Feature Channels: Dermatology

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Myositis Awareness Month brings attention to a rare autoimmune disease of the muscle that can cause disability for children and adults.

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Targeting telomerase was effective at killing NRAS-mutant melanoma cells, and the impact was further enhanced when the strategy was paired with an inhibitor of mitochondrial function, according to study results by The Wistar Institute published in Oncogene.

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It's important for everyone to perform regular skin self-exams to detect skin cancer early, when it's most treatable.

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In a groundbreaking new study, researchers at the University of Minnesota used a customized, low-cost 3D printer to print electronics on a real hand for the first time.

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TAMPA, Fla. – Patients with advanced or metastatic melanoma have been able to live longer cancer-free lives because of several new therapies approved over the last decade, such as BRAF and MEK inhibitors. However, despite the success of these targeted agents, most patients eventually develop drug resistance and their cancer regrows.

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Skin cancer is the most common cancer in the United States, and it only takes one blistering sunburn during childhood or adolescence to nearly double a person’s chance of developing melanoma, the deadliest form of skin cancer, later in life. To help protect children and adolescents from the sun’s harmful ultraviolet rays, the American Academy of Dermatology has awarded Shade Structure grants to 26 schools and nonprofit organizations across the country.

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University of Delaware assistant professor Karin Gravare Silbernagel has received a five-year, $2.3 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to study Achilles tendinopathy, an overuse injury.

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PAs increasingly used in dermatology to cut costs and improve access, but are less likely than dermatologists to accurately diagnose early stage skin cancers, according to new research.

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Are indoor tanners taking measures to prevent skin cancer? A researcher from Rutgers Cancer Institute of New Jersey and colleagues at Fox Chase Cancer Center found a majority of the indoor tanners analyzed in this study are not taking part in skin cancer screening.

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The Melanoma and Skin Cancer Center at Mercy offers comprehensive care and leading edge treatment options for skin cancers including advanced-stage melanoma.

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A team of Cornell University food scientists has discovered a way to process natural beet juice so that it maintains its bright red color and will allow food manufacturers to use it in place of synthetic dyes in a much greater variety of foods.

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Roswell Park Comprehensive Cancer Center researchers have identified a potential key player promoting cancer progression through changes in the cell environment that are conducive to metastasis.

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A pre-clinical study of two drugs designed to boost T cell performance, has revealed the agents, when give in combination, may enhance the immune system’s ability to kill melanoma tumors deficient in the tumor suppressor gene PTEN. The study was led by investigators at The University of Texas MD Anderson Cancer Center.

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University of Colorado Cancer Center study presented at AACR 2018 shows that even within three days of treatment, melanoma cells find a way to activate MEK – not with mutations, but with a more flexible and temporary way to allow these cancer cells to signal through the MAPK pathway even in the presence of BRAF inhibition.

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Checkpoint inhibitors that block the protein PD-1 are used in melanoma patients after they’ve had surgery to remove their cancer, but not all patients benefit from the immunotherapy. Now a new study from the Abramson Cancer Center of the University of Pennsylvania found that shifting use of anti-PD-1 drugs to before surgery may provide clues about which patients will benefit and which may be at increased risk for recurrence.

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Melanoma, a relatively rare but deadly skin cancer, has been shown to switch differentiation states, which can lead it to become resistant to treatment. Now, UCLA researchers have found that melanomas can be divided into four distinct subtypes according to their stages of differentiation.

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Wistar researchers have identified a novel therapeutic vulnerability in NRAS mutant melanoma and an effective strategy to address it, using a combination of two clinically relevant inhibitors, according to study results published online in EMBO Molecular Medicine.

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In recognition of May’s Melanoma Monday and Skin Cancer Awareness Month, Mount Sinai experts are using new imaging devices to detect early skin cancers, arming the public with vital tips on prevention and offering free skin cancer screenings.

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It can happen fast. One minute the kids are all playing peacefully outside on a warm, spring day. The next minute a piercing scream reveals that one of them has been stung by a bee. To help alleviate the panic, dermatologists from the American Academy of Dermatology say it’s a good idea to know what to do – and not do – to treat a bee sting.

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Click here for the latest research and features on Children's Health.

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Researchers from UT Southwestern’s Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine’s Division of Nephrology recently published work in Nature that reveals the molecular structure of the so-called “anti-aging” protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes.

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A team of researchers at the GW School of Medicine and Health Sciences compared the toxicological impact of cryosurgery with an FDA-approved topical 40 percent hydrogen peroxide solution (A-101) for the treatment of seborrheic keratosis, in human skin equivalents derived from darker skin types. The findings were recently published in the Journal of the American Academy of Dermatology.

