Scientists have identified a new target in ovarian cancer that is particularly vulnerable to chemotherapy. The discovery will allow researchers to better predict how this cancer will behave, particularly the most common and lethal, high-grade serous ovarian cancer (HGSOC). Ovarian cancer is one of the leading causes of cancer deaths among women.
Extracytoplasmic function sigma factors (ECFs) have been successfully used for constructing predictable artificial gene circuits bacteria like Escherichia coli, but their transferability between species within the same phylum remained unknown.
Middle-age veterans who experienced concussions due to blasts from explosive devices may have biomarkers in their spinal fluid similar to people who develop Alzheimer’s disease, according to a new study published in the March 13, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Soil stores 80 percent of carbon on earth, yet with increasing cycles of drought, that crucial reservoir is cracking and breaking down, releasing even more greenhouse gases creating an amplified feedback loop that could accelerate climate change.
Researchers from Rutgers Health and other institutions dispute claims that the maternal death rate in the United States has climbed steeply in the past two decades.
A research team led by Dr. Sangheon Kim of the Center for Biomaterials Research at the Korea Institute of Science and Technology (KIST) announced that they have developed a three-dimensional stem cell therapy to treat critical limb ischemia through a self-assembling platform technology using a new material microgel.
The fertility of both female and male tsetse flies is affected by a single burst of hot weather, researchers at the University of Bristol and Stellenbosch University in South Africa have found.
New research led by the University of South Australia explains how eating faeces (known as coprophagy) shapes wild birds’ digestive tracts (gut biota), enabling them to absorb lost or deficient nutrients and adjust to seasonal variations in food sources.
Supporting kids with maths homework is a common afterschool activity. But beyond the basics, new curricula and teaching strategies are making it harder for parents to help and it’s taking a serious toll on children’s confidence and learning.
Participants in the program saw improved blood pressure, BMI, and triglycerides.
In two experiments, Temple and Pitt researchers asked participants to repeatedly study pairs of items and scenes that were either identical on each repetition or in which the item stayed the same but the scene changed each time.
Adults 65 and older, who were hospitalized for a variety of medical conditions, had highly satisfying conversations about whether they wanted CPR, regardless of whether doctors used the terms “allow a natural death” or “do not resuscitate” for indicating no CPR, according to a pilot study by Rutgers Health researchers. The study, which found 83 percent wished to be resuscitated, is the first to report on the resuscitation preferences for general inpatients older than age 65.
A team of researchers at ORNL demonstrated that a light-duty passenger electric vehicle can be wirelessly charged at 100-kW with 96% efficiency using polyphase electromagnetic coupling coils with rotating magnetic fields.
New sociological research looks into the relationship between a lower-class background and the experience of imposter syndrome in academia, examining it as something borne of sociological processes as opposed to how it is typically understood—as the result of individual shortcomings.
A new telescope called the “Condor Array Telescope” may open up a new world of the very-low-brightness Universe for astrophysicists.
Irvine, Calif., March 12, 2024 — Scientists know relatively little about particles released into the air when a vehicle driver brakes, though evidence suggests those particles may be more harmful to health than particles exiting the tailpipe.
JMIR Publications is pleased to announce a new theme issue titled “Diversity in Dermatology” in JMIR Dermatology. The premier, peer-reviewed journal is indexed in Sherpa Romeo, Scopus, DOAJ, CABI, and PubMed Central/PubMed and is the official journal of the International Society of Digital Health in Dermatology (ISDHD).
A new University of Miami study shows that a person’s ability to sustain their attention while performing a task decreases over time.
For telescopes operating in the vacuum of space, or optical equipment in extreme environments, existing coatings are often insufficient. In the Journal of Vacuum Science & Technology Aresearchers in China turned to atomic layer deposition and developed an ultrablack thin-film coating for aerospace-grade magnesium alloys. The team used alternating layers of aluminum-doped titanium carbide and silicon nitride and together the materials prevent nearly all light from reflecting off the coated surface. The coating absorbs 99.3% of light while being durable enough to survive in harsh conditions.
A collaborative study between a bariatric and transplant surgery team has introduced new hope for patients suffering from end-stage renal disease (ESRD) who are also struggling with obesity. The study authors explored the outcomes of metabolic and bariatric surgery in ESRD patients and whether the surgery can improve their eligibility for kidney transplants. The findings are published in the Journal of the American College of Surgeons (JACS).
There is enough evidence to evaluate several health benefits in children associated with adding isolated and synthesized fibers to food.
Declining atmospheric sulfur dioxide levels might be related to the global rise in Legionnaires’ disease, according to a new UAlbany study which examined trends in atmospheric sulfur dioxide, Legionnaires’ disease incidence, and the role of cooling towers in harboring Legionella.
Researchers investigating how exactly the brain processes the incoming stream of information from the heart and lungs, discovered that specific neurons in the thalamus are actively involved in processing cardiac and respiratory signals.
If left to their own devices, bacteria on our teeth or wounded skin can encase themselves in a slimy scaffolding, turning into what is called biofilm. These bacteria wreak havoc on our tissue and, being shielded from antibiotic medication by the slime, are difficult to dislodge.
