Feature Channels: Diabetes

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• Although clinical trials have linked diabetes medications called sodium glucose transport-2 inhibitors to higher bone fracture risks, a large study found no additional risks when the medications were compared with diabetes drugs not associated with fractures. • The findings applied to older adults with normal kidney function as well as to those with mild or moderate kidney disease.

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Old dogs may not learn new tricks, but old drugs can, according to a research team based in China.

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A $2.3 million National Institutes of Health (NIH) grant will fund Jianjun Guan and Fuzhong Zhang’s effort to develop and deliver therapeutic proteins to help treat injured limbs.

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Roma Gianchandani, MD, has joined Cedars-Sinai as the new medical director of Diabetes Quality and vice-chair of Quality and Innovation.

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UCLA researchers have taken the initial step in identifying what may be an effective way to detect gestational diabetes mellitus (GDM) earlier in pregnancy, potentially improving diagnosis and treatment for what is the most common disorder of pregnancy.

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Researchers will delve into the latest research in diabetes, obesity, thyroid health and other endocrine conditions during the Endocrine Society’s ENDO 2022 news conferences June 11-14.

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Scientists have demonstrated that normal brain aging is accelerated by approximately 26% in people with progressive type 2 diabetes compared with individuals without the disease, reports a study published today in eLife.

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A lifestyle intervention program of increased physical activity, healthy eating and aiming for weight loss of 7% or more, or taking the medication metformin were effective long-term to delay or prevent Type 2 diabetes in adults with prediabetes.

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UT Southwestern researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The findings, reported in Nature, might someday lead to new ways to combat metabolic disorders and a variety of other health conditions.

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Studies have demonstrated that exposure to physical and psychological abuse in childhood is associated with cardiovascular risk factors in adulthood, such as high blood pressure, high cholesterol and type 2 diabetes. A new study shows for the first time that well-organized households protect children who have experienced abuse from developing some precursors to heart disease.

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Arterial stiffness was a better predictor of future risk of Type 2 diabetes than blood pressure, and people with a combination of high blood pressure and stiffer arteries had the highest risk of developing diabetes, according to new research published today in Hypertension, a peer-reviewed journal of the American Heart Association.

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New research examines how cavefish developed unique metabolic adaptations to survive in nutrient-scarce environments. The study created a genome-wide map of liver tissue for two independent colonies of cavefish along with river fish to understand how cavefish metabolism evolved and how this may be applicable for humans.

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Endocrine experts will deliver free health services to underrepresented communities, including Latinx and Hispanic residents, during EndoCares® Seattle, an in-person health education event being held on May 14.

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Gary Hammer, M.D., Ph.D., Millie Schembechler Professor of Adrenal Cancer at the University of Michigan in Ann Arbor, Mich., won the Endocrine Society's Endocrine Images Art Competition, a contest celebrating the beauty of endocrine science.

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Healthy sight allows us to experience all of the world’s wonders. Our retinas make good vision possible. The American Society of Retina Specialists (ASRS) encourages the public to learn about the healthy habits that can help safeguard your retinas and your sight.

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Being overweight in childhood increases the risk of developing type 1 diabetes in later life, according to the findings of a new study that analysed genetic data on over 400,000 individuals. The study, co-led by researchers from the Universities of Bristol and Oxford and published today in Nature Communications, also provides evidence that being overweight over many years from childhood influences the risk of other diseases including asthma, eczema and hypothyroidism.

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A poor diet, irrespective of genetic risk factors, is associated with a 30% increased risk of diabetes

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Undertreatment with thyroid hormone replacement can put patients with hypothyroidism at risk for worse hospital outcomes, including longer length of stay and higher rates of readmission, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology and Metabolism.

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Scientists sought to determine whether high blood glucose blunts the body’s response to exercise and whether lowering it can restore the ability to improve aerobic capacity with training.

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Joslin Diabetes Center, the preeminent institution for diabetes research and care, affiliated with Harvard Medical School and a part of Beth Israel Lahey Health, has again been awarded $8.5 million from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK) in continued support for Joslin’s Diabetes Research Center (DRC) program. The grant, which officially began April 1, 2022, marks the 36th continuous year of NIH investment in Joslin’s DRC.

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People with type 2 diabetes who have cognitive impairment could be at greater risk for stroke, heart attack or death than other individuals with diabetes, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology and Metabolism.

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In a new Scientific Statement released today, the Endocrine Society describes the importance of extracellular vesicles as a new research target for understanding the causes of certain endocrine disorders such as cancer and diabetes and discovering new treatments for these disorders.

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Researchers at Children’s Hospital of Philadelphia (CHOP) have shown that a targeted treatment they developed is effective at controlling blood sugar in patients with hyperinsulinism (HI), a genetic disease in which the pancreas produces too much insulin. The findings, which were published today in Diabetes Care, provide further evidence that the treatment could prevent hypoglycemia in patients with HI and may preclude the need for a full removal of their pancreas, a current standard treatment for severe diffuse HI.

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About 5,000 children and teens in the United States are diagnosed with type 2 diabetes each year, and the rate is increasing about 5% annually, putting thousands of children at risk for diabetic kidney disease (DKD). While DKD is still considered relatively rare in children, Katherine Kutney, an assistant professor of pediatrics at Case Western Reserve University, expects cases to increase from pandemic-induced obesity—the lack of physical activity, more time spent stationary in front of computer screens. But DKD in children may be slowed with medication therapy if signs of the disease can be detected early and monitored—the goal of new research Kutney will pursue with a 2021 Hartwell Individual Biomedical Research Award.

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Metabolic syndrome increases a person’s risk for diabetes, heart disease, and stroke, and includes conditions such as obesity, high blood pressure and high blood sugar. In a recent mouse-model study, published in Cell Metabolism, researchers at University Hospitals (UH), Harrington Discovery Institute at UH, and Case Western Reserve University have furthered their progress to develop a drug to treat metabolic syndrome by identifying a receptor that controls appetite and body weight.

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Investigators at the University of Miami Miller School of Medicine have designed RNA molecules that home to human pancreatic beta cells, the cells that produce insulin and are destroyed in patients with type 1 and type 2 diabetes. This targeting approach could help researchers study how these diseases progress and provide new ways to deliver treatments. The study titled “was published on April 5 in Nature Communications.

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People who have difficulty getting to sleep or staying asleep had higher blood sugar levels than people who rarely had sleep issues, new research has found. The findings suggest insomnia could increase people’s risk of type 2 diabetes, and that lifestyle or pharmacological treatments that improve insomnia could help to prevent or treat the condition.

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Here are some of the latest articles that have been added to the Clinical Trials channel on Newswise.

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Black people with diabetes were more likely to develop cases of a life-threatening complication called diabetic ketoacidosis during the pandemic, even in people without COVID-19, according to a new study from the TID Exchange published in the Endocrine Society’s Journal of Clinical Endocrinology and Metabolism.

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Treating wounds with an extract taken from wild blueberries may improve healing, according to a new study. The research will be presented this week in Philadelphia at the American Physiological Society’s (APS) annual meeting at Experimental Biology 2022.

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Researchers have successfully used a virtual population to replicate a clinical trial that examined kidney damage in Black Americans, according to a new study at the University of Mississippi Medical Center in Jackson.