analysis Consortium (CPTAC), a program under the National Cancer Institute.
New research from the University of Ottawa proposes using vanoxerine as a safe method for potentially eliminating cancer stem cells in colorectal tumors.
Researchers at Children’s Hospital Los Angeles report in The Journal of Molecular Diagnostics about a new tool that effectively integrates data from four fusion callers and identifies disease-related gene fusions.
Below are some of the latest research and features on this growing population of older adults in the Seniors channel on Newswise.
Labeling cancer cells with genetic barcodes “In ReSisTrace, we label cancer cells uniquely with genetic barcodes and allow them to divide once, so that we get two identical sister cells that share the same barcode.
The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon ageing.
Scientists have developed a new AI tool that maps the function of proteins in a cancerous tumour, enabling clinicians to decide how to target treatment in a more precise way.
Improving the way scientists can see the microscopic structures of the brain can improve our understanding of a host of brain diseases, like Alzheimer’s or multiple sclerosis. Studying these diseases is challenging and has been limited by accuracy of available models.To see the smallest parts of cells, scientists often use a technique called electron microscopy.
A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).
Space exploration is a complex and risky mission that requires careful preparation and a thorough understanding of the challenges inherent to life in space
Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages.
The company, based on science from the Hackensack Meridian Center for Discovery and Innovation, promises to capture biomarkers for early detection of disease
Investigators from Cedars-Sinai; the University of California, San Francisco (UCSF); Harvard University; and the Weizmann Institute of Science in Israel conducted a study to determine where individual nutrients are absorbed in the small intestine. For the first time, they identified the molecular markers that define five distinct intestinal regions.
Leguminous plants have a mechanism (rhizobial symbiosis) to efficiently acquire nitrogen, which is an essential macronutrient for growth, through the nitrogen-fixing bacteria rhizobia.
Reporters are invited to register for a complimentary press pass to attend #DiscoverBMB in San Antonio or access press materials electronically. Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology will be held March 23–26 in San Antonio.
The research team investigated the four extracellular matrix proteins Brevican, Neurocan, Tenascin-C and Tenascin-R, which occur in the cell environment of nerve cells of the retina.
University at Albany scientist Scott Tenenbaum, founder of UAlbany spinoff company sxRNA Technologies, Inc. (sxRNA Tech), has received $500,000 from the National Institute on Aging, part of the National Institutes of Health, to study how aging brain cells shape the progression of Alzheimer’s disease, and advance RNA technology that could inform new therapeutics to prevent and treat Alzheimer's and related dementias.
New research led by the University of Washington demonstrates a new class of hydrogels that can form not just outside cells, but also inside of them. These hydrogels exhibited similar mechanical properties both inside and outside of cells, providing researchers with a new tool to group proteins together inside of cells.
The latest research and expertise on the flue can be found in the Influenza channel on Newswise.
Activating calcium channels leads to a deadly influx of calcium ions into tumor cells.
BACKGROUNDPeripheral nerve injury can result in significant clinical complications that have uncertain prognoses. Currently, there is a lack of effective pharmacological interventions for nerve damage, despite the existence of several small
‘Lymphatic plexus’ behind the nose drains cerebrospinal fluid from the brain, potentially impacting neurodegenerative conditions.
A valuable molecule sourced from the soapbark tree and used as a key ingredient in vaccines, has been replicated in an alternative plant host for the first time, opening unprecedented opportunities for the vaccine industry.
Staying hydrated and consuming appropriate amounts of salt is essential for the survival of terrestrial animals, including humans. The human brain has several regions constituting neural circuits that regulate thirst and salt appetite, in intriguing ways.
The intricate dance of nature often unfolds in mysterious ways, hidden from the naked eye. At the heart of this enigmatic tango lies a vital partnership: the symbiosis between plants and a type of fungi known as arbuscular mycorrhizal (AM) fungi.
One major hurdle in the development of safe and effective immunotherapies has been the risk of depleting healthy T cells during CAR-T treatment that seeks out and kills cancerous T-cells. In a new study published in Nature Communications, Yale Cancer Center researchers have developed a novel CAR-T cell therapy designed to efficiently kill cancerous T cells while leaving most healthy cells intact.
Nonfunctional pancreatic neuroendocrine tumors, while rare, are primarily treated through surgery. The presence or absence of lymph node metastasis considerably influences the selection of surgical and other treatment approaches.
New research indicates that it is possible to forestall the onset of menopause, perhaps indefinitely, by implanting a woman’s own previously harvested ovarian tissue back into her body.
In a new article published in Nature Chemistry, Moffitt Cancer Center researchers describe their development of a new reagent that allows a more efficient approach to make sulfoximines, sulfonimidoyl fluorides and sulfonimidamides that may be used in medicines.
Researchers have identified a receptor protein known as CHRM1 as a key player in prostate cancer cells’ resistance to docetaxel, a commonly used chemotherapy drug to treat advanced cancer that has spread beyond the prostate.
As AD for Basic Sciences, Macleod will have oversight of basic research activities across the Center and oversee research program infrastructure.
Live cell imaging is a foundational part of biological research. A variety of methods of time-lapse, 3-D microscopy platforms allow researchers to visualize and follow the dynamic processes of single cells, whole cell populations, and subcellular activity.
Researchers from McGill University, led by Professor Alanna Watt of the Department of Biology, have identified previously unknown changes in brain cells affected by a neurological disease.
Molecular defense system protects bacteria from viruses and at the same time makes them susceptible to antibiotics.
New study shows effectiveness of first drug to focus on cancer-causing protein.
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Researchers with McMaster University have created the instruction manual that will help scientists across the globe find hard to detect B cells.
New study provides insights on role of ‘hunger hormone’ receptor in obesity-realted chronic inflammation.
A new study in Cell Metabolism by a team from the Monell Chemical Senses Center unravels the internal neural wiring of separate fat and sugar craving pathways in a mouse model. However, combining these pathways overly triggers a desire to eat more than usual.
Researchers from The University of Texas MD Anderson Cancer Center reported promising results in a Phase I/II trial of 37 patients with relapsed or refractory B-cell malignancies who were treated with cord blood-derived chimeric antigen receptor (CAR) natural killer (NK) cell therapy targeting CD19.
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