In an article recently published in Scientific Reports, researchers from Bar-Ilan University reveal the mechanism underlying successful machine learning, which enables it to perform classification tasks with resounding success.
The risk of dying while waiting for a liver transplant or having a transplant fail for patients with alcohol-associated liver diseases is higher among racial and ethnic minorities, according to UT Southwestern Medical Center researchers.
"Just talking" is a common phrase used by college students to describe a type of relationship.
A new study offers potential insights into how and when we fill out March Madness brackets. The paper found that people are more risk seeking (more likely to predict a relatively improbable outcome) in their later forecasts and are thus more likely to make an incorrect prediction for them.
A new analysis of 5.8 million Americans finds that earning a college degree is still a sound investment, although the rate of economic return varies across college majors and student demographics.
Gait impairments often are prevalent in the early stages of cognitive decline. Researchers quantitatively compared straight walking and curved walking – a more natural yet complex activity – in healthy older adults and adults with mild cognitive impairment (MCI). A depth camera detected and tracked 25 joints of body movement and signals were processed to extract 50 gait markers. Intriguingly, curved walking illuminated notable disparities between the study groups.
Pioneering research unveils lignin nanoparticles as potent UV-blocking agents, with their chemical structure and size effects extensively altering the sun protection efficacy of cosmetics. LNPs with tailored structures outperform conventional additives, offering enhanced UV resistance and eco-friendly solutions for skincare formulations.
The researchers carried out a hybridization experiment between female koi carp and male Chinese rare minnow, eventually obtaining allodiploid and allotriploid hybrid offspring. They made a systemic comparison between them and found that the triploid hybrids showed faster growth, higher expression of growth-promoting genes and lower expression of growth-inhibiting genes than the diploid hybrids. This study provides implications to explain the faster growth of polyploid fish.
Researchers use game theory to analyze the eco-label strategy selection of the manufacturer in green supply chain.
A recent study has highlighted the insignificant health hazards posed by the emissions from waste-to-energy (WtE) facilities in China's Bohai Rim. This investigation brings to light the negligible impact of WtE plant emissions on public health, grounded in sophisticated regression analysis techniques.
This study discovers that upon induction of different autophagy processes, mitochondria immediately import calcium and calcium concentrations at the ER membrane start to fluctuate. The major calcium import channel in the inner mitochondrial membrane, mitochondrial calcium uniporter (MCU), is required for mitophagy-inducer-initiated mitochondrial calcium uptake. Inhibiting MCU accelerates mitophagy. In neurons derived from a Parkinson’s patient, mitophagy-inducer-triggered mitochondrial calcium influx is faster, which may slow the ensuing mitophagy.
UC San Diego Professor of Physics Nigel Goldenfeld has shown in theoretical models of turbulence that even molecular motions can create large-scale patterns of randomness over a defined period of time.
While lifesaving, bone marrow transplants can affect various organs, including the cardiovascular system. Researchers led by Michigan Medicine have not only determined the contemporary prevalence of cardiovascular complications after bone marrow transplant — they developed a novel tool to predict a person’s risk for such problems following the procedure and help guide the pre-transplant process.The work formed the basis of a scientific statement published by the American Health Association geared towards the cardiovascular management of patients undergoing bone marrow transplant.
Researchers at the University of Minnesota Twin Cities may have discovered a mechanical explanation for instability observed in the lungs in cases of acute respiratory distress syndrome (ARDS), particularly in the aftermath of respiratory illnesses such as COVID-19 or pneumonia.
The effort to find and fight health disparities relies on data from millions of patients, including their race and ethnicity. But a new study finds the same patient might have different data recorded at separate ER visits.
Age-related changes that cause the skin to stiffen and become less elastic may also contribute to higher rates of metastatic skin cancer in older people, according to research by investigators from the Johns Hopkins Kimmel Cancer Center.
Individual wellbeing doesn’t always add up to team wellbeing – but reflection and open communication can help
A new study highlights a potential therapeutic target for immune-related disorders, such as multiple sclerosis and asthma.
Researchers found that a formula used in statistical analysis provides a streamlined mathematical description of how neural networks, such as GPT-2, a precursor to ChatGPT, learn relevant patterns in data, known as features. This formula also explains how neural networks use these relevant patterns to make predictions. The team presented their findings in the March 7 issue of the journal Science.
Researchers at the U.S. Department of Energy’s Argonne National Laboratory have tested the performance of a new device that boosts particle signals.
At high temperatures and densities, plasmas in fusion devices can develop gradients that can grow into instabilities, including edge localized modes (ELMs) that can damage reactor walls. In this research, scientists studied negative triangularity, a way the plasma shape can deviate from an oval. The research found this shaping was inherently free of instabilities across various plasma conditions, including operating reactor conditions.
New research from the UW examines how three wellness Instagram influencers profited from anti-vaccine misinformation.
Michigan State University researchers have provided new answers to that question by analyzing soil microbes near a mine fire that’s been burning for more than 60 years.
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