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Special report details serious concerns that medical community would be able to do much, if anything, to assist people in event of major nuclear event. Prevention is best option as well as carefully conceived, long-term plan within the public education system to provide lessons on radiation biology

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Board-certified dermatologist Bruce H. Thiers, MD, FAAD, has been elected to lead the American Academy of Dermatology. He will be installed as president-elect in March 2019 and hold the office of president for one year beginning in March 2020.

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The American Academy of Dermatology has announced the results of its annual election.

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Optimizing the timing of targeted therapies for melanoma reverses tumor growth, and resistance can be mitigated.

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A study conducted at The Wistar Institute in collaboration with The University of Texas Southwestern Medical Center has demonstrated the efficacy of targeting aberrantly active telomerase to treat therapy-resistant melanoma.

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The American Academy of Dermatology Association recommends that everyone protect themselves from the sun's harmful ultraviolet rays and perform regular self-exams to check themselves for signs of skin cancer.

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Some cannabis-derived treatments are now being tested for their ability to help certain skin diseases in a new story from nonprofit journalism news service Inside Science (ISNS)

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Although oily skin can clog pores and lead to increased acne breakouts, dermatologists from the American Academy of Dermatology say oily skin also has many benefits. Oil helps preserve the skin, and people with oily skin tend to have thicker skin and fewer wrinkles. The key, say dermatologists, is to strike a balance between having too much oil and maintaining your skin’s natural moisture.

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The American Academy of Dermatology’s 2018 Annual Meeting, which took place Feb. 16-20, drew more than 18,750 attendees from 100 countries to the San Diego Convention Center.

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Researchers in France have discovered that, though a tattoo may be forever, the skin cells that carry the tattoo pigment are not. Instead, the researchers say, the cells can pass on the pigment to new cells when they die. The study, which will be published March 6 in the Journal of Experimental Medicine, suggests ways to improve the ability of laser surgery to remove unwanted tattoos.

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A powerful resistance mutation that appeared to emerge in melanoma after a patient received a targeted therapy combination, instead was lurking in the tumor all along, primed to thwart treatment before it began, researchers at The University of Texas MD Anderson Cancer Center report online at Cancer Discovery.

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Surgical oncologist Dr. Cristina O’Donoghue is one of less than 30 surgeons in the country to trained to perform isolated limb infusion, which delivers high doses of chemotherapy to an affected arm or leg but not the rest of the body

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Science continues to peel away layers of the skin microbiome to reveal its protective properties. In a study published in Science Advances on February 28, University of California San Diego School of Medicine researchers report a potential new role for some bacteria on the skin: protecting against cancer.

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Still’s disease is a serious orphan disease manifested by high fevers, skin and joint involvement, including paralysis, as well as damage to other organs such as the liver or spleen.

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Data from a new study led by University of Kentucky Markey Cancer Center researchers shows that repurposing drugs used to treat leukemia has promise for preventing melanoma metastasis.

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In JCI Insight, researchers reported the results of a phase I, multi-institution clinical trial for an investigational treatment for melanoma and other cancers with mutations in the BRAF or RAS genes.

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UNC and NC State scientists created an injectable gel-like scaffold that can hold combination chemo-immunotherapeutic drugs and deliver them locally to tumors in a sequential manner. The results in animal models suggest this approach could one day ramp up therapeutic benefits for cancer patients.

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Researchers have shown for the first time that a key protein called KMT2D involved in the epigenetic regulation of gene expression guides this renewal.

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Suzanne M. Olbricht, MD, FAAD, a Boston-based dermatologist, will begin her one-year term as president of the American Academy of Dermatology on Tuesday, Feb. 20, at the conclusion of the 2018 AAD Annual Meeting in San Diego.

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The American Academy of Dermatology will install two new officers and four new members of its board of directors on Tuesday, Feb. 20, at the conclusion of the 2018 AAD Annual Meeting in San Diego.

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Microneedling treatments can improve the appearance of large pores, fine lines and wrinkles, scars, and stretch marks, but at-home devices won’t provide the same effects as an in-office treatment from a board-certified dermatologist.

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Because cannabis has anti-inflammatory properties, there may be potential for topical cannabis to improve conditions such as acne, psoriasis and eczema by reducing the inflammation associated with these diseases.

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A survey of more than 1,200 parents indicates that some groups are more likely than others to have favorable attitudes toward adolescent indoor tanning, which can increase young people’s risk of developing skin cancer later in life.

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To get the best possible results and avoid complications, those interested in cosmetic procedures should seek care from a qualified, experienced doctor like a board-certified dermatologist.

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While it may not be as common as other skin cancers, Merkel cell carcinoma is highly aggressive and often deadly — and according to new research, it’s also becoming more